Protein kinase C-δ is involved in the inflammatory effect of IL-6 in mouse adipose cells

Diabetologia

Volumn 53, Issue 5, 2010, Pages 946-954

  Wallerstedt, E ^a   Smith, U ^a   Andersson, C X ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

3T3 L1; IL 6; Inflammation; Insulin resistance; Obesity; PKC delta; STAT3

Indexed keywords

HAPTOGLOBIN; INSULIN; INTERLEUKIN 6; PROTEIN KINASE C DELTA; ROTTLERIN; SERINE; SERUM AMYLOID A; SERUM AMYLOID A 3; STAT3 PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING 3; TYROSINE; UNCLASSIFIED DRUG;

ADIPOSE TISSUE CELL; ANIMAL CELL; ARTICLE; CELL LYSATE; CELL NUCLEUS; CONTROLLED STUDY; CYTOPLASM; EMBRYO; EMBRYO CELL; ENZYME DEFICIENCY; ENZYME INHIBITION; FIBROBLAST; GENE ACTIVATION; GENE EXPRESSION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; PROTEIN TARGETING; PROTEIN TRANSPORT; RNA EXTRACTION; TRANSCRIPTION REGULATION; WILD TYPE;

ACETOPHENONES; ADIPOCYTES; ANIMALS; BENZOPYRANS; BLOTTING, WESTERN; CELL LINE; CELLS, CULTURED; GENE EXPRESSION; INFLAMMATION; INTERLEUKIN-6; MICE; PHOSPHORYLATION; PROTEIN KINASE C-DELTA; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SERUM AMYLOID A PROTEIN; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; STATISTICS, NONPARAMETRIC; TRANSCRIPTIONAL ACTIVATION;

EID: 77952089532     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-010-1668-1     Document Type: Article

References (37)

1. B Gustafson A Hammarstedt CX Andersson U Smith 2007 Inflamed adipose tissue: a culprit underlying the metabolic syndrome and atherosclerosis Arterioscler Thromb Vasc Biol 27 2276 2283 10.1161/ATVBAHA.107.147835 1:CAS:528:DC%2BD2sXhtFKitbbM 17823366 (Pubitemid 350203940)
2. JC Pickup MB Mattock GD Chusney D Burt 1997 NIDDM as a disease of the innate immune system: association of acute-phase reactants and interleukin-6 with metabolic syndrome X Diabetologia 40 1286 1292 10.1007/s001250050822 1:CAS:528:DyaK2sXntFynsbc%3D 9389420 (Pubitemid 27469668)
3. VR Sopasakis M Sandqvist B Gustafson, et al. 2004 High local concentrations and effects on differentiation implicate interleukin-6 as a paracrine regulator Obes Res 12 454 460 10.1038/oby.2004.51 1:CAS:528: DC%2BD2cXjs1Srtro%3D 15044662 (Pubitemid 41132524)
4. V Mohamed-Ali S Goodrick A Rawesh, et al. 1997 Subcutaneous adipose tissue releases interleukin-6, but not tumor necrosis factor-alpha, in vivo J Clin Endocrinol Metab 82 4196 4200 10.1210/jc.82.12.4196 1:CAS:528: DyaK2sXnvFyrsrw%3D 9398739 (Pubitemid 27525539)
5. JJ Senn PJ Klover IA Nowak RA Mooney 2002 Interleukin-6 induces cellular insulin resistance in hepatocytes Diabetes 51 3391 3399 10.2337/diabetes.51.12. 3391 1:CAS:528:DC%2BD38Xptl2ntbk%3D 12453891 (Pubitemid 35403441)
6. JP Bastard M Maachi JT van Nhieu, et al. 2002 Adipose tissue IL-6 content correlates with resistance to insulin activation of glucose uptake both in vivo and in vitro J Clin Endocrinol Metab 87 2084 2089 10.1210/jc.87.5.2084 1:CAS:528:DC%2BD38XjsFGhtLo%3D 11994345 (Pubitemid 34521492)
7. PA Kern S Ranganathan C Li L Wood G Ranganathan 2001 Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistance Am J Physiol Endocrinol Metab 280 E745 E751 1:CAS:528: DC%2BD3MXjsVahs7s%3D 11287357 (Pubitemid 32466842)
8. V Rotter I Nagaev U Smith 2003 Interleukin-6 (IL-6) induces insulin resistance in 3T3-L1 adipocytes and is, like IL-8 and tumor necrosis factor-alpha, overexpressed in human fat cells from insulin-resistant subjects J Biol Chem 278 45777 45784 10.1074/jbc.M301977200 1:CAS:528:DC%2BD3sXosl2itrs%3D 12952969 (Pubitemid 37432722)
9. S Franckhauser I Elias V Rotter Sopasakis, et al. 2008 Overexpression of Il6 leads to hyperinsulinaemia, liver inflammation and reduced body weight in mice Diabetologia 51 1306 1316 10.1007/s00125-008-0998-8 1:CAS:528: DC%2BD1cXmslWhurc%3D 18437347
10. M Fasshauer S Kralisch M Klier, et al. 2003 Adiponectin gene expression and secretion is inhibited by interleukin-6 in 3T3-L1 adipocytes Biochem Biophys Res Commun 301 1045 1050 10.1016/S0006-291X(03)00090-1 1:CAS:528: DC%2BD3sXhtVerurs%3D 12589818 (Pubitemid 36279218)
11. B Emanuelli P Peraldi C Filloux D Sawka-Verhelle D Hilton E van Obberghen 2000 SOCS-3 is an insulin-induced negative regulator of insulin signaling J Biol Chem 275 15985 15991 10.1074/jbc.275.21.15985 1:CAS:528: DC%2BD3cXjvFaisbo%3D 10821852 (Pubitemid 30366903)
12. L Rui M Yuan D Frantz S Shoelson MF White 2002 SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2 J Biol Chem 277 42394 42398 10.1074/jbc.C200444200 1:CAS:528:DC%2BD38XotF2gu7g%3D 12228220 (Pubitemid 35257562)
13. K Ueki T Kondo CR Kahn 2004 Suppressor of cytokine signaling 1 (SOCS-1) and SOCS-3 cause insulin resistance through inhibition of tyrosine phosphorylation of insulin receptor substrate proteins by discrete mechanisms Mol Cell Biol 24 5434 5446 10.1128/MCB.24.12.5434-5446.2004 1:CAS:528: DC%2BD2cXkvFOqtLg%3D 15169905 (Pubitemid 38738176)
14. H Shi B Cave K Inouye C Bjorbaek JS Flier 2006 Overexpression of suppressor of cytokine signaling 3 in adipose tissue causes local but not systemic insulin resistance Diabetes 55 699 707 10.2337/diabetes.55.03.06.db05- 0841 1:CAS:528:DC%2BD28XisVWis7g%3D 16505233 (Pubitemid 43343226)
15. PC Heinrich I Behrmann S Haan HM Hermanns G Muller-Newen F Schaper 2003 Principles of interleukin (IL)-6-type cytokine signalling and its regulation Biochem J 374 1 20 10.1042/BJ20030407 1:CAS:528:DC%2BD3sXmtF2hurs%3D 12773095 (Pubitemid 37046923)
16. PC Heinrich I Behrmann G Muller-Newen F Schaper L Graeve 1998 Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway Biochem J 334 297 314 1:CAS:528:DyaK1cXmtFOls7c%3D 9716487 (Pubitemid 28448572)
17. X Zhang J Blenis HC Li C Schindler S Chen-Kiang 1995 Requirement of serine phosphorylation for formation of STAT-promoter complexes Science 267 1990 1994 10.1126/science.7701321 1:CAS:528:DyaK2MXkslOktbc%3D 7701321
18. JJ Schuringa LV Dekker E Vellenga W Kruijer 2001 Sequential activation of Rac-1, SEK-1/MKK-4, and protein kinase Cdelta is required for interleukin-6-induced STAT3 Ser-727 phosphorylation and transactivation J Biol Chem 276 27709 27715 10.1074/jbc.M009821200 1:CAS:528:DC%2BD3MXlsV2itrY%3D 11335711 (Pubitemid 37410695)
19. Z Wen Z Zhong JE Darnell Jr 1995 Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation Cell 82 241 250 10.1016/0092-8674(95)90311-9 1:CAS:528:DyaK2MXnt1Gltrk%3D 7543024
20. J Turkson T Bowman J Adnane, et al. 1999 Requirement for Ras/Rac1-mediated p38 and c-Jun N-terminal kinase signaling in Stat3 transcriptional activity induced by the Src oncoprotein Mol Cell Biol 19 7519 7528 1:CAS:528:DyaK1MXmvFekt7o%3D 10523640 (Pubitemid 29493415)
21. K Abe M Hirai K Mizuno, et al. 2001 The YXXQ motif in gp 130 is crucial for STAT3 phosphorylation at Ser727 through an H7-sensitive kinase pathway Oncogene 20 3464 3474 10.1038/sj.onc.1204461 1:CAS:528:DC%2BD3MXkvVals7o%3D 11429693 (Pubitemid 32619401)
22. N Jain T Zhang WH Kee W Li X Cao 1999 Protein kinase C delta associates with and phosphorylates Stat3 in an interleukin-6-dependent manner J Biol Chem 274 24392 24400 10.1074/jbc.274.34.24392 1:CAS:528:DyaK1MXlsVOmsrg%3D 10446219 (Pubitemid 29390380)
23. CX Andersson VR Sopasakis E Wallerstedt U Smith 2007 Insulin antagonizes interleukin-6 signaling and is anti-inflammatory in 3T3-L1 adipocytes J Biol Chem 282 9430 9435 10.1074/jbc.M609980200 1:CAS:528:DC%2BD2sXjtlCitrY%3D 17267401 (Pubitemid 47104618)
24. D Jackson Y Zheng D Lyo, et al. 2005 Suppression of cell migration by protein kinase Cdelta Oncogene 24 3067 3072 10.1038/sj.onc.1208465 1:CAS:528:DC%2BD2MXjsVeqtr8%3D 15735725 (Pubitemid 40675540)
25. P Ramadoss NE Unger-Smith FS Lam AN Hollenberg 2009 STAT3 targets the regulatory regions of gluconeogenic genes in vivo Mol Endocrinol 23 827 837 10.1210/me.2008-0264 1:CAS:528:DC%2BD1MXntFaltbY%3D 19264844
26. K Almind CR Kahn 2004 Genetic determinants of energy expenditure and insulin resistance in diet-induced obesity in mice Diabetes 53 3274 3285 10.2337/diabetes.53.12.3274 1:CAS:528:DC%2BD2cXhtVOls7bL 15561960 (Pubitemid 39571714)
27. Frangioudakis G, Burchfield JG, Narasimhan S et al. (2009) Diverse roles for protein kinase C delta and protein kinase C epsilon in the generation of high-fat-diet-induced glucose intolerance in mice: regulation of lipogenesis by protein kinase C delta. Diabetologia 52:2616-2620
28. I Talior M Yarkoni N Bashan H Eldar-Finkelman 2003 Increased glucose uptake promotes oxidative stress and PKC-delta activation in adipocytes of obese, insulin-resistant mice Am J Physiol Endocrinol Metab 285 E295 E302 1:CAS:528:DC%2BD3sXmsVahsL0%3D 12857675 (Pubitemid 36899702)
29. AM Hennige N Stefan K Kapp, et al. 2006 Leptin down-regulates insulin action through phosphorylation of serine-318 in insulin receptor substrate 1 FASEB J 20 1206 1208 10.1096/fj.05-4635fje 1:CAS:528:DC%2BD28XlvFWrsL4%3D 16611834 (Pubitemid 44943873)
30. M Gschwendt HJ Muller K Kielbassa, et al. 1994 Rottlerin, a novel protein kinase inhibitor Biochem Biophys Res Commun 199 93 98 10.1006/bbrc.1994.1199 1:CAS:528:DyaK2cXitlyqsLc%3D 8123051 (Pubitemid 24179919)
31. SP Soltoff 2001 Rottlerin is a mitochondrial uncoupler that decreases cellular ATP levels and indirectly blocks protein kinase Cdelta tyrosine phosphorylation J Biol Chem 276 37986 37992 1:CAS:528:DC%2BD3MXotFOrtb8%3D 11498535 (Pubitemid 37384049)
32. SP Soltoff 2007 Rottlerin: an inappropriate and ineffective inhibitor of PKCdelta Trends Pharmacol Sci 28 453 458 10.1016/j.tips.2007.07.003 1:CAS:528:DC%2BD2sXhtVWiu7zK 17692392 (Pubitemid 47371266)
33. B Xu A Bhattacharjee B Roy GM Feldman MK Cathcart 2004 Role of protein kinase C isoforms in the regulation of interleukin-13-induced 15-lipoxygenase gene expression in human monocytes J Biol Chem 279 15954 15960 10.1074/jbc.M400413200 1:CAS:528:DC%2BD2cXivF2qsr8%3D 14757756 (Pubitemid 38509283)
34. CA Peters ET Maizels MC Robertson RP Shiu MS Soloff M Hunzicker-Dunn 2000 Induction of relaxin messenger RNA expression in response to prolactin receptor activation requires protein kinase C delta signaling Mol Endocrinol 14 576 590 10.1210/me.14.4.576 1:CAS:528:DC%2BD3cXisFOrs74%3D 10770494 (Pubitemid 32260526)
35. HW Koon D Zhao Y Zhan SH Rhee MP Moyer C Pothoulakis 2006 Substance P stimulates cyclooxygenase-2 and prostaglandin E2 expression through JAK-STAT activation in human colonic epithelial cells J Immunol 176 5050 5059 1:CAS:528:DC%2BD28XjtV2gtL4%3D 16585602
36. A Bhattacharjee B Xu DA Frank GM Feldman MK Cathcart 2006 Monocyte 15-lipoxygenase expression is regulated by a novel cytosolic signaling complex with protein kinase C delta and tyrosine-phosphorylated Stat3 J Immunol 177 3771 3781 1:CAS:528:DC%2BD28XptlOgs7w%3D 16951338 (Pubitemid 44359910)
37. V Novotny-Diermayr T Zhang L Gu X Cao 2002 Protein kinase C delta associates with the interleukin-6 receptor subunit glycoprotein (gp) 130 via Stat3 and enhances Stat3-gp130 interaction J Biol Chem 277 49134 49142 10.1074/jbc.M206727200 1:CAS:528:DC%2BD38XpsFaltbg%3D 12361954 (Pubitemid 36014342)