Synthesis and in vitro antimycobacterial activity of B-ring modified diaryl ether InhA inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 10, 2008, Pages 3029-3033

  am Ende, Christopher W ^a   Knudson, Susan E ^b   Liu, Nina ^a   Childs, James ^c   Sullivan, Todd J ^a   Boyne, Melissa ^b   Xu, Hua ^a   Gegina, Yelizaveta ^a   Knudson, Dennis L ^b   Johnson, Francis ^a   Peloquin, Charles A ^c   Slayden, Richard A ^b   Tonge, Peter J ^a  

^a STONY BROOK UNIVERSITY   (United States)

^b Department of Environmental and Radiological Health Sciences   (United States)

^c NATIONAL JEWISH MEDICAL AND RESEARCH CENTER   (United States)

Author keywords

Antitubercular drug; Bioavailability; Diaryl ether; Diphenyl ether; Enoyl reductase; FabI; InhA; Isoniazid; Lipinski parameter; Mycolic acids; Tuberculosis

Indexed keywords

5 HEXYL 2 PHENOXYPHENOL; AMIDE; AMINE; BACTERIAL PROTEIN; ETHER DERIVATIVE; HETEROCYCLIC NITRO COMPOUND; INHA PROTEIN; ISONIAZID; POLYCYCLIC AROMATIC HYDROCARBON DERIVATIVE; TUBERCULOSTATIC AGENT;

ARTICLE; BACTERIAL GROWTH; BIOAVAILABILITY; CONTROLLED STUDY; DRUG ACTIVITY; DRUG SENSITIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; GROWTH INHIBITION; IN VITRO STUDY; LIPOPHILICITY; MINIMUM INHIBITORY CONCENTRATION; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN;

ANILINE COMPOUNDS; ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BIOLOGICAL AVAILABILITY; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; MYCOBACTERIUM TUBERCULOSIS; OXIDOREDUCTASES; PHENYL ETHERS; PIPERAZINES; STRUCTURE-ACTIVITY RELATIONSHIP;

MYCOBACTERIUM TUBERCULOSIS;

EID: 43549103754     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.04.038     Document Type: Article

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