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Volumn 72, Issue , 2009, Pages 437-462

It's not all smooth muscle: Non-smooth-muscle elements in control of resistance to airflow

Author keywords

Airway closure; Airway heterogeneity; Airway hyperresponsiveness; Airway obliteration; Airway occlusion; Airway remodeling; Airway resistance; Airway parenchymal interdependence; Anatomy; Lung imaging; Physiology; Structure function

Indexed keywords

ADVENTITIA; AIRWAY OBSTRUCTION; AIRWAY REMODELING; AIRWAY RESISTANCE; BASEMENT MEMBRANE; BRONCHUS MUCUS; BRONCHUS OBSTRUCTION; CARTILAGE; CELL HYPERPLASIA; CELL INFILTRATION; CHRONIC OBSTRUCTIVE LUNG DISEASE; CONNECTIVE TISSUE; EDEMA; ELASTIC FIBER; GAS FLOW; GOBLET CELL; HUMAN; INFLAMMATORY CELL; INSPIRATORY CAPACITY; LAMINA PROPRIA; LUNG ALVEOLUS SURFACE TENSION; LUNG CLEARANCE; LUNG COMPLIANCE; LUNG EMPHYSEMA; LUNG FUNCTION; LUNG INFLATION; LUNG PARENCHYMA; LUNG VOLUME; MAST CELL; MUCUS SECRETION; NEUTROPHIL; PRIORITY JOURNAL; RESIDUAL VOLUME; RESPIRATORY EPITHELIUM; REVIEW; SMOOTH MUSCLE; SMOOTH MUSCLE CONTRACTION; SUBMUCOSA; TIDAL VOLUME; TOTAL LUNG CAPACITY; TRACHEOBRONCHIAL TREE; ANIMAL; BIOMECHANICS; HISTOLOGY; LUNG; MUCOSA; MUSCLE CONTRACTION; PHYSIOLOGY; RESPIRATORY FUNCTION;

EID: 77951912099     PISSN: 00664278     EISSN: 15451585     Source Type: Book Series    
DOI: 10.1146/annurev-physiol-021909-135851     Document Type: Review
Times cited : (66)

References (175)
  • 1
    • 31844435204 scopus 로고    scopus 로고
    • Chronic obstructive pulmonary disease: Current burden and future projections
    • Lopez AD, Shibuya K, Rao C, Mathers CD, Hansell AL, et al. 2006. Chronic obstructive pulmonary disease: current burden and future projections. Eur. Respir. J. 27:397-412
    • (2006) Eur. Respir. J. , vol.27 , pp. 397-412
    • Lopez, A.D.1    Shibuya, K.2    Rao, C.3    Mathers, C.D.4    Hansell, A.L.5
  • 2
    • 33747771435 scopus 로고    scopus 로고
    • Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood: ISAAC Phases One and Three repeat multicountry cross-sectional surveys
    • Asher MI, Montefort S, Bjorksten B, Lai CK, Strachan DP, et al. 2006. Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood: ISAAC Phases One and Three repeat multicountry cross-sectional surveys. Lancet 368:733-743
    • (2006) Lancet , vol.368 , pp. 733-743
    • Asher, M.I.1    Montefort, S.2    Bjorksten, B.3    Lai, C.K.4    Strachan, D.P.5
  • 4
    • 4344675455 scopus 로고    scopus 로고
    • Pathophysiology of airflow limitation in chronic obstructive pulmonary disease
    • Hogg JC. 2004. Pathophysiology of airflow limitation in chronic obstructive pulmonary disease. Lancet 364:709-721
    • (2004) Lancet , vol.364 , pp. 709-721
    • Hogg, J.C.1
  • 5
    • 0001320185 scopus 로고
    • Resistance to breathing
    • Baltimore:Williams &Wilkins
    • Dubois AB. 1964. Resistance to breathing. In Handbook of Physiology, ed.WOFenn,HRahn, pp. 451-476 Baltimore:Williams &Wilkins
    • (1964) Handbook of Physiology, Ed.WOFenn,HRahn , pp. 451-476
    • Dubois, A.B.1
  • 7
    • 0005643124 scopus 로고
    • How big are the bronchioles?
    • Green M. 1967. How big are the bronchioles? St. Thomas's Gaz. 63:136-139
    • (1967) St. Thomas's Gaz. , vol.63 , pp. 136-139
    • Green, M.1
  • 8
    • 0014424329 scopus 로고
    • Site and nature of airway obstruction in chronic obstructive lung disease
    • Hogg JC, Macklem PT, Thurlbeck WM. 1968. Site and nature of airway obstruction in chronic obstructive lung disease. N. Engl. J. Med. 278:1355-1360
    • (1968) N. Engl. J. Med. , vol.278 , pp. 1355-1360
    • Hogg, J.C.1    MacKlem, P.T.2    Thurlbeck, W.M.3
  • 9
    • 0026538877 scopus 로고
    • Site of airway obstruction in pulmonary disease: Direct measurement of intrabronchial pressure
    • Yanai M, Sekizawa K, Ohrui T, Sasaki H, Takishima T. 1992. Site of airway obstruction in pulmonary disease: direct measurement of intrabronchial pressure. J. Appl. Physiol. 72:1016-1023
    • (1992) J. Appl. Physiol. , vol.72 , pp. 1016-1023
    • Yanai, M.1    Sekizawa, K.2    Ohrui, T.3    Sasaki, H.4    Takishima, T.5
  • 10
    • 0017137385 scopus 로고
    • Distribution of pulmonary resistance: Effects of gas density, viscosity, and flow rate
    • Drazen JM, Loring SH, IngramRHJr. 1976. Distribution of pulmonary resistance: effects of gas density, viscosity, and flow rate. J. Appl. Physiol. 41:388-395
    • (1976) J. Appl. Physiol. , vol.41 , pp. 388-395
    • Drazen, J.M.1    Loring, S.H.2    Ingram Jr., R.H.3
  • 12
    • 0021088804 scopus 로고
    • Mechanical and physical factors in lung function during work in dense environments
    • Van LiewHD.1983. Mechanical and physical factors in lung function during work in dense environments. Undersea Biomed. Res. 10:255-264
    • (1983) Undersea Biomed. Res. , vol.10 , pp. 255-264
    • Van Liew, H.D.1
  • 15
    • 0014330597 scopus 로고
    • Relative hysteresis of the dead space and lung in vivo
    • Froeb HF, Mead J. 1968. Relative hysteresis of the dead space and lung in vivo. J. Appl. Physiol. 25:244-248
    • (1968) J. Appl. Physiol. , vol.25 , pp. 244-248
    • Froeb, H.F.1    Mead, J.2
  • 16
    • 0024450919 scopus 로고
    • The effects of deep inhalation on maximal expiratory flow during intensive treatment of spontaneous asthmatic episodes
    • Lim TK, Ang SM, Rossing TH, Ingenito EP, Ingram RH Jr. 1989. The effects of deep inhalation on maximal expiratory flow during intensive treatment of spontaneous asthmatic episodes. Am. Rev. Respir. Dis. 140:340-343
    • (1989) Am. Rev. Respir. Dis. , vol.140 , pp. 340-343
    • Lim, T.K.1    Ang, S.M.2    Rossing, T.H.3    Ingenito, E.P.4    Ingram Jr., R.H.5
  • 17
    • 12044255421 scopus 로고
    • The comparative mechanics and morphology of airways in asthma and in chronic obstructive pulmonary disease
    • Pare PD,Wiggs BR, James A, Hogg JC, Bosken C. 1991. The comparative mechanics and morphology of airways in asthma and in chronic obstructive pulmonary disease. Am. Rev. Respir. Dis. 143:1189-1193
    • (1991) Am. Rev. Respir. Dis. , vol.143 , pp. 1189-1193
    • Pare Pdwiggs, B.R.1    James, A.2    Hogg, J.C.3    Bosken, C.4
  • 18
    • 0037297866 scopus 로고    scopus 로고
    • Bronchodilation and bronchoprotection by deep inspiration and their relationship to bronchial hyperresponsiveness
    • Skloot G, Togias A. 2003. Bronchodilation and bronchoprotection by deep inspiration and their relationship to bronchial hyperresponsiveness. Clin. Rev. Allergy Immunol. 24:55-72
    • (2003) Clin. Rev. Allergy Immunol. , vol.24 , pp. 55-72
    • Skloot, G.1    Togias, A.2
  • 20
    • 12344258191 scopus 로고    scopus 로고
    • Postural changes in lung volumes and respiratory resistance in subjects with obesity
    • Watson RA, Pride NB. 2005. Postural changes in lung volumes and respiratory resistance in subjects with obesity. J. Appl. Physiol. 98:512-517
    • (2005) J. Appl. Physiol. , vol.98 , pp. 512-517
    • Watson, R.A.1    Pride, N.B.2
  • 21
    • 0029119733 scopus 로고
    • Pulmonary function testing in spinal cord injury: Correlation with vital capacity
    • Roth EJ, Nussbaum SB, Berkowitz M, Primack S, Oken J, et al. 1995. Pulmonary function testing in spinal cord injury: correlation with vital capacity. Paraplegia 33:454-457
    • (1995) Paraplegia , vol.33 , pp. 454-457
    • Roth, E.J.1    Nussbaum, S.B.2    Berkowitz, M.3    Primack, S.4    Oken, J.5
  • 22
    • 9144240147 scopus 로고    scopus 로고
    • Postural changes in nasal and pulmonary resistance in subjects with asthma
    • Duggan CJ,Watson RA, Pride NB. 2004. Postural changes in nasal and pulmonary resistance in subjects with asthma. J. Asthma 41:701-707
    • (2004) J. Asthma , vol.41 , pp. 701-707
    • Duggan Cjwatson, R.A.1    Pride, N.B.2
  • 28
    • 0036202837 scopus 로고    scopus 로고
    • Unsuspected loss of lung elastic recoil in chronic persistent asthma
    • Gelb AF, Licuanan J, Shinar CM, Zamel N. 2002. Unsuspected loss of lung elastic recoil in chronic persistent asthma. Chest 121:715-721
    • (2002) Chest , vol.121 , pp. 715-721
    • Gelb, A.F.1    Licuanan, J.2    Shinar, C.M.3    Zamel, N.4
  • 29
    • 0030879656 scopus 로고    scopus 로고
    • Effect of tidal volume and frequency on airway responsiveness in mechanically ventilated rabbits
    • Shen X, Gunst SJ, Tepper RS. 1997. Effect of tidal volume and frequency on airway responsiveness in mechanically ventilated rabbits. J. Appl. Physiol. 83:1202-1208
    • (1997) J. Appl. Physiol. , vol.83 , pp. 1202-1208
    • Shen, X.1    Gunst, S.J.2    Tepper, R.S.3
  • 32
    • 0014039731 scopus 로고
    • Significance of the relationship between lung recoil and maximum expiratory flow
    • Mead J, Turner JM, Macklem PT, Little JB. 1967. Significance of the relationship between lung recoil and maximum expiratory flow. J. Appl. Physiol. 22:95-108
    • (1967) J. Appl. Physiol. , vol.22 , pp. 95-108
    • Mead, J.1    Turner, J.M.2    MacKlem, P.T.3    Little, J.B.4
  • 33
    • 34447572685 scopus 로고    scopus 로고
    • Clinical relevance of airway remodelling in airway diseases
    • James AL, Wenzel S. 2007. Clinical relevance of airway remodelling in airway diseases. Eur. Respir. J. 30:134-155
    • (2007) Eur. Respir. J. , vol.30 , pp. 134-155
    • James, A.L.1    Wenzel, S.2
  • 34
    • 1342283039 scopus 로고    scopus 로고
    • Contribution of airway closure to chronic postbronchiolitis airway dysfunction in rats
    • Sorkness RL, Tuffaha A. 2004. Contribution of airway closure to chronic postbronchiolitis airway dysfunction in rats. J. Appl. Physiol. 96:904-910
    • (2004) J. Appl. Physiol. , vol.96 , pp. 904-910
    • Sorkness, R.L.1    Tuffaha, A.2
  • 36
    • 0023183249 scopus 로고
    • Effects of lung volume on maximal methacholine-induced bronchoconstriction in normal humans
    • Ding DJ, Martin JG, Macklem PT. 1987. Effects of lung volume on maximal methacholine-induced bronchoconstriction in normal humans. J. Appl. Physiol. 62:1324-1330
    • (1987) J. Appl. Physiol. , vol.62 , pp. 1324-1330
    • Ding, D.J.1    Martin, J.G.2    MacKlem, P.T.3
  • 37
    • 0033949176 scopus 로고    scopus 로고
    • Effects of length oscillation on the subsequent force development in swine tracheal smooth muscle
    • Wang L, Pare PD, Seow CY. 2000. Effects of length oscillation on the subsequent force development in swine tracheal smooth muscle. J. Appl. Physiol. 88:2246-2250
    • (2000) J. Appl. Physiol. , vol.88 , pp. 2246-2250
    • Wang, L.1    Pare, P.D.2    Seow, C.Y.3
  • 40
    • 0035065323 scopus 로고    scopus 로고
    • High-resolution computed tomographic evaluation of airway distensibility and the effects of lung inflation on airway caliber in healthy subjects and individuals with asthma
    • Brown RH, Scichilone N, Mudge B, Diemer FB, Permutt S, Togias A. 2001. High-resolution computed tomographic evaluation of airway distensibility and the effects of lung inflation on airway caliber in healthy subjects and individuals with asthma. Am. J. Respir. Crit. Care Med. 163:994-1001
    • (2001) Am. J. Respir. Crit. Care Med. , vol.163 , pp. 994-1001
    • Brown, R.H.1    Scichilone, N.2    Mudge, B.3    Diemer, F.B.4    Permutt, S.5    Togias, A.6
  • 41
    • 0024415635 scopus 로고
    • Is a myogenic response involved in deep inspiration-induced bronchoconstriction in asthmatics?
    • Marthan R, Woolcock AJ. 1989. Is a myogenic response involved in deep inspiration-induced bronchoconstriction in asthmatics? Am. Rev. Respir. Dis. 140:1354-1358
    • (1989) Am. Rev. Respir. Dis. , vol.140 , pp. 1354-1358
    • Marthan, R.1    Woolcock, A.J.2
  • 42
    • 0028817013 scopus 로고
    • Airway hyperresponsiveness in asthma: A problem of limited smooth muscle relaxation with inspiration
    • Skloot G, Permutt S,Togias A. 1995. Airway hyperresponsiveness in asthma: a problem of limited smooth muscle relaxation with inspiration. J. Clin. Investig. 96:2393-2403
    • (1995) J. Clin. Investig. , vol.96 , pp. 2393-2403
    • Skloot, G.1    Permutt, S.2    Togias, A.3
  • 43
    • 0032789318 scopus 로고    scopus 로고
    • Time course of increased airway narrowing caused by inhibition of deep inspiration during methacholine challenge
    • King GG, Moore BJ, Seow CY, Pare PD. 1999. Time course of increased airway narrowing caused by inhibition of deep inspiration during methacholine challenge. Am. J. Respir. Crit. Care Med. 160:454-457
    • (1999) Am. J. Respir. Crit. Care Med. , vol.160 , pp. 454-457
    • King, G.G.1    Moore, B.J.2    Seow, C.Y.3    Pare, P.D.4
  • 44
    • 0035880168 scopus 로고    scopus 로고
    • Airway narrowing associated with inhibition of deep inspiration during methacholine inhalation in asthmatics
    • King GG, Moore BJ, Seow CY, Pare PD. 2001. Airway narrowing associated with inhibition of deep inspiration during methacholine inhalation in asthmatics. Am. J. Respir. Crit. Care Med. 164:216-218
    • (2001) Am. J. Respir. Crit. Care Med. , vol.164 , pp. 216-218
    • King, G.G.1    Moore, B.J.2    Seow, C.Y.3    Pare, P.D.4
  • 45
    • 0020516903 scopus 로고
    • Load compensation in obese patients during quiet tidal breathing
    • Sampson MG, Grassino AE. 1983. Load compensation in obese patients during quiet tidal breathing. J. Appl. Physiol. 55:1269-1276
    • (1983) J. Appl. Physiol. , vol.55 , pp. 1269-1276
    • Sampson, M.G.1    Grassino, A.E.2
  • 46
    • 28644435555 scopus 로고    scopus 로고
    • Deep inspiration avoidance and airway response to methacholine: Influence of body mass index
    • Boulet LP, Turcotte H, Boulet G, Simard B, Robichaud P. 2005. Deep inspiration avoidance and airway response to methacholine: influence of body mass index. Can. Respir. J. 12:371-376
    • (2005) Can. Respir. J. , vol.12 , pp. 371-376
    • Boulet, L.P.1    Turcotte, H.2    Boulet, G.3    Simard, B.4    Robichaud, P.5
  • 47
    • 0024270331 scopus 로고
    • Parenchymal interdependence and airway response to methacholine in excised dog lobes
    • Gunst SJ,Warner DO,Wilson TA, Hyatt RE. 1988. Parenchymal interdependence and airway response to methacholine in excised dog lobes. J. Appl. Physiol. 65:2490-2497
    • (1988) J. Appl. Physiol. , vol.65 , pp. 2490-2497
    • Gunst, S.J.1    Warner, D.O.2    Wilson, T.A.3    Hyatt, R.E.4
  • 49
    • 0027151812 scopus 로고
    • Airway smooth muscle shortening in excised canine lung lobes
    • Okazawa M, Bai TR, Wiggs BR, Pare PD. 1993. Airway smooth muscle shortening in excised canine lung lobes. J. Appl. Physiol. 74:1613-1621
    • (1993) J. Appl. Physiol. , vol.74 , pp. 1613-1621
    • Okazawa, M.1    Bai, T.R.2    Wiggs, B.R.3    Pare, P.D.4
  • 50
    • 0018392770 scopus 로고
    • Respiratory mechanics in recumbent dogs anesthetized with thiopental sodium
    • Lai YL, Rodarte JR, Hyatt RE. 1979. Respiratory mechanics in recumbent dogs anesthetized with thiopental sodium. J. Appl. Physiol. 46:716-720
    • (1979) J. Appl. Physiol. , vol.46 , pp. 716-720
    • Lai, Y.L.1    Rodarte, J.R.2    Hyatt, R.E.3
  • 51
    • 33645984858 scopus 로고    scopus 로고
    • Stress transmission in the lung: Pathways from organ to molecule
    • Fredberg JJ, Kamm RD. 2006. Stress transmission in the lung: pathways from organ to molecule. Annu. Rev. Physiol. 68:507-541
    • (2006) Annu. Rev. Physiol. , vol.68 , pp. 507-541
    • Fredberg, J.J.1    Kamm, R.D.2
  • 52
    • 33645973265 scopus 로고    scopus 로고
    • Chronic effects of mechanical force on airways
    • Tschumperlin DJ, Drazen JM. 2006. Chronic effects of mechanical force on airways. Annu. Rev. Physiol. 68:563-583
    • (2006) Annu. Rev. Physiol. , vol.68 , pp. 563-583
    • Tschumperlin, D.J.1    Drazen, J.M.2
  • 53
    • 0023522166 scopus 로고
    • Quantitative measurement of smooth muscle shortening in isolated pig trachea
    • James AL, Pare PD, Moreno RH, Hogg JC. 1987. Quantitative measurement of smooth muscle shortening in isolated pig trachea. J. Appl. Physiol. 63:1360-1365
    • (1987) J. Appl. Physiol. , vol.63 , pp. 1360-1365
    • James, A.L.1    Pare, P.D.2    Moreno, R.H.3    Hogg, J.C.4
  • 54
    • 0014107075 scopus 로고
    • Structural basis for decreased compressibility of constricted tracheae and bronchi
    • Olsen CR, Stevens AE, Pride NB, Staub NC. 1967. Structural basis for decreased compressibility of constricted tracheae and bronchi. J. Appl. Physiol. 23:35-39
    • (1967) J. Appl. Physiol. , vol.23 , pp. 35-39
    • Olsen, C.R.1    Stevens, A.E.2    Pride, N.B.3    Staub, N.C.4
  • 55
    • 0036089787 scopus 로고    scopus 로고
    • Relationship of airway narrowing, compliance, and cartilage in isolated bronchial segments
    • Noble PB, Turner DJ, Mitchell HW. 2002. Relationship of airway narrowing, compliance, and cartilage in isolated bronchial segments. J. Appl. Physiol. 92:1119-1124
    • (2002) J. Appl. Physiol. , vol.92 , pp. 1119-1124
    • Noble, P.B.1    Turner, D.J.2    Mitchell, H.W.3
  • 56
    • 0027404742 scopus 로고
    • The structure of large and small airways in nonfatal and fatal asthma
    • Carroll N, Elliot J, Morton A, James A. 1993. The structure of large and small airways in nonfatal and fatal asthma. Am. Rev. Respir. Dis. 147:405-410
    • (1993) Am. Rev. Respir. Dis. , vol.147 , pp. 405-410
    • Carroll, N.1    Elliot, J.2    Morton, A.3    James, A.4
  • 57
    • 0032986214 scopus 로고    scopus 로고
    • Morphometric analysis of bronchial cartilage in chronic obstructive pulmonary disease and bronchial asthma
    • Haraguchi M, Shimura S, Shirato K. 1999. Morphometric analysis of bronchial cartilage in chronic obstructive pulmonary disease and bronchial asthma. Am. J. Respir. Crit. Care Med. 159:1005-1013
    • (1999) Am. J. Respir. Crit. Care Med. , vol.159 , pp. 1005-1013
    • Haraguchi, M.1    Shimura, S.2    Shirato, K.3
  • 58
    • 0000385474 scopus 로고
    • Measurement of the bronchial mucous gland layer: A diagnostic yardstick in chronic bronchitis
    • Reid L. 1960. Measurement of the bronchial mucous gland layer: a diagnostic yardstick in chronic bronchitis. Thorax 15:132-141
    • (1960) Thorax , vol.15 , pp. 132-141
    • Reid, L.1
  • 59
    • 33645968109 scopus 로고    scopus 로고
    • Structural changes in airway diseases: Characteristics, mechanisms, consequences, and pharmacologic modulation
    • Bergeron C, Boulet LP. 2006. Structural changes in airway diseases: characteristics, mechanisms, consequences, and pharmacologic modulation. Chest 129:1068-1087
    • (2006) Chest , vol.129 , pp. 1068-1087
    • Bergeron, C.1    Boulet, L.P.2
  • 60
    • 0026503978 scopus 로고
    • Marked goblet cell hyperplasia with mucus accumulation in the airways of patients who died of severe acute asthma attack
    • Aikawa T, Shimura S, Sasaki H, Ebina M,Takishima T. 1992. Marked goblet cell hyperplasia with mucus accumulation in the airways of patients who died of severe acute asthma attack. Chest 101:916-921
    • (1992) Chest , vol.101 , pp. 916-921
    • Aikawa, T.1    Shimura, S.2    Sasaki, H.3    Ebina Mtakishima, T.4
  • 62
    • 0036268342 scopus 로고    scopus 로고
    • Expression of respiratory mucins in fatal status asthmaticus and mild asthma
    • Groneberg DA, Eynott PR, Lim S, Oates T,Wu R, et al. 2002. Expression of respiratory mucins in fatal status asthmaticus and mild asthma. Histopathology 40:367-373
    • (2002) Histopathology , vol.40 , pp. 367-373
    • Groneberg, D.A.1    Eynott, P.R.2    Lim, S.3    Oates, T.4    Wu, R.5
  • 63
    • 0036341331 scopus 로고    scopus 로고
    • Increased mast cells and neutrophils in submucosal mucous glands and mucus plugging in patients with asthma
    • Carroll NG, Mutavdzic S, James AL. 2002. Increased mast cells and neutrophils in submucosal mucous glands and mucus plugging in patients with asthma. Thorax 57:677-682
    • (2002) Thorax , vol.57 , pp. 677-682
    • Carroll, N.G.1    Mutavdzic, S.2    James, A.L.3
  • 64
    • 36849037262 scopus 로고
    • The pathogenesis of fibrocystic disease of the pancreas; a study of 36 cases with special reference to the pulmonary lesions
    • Zuelzer WW, NewtonWA Jr. 1949. The pathogenesis of fibrocystic disease of the pancreas; a study of 36 cases with special reference to the pulmonary lesions. Pediatrics 4:53-69
    • (1949) Pediatrics , vol.4 , pp. 53-69
    • Zuelzer, W.W.1    Newton Jr., W.A.2
  • 65
    • 36148931010 scopus 로고    scopus 로고
    • Fluid secretion by submucosal glands of the tracheobronchial airways
    • Ballard ST, Spadafora D. 2007. Fluid secretion by submucosal glands of the tracheobronchial airways. Respir. Physiol. Neurobiol. 159:271-277
    • (2007) Respir. Physiol. Neurobiol. , vol.159 , pp. 271-277
    • Ballard, S.T.1    Spadafora, D.2
  • 69
    • 0028966881 scopus 로고
    • The consequences of chronic allergic inflammation
    • Pare PD, Bai TR. 1995. The consequences of chronic allergic inflammation. Thorax 50:328-332
    • (1995) Thorax , vol.50 , pp. 328-332
    • Pare, P.D.1    Bai, T.R.2
  • 70
    • 0027318687 scopus 로고
    • Functional significance of increased airway smooth muscle in asthma and COPD
    • Lambert RK, Wiggs BR, Kuwano K, Hogg JC, Pare PD. 1993. Functional significance of increased airway smooth muscle in asthma and COPD. J. Appl. Physiol. 74:2771-2781
    • (1993) J. Appl. Physiol. , vol.74 , pp. 2771-2781
    • Lambert, R.K.1    Wiggs, B.R.2    Kuwano, K.3    Hogg, J.C.4    Pare, P.D.5
  • 72
    • 0034120111 scopus 로고    scopus 로고
    • The bronchial microcirculation in asthma
    • Wilson J. 2000. The bronchial microcirculation in asthma. Clin. Exp. Allergy 30(Suppl. 1):51-53
    • (2000) Clin. Exp. Allergy , vol.30 , Issue.SUPPL. 1 , pp. 51-53
    • Wilson, J.1
  • 75
  • 76
    • 34248204113 scopus 로고    scopus 로고
    • Airway smooth muscle dynamics: A common pathway of airway obstruction in asthma
    • An SS, Bai TR, Bates JH, Black JL, Brown RH, et al. 2007. Airway smooth muscle dynamics: a common pathway of airway obstruction in asthma. Eur. Respir. J. 29:834-860
    • (2007) Eur. Respir. J. , vol.29 , pp. 834-860
    • An, S.S.1    Bai, T.R.2    Bates, J.H.3    Black, J.L.4    Brown, R.H.5
  • 78
    • 0032904860 scopus 로고    scopus 로고
    • Influence of intercellular tissue connections on airway muscle mechanics
    • Meiss RA. 1999. Influence of intercellular tissue connections on airway muscle mechanics. J. Appl. Physiol. 86:5-15
    • (1999) J. Appl. Physiol. , vol.86 , pp. 5-15
    • Meiss, R.A.1
  • 79
    • 0002543851 scopus 로고
    • The pathology of asthma, with special reference to changes in the bronchial mucosa
    • Dunnill MS. 1960. The pathology of asthma, with special reference to changes in the bronchial mucosa. J. Clin. Pathol. 13:27-33
    • (1960) J. Clin. Pathol. , vol.13 , pp. 27-33
    • Dunnill, M.S.1
  • 80
    • 0031957991 scopus 로고    scopus 로고
    • Expression of growth factors and remodelling of the airway wall in bronchial asthma
    • Hoshino M, Nakamura Y, Sim JJ. 1998. Expression of growth factors and remodelling of the airway wall in bronchial asthma. Thorax 53:21-27
    • (1998) Thorax , vol.53 , pp. 21-27
    • Hoshino, M.1    Nakamura, Y.2    Sim, J.J.3
  • 81
    • 0030036701 scopus 로고    scopus 로고
    • Effects of bronchial vascular engorgement on airway dimensions
    • Wagner EM, Mitzner W. 1996. Effects of bronchial vascular engorgement on airway dimensions. J. Appl. Physiol. 81:293-301
    • (1996) J. Appl. Physiol. , vol.81 , pp. 293-301
    • Wagner, E.M.1    Mitzner, W.2
  • 82
    • 0033972093 scopus 로고    scopus 로고
    • The airway longitudinal elastic fiber network and mucosal folding in patients with asthma
    • Carroll NG, Perry S, Karkhanis A, Harji S, Butt J, et al. 2000. The airway longitudinal elastic fiber network and mucosal folding in patients with asthma. Am. J. Respir. Crit. Care Med. 161:244-248
    • (2000) Am. J. Respir. Crit. Care Med. , vol.161 , pp. 244-248
    • Carroll, N.G.1    Perry, S.2    Karkhanis, A.3    Harji, S.4    Butt, J.5
  • 83
    • 0035186301 scopus 로고    scopus 로고
    • Quantitative and morphological analysis of the vascular bed in bronchial biopsy specimens from asthmatic and non-asthmatic subjects
    • Salvato G. 2001. Quantitative and morphological analysis of the vascular bed in bronchial biopsy specimens from asthmatic and non-asthmatic subjects. Thorax 56:902-906
    • (2001) Thorax , vol.56 , pp. 902-906
    • Salvato, G.1
  • 87
    • 0036037291 scopus 로고    scopus 로고
    • Airway goblet cell hyperplasia in asthma: Hypersecretory and anti-inflammatory?
    • Rogers DF. 2002. Airway goblet cell hyperplasia in asthma: hypersecretory and anti-inflammatory? Clin. Exp. Allergy 32:1124-1127
    • (2002) Clin. Exp. Allergy , vol.32 , pp. 1124-1127
    • Rogers, D.F.1
  • 88
    • 33846213877 scopus 로고    scopus 로고
    • The role of epithelial injury and repair in the origins of asthma
    • Hackett TL, Knight DA. 2007. The role of epithelial injury and repair in the origins of asthma. Curr. Opin. Allergy Clin. Immunol. 7:63-68
    • (2007) Curr. Opin. Allergy Clin. Immunol. , vol.7 , pp. 63-68
    • Hackett, T.L.1    Knight, D.A.2
  • 89
    • 0037674020 scopus 로고    scopus 로고
    • Mucin-producing elements and inflammatory cells
    • 277-282 discussion 75
    • Jeffery P, Zhu J. 2002. Mucin-producing elements and inflammatory cells. Novartis Found. Symp. 248:51-68; discussion 75, 277-282
    • (2002) Novartis Found. Symp. , vol.248 , pp. 51-68
    • Jeffery, P.1    Zhu, J.2
  • 90
    • 0035132115 scopus 로고    scopus 로고
    • Mild and moderate asthma is associated with airway goblet cell hyperplasia and abnormalities in mucin gene expression
    • Ordonez CL, Khashayar R, Wong HH, Ferrando R, Wu R, et al. 2001. Mild and moderate asthma is associated with airway goblet cell hyperplasia and abnormalities in mucin gene expression. Am. J. Respir. Crit. Care Med. 163:517-523
    • (2001) Am. J. Respir. Crit. Care Med. , vol.163 , pp. 517-523
    • Ordonez, C.L.1    Khashayar, R.2    Wong, H.H.3    Ferrando, R.4    Wu, R.5
  • 91
  • 92
    • 0015338431 scopus 로고
    • The number and dimensions of small airways in emphysematous lungs
    • Matsuba K, Thurlbeck WM. 1972. The number and dimensions of small airways in emphysematous lungs. Am. J. Pathol. 67:265-275
    • (1972) Am. J. Pathol. , vol.67 , pp. 265-275
    • Matsuba, K.1    Thurlbeck, W.M.2
  • 94
    • 0001307488 scopus 로고
    • Composition of tracheobronchial secretions in cystic fibrosis of the pancreas and bronchiectasis
    • Chernick WS, Barbero GJ. 1959. Composition of tracheobronchial secretions in cystic fibrosis of the pancreas and bronchiectasis. Pediatrics 24:739-745
    • (1959) Pediatrics , vol.24 , pp. 739-745
    • Chernick, W.S.1    Barbero, G.J.2
  • 95
    • 0036198121 scopus 로고    scopus 로고
    • Antimicrobial polypeptides in host defense of the respiratory tract
    • Ganz T. 2002. Antimicrobial polypeptides in host defense of the respiratory tract. J. Clin. Investig. 109:693-697
    • (2002) J. Clin. Investig. , vol.109 , pp. 693-697
    • Ganz, T.1
  • 96
    • 0031048168 scopus 로고    scopus 로고
    • The role of pulmonary surfactant in obstructive airways disease
    • Hohlfeld J, Fabel H, Hamm H. 1997. The role of pulmonary surfactant in obstructive airways disease. Eur. Respir. J. 10:482-491
    • (1997) Eur. Respir. J. , vol.10 , pp. 482-491
    • Hohlfeld, J.1    Fabel, H.2    Hamm, H.3
  • 98
    • 0031015934 scopus 로고    scopus 로고
    • Effects of surface tension and intraluminal fluid on mechanics of small airways
    • Hill MJ,Wilson TA, Lambert RK. 1997. Effects of surface tension and intraluminal fluid on mechanics of small airways. J. Appl. Physiol. 82:233-239
    • (1997) J. Appl. Physiol. , vol.82 , pp. 233-239
    • Hill Mjwilson, T.A.1    Lambert, R.K.2
  • 99
    • 0037055048 scopus 로고    scopus 로고
    • Airway closure: Surface-tension-driven non-axisymmetric instabilities of liquidlined elastic rings
    • Heil M, White JP. 2002. Airway closure: surface-tension-driven non-axisymmetric instabilities of liquidlined elastic rings. J. Fluid Mech. 462:79-109
    • (2002) J. Fluid Mech. , vol.462 , pp. 79-109
    • Heil, M.1    White, J.P.2
  • 101
    • 70349405090 scopus 로고    scopus 로고
    • Microfluidics, lung surfactant, and respiratory disorders
    • Tavana H, Huh D, Grotberg JB, Takayama S. 2009. Microfluidics, lung surfactant, and respiratory disorders. Lab. Med. 40:203-209
    • (2009) Lab. Med. , vol.40 , pp. 203-209
    • Tavana, H.1    Huh, D.2    Grotberg, J.B.3    Takayama, S.4
  • 102
    • 0014317137 scopus 로고
    • Airway closure: Demonstration by breathing 100 percent O2 at low lung volumes and by N2 washout
    • Burger EJ Jr, Macklem P. 1968. Airway closure: demonstration by breathing 100 percent O2 at low lung volumes and by N2 washout. J. Appl. Physiol. 25:139-148
    • (1968) J. Appl. Physiol. , vol.25 , pp. 139-148
    • Burger Jr., E.J.1    MacKlem, P.2
  • 105
    • 42149124309 scopus 로고    scopus 로고
    • Surfactant in airway disease
    • Enhorning G. 2008. Surfactant in airway disease. Chest 133:975-980
    • (2008) Chest , vol.133 , pp. 975-980
    • Enhorning, G.1
  • 106
    • 0027374813 scopus 로고
    • Role of pulmonary surfactant in airway closure: A computational study
    • Otis DR Jr, Johnson M, Pedley TJ, Kamm RD. 1993. Role of pulmonary surfactant in airway closure: a computational study. J. Appl. Physiol. 75:1323-1333
    • (1993) J. Appl. Physiol. , vol.75 , pp. 1323-1333
    • Otis Jr., D.R.1    Johnson, M.2    Pedley, T.J.3    Kamm, R.D.4
  • 107
    • 0037308661 scopus 로고    scopus 로고
    • Mechanisms of surface-tension-induced epithelial cell damage in a model of pulmonary airway reopening
    • Bilek AM, Dee KC, Gaver DP 3rd. 2003. Mechanisms of surface-tension- induced epithelial cell damage in a model of pulmonary airway reopening. J. Appl. Physiol. 94:770-783
    • (2003) J. Appl. Physiol. , vol.94 , pp. 770-783
    • Bilek, A.M.1    Dee, K.C.2    Gaver III, D.P.3
  • 109
    • 0033774787 scopus 로고    scopus 로고
    • Altered airway surfactant phospholipid composition and reduced lung function in asthma
    • Wright SM, Hockey PM, Enhorning G, Strong P, Reid KB, et al. 2000. Altered airway surfactant phospholipid composition and reduced lung function in asthma. J. Appl. Physiol. 89:1283-1292
    • (2000) J. Appl. Physiol. , vol.89 , pp. 1283-1292
    • Wright, S.M.1    Hockey, P.M.2    Enhorning, G.3    Strong, P.4    Reid, K.B.5
  • 110
    • 2442715233 scopus 로고    scopus 로고
    • The allergic mouse model of asthma: Normal smooth muscle in an abnormal lung?
    • Wagers S, Lundblad LK, Ekman M, Irvin CG, Bates JH. 2004. The allergic mouse model of asthma: normal smooth muscle in an abnormal lung? J. Appl. Physiol. 96:2019-2027
    • (2004) J. Appl. Physiol. , vol.96 , pp. 2019-2027
    • Wagers, S.1    Lundblad, L.K.2    Ekman, M.3    Irvin, C.G.4    Bates, J.H.5
  • 112
    • 0028926276 scopus 로고
    • Conference summary: Aspen Lung Conference, 37th
    • Pare PD. 1995. Conference summary: Aspen Lung Conference, 37th. Chest 107:163S-99S
    • (1995) Chest , vol.107
    • Pare, P.D.1
  • 116
    • 0034131479 scopus 로고    scopus 로고
    • Recurrent exacerbations in severe asthma are associated with enhanced airway closure during stable episodes
    • in't Veen JCCM, Beekman AJ, Bel EH, Sterk PJ. 2000. Recurrent exacerbations in severe asthma are associated with enhanced airway closure during stable episodes. Am. J. Respir. Crit. CareMed. 161:1902-1906
    • (2000) Am. J. Respir. Crit. CareMed. , vol.161 , pp. 1902-1906
    • Veen Jccm, I.1    Beekman, A.J.2    Bel, E.H.3    Sterk, P.J.4
  • 118
    • 0033938927 scopus 로고    scopus 로고
    • Effects of cool, dry air stimulation on peripheral lung mechanics in asthma
    • Kaminsky DA, Bates JH, Irvin CG. 2000. Effects of cool, dry air stimulation on peripheral lung mechanics in asthma. Am. J. Respir. Crit. Care Med. 162:179-186
    • (2000) Am. J. Respir. Crit. Care Med. , vol.162 , pp. 179-186
    • Kaminsky, D.A.1    Bates, J.H.2    Irvin, C.G.3
  • 120
    • 0031792957 scopus 로고    scopus 로고
    • The myth of maximal airway responsiveness in vivo
    • Brown RH, Mitzner W. 1998. The myth of maximal airway responsiveness in vivo. J. Appl. Physiol. 85:2012-2017
    • (1998) J. Appl. Physiol. , vol.85 , pp. 2012-2017
    • Brown, R.H.1    Mitzner, W.2
  • 122
    • 33745843638 scopus 로고    scopus 로고
    • Lessons from structure-function studies in asthma: Myths and truths about what we teach
    • Irvin CG. 2006. Lessons from structure-function studies in asthma: myths and truths about what we teach. J. Appl. Physiol. 101:7-9
    • (2006) J. Appl. Physiol. , vol.101 , pp. 7-9
    • Irvin, C.G.1
  • 124
    • 0032415784 scopus 로고    scopus 로고
    • Differences in airway closure between normal and asthmatic subjects measured with single-photon emission computed tomography and Technegas
    • King GG, Eberl S, Salome CM, Young IH,Woolcock AJ. 1998. Differences in airway closure between normal and asthmatic subjects measured with single-photon emission computed tomography and Technegas. Am. J. Respir. Crit. Care Med. 158:1900-1906
    • (1998) Am. J. Respir. Crit. Care Med. , vol.158 , pp. 1900-1906
    • King, G.G.1    Eberl, S.2    Salome, C.M.3    Young, I.H.4    Woolcock, A.J.5
  • 125
    • 31144450284 scopus 로고    scopus 로고
    • Hyperpolarized 3-helium magnetic resonance imaging to probe lung function
    • 32
    • van Beek EJ, Wild JM. 2005. Hyperpolarized 3-helium magnetic resonance imaging to probe lung function. Proc. Am. Thorac. Soc. 2:528-32, 510
    • (2005) Proc. Am. Thorac. Soc. , vol.2 , Issue.528 , pp. 510
    • Van Beek, E.J.1    Wild, J.M.2
  • 126
    • 33750043741 scopus 로고    scopus 로고
    • Evaluation of asthma with hyperpolarized helium-3 MRI: Correlation with clinical severity and spirometry
    • de Lange EE, Altes TA, Patrie JT, Gaare JD, Knake JJ, et al. 2006. Evaluation of asthma with hyperpolarized helium-3 MRI: correlation with clinical severity and spirometry. Chest 130:1055-1062
    • (2006) Chest , vol.130 , pp. 1055-1062
    • De Lange, E.E.1    Altes, T.A.2    Patrie, J.T.3    Gaare, J.D.4    Knake, J.J.5
  • 127
    • 61749083987 scopus 로고    scopus 로고
    • Changes in regional airflow obstruction over time in the lungs of patients with asthma: Evaluation with 3He MR imaging
    • de Lange EE, Altes TA, Patrie JT, Battiston JJ, Juersivich AP, et al. 2009. Changes in regional airflow obstruction over time in the lungs of patients with asthma: evaluation with 3He MR imaging. Radiology 250:567-575
    • (2009) Radiology , vol.250 , pp. 567-575
    • De Lange, E.E.1    Altes, T.A.2    Patrie, J.T.3    Battiston, J.J.4    Juersivich, A.P.5
  • 128
    • 0020678593 scopus 로고
    • The immotile-cilia syndrome compared to other obstructive lung diseases: A clue to their pathogenesis
    • Mossberg B, Camner P, Afzelius BA. 1983. The immotile-cilia syndrome compared to other obstructive lung diseases: a clue to their pathogenesis. Eur. J. Respir. Dis. Suppl. 127:129-136
    • (1983) Eur. J. Respir. Dis. Suppl. , vol.127 , pp. 129-136
    • Mossberg, B.1    Camner, P.2    Afzelius, B.A.3
  • 129
    • 0025033561 scopus 로고
    • Relation of ventilatory impairment and of chronic mucus hypersecretion to mortality from obstructive lung disease and from all causes
    • Lange P, Nyboe J, Appleyard M, Jensen G, Schnohr P. 1990. Relation of ventilatory impairment and of chronic mucus hypersecretion to mortality from obstructive lung disease and from all causes. Thorax 45:579-585
    • (1990) Thorax , vol.45 , pp. 579-585
    • Lange, P.1    Nyboe, J.2    Appleyard, M.3    Jensen, G.4    Schnohr, P.5
  • 132
    • 34548448180 scopus 로고    scopus 로고
    • Survival after lung volume reduction in chronic obstructive pulmonary disease: Insights from small airway pathology
    • Hogg JC, Chu FS, Tan WC, Sin DD, Patel SA, et al. 2007. Survival after lung volume reduction in chronic obstructive pulmonary disease: insights from small airway pathology. Am. J. Respir. Crit. Care Med. 176:454-459
    • (2007) Am. J. Respir. Crit. Care Med. , vol.176 , pp. 454-459
    • Hogg, J.C.1    Chu, F.S.2    Tan, W.C.3    Sin, D.D.4    Patel, S.A.5
  • 133
    • 0017683459 scopus 로고
    • Isometric and isotonic contractions in airway smooth muscle
    • Stephens NL, Van Niekerk W. 1977. Isometric and isotonic contractions in airway smooth muscle. Can. J. Physiol. Pharmacol. 55:833-838
    • (1977) Can. J. Physiol. Pharmacol. , vol.55 , pp. 833-838
    • Stephens, N.L.1    Van Niekerk, W.2
  • 134
    • 0021812987 scopus 로고
    • Bronchial hyporesponsiveness
    • Macklem PT. 1985. Bronchial hyporesponsiveness. Chest 87:158S-9S
    • (1985) Chest , vol.87
    • MacKlem, P.T.1
  • 138
    • 0019797098 scopus 로고
    • 2 receptors
    • Michoud MC, Lelorier J, Amyot R. 1981. Factors modulating the interindividual variability of airway responsiveness to histamine. The influence ofH1andH2receptors. Bull. Eur. Physiopathol. Respir. 17:807-821 (Pubitemid 11022173)
    • (1981) Clinical Respiratory Physiology , vol.17 , Issue.5 , pp. 807-821
    • Michoud, M.C.1    Lelorier, J.2    Amyot, R.3
  • 139
    • 0022414511 scopus 로고
    • Limited maximal airway narrowing in nonasthmatic subjects. Role of neural control and prostaglandin release
    • Sterk PJ, Daniel EE, Zamel N, Hargreave FE. 1985. Limited maximal airway narrowing in nonasthmatic subjects. Role of neural control and prostaglandin release. Am. Rev. Respir. Dis. 132:865-870
    • (1985) Am. Rev. Respir. Dis. , vol.132 , pp. 865-870
    • Sterk, P.J.1    Daniel, E.E.2    Zamel, N.3    Hargreave, F.E.4
  • 140
    • 0021273449 scopus 로고
    • The shape of the dose-response curve to histamine in asthmatic and normal subjects
    • Woolcock AJ, Salome CM, Yan K. 1984. The shape of the dose-response curve to histamine in asthmatic and normal subjects. Am. Rev. Respir. Dis. 130:71-75
    • (1984) Am. Rev. Respir. Dis. , vol.130 , pp. 71-75
    • Woolcock, A.J.1    Salome, C.M.2    Yan, K.3
  • 141
    • 0028946448 scopus 로고
    • Visualization of airway obstruction in vivo during pulmonary vascular engorgement and edema
    • Brown RH, Zerhouni EA, Mitzner W.1995.Visualization of airway obstruction in vivo during pulmonary vascular engorgement and edema. J. Appl. Physiol. 78:1070-1078
    • (1995) J. Appl. Physiol. , vol.78 , pp. 1070-1078
    • Brown, R.H.1    Zerhouni, E.A.2    Mitzner, W.3
  • 142
    • 0017816443 scopus 로고
    • The relations between structural changes in small airways and pulmonary-function tests
    • Cosio M, Ghezzo H, Hogg JC, Corbin R, Loveland M, et al. 1978. The relations between structural changes in small airways and pulmonary-function tests. N. Engl. J. Med. 298:1277-1281
    • (1978) N. Engl. J. Med. , vol.298 , pp. 1277-1281
    • Cosio, M.1    Ghezzo, H.2    Hogg, J.C.3    Corbin, R.4    Loveland, M.5
  • 143
    • 5144221335 scopus 로고    scopus 로고
    • Abnormal alveolar attachments with decreased elastic fiber content in distal lung in fatal asthma
    • Mauad T, Silva LF, Santos MA, Grinberg L, Bernardi FD, et al. 2004. Abnormal alveolar attachments with decreased elastic fiber content in distal lung in fatal asthma. Am. J. Respir. Crit. CareMed. 170:857-862
    • (2004) Am. J. Respir. Crit. CareMed. , vol.170 , pp. 857-862
    • Mauad, T.1    Silva, L.F.2    Santos, M.A.3    Grinberg, L.4    Bernardi, F.D.5
  • 145
    • 38449116846 scopus 로고    scopus 로고
    • Kinetics of in vitro bronchoconstriction in an elastolytic mouse model of emphysema
    • Khan MA, Kianpour S, Stampfli MR, Janssen LJ. 2007. Kinetics of in vitro bronchoconstriction in an elastolytic mouse model of emphysema. Eur. Respir. J. 30:691-700
    • (2007) Eur. Respir. J. , vol.30 , pp. 691-700
    • Khan, M.A.1    Kianpour, S.2    Stampfli, M.R.3    Janssen, L.J.4
  • 146
    • 0031468785 scopus 로고    scopus 로고
    • On the mechanism of mucosal folding in normal and asthmatic airways
    • Wiggs BR, Hrousis CA, Drazen JM, Kamm RD. 1997. On the mechanism of mucosal folding in normal and asthmatic airways. J. Appl. Physiol. 83:1814-1821
    • (1997) J. Appl. Physiol. , vol.83 , pp. 1814-1821
    • Wiggs, B.R.1    Hrousis, C.A.2    Drazen, J.M.3    Kamm, R.D.4
  • 148
    • 0030814301 scopus 로고    scopus 로고
    • Bronchial subepithelial fibrosis correlates with airway responsiveness to methacholine
    • Boulet LP, Laviolette M, Turcotte H, Cartier A, Dugas M, et al. 1997. Bronchial subepithelial fibrosis correlates with airway responsiveness to methacholine. Chest 112:45-52
    • (1997) Chest , vol.112 , pp. 45-52
    • Boulet, L.P.1    Laviolette, M.2    Turcotte, H.3    Cartier, A.4    Dugas, M.5
  • 150
    • 0030933944 scopus 로고    scopus 로고
    • Airways remodeling is a distinctive feature of asthma and is related to severity of disease
    • Chetta A, Foresi A, Del Donno M, Bertorelli G, Pesci A, Olivieri D. 1997. Airways remodeling is a distinctive feature of asthma and is related to severity of disease. Chest 111:852-857
    • (1997) Chest , vol.111 , pp. 852-857
    • Chetta, A.1    Foresi, A.2    Del Donno, M.3    Bertorelli, G.4    Pesci, A.5    Olivieri, D.6
  • 151
    • 0036435872 scopus 로고    scopus 로고
    • Structural changes of the airway wall impair respiratory function, even in mild asthma
    • Shiba K, Kasahara K, Nakajima H, Adachi M. 2002. Structural changes of the airway wall impair respiratory function, even in mild asthma. Chest 122:1622-1626
    • (2002) Chest , vol.122 , pp. 1622-1626
    • Shiba, K.1    Kasahara, K.2    Nakajima, H.3    Adachi, M.4
  • 152
    • 50349100424 scopus 로고    scopus 로고
    • Airway wall remodeling in asthma: From the epithelial layer to the adventitia
    • Bosse Y, Pare PD, Seow CY. 2008. Airway wall remodeling in asthma: from the epithelial layer to the adventitia. Curr. Allergy Asthma Rep. 8:357-366
    • (2008) Curr. Allergy Asthma Rep. , vol.8 , pp. 357-366
    • Bosse, Y.1    Pare, P.D.2    Seow, C.Y.3
  • 153
    • 0021319905 scopus 로고
    • Asthma and irreversible airflow obstruction
    • Brown PJ, Greville HW ,Finucane KE. 1984. Asthma and irreversible airflow obstruction. Thorax 39:131-136
    • (1984) Thorax , vol.39 , pp. 131-136
    • Brown, P.J.1    Greville, H.W.2    Finucane, K.E.3
  • 154
    • 0028414984 scopus 로고
    • Myofibroblast and elastic and collagen fiber hyperplasia in the bronchial mucosa: A possible basis for the progressive irreversibility of airway obstruction in chronic asthma
    • Gabbrielli S, Di Lollo S, Stanflin N, Romagnoli P. 1994. Myofibroblast and elastic and collagen fiber hyperplasia in the bronchial mucosa: a possible basis for the progressive irreversibility of airway obstruction in chronic asthma. Pathologica 86:157-160
    • (1994) Pathologica , vol.86 , pp. 157-160
    • Gabbrielli, S.1    Di Lollo, S.2    Stanflin, N.3    Romagnoli, P.4
  • 158
  • 159
  • 160
    • 0028965187 scopus 로고
    • Is asthma a fibrotic disease?
    • Roberts CR. 1995. Is asthma a fibrotic disease? Chest 107:111S-7S
    • (1995) Chest , vol.107
    • Roberts, C.R.1
  • 162
    • 0033968827 scopus 로고    scopus 로고
    • Airway narrowing and internal structural constraints
    • Seow CY,Wang L, Pare PD. 2000. Airway narrowing and internal structural constraints. J. Appl. Physiol. 88:527-533
    • (2000) J. Appl. Physiol. , vol.88 , pp. 527-533
    • Seow Cywang, L.1    Pare, P.D.2
  • 163
    • 0034997670 scopus 로고    scopus 로고
    • Stiffness of peripheral airway folding membrane in rabbits
    • Lambert RK, Pare PD, Okazawa M. 2001. Stiffness of peripheral airway folding membrane in rabbits. J. Appl. Physiol. 90:2041-2047
    • (2001) J. Appl. Physiol. , vol.90 , pp. 2041-2047
    • Lambert, R.K.1    Pare, P.D.2    Okazawa, M.3
  • 164
    • 0026076708 scopus 로고
    • Role of bronchial basement membrane in airway collapse
    • Lambert RK. 1991. Role of bronchial basement membrane in airway collapse. J. Appl. Physiol. 71:666-673
    • (1991) J. Appl. Physiol. , vol.71 , pp. 666-673
    • Lambert, R.K.1
  • 166
    • 0027750851 scopus 로고
    • Stochastic model of the pulmonary airway tree and its implications for bronchial responsiveness
    • Bates JH. 1993. Stochastic model of the pulmonary airway tree and its implications for bronchial responsiveness. J. Appl. Physiol. 75:2493-2499
    • (1993) J. Appl. Physiol. , vol.75 , pp. 2493-2499
    • Bates, J.H.1
  • 167
    • 0030860394 scopus 로고    scopus 로고
    • Relationship between heterogeneous changes in airway morphometry and lung resistance and elastance
    • Lutchen KR, Gillis H. 1997. Relationship between heterogeneous changes in airway morphometry and lung resistance and elastance. J. Appl. Physiol. 83:1192-1201
    • (1997) J. Appl. Physiol. , vol.83 , pp. 1192-1201
    • Lutchen, K.R.1    Gillis, H.2
  • 168
    • 0034878620 scopus 로고    scopus 로고
    • Airway stability and heterogeneity in the constricted lung
    • Anafi RC,Wilson TA. 2001. Airway stability and heterogeneity in the constricted lung. J. Appl. Physiol. 91:1185-1192
    • (2001) J. Appl. Physiol. , vol.91 , pp. 1185-1192
    • Anafi Rcwilson, T.A.1
  • 169
    • 0014062847 scopus 로고
    • Resistance of central and peripheral airways measured by a retrograde catheter
    • Macklem PT, Mead J. 1967. Resistance of central and peripheral airways measured by a retrograde catheter. J. Appl. Physiol. 22:395-401
    • (1967) J. Appl. Physiol. , vol.22 , pp. 395-401
    • MacKlem, P.T.1    Mead, J.2
  • 170
    • 4344582266 scopus 로고    scopus 로고
    • Heterogeneity of narrowing in normal and asthmatic airways measured by HRCT
    • King GG, Carroll JD, Muller NL, Whittall KP, Gao M, et al. 2004. Heterogeneity of narrowing in normal and asthmatic airways measured by HRCT. Eur. Respir. J. 24:211-218
    • (2004) Eur. Respir. J. , vol.24 , pp. 211-218
    • King, G.G.1    Carroll, J.D.2    Muller, N.L.3    Whittall, K.P.4    Gao, M.5
  • 171
    • 0022568923 scopus 로고
    • Ventilation imaging with positron emission tomography and nitrogen 13
    • Murata K, Itoh H, Senda M, Todo G, Yonekura Y, Torizuka K. 1986. Ventilation imaging with positron emission tomography and nitrogen 13. Radiology 158:303-307
    • (1986) Radiology , vol.158 , pp. 303-307
    • Murata, K.1    Itoh, H.2    Senda, M.3    Todo, G.4    Yonekura, Y.5    Torizuka, K.6
  • 172
    • 7544251114 scopus 로고    scopus 로고
    • Dynamic lung morphology of methacholine-induced heterogeneous bronchoconstriction
    • Chen BT, Johnson GA. 2004. Dynamic lung morphology of methacholine-induced heterogeneous bronchoconstriction. Magn. Reson. Med. 52:1080-1086
    • (2004) Magn. Reson. Med. , vol.52 , pp. 1080-1086
    • Chen, B.T.1    Johnson, G.A.2
  • 173
    • 0037841783 scopus 로고    scopus 로고
    • Imaging the lungs in asthmatic patients by using hyperpolarized helium-3 magnetic resonance: Assessment of response to methacholine and exercise challenge
    • Samee S, Altes T, Powers P, de Lange EE, Knight-Scott J, et al. 2003. Imaging the lungs in asthmatic patients by using hyperpolarized helium-3 magnetic resonance: assessment of response to methacholine and exercise challenge. J. Allergy Clin. Immunol. 111:1205-1211
    • (2003) J. Allergy Clin. Immunol. , vol.111 , pp. 1205-1211
    • Samee, S.1    Altes, T.2    Powers, P.3    De Lange, E.E.4    Knight-Scott, J.5
  • 174
    • 17144407246 scopus 로고    scopus 로고
    • Self-organized patchiness in asthma as a prelude to catastrophic shifts
    • Venegas JG, Winkler T, Musch G, Vidal Melo MF, Layfield D, et al. 2005. Self-organized patchiness in asthma as a prelude to catastrophic shifts. Nature 434:777-782
    • (2005) Nature , vol.434 , pp. 777-782
    • Venegas, J.G.1    Winkler, T.2    Musch, G.3    Vidal Melo, M.F.4    Layfield, D.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.