Hormone activity of hydroxylated polybrominated diphenyl ethers on human thyroid receptor-β: In vitro and in silico investigations

Environmental Health Perspectives

Volumn 118, Issue 5, 2010, Pages 602-606

  Li, Fei ^a   Xie, Qing ^a   Li, Xuehua ^a   Li, Na ^b   Chi, Ping ^a   Chen, Jingwen ^a   Wang, Zijian ^b   Hao, Ce ^a  

^a DALIAN UNIVERSITY OF TECHNOLOGY   (China)

^b RESEARCH CENTER FOR ECO ENVIRONMENTAL SCIENCES   (China)

Author keywords

Application domain; Density functional theory; Docking; HO PBDEs; Hydroxylated polybrominated diphenyl ethers; PBDEs; Quantitative structure activity relationship; Thyroid hormone receptor

Indexed keywords

POLYBROMINATED DIPHENYL ETHER; THYROID HORMONE; THYROID HORMONE RECEPTOR BETA;

ARTICLE; BINDING KINETICS; CHEMICAL STRUCTURE; COMPUTER MODEL; CONTROLLED STUDY; HORMONE ACTION; HYDROGEN BOND; HYDROXYLATION; IN VITRO STUDY; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; QUANTITATIVE STRUCTURE ACTIVITY RELATION;

BINDING SITES; BINDING, COMPETITIVE; ENDOCRINE DISRUPTORS; ENVIRONMENTAL POLLUTANTS; FLAME RETARDANTS; HALOGENATED DIPHENYL ETHERS; HUMANS; HYDROGEN BONDING; HYDROXYLATION; MODELS, MOLECULAR; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; RECOMBINANT PROTEINS; STATIC ELECTRICITY; THYROID HORMONE RECEPTORS BETA; TWO-HYBRID SYSTEM TECHNIQUES;

EID: 77951758435     PISSN: 00916765     EISSN: 15529924     Source Type: Journal    
DOI: 10.1289/ehp.0901457     Document Type: Article

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