Imaging the lungs in asthmatic patients by using hyperpolarized helium-3 magnetic resonance: Assessment of response to methacholine and exercise challenge

Journal of Allergy and Clinical Immunology

Volumn 111, Issue 6, 2003, Pages 1205-1211

  Samee, Saba ^a   Altes, Talissa ^a   Powers, Patrick ^a   De Lange, Eduard E ^a   Knight Scott, Jack ^b   Rakes, Gary ^a   Mugler III, John P ^a   Ciambotti, Jonathan M ^a   Alford, Bennet A ^a   Brookeman, James R ^a   Platts Mills, Thomas A E ^a,c  

^a UNIVERSITY OF VIRGINIA   (United States)

^b University of Virginia School of Medicine   (United States)

^c UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

Author keywords

Asthma; Helium; Imaging; Lungs; Magnetic resonance imaging; Ventilation

Indexed keywords

HELIUM; METHACHOLINE;

ADULT; AIRWAY OBSTRUCTION; ARTICLE; ASTHMA; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; EXERCISE TEST; FEMALE; FORCED EXPIRATORY VOLUME; HUMAN; INHALATION; LUNG; LUNG DIFFUSION; LUNG VENTILATION; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL;

EID: 0037841783     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1067/mai.2003.1544     Document Type: Article

References (19)

1. National Asthma Education and Prevention Program (National Heart Lung and Blood Institute). Practical guide for the diagnosis and management of asthma. Bethesda, Md: US Department of Health and Human Services Public Health Service NIH NHLBI: 1997. NIH publication no. 97-4053.
2. King GG, Muller NL, Pare PD. Evaluation of airways in obstructive pulmonary disease using high-resolution computed tomography. Am J Respir Crit Care Med 1999:159:992-1004.
3. Newman KB, Lynch DA, Newman LS, Ellegood D, Newell JD Jr. Quantitative computed tomography detects air trapping due to asthma. Chest 1994;106:105-9.
4. Middleton H, Black RD, Saam B, Cates GD, Cofer GP, Guenther R, et al. MR imaging with hyperpolarized 3He gas. Magn Reson Med 1995;33:271-5.
5. McFall JR, Charles HC, Black RD, Middleton H, Swartz JC, Saam B, et al. Human lung air spaces: potential for MR imaging with hyperpolarized He-3. Radiology 1996;200:553-8.
6. de Lange EE, Mugler JP 3rd, Brookeman JR, Knight-Scott J, Truwit JD, Teates CD, et al. Lung air spaces: MR imaging evaluation with hyperpolarized 3He gas. Radiology 1999;210:851-7.
7. Kauczor HU, Ebert M, Kreitner KF, Nilgens H, Surkau R, Heil W, et al. Imaging of the lungs using 3He MRI: preliminary clinical experience in 18 patients with and without lung disease. J Magn Reson Imaging 1997;7:538-43.
8. Altes TA, Powers PL, Knight-Scott J, Rakes G, Platts-Mills TAE, de Lange EE, et al. Hyperpolarized 3 He MR lung ventilation imaging in asthmatics: preliminary findings. J Magn Reson Imaging 2001;13:378-84.
9. Crapo RO, Casaburi R, Coates AL, Enright PL, Hankinson JL, Irvin CG, et al. Guidelines for methacholine and exercise challenge testing - 1999. Am J Respir Crit Care Med 2000;161:309-29.
10. Enright PL, Connett JE, Kanner RE, Johnson LR, Lee WW. Spirometry in the Lung Health Study. 1. Methods and quality control. Am Rev Respir Dis 1991;143:1215-23.
11. Enright PL, Lebowitz MD, Cockroft DW. Physiologic measures: pulmonary function tests. Asthma outcome. Am J Respir Crit Care Med 1994;149:S9-20.
12. Woolcock AJ, Colman MH, Blackburn CR. Factors affecting normal values for ventilatory lung function. Am Rev Respir Dis 1972;106:692-709.
13. Woolcock AJ. Regional lung function studies in clinical medicine. Aust N Z J Med 1972;2:294-6.
14. Kaminsky DA, Bates JH, Irvin CG. Effects of cool, dry air stimulation on peripheral lung mechanics in asthma. Am J Respir Crit Care Med 2000;162:179-86.
15. Parker JA, Yester MV, Daube-Witherspoon E, Todd-Pokropek AE, Royal HJ. Procedure guideline for lung scintigraphy: 1.0. Society of Nuclear Medicine. J Nucl Med 1996;37:1906-10.
16. Barnes PJ. Neural control of human airways in health and disease. Am Rev Respir Dis 1986;134:1289-314.
17. Bodey KJ, Semper AE, Redington AE, Madden J, Teran LM, Holgate ST, et al. Cytokine profiles of BAL T cells and T-cell clones obtained from human asthmatic airways after local allergen challenge. Allergy 1999;54:1083-93.
18. Crater SE, Peters EJ, Martin ML, Murphy AW, Platts-Mills TAE. Expired nitric oxide and airway obstruction in asthma patients with an acute exacerbations. Am J Crit Care Med 1999;159:806-11.
19. Hunt J. Exhaled breath condensate: an evolving tool for noninvasive evaluation of lung disease. J Allergy Clin Immunol 2002;110:28-34.