Altered airway surfactant phospholipid composition and reduced lung function in asthma

Journal of Applied Physiology

Volumn 89, Issue 4, 2000, Pages 1283-1292

  Wright, Sarah M ^a   Hockey, Peter M ^a   Enhorning, Goran ^b   Strong, Peter ^c   Reid, Kenneth B M ^c   Holgate, Stephen T ^a   Djukanovic, Ratko ^a   Postle, Anthony D ^a,d  

^a UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^b UNIVERSITY AT BUFFALO   (United States)

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d SOUTHAMPTON GENERAL HOSPITAL   (United Kingdom)

Author keywords

Asthma; Mass spectrometry; Phospholipid; Surfactant

Indexed keywords

ALLERGEN; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; CORTICOSTEROID; DIPALMITOYLPHOSPHATIDYLCHOLINE; LUNG SURFACTANT; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLGLYCEROL; PHOSPHATIDYLINOSITOL; PHOSPHOLIPID; SURFACTANT PROTEIN A;

ADULT; ARTICLE; ASTHMA; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; FIBEROPTIC BRONCHOSCOPY; HUMAN; LIPID COMPOSITION; LUNG FUNCTION; LUNG LAVAGE; MALE; MASS SPECTROMETRY; PRIORITY JOURNAL; PROTEIN ANALYSIS; SPIROMETRY; SPUTUM ANALYSIS;

EID: 0033774787     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/jappl.2000.89.4.1283     Document Type: Article

References (37)

1. Phosphorous assay in column chromatography
2. Conductive airway surfactant: Surface-tension function, biochemical composition, and possible alveolar origin
3. Summary and recommendations of a workshop in the investigative use of fibreoptic bronchoscopy and bronchoalveolar lavage in asthmatic patients
4. A rapid method of total lipid extraction and purification
5. Phospholipase A(2) and arachidonate increase in bronchoalveolar lavage fluid after inhaled antigen challenge in asthmatics
6. 2 show different specificities for phospholipid molecular species
7. Antigen induced generation of lysophospholipids in human airways
8. Breathing and pulmonary surfactant function in mice 24 h after ozone exposure
9. Pulmonary surfactant maintains patency of conducting airways in the rat
10. Genetics of the hydrophilic surfactant proteins A and D
11. Artificial pulmonary surfactant inhibited by proteins
12. Extracellular lining of bronchioles after perfusion-fixation of rat lungs for electron microscopy
13. Inhibition of pulmonary surfactant by oleic acid: Mechanisms and characteristics
14. Phospholipid molecular species of bronchoalveolar lavage fluid after local allergen challenge in asthma
15. Human lung surfactant protein-A exists in several different oligomeric states: Oligomer size distribution varies between patient groups
16. Dysfunction of pulmonary surfactant in asthmatics after allergen challenge
17. A biophysical mechanism by which plasma proteins inhibit lung surfactant activity
18. Effects of hemoglobin and cell membrane lipids on pulmonary surfactant activity
19. Developmental variation in whole human lung phosphatidylcholine molecular species: A comparison with guinea pig and rat
20. Antigen-induced airway inflammation in atopic subjects generates dysfunction of pulmonary surfactant
21. Phosphatidylcholine molecular species of calf lung surfactant
22. Surface activity of sputum from acute asthmatic patients
23. A pilot study of surfactant inhalation for the treatment of asthma attack
24. Surfactant and ARDS
25. Surfactant dysfunction develops when the immunised guinea-pig is challenged with ovalbumin aerosol
26. Pulmonary surfactant will secure free air-flow through a narrow tube
27. Pulmonary surfactant given prophylactically alleviates an asthma attack in guinea-pigs
28. The effect of processing on inflammatory markers in induced sputum
29. Protein measurement with the Folin phenol reagent
30. Use of induced sputum cell counts to investigate airway inflammation in asthma
31. Deficient hydrophilic lung surfactant proteins A and D with normal surfactant phospholipid molecular species in cystic fibrosis
32. Alveolar surfactant and adult respiratory distress syndrome: Pathogenic role and therapeutic prospects
33. Alteration of surfactant function due to protein leakage: Special interaction with fibrin monomer
34. A novel method of purifying lung surfactant proteins A and D from the lung lavage of alveolar proteinosis patients and from pooled amniotic fluid
35. Surfactant protein A in bronchoalveolar lavage fluid
36. Respiratory syncytial virus affects pulmonary function in BALB/c mice