On the mechanism of mucosal folding in normal and asthmatic airways

Journal of Applied Physiology

Volumn 83, Issue 6, 1997, Pages 1814-1821

  Wiggs, Barry R ^a   Hrousis, Constantine A ^a   Drazen, Jeffrey M ^b   Kamm, Roger D ^a,c  

^a Massachusetts Institute of Technology Cambridge   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

Asthma; Computational model; Epithelium; Finite element analysis; Mechanics; Remodeling

Indexed keywords

ARTICLE; ASTHMA; CHRONIC OBSTRUCTIVE LUNG DISEASE; EPITHELIUM CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; PHYSICAL MODEL; PRIORITY JOURNAL; RESPIRATORY TRACT MUCOSA; RIGIDITY; SMOOTH MUSCLE;

EID: 0031468785     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/jappl.1997.83.6.1814     Document Type: Article

References (30)

1. Allen, H. G. Analysis and Design of Structural Sandwich Panels. Toronto: Pergamon, 1969.
2. Bai, A., D. H. Eidel, J. C. Hogg, A. L. James, R. K. Lambert, M. S. Ludwig, M. Martin, D. M. McDonald, W. A. Mitzner, M. Okazawa, R. J. Pack, P. D. Paré, R. R. Schellenberg, H. A. Tiddens, E. M. Wagner, and D. Yager. Proposed nomenclature for quantifying subdivisions of the bronchial wall. J. Appl. Physiol. 77: 1011-1014, 1994.
3. Bates, J. H. T., and J. G. Martin. A theoretical study of the effect of airway smooth muscle orientation on bronchoconstriction. J. Appl. Physiol. 69: 995-1001, 1990.
4. Bathe, K. Finite Element Procedures in Engineering Analysis. Toronto: Prentice-Hall, 1982, chapt. 6, p. 301-406.
5. Brewster, C. E. P., P. H. Howarth, R. Djukanovic, J. Wilson, S. T. Holgate, and W. R. Roche. Myofibroblasts and subepithelial fibrosis in bronchial asthma. Am. J. Respir. Cell Mol. Biol. 3: 507-511, 1990.
6. Dunnill, M. S. The pathology of asthma, with special reference to changes in the bronchial mucosa. J. Clin. Pathol. 13: 27-33, 1960.
7. Ebina, M., H. Yaegashi, T. Takahashi, M. Motomiya, and M. Tanemura. Distribution of smooth muscles along the bronchial tree. Am. Rev. Respir. Crit. Care Med. 141: 1322-1326, 1990.
8. Gunst, S. J., and J. Q. Stropp. Pressure-volume and length-stress relationships in canine bronchi in vitro. J. Appl. Physiol. 64: 2522-2531, 1988.
9. Heard, B. E., and S. Hossain. Hyperplasia of bronchial muscle in asthma. J. Pathol. 110: 319-331, 1971.
10. Huber, H. L., and K. K. Koessler. The pathology of bronchial asthma. Arch. Intern. Med. 30: 689-760, 1922.
11. James, A. L., J. C. Hogg, L. Dunn, and P. D. Paré. The use of internal perimeter to compare airway size and to calculate smooth muscle shortening. Am. Rev. Respir. Dis. 138: 136-139, 1988.
12. James, A. L., P. D. Paré, and J. C. Hogg. The mechanics of airway narrowing in asthma. Am. Rev. Respir. Dis. 139: 242-246, 1989.
13. Jeffery, P. K., R. W. A. Godfrey E. Adelroth, F. Nelson, A. Rogers, and S.-A. Johansson. Effects of treatment on airway inflammation and thickening of reticular collagen in asthma: a quantitative light and electron microscopic study. Am. Rev. Respir. Crit. Care Med. 145: 890-899, 1992.
14. Kuwano, K., C. Bosken, P. D. Paré, T. R. Bai, B. R. Wiggs, and J. C. Hogg. Small airways dimensions in asthma and chronic obstructive lung disease. Am. Rev. Respir. Crit. Care Med. 148: 1220-1225, 1992.
15. Lai-Fook, S. J., R. E. Hyatt, J. R. Rodarte, and T. A. Wilson. Behavior of artificially produced holes in lung parenchyma. J. Appl. Physiol. 43: 648-655, 1977.
16. Laitinen, L. A., and A. Laitinen. Modulation of bronchial inflammation: corticosteroids and other therapeutic agents. Am. Rev. Respir. Crit. Care Med. 150: S87-S90, 1994.
17. Lambert, R. K. Role of bronchial basement membrane in airway collapse. J. Appl. Physiol. 71: 666-673, 1991.
18. Lambert, R. K., S. L. Codd, M. R. Alley, and R. J. Pack. Physical determinants of bronchial mucosal folding. J. Appl. Physiol. 77: 1206-1216, 1994.
19. Miller, W. S. The Lung. Baltimore, MD: Thomas, 1937.
20. Moreno, R. H., J. C. Hogg, and P. D. Paré. Mechanics of airway narrowing. Am. Rev. Respir. Crit. Care Med. 133: 1171-1180, 1986.
21. Ogawa, Y. Study on the strength of human lower air-passages. J. Kyoto Prefect Univ. Med. 66: 781-800, 1959.
22. Okazawa, M., P. D. Paré, J. C. Hogg, and R. K. Lambert. Mechanical consequences of remodelling of the airwall. In: Airways and Vascular Remodelling in Asthma and Cardiovascular Disease, edited by C. Page and J. Black. Toronto: Academic, 1994, chapt. 8, p. 91-101.
23. Okazawa, M., L. Wang, J. Bert, and P. D. Paré. The elastic properties of airway mucosal membrane in rabbits (Abstract). Am. Rev. Respir. Crit. Care Med. 147: A856, 1993.
24. Roberts, C. R. Is asthma a fibrotic disease? Chest 107: 111S-117S, 1995.
25. Roche, W. R., R. Beasley, J. H. Williams, and S. T. Holgate. Subepithelial fibrosis in the bronchi of asthmatics. Lancet 1: 520-524, 1989.
26. Sasaki, F., D. English, P. D. Paré, and M. Okazawa. Airway wall dimensions during carbachol induced bronchoconstriction (Abstract). Am. Rev. Respir. Crit. Care Med. 149: A586, 1994.
27. Timoshenko, S. P., and J. M. Gere. Buckling of shells. In: Theory of Elastic Stability (2nd ed.). Toronto: McGraw-Hill, 1961, chapt. 11, p. 457-520.
28. Yager, D., J. P. Butler, J. Bastacky, E. Israel, G. Smith, and J. M. Drazen. Amplification of airway constriction due to liquid filling of airway interstices J. Appl. Physiol. 66: 2873-2884, 1989.
29. Wagner, E. M., and W. Mitzner. Bronchial vascular engorgement and ail-way narrowing (Abstract). Am. Rev. Respir. Crit. Care Med. 149: A585, 1994.
30. Wiggs, B. R., C. Bosken, P. D. Paré, A. J. James, and J. C. Hogg. A model of airway narrowing in asthma and chronic obstructive pulmonary disease. Am. Rev. Respir. Dis. 145: 1251-1258, 1992.