Hydroxylated metabolites of the polybrominated diphenyl ether mixture DE-71 Are weak estrogen receptor-α ligands

Environmental Health Perspectives

Volumn 116, Issue 10, 2008, Pages 1315-1321

  Mercado Feliciano, Minerva ^a   Bigsby, Robert M ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cytochrome P450; DE 71; Endocrine disruptors; ERE luciferase; Estrogens; Mice; Ovariectomized; PBDEs; Polybrominated diphenyl ethers

Indexed keywords

ENDOCRINE DISRUPTOR; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; LUCIFERASE; POLYBROMINATED DIPHENYL ETHER; DIPHENYL ETHER DERIVATIVE; LIGAND; PENTABROMODIPHENYL ETHER; POLYBROMINATED BIPHENYL; RECOMBINANT PROTEIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL CULTURE; CONTROLLED STUDY; ENVIRONMENTAL EXPOSURE; ESTROGEN ACTIVITY; FEMALE; GENE ACTIVITY; GENE INDUCTION; HUMAN; HUMAN CELL; HYDROXYLATION; INCUBATION TIME; LIGAND BINDING; LIVER MICROSOME; METABOLIC ACTIVATION; METABOLITE; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR AFFINITY; REPORTER GENE; ANIMAL; BIOTRANSFORMATION; DRUG EFFECT; METABOLISM;

MUS; RATTUS;

ANIMALS; BIOTRANSFORMATION; ESTROGEN RECEPTOR ALPHA; GENES, REPORTER; HYDROXYLATION; LIGANDS; MICROSOMES, LIVER; PHENYL ETHERS; POLYBROMINATED BIPHENYLS; RATS; RECOMBINANT PROTEINS;

EID: 55949090982     PISSN: 00916765     EISSN: 15529924     Source Type: Journal    
DOI: 10.1289/ehp.11343     Document Type: Article

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