The myth of maximal airway responsiveness in vivo

Journal of Applied Physiology

Volumn 85, Issue 6, 1998, Pages 2012-2017

  Brown, Robert H ^a   Mitzner, Wayne ^a  

^a JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

Airway closure; Airways; Asthma; Dose response curve; High resolution computed tomography; Hyperresponsiveness; Methacholine

Indexed keywords

METHACHOLINE;

AEROSOL; AIRWAY CONDUCTANCE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ASTHMA; BRONCHOSCOPY; COMPUTER ASSISTED TOMOGRAPHY; DATA ANALYSIS; DIAGNOSTIC IMAGING; DOG; DOSE RESPONSE; ELASTICITY; HIGH RESOLUTION COMPUTER TOMOGRAPHY; LUNG FUNCTION; NONHUMAN; PRIORITY JOURNAL; RESPIRATORY TRACT DISEASE;

EID: 0031792957     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/jappl.1998.85.6.2012     Document Type: Article

References (31)

1. Amirav, I., S. S. Kramer, M. M. Grunstein, and E. A. Hoffman. Assessment of methacholine-induced airway constriction by ultrafast high-resolution computed tomography. J. Appl. Physiol. 75: 2239-2250, 1993.
2. Armour, C. L., J. L. Black, N. Berend, and A. J. Woolcock. The relationship between bronchial hyperresponsiveness to methacholine and airway smooth muscle structure and reactivity. Respir. Physiol. 58: 223-233, 1984.
3. Brown, R. H., J. Georgakopoulos, and W. Mitzner. Individual airway responsiveness to aerosol histamine and methacholine in vivo. Am. J. Respir. Crit. Care Med. 157: 491-497, 1998.
4. Brown, R. H., and W. Mitzner. Effect of lung inflation and airway muscle tone on airway diameter in vivo. J. Appl. Physiol. 80: 1581-1588, 1996.
5. Brown, R. H., W. Mitzner, Y. Bulut, and E. M. Wagner. Effects of lung inflation in vivo on airways with smooth muscle tone or edema. J. Appl. Physiol. 82: 491-499, 1997.
6. Brown, R. H., E. A. Zerhouni, and C. A. Hirshman. Reversal of bronchoconstriction by inhaled nitric oxide: histamine versus methacholine. Am. J. Respir. Crit. Care Med. 150: 233-237, 1994.
7. DeJonste, J. C., P. J. Sterk, L. N. A. Willems, H. Mons, M. C. Timmers, and K. T. Kerrebijn. Comparison of maximal bronchoconstriction in vivo and airway smooth muscle responses in vitro in non-asthmatic humans. Am. Rev. Respir. Dis. 138: 321-326, 1988.
8. Ding, D. J., J. G. Martin, and P. T. Macklem. Effects of lung volume on maximal methacholine-induced bronchoconstriction in normal humans. J. Appl. Physiol. 62: 1324-1330, 1987.
9. Gunst, S. J., J. Q. Stropp, and J. Service. Mechanical modulation of pressure-volume characteristics of contracted canine airways in vitro. J. Appl. Physiol. 68: 2223-2229, 1990.
10. Herold, C. J., R. H. Brown, W. Mitzner, J. M. Links, C. A. Hirshman, and E. A. Zerhouni. Assessment of pulmonary airway reactivity with high-resolution CT. Radiology 181: 369-374, 1991.
11. Hulbert, W. C., T. McLean, B. Wiggs, P. Pare, and J. C. Hogg. Histamine dose-response curves in guinea pigs. J. Appl. Physiol. 58: 625-634, 1985.
12. 3 exposure. J. Appl. Physiol. 65: 2679-2686, 1988.
13. Lay, J. C., C. R. Berry, C. S. Kim, and W. D. Bennett. Retention of insoluble particles after local intrabronchial deposition in dogs. J. Appl. Physiol. 79: 1921-1929, 1995.
14. Lippmann, M. Regional deposition of particles in the human respiratory tract. In: Handbook of Physiology. Reactions to Environmental Agents. Bethesda, MD: Am. Physiol. Soc., 1977, sect. 9, chapt. 14, p. 213-232.
15. Ludwig, M. S., P. V. Romero, and J. H. T. Bates. A comparison of the dose-response behavior of canine airways and parenchyma. J. Appl. Physiol. 67: 1220-1225, 1989.
16. 1 measurements in a methacholine provocation test. Eur. Respir. J. 6: 680-686, 1993.
17. 2 receptors. Bull. Eur. Physiopath. Respir. 17: 807-821, 1981.
18. Mitzner, W., S. Blosser, D. Yager, and E. Wagner. Effect of bronchial smooth muscle contraction on lung compliance. J. Appl. Physiol. 72: 158-167, 1992.
19. Moore, B. J., C. C. Hilliam, L. M. Verburgt, B. R. Wiggs, S. Vedal, and P. D. Pare. Shape and position of the complete dose-response curve for inhaled methacholine in normal subjects. Am. J. Respir. Crit. Care Med. 154: 642-648, 1996.
20. Rinard, G. A., A. Jensen, and A. M. Puckett. Hydrocortisone and isoproterenol effects on trachealis cAMP and relaxation. J. Appl. Physiol. 55: 1609-1613, 1983.
21. Robatto, F. M., S. Simard, and M. S. Ludwig. How changes in the serial distribution of bronchoconstriction affect lung mechanics. J. Appl. Physiol. 74: 2838-2847, 1993.
22. Robatto, F. M., S. Simard, H. Orana, P. T. Macklem, and M. S. Ludwig. Effect of lung volume on plateau response of airways and tissue to methacholine in dogs. J. Appl. Physiol. 73: 1908-1913, 1992.
23. Shen, X., M. F. Wu, R. S. Tepper, and S. J. Gunst. Mechanisms for the mechanical response of airway smooth muscle to length oscillation. J. Appl. Physiol. 83: 731-738, 1997.
24. Shioya, T., J. Solway, N. M. Munoz, M. Mack, and A. R. Leff. Distribution of airway contractile responses within the major diameter bronchi during exogenous bronchoconstriction. Am. Rev. Respir. Dis. 135: 1105-1111, 1987.
25. Sly, P. D., K. A. Brown, J. H. T. Bates, P. T. Macklem, J. Milic-Emili, and J. G. Martin. Effect of lung volume on interrupter resistance in cats challenged with methacholine. J. Appl. Physiol. 64: 360-366, 1988.
26. Sterk, P. J., E. E. Daniel, N. Zamel, and F. E. Hargreave. Limited bronchoconstriction to methacholine using partial flow-volume curves in nonasthmatic subjects. Am. Rev. Respir. Dis. 132: 272-277, 1985.
27. Sterk, P. J., M. C. Timmers, and J. H. Dijkman. Maximal airway narrowing in humans in vivo histamine compared with methacholine. Am. Rev. Respir. Dis. 134: 714-718, 1986.
28. Sweeney, T. D., D. Cipolla, and I. Gonda. Localized delivery of particles to a small region of the airways (Abstract). Am. J. Respir. Crit. Care Med. 151: A61, 1995.
29. Warner, D. O., and S. J. Gunst. Limitation of maximal bronchoconstriction in living dogs. Am. Rev. Respir. Dis. 145: 553-560, 1992.
30. Wood, S. A., E. A. Zerhouni, J. D. Hoford, E. A. Hoffman, and W. Mitzner. Measurement of three-dimensional lung tree structures by using computed tomography. J. Appl. Physiol. 79: 1687-1697, 1995.
31. Woolcock, A. J., C. M. Salome, and K. Yan. The shape of the dose-response curve to histamine in asthmatic and normal subjects. Am. Rev. Respir. Dis. 130: 71-75, 1984.