Alterations in rat brain thyroid hormone status following pre-and postnatal exposure to polychlorinated biphenyls (Aroclor 1254)

Toxicology and Applied Pharmacology

Volumn 136, Issue 2, 1996, Pages 269-279

  Morse, Dennis C ^a   Wehler, Eva Klasson ^b   Wesseling, Wendelien ^a   Koeman, Jan H ^a   Brouwer, Abraham ^a  

^a WAGENINGEN UNIVERSITY   (Netherlands)

^b STOCKHOLM UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

AROCLOR 1254; POLYCHLORINATED BIPHENYL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN; CONTROLLED STUDY; FEMALE; GLUCURONIDATION; LIVER MICROSOME; MALE; METABOLITE; NONHUMAN; PERINATAL DRUG EXPOSURE; PRENATAL EXPOSURE; RAT; THYROID HORMONE METABOLISM; THYROXINE BLOOD LEVEL;

ANIMALS; ANIMALS, NEWBORN; ANTITHYROID AGENTS; AROCLOR 1254; AROCLORS; BRAIN; FEMALE; FETUS; GLUCURONATES; IODIDE PEROXIDASE; MALE; MATERNAL EXPOSURE; MICROSOMES, LIVER; POLYCHLORINATED BIPHENYLS; PREGNANCY; RATS; RATS, WISTAR; THYROTROPIN; THYROXINE; TRIIODOTHYRONINE;

EID: 0030060262     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1006/taap.1996.0034     Document Type: Article

References (44)

1. Barter, R. A., and Klaassen, C. D. (1992). UDP-glucuronosyltransferase inducers reduce thyroid hormone levels in rats by an extrathyroidal mechanism. Toxicol. Appl. Pharmacol. 113, 36-42.
2. Barter, R. A., and Klaassen, C. D. (1994). Reduction of thyroid hormone levels and alteration of thyroid function by four representative UDP-glucuronyltransferase inducers in rats. Toxicol. Appl. Pharmacol. 128, 9-17.
3. Bastomsky, C. H. (1976). Goiters in rats fed polychlorinated biphenyls. Can. J. Physiol. Pharmacol. 55, 288-293.
4. Bastomsky, C. H. (1977). Enhanced thyroxine metabolism and high uptake goiters after a single dose of 2,3,7,8-tetrachlorodibenzo-p-dioxin. Endocrinology 101, 292-296.
5. Beetstra, J. B., Van Engelen, J. G. M., Karels, P., Van der Hoek, H. J., De Jong, M., Docter, R., Krenning, E. P., Henneman, G., Brouwer, A., and Visser, T. J. (1991). Thyroxine and 3,3′,5-triiodothyronine are glucuronidated in rat liver by different uridine diphosphate-glucuronyltransferases. Endocrinology 128, 741-746.
6. Bergman, Å., Klasson Wehler, E., and Kuroki, H. (1994). Selective retention of hydroxylated PCB metabolites in blood. Environ. Health Perspect. 102, 464-469.
7. Brewster, D. W., Elwell, M. R., Birnbaum, L. S. (1988). Toxicity and disposition of 2,3,4,7,8-pentachlorodibenzofuran (4PeCDF) in the rhesus monkey (Macaco mulatta). Toxicol. Appl. Pharmacol. 93, 231-246.
8. Brouwer, A., and van den Berg, K. J. (1986). Binding of a metabolite of 3,4,3′,4′-tetrachlorobiphenyl to transthyretin reduces serum vitamin A transport by inhibiting the formation of the protein complex carrying both retinol and thyroxin. Toxicol. Appl. Pharmacol. 85, 301-312.
9. Brouwer, A., Klasson-Wehler, E., Bokdam, M., Morse, D. C., and Traag, W. A. (1990). Competitve inhibition of thyroxin binding to transthyretin by monohydroxy metabolites of 3,4,3′,4′-tetrachlorobiphenyl. Chemosphere 20, 1257-1262.
10. Byrne, J. J., Carbone, J. P., and Hanson, E. A. (1987). Hypothyroidism and abnormalities in the kinetics of thyroid hormone metabolism in rats treated chronically with polychlorinated biphenyl and polybrominated biphenyl. Endocrinology 121, 520-527.
11. Calvo, R., Obregón, M. J., Ruiz de Oña, C., Escobar del Rey, F., and Morreale de Escobar, G. (1990). Congenital hypothyroidism, as studied in rats: The crucial role of maternal thyroxine but not of 3,5,3′-triiodothyronine in the protection of the fetal brain. J. Clin. Invest. 86, 889-899.
12. Collins, W. T., and Capen, C. C. (1980a). Fine structural lesions and hormone alterations in thyroid glands of perinatal rats exposed in utero and by the milk to polychlorinated biphenyls. Am. J. Pathol. 99, 125-142.
13. 125I-thyroxine and fine structural alterations in the thyroid glands of Gunn rats fed polychlorinated biphenyls (PCB). Lab. Invest. 43, 158-164.
14. 14C]-biphenyl in pregnant mice: Enrichment of phenol and methyl sulphone metabolites in late gestational fetuses. Xenobiotica 16, 295-306.
15. Davis, P. J. (1991). In The Thyroid (R. D. Utiger and L. E. Braverman, Eds.), pp. 190-203, Lippincott, Philadelphia.
16. Emmett, E. A., Maroni, M., Jefferys, J., Schmith, J., Levin, B. K., and Alvares, A. (1988). Studies of transformer repair workers exposed to PCBs. II. Results of clinical laboratory investigations. Am. J. Ind. Med. 14, 47-62.
17. Jansen, H. T., Cooke, P. S., Porcelli, J., Liu, T.-C., and Hansen, L. G. (1993). Estrogenic and anti-estrogenic actions of PCBs in the female rat: In vitro and in vivo studies. Reprod. Toxicol. 7, 237-248.
18. Juárez de Ku, L. M., Sharma-Stokkermans, M., and Meserve, L. A. (1995). Thyroxine normalizes polychlorinated biphenyl (PCB) dose-related depression of choline acetyltransferase (ChAT) activity in hippocampus and basal forebrain of 15-day-old rats. Toxicology 94, 19-30.
19. Kaplan, M. M., Visser, T. J., Yaskoski, K. A., and Leonard, J. L. (1983). Characteristics of iodothyronine tyrosyl ring deiodination by rat cerbral cortical microsomes. Endocrinology 112, 35-42.
20. Klasson Wehler, E., Lindberg, L., Jönsson, C.-J., and Bergman, Å. (1993). Tissue retention and metabolism of 2,3,4,3′,4′-pentachlorobiphenyl in mink and mouse. Chemosphere 27, 2397-2412.
21. Koopman-Esseboom, C., Morse, D. C., Weisglas-Kuperus, N., Lutke-Schipholt, I., Van der Paauw, C. G., Tuinstra, L. G. M. Th., Brouwer, A., and Sauer, P. J. J. (1994). Effects of dioxins and polychlorinated biphenyls on thyroid hormone status of pregnant women and their infants. Pediatr. Res. 36, 468-473.
22. Korach, K. S., Sarver, P., Chae, K., McLachlan, J. A., and McKinney, J. D. (1988). Estrogen receptor-binding activity of polychlorinated hydroxybiphenyls: Conformationally restricted structural probes. Mol. Pharmacol. 33, 120-126.
23. Lans, M. C., Klasson Wehler, E., Willemsen, M., Meussen, E., Safe, S., and Brouwer, A. (1993). Structure-dependent, competitive interaction of hydroxy-polychlorobiphenyls, -dibenzo-p-dioxins and -dibenzofurans with human transthyretin. Chem.-Biol. Interact. 88, 7-21.
24. Lucier, G. W., McDaniel, O. S., Schiller, C. M., and Matthews, H. B. (1978). Structural requirements for the accumulation of chlorinated biphenyl metabolites in the fetal rat intestine. Drug. Metab. Dispos. 6, 584-590.
25. McKinney, J. D., Fannin, R., Jordan, S., Chae, K., Rickenbacher, U., and Pederson, L. (1987). Polychlorinated biphenyls and related compound interactions with specific binding sites for thyroxine in rat nuclear extracts. J. Med. Chem. 30, 79-86.
26. Morreale de Escobar, G., Pastor, R., Obregon, M. J., and Escobar del Rey, F. (1985). Effects of maternal hypothyroidism on the weight and thyroid hormone content of rat embryonic tissues before and after the onset of fetal thyroid function. Endocrinology 117, 1890-1900.
27. Morreale de Escobar, G., Obregon, M. J., Ruiz de Ona, C., and Escobar del Rey, F. (1989). Comparison of maternal to fetal transfer of 3,5,3′-triiodothyronine versus thyroxine in rats, as assessed from triiodothyronine levels in fetal tissues. Acta Endocrinol. 120, 20-30.
28. Morreale de Escobar, G., Calvo, R., Obregon, M. J., and Escobar del Rey, F. (1990). Contribution of maternal thyroxine to fetal thyroxine pools in normal rats near term. Endocrinology 126, 2765-2767.
29. Morreale de Escobar, G., Calvo, R., Escobar del Rey, F., and Obregon, M. J. (1993). Differential effects of thyroid hormones on growth and thyrotropic hormones in rat fetuses near term. Endocrinology 132, 2056-2064.
30. Morse, D. C., Groen, D., Veerman, M., Van Amerongen, C. J., Koëter, H. B. W. M., Smits Van Prooije, A. E., Visser, T. J., Koeman, J. H., and Brouwer, A. (1993a). Interference of polychlorinated biphenyls in hepatic and brain thyroid hormone metabolism in fetal and neonatal rats. Toxicol. Appl. Pharmacol. 122, 27-33.
31. Morse, D. C., Wesseling, W., Brouwer, A., and Van den Berg, K. J. (1993b). Prenatal Aroclor 1254 exposure selectively alters regional glial fibrillary acidic protein levels in the rat brain. In Organohalogen Compounds (H. Fielder, H. Frank, O. Hutzinger, W. Parzefall, A. Riss, and S. Safe, Eds.), Vol. 14. Federal Environmental Agency, Vienna.
32. Morse, D. C., and Brouwer, A. (1995). Fetal, neonatal and long-term alterations in hepatic retinoid levels following maternal polychlorinated biphenyl exposure in rats. Toxicol. Appl. Pharmacol. 131, 175-182.
33. Morse, D. C., Klasson Wehler, E., van de Pas, M., de Bie, A. Th. H. J., van Bladeren, P. J., and Brouwer, A. (1995a). Metabolism and biochemical effects of 3,3′,4,4′-tetrachlorobiphenyl in pregnant and fetal rats. Chem.-Biol. Interact. 95, 41-56.
34. Morse, D. C., van Bladeren, P. J., Klasson Wehler, E., and Brouwer, A. (1995b). β-Naphthoflavone-and self-induced metabolism of 3,3′,4,4′-tetrachlorobiphenyl in hepatic microsomes of the male, pregnant female and foetal rat. Xenobiotica 25, 245-260.
35. Ness, D. K., Schantz, S. L., and Hansen, L. G. (1994). PCB congeners in the rat brain: Selective accumulation and lack of regionalization. J. Toxicol. Environ. Health 43, 453-468.
36. Ness, D. K., Schantz, S. L., Moshtaghian, J., and Hanson, L. G. (1993). Effects of perinatal exposure to specific PCB congeners on thyroid hormone concentrations and thyroid histology in the rat. Toxicol. Lett. 68, 311-323.
37. Pluim, H. J., Koppe, J. G., Olie, K., Van der Slikke, J. W., Vulsma, T., Kok, J. H., Van Tijn, D., and De Vijlder, J. J. M. (1992). Effects of dioxins on thyroid function in newborn babies. Lancet 339, 1303.
38. Rickenbacher, U., McKinney, J. D., Oatley, S. J., and Blake, C. C. F. (1986). Structurally specific binding of halogenated biphenyls to thyroxine transport protein. J. Med. Chem. 29, 641-648.
39. Rogan, W. J., Gladen, B. C., McKinney, J. D., Carreras, N. C., Hardy, P., Thullen, J., Tingelstad, J., and Tulley, M. (1986). Neonatal effects of transplacental exposure to PCBs and DDE. J. Pediatr. 109, 335-341.
40. Shain, W., Overmann, S. R., Wilson, L. R., Kostas, J., and Bush, B. (1986). A congener analysis of polychlorinated biphenyls accumulating in rat pups after perinatal exposure. Arch. Environ. Contam. Toxicol. 15, 687-707.
41. 125I]-triiodothyronine degradation in rats pretreated with polyhalogenated biphenyls. Food Chem. Toxicol 22, 743-747.
42. Van den Berg, K. J., Zurcher, C., and Brouwer, A. (1988). Effects of 3,4,3′,4′-tetrachlorobiphenyl on thyroid function and histology in marmoset monkeys. Toxicol. Lett. 41, 77-86.
43. Visser, T. J., Leonard, J. L., Kaplan, M. M., and Larsen, P. R. (1982). Kinetic evidence suggesting two mechanisms for iodothyronine 5′-deiodination in rat cerebral cortex. Proc. Natl. Acad. Sci. USA 79, 5080-5084.
44. Yoshimura, H., Yonemoto, Y., Yamada, H., Koga, N., Oguri, K., and Saeki, S. (1987). Metabolism in vivo of 3,4,3′,4′-tetrachlorobiphenyl and toxicological assessment of the metabolites in rats. Xenobiotica 19, 1307-1318.