Effect of tidal volume and frequency on airway responsiveness in mechanically ventilated rabbits

Journal of Applied Physiology

Volumn 83, Issue 4, 1997, Pages 1202-1208

  Shen, X ^a   Gunst, S J ^a   Tepper, R S ^a,b  

^a INDIANA UNIVERSITY   (United States)

^b RILEY HOSPITAL FOR CHILDREN   (United States)

Author keywords

Airway narrowing; Airway smooth muscle; Tidal breathing

Indexed keywords

METHACHOLINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ARTIFICIAL VENTILATION; BREATHING; BRONCHUS REACTIVITY; CONTROLLED STUDY; NONHUMAN; PRIORITY JOURNAL; RABBIT; SMOOTH MUSCLE; TIDAL VOLUME;

EID: 0030879656     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/jappl.1997.83.4.1202     Document Type: Article

References (27)

1. Brusasco, V., R. Pellegrino, B. Violante, and E. Crimi. Relationship between quasi-static pulmonary hysteresis and maximal airway narrowing in humans. J. Appl. Physiol. 72: 2075-2080, 1992.
2. Fish, J. E., M. G. Ankin, J. F. Kelly, and V. I. Peterman. Regulation of bronchomotor tone by lung inflation in asthmatic and nonasthmatic subjects. J. Appl. Physiol. 50: 1079-1086, 1981.
3. Fish, J. E., R. R. Rosenthal, G. Batra, H. Menkes, W. Summer, S. Permutt, and P. Norman. Airway responses to methacholine in allergic and nonallergic subjects. Am. Rev. Respir. Dis. 579-586, 1976.
4. Gayrard, P., J. Orehek, C. Grimaud, and J. Charpin. Bronchoconstrictor effects of a deep inspiration in patients with asthma. Am. Rev. Respir. Dis. 111: 433-438, 1975.
5. Green, M., and J. Mead. Time-dependence of flow-volume curves. J. Appl. Physiol. 37: 793-797, 1974.
6. Gunst, S. J. Contractile force of canine airway smooth muscle during cyclical length changes. J. Appl. Physiol. 55: 759-769, 1983.
7. Gunst, S. J., R. Meiss, M. F. Wu, and M. A. Rowe. Mechanisms for the mechanical plasticity of tracheal smooth muscle. Am. J. Physiol. 268 (Cell Physiol. 37): C1267-C1276, 1995.
8. Gunst, S. J., and J. Q. Stropp. Pressure-volume and length-stress relationships in canine bronchi in vitro. J. Appl. Physiol. 64: 2522-2531, 1988.
9. Gunst, S. J., J. Q. Stropp, and J. Service. Mechanical modulation of pressure-volume characteristics of contracted canine airways in vitro. J. Appl. Physiol. 68: 2223-2229, 1990.
10. Gunst, S. J., M. F. Wu, and D. D. Smith. Contraction history modulates isotonic shortening velocity in smooth muscle. Am. J. Physiol. 265 (Cell Physiol. 34): C467-C476, 1993.
11. Harris, D. E., and D. M. Warshaw. Length vs. active force relationship in single isolated smooth muscle cells. Am. J. Physiol. 254 (Cell Physiol. 23): C99-C106, 1988.
12. Lutchen, K., Z. Hantos, F. Petak, A. Adamicza, and B. Suki. Airway inhomogeneities contribute to apparent lung tissue resistance during constriction. J. Appl. Physiol. 80: 1841-1849, 1996.
13. Mehta, D., M. F. Wu, and S. J. Gunst. Role of contractile protein activation in the length-dependent modulation of tracheal smooth muscle force. Am. J. Physiol. 270 (Cell Physiol. 39): C243-C252, 1996.
14. Nadel, J. A., and D. F. Tierney. Effect of a previous deep inspiration on airway resistance in man. J. Appl. Physiol. 16: 717-719, 1961.
15. Orehek, J. Airway responses to stretch in asthmatic and nonasthmatic subjects. Prog. Respir. Res. 19: 290-294, 1985.
16. Orehek, J., P. Gayrard, C. Grimaud, and J. Charpin. Effect of maximal respiratory maneuvers on bronchial sensitivity of asthmatic patients as compared to normal people. Br. Med. J. 1: 123-125, 1975.
17. Parham, W. M., R., H. Shepard, P. S. Norman, and J. E. Fish. Analysis of time course and magnitude of lung inflation effects on airway tone: relation to airway reactivity. Am. Rev. Respir. Dis. 128: 240-245, 1983.
18. Pellegrino, R., B. Violante, and V. Brusasco. Maximal bronchoconstriction in humans: relationship to deep inhalation and airway sensitivity. Am. J. Respir. Crit. Care Med. 153: 115-121, 1996.
19. Pichurko, B. M., and R. H. Ingram. Effects of airway tone and volume history on maximal expiratory flow in asthma. J. Appl. Physiol. 62: 1133-1140, 1987.
20. Pratusevich, V. R., C. Y. Seow, and L. E. Ford. Plasticity in canine airway smooth muscle. J. Gen. Physiol. 105: 73-94, 1995.
21. Shen, X., V. Bhargava, G. R. Wodicka, C. M. Doerschuk, S. J. Gunst, and R. S. Tepper. Greater airway narrowing in immature than in mature rabbits during methacholine challenge. J. Appl. Physiol. 81: 2637-2643, 1996.
22. Shen, X., M. F. Wu, R. S. Tepper, and S. J. Gunst. Mechanisms for the mechanical response of airway smooth muscle to length oscillation. J. Appl. Physiol. 83: 731-738, 1997.
23. Skloot, G., S. Permutt, and A. Togias. Airway hyperresponsiveness in asthma: a problem of limited smooth muscle relaxation with inspiration. J. Clin. Invest. 96: 2393-2403, 1995.
24. Tepper, R. S., J. Sato, B. Suki, J. G. Martin, and J. H. T. Bates. Low-frequency pulmonary impedance in rabbits and its response to inhaled methacholine. J. Appl. Physiol. 73: 290-295, 1992.
25. Tepper, R. S., X. Shen, E. Bakan, and S. J. Gunst. Maximal airway response in mature and immature rabbits during tidal ventilation. J. Appl. Physiol. 79: 1190-1198, 1995.
26. Wagner, E. M., and W. A. Mitzner. Contribution of pulmonary versus systemic perfusion of airway smooth muscle. J. Appl. Physiol. 78: 403-409, 1995.
27. Warner, D. O., and S. J. Gunst. Limitation of maximal bronchoconstriction in dogs. Am. Rev. Respir. Dis. 145: 553-560, 1992.