Effects of Ginkgo biloba extract on the embryo-fetal development in wistar rats

Birth Defects Research Part B - Developmental and Reproductive Toxicology

Volumn 89, Issue 2, 2010, Pages 133-138

  Fernandes, Eduardo Siqueira ^a   Pinto, Rafael Moraes ^a   Reis, João Evangelista De Paula ^a   Guerra, Martha De Oliveira ^a   Peters, Vera Maria ^a  

^a FEDERAL UNIVERSITY OF JUIZ DE FORA   (Brazil)

Author keywords

Development; Embryogenesis; Ginkgo biloba; Implantation; Pregnant; Rats

Indexed keywords

GINKGO BILOBA EXTRACT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLASTOCYST; BODY WEIGHT; CONTROLLED STUDY; EMBRYO; EMBRYO DEVELOPMENT; EMBRYOTOXICITY; FEMALE; FETOTOXICITY; FETUS; FETUS DEVELOPMENT; FLUID INTAKE; FOOD INTAKE; KIDNEY; LIVER; MALE; NONHUMAN; PLACENTA; PREGNANCY; PRIORITY JOURNAL; RAT; SYMPTOMATOLOGY;

ADMINISTRATION, ORAL; ANIMALS; BODY WEIGHT; EATING; EMBRYO, MAMMALIAN; EMBRYONIC DEVELOPMENT; FEMALE; FETAL DEVELOPMENT; GINKGO BILOBA; MATERNAL EXPOSURE; ORGAN SIZE; PLANT EXTRACTS; PREGNANCY; RATS; RATS, WISTAR; TERATOGENS;

GINKGO BILOBA; RATTUS; RATTUS NORVEGICUS;

EID: 77951743028     PISSN: 15429733     EISSN: 15429741     Source Type: Journal    
DOI: 10.1002/bdrb.20235     Document Type: Article

References (65)

1. Acker G, Hecquet F, Etienne A, Braquet P, Mencia-Huerta JM. 1988. Role of platelet-activating factor (PAF) in the ovoimplantation in the rat: effect of the specific PAF-acether antagonist, BN 52021. Prostaglandins 35:233-241.
2. Arnold KR. 2003. Ginkgo and memory. JAMA 289:546; author reply 547-548.
3. Ashton AK, Ahrens K, Gupta S, Masand PS. 2000. Antidepressant-induced sexual dysfunction and Ginkgo Biloba. Am J Psychiatry 157:836-837. (Pubitemid 30249674)
4. Baron-Ruppert G, Luepke NP. 2001. Evidence for toxic effects of alkylphenols from Ginkgo biloba in the hen's egg test (HET). Phytomedicine 8:133-138. (Pubitemid 32267098)
5. Bilia AR. 2002. Ginkgo biloba L. Fitoterapia 73:276-279.
6. Blumenthal M, Brinckmann J, Wollschlaeger B. 2003. The ABC clinical guide to herbs. New York: Thieme.
7. Carlson JJ, Farquhar JW, DiNucci E, Ausserer L, Zehnder J, Miller D, Berra K, Hagerty L, Haskell WL. 2007. Safety and efficacy of a ginkgo biloba-containing dietary supplement on cognitive function, quality of life, and platelet function in healthy, cognitively intact older adults. J Am Diet Assoc 107:422-432. (Pubitemid 46281825)
8. Chahoud I, Ligensa A, Dietzel L, Faqi AS. 1999. Correlation between maternal toxicity and embryo/fetal effects. Reprod Toxicol 13:375-381. (Pubitemid 29508427)
9. Chan WH. 2005. Ginkgolides induce apoptosis and decrease cell numbers in mouse blastocysts. Biochem Biophys Res Commun 338:1263-1267.
10. Chan WH. 2006. Ginkgolide B induces apoptosis and developmental injury in mouse embryonic stem cells and blastocysts. Hum Reprod 21: 2985-2995.
11. Chen WD, Liang Y, Xie L, Lu T, Liu XD, Wang GJ. 2007. Pharmacokinetics of the ginkgo B following intravenous administration of ginkgo B emulsion in rats. Biol Pharm Bull 30:1-5. (Pubitemid 46066309)
12. Chernoff N, Rogers EH, Gage MI, Francis BM. 2008. The relationship of maternal and fetal toxicity in developmental toxicology bioassays with notes on the biological significance of the "no observed adverse effect level." Reprod Toxicol 25:192-202.
13. Cheuvront SN, Carter 3rd R. 2003. Ginkgo and memory. JAMA 289:547; author reply 547-548.
14. Christian MS. 2001. Test methods for assessing female reproductive and developmental toxicology. In: Hayes AW, editor. Principles and methods of toxicology. New York: Raven Press. p 1301-1381.
15. Cohen AJ, Bartlik B. 1998. Ginkgo biloba for antidepressant-induced sexual dysfunction. J Sex Marital Ther 24:139-143. (Pubitemid 28189166)
16. Diamond BJ, Shiflett SC, Feiwel N, Matheis RJ, Noskin O, Richards JA, Schoenberger NE. 2000. Ginkgo biloba extract: mechanisms and clinical indications. Arch Phys Med Rehab 81:668-678. (Pubitemid 30257692)
17. Di Stasi LC, Oliveira GP, Carvalhaes MA, Queiroz-Junior M, Tiena OS, Hakinami SH, Reis MS. 2002. Medicinal plants popularly used in the Brazilian Tropical Atlantic Forest. Fitoterapia 73:69-91. (Pubitemid 34195540)
18. Doraiswamy PM, Pomara N. 2003. Ginkgo and memory. JAMA 289:547; author reply 547-548.
19. Dugoua JJ, Mills E, Perri D, Koren G. 2006. Safety and efficacy of ginkgo (Ginkgo biloba) during pregnancy and lactation. Can J Clin Pharmacol 13:e277-e284. (Pubitemid 44706205)
20. Eisenberg DM, Davis RB, Ettner SL, Appel S, Wilkey S, Van Rompay M, Kessler RC. 1998. Trends in alternative medicine use in the United States, 1990-1997: results of a follow-up national survey. JAMA 280:1569-1575. (Pubitemid 28520643)
21. Faria DE, Reis JEP, Ribeiro LC, Peters VM, Guerra MO. 2006. [Behavior of female rats (Rattus norvegicus Berkenhout, 1769) exposed to GBE during lactation]. Revista Brasileira de Zoociências 8:91-98.
22. Fourtillan JB, Brisson AM, Girault J, Ingrand I, Decourt JP, Drieu K, Jouenne P, Biber A. 1995. [Pharmacokinetics of bilobalide, Ginkgolide A and Ginkgolide B in healthy volunteers following oral and intravenous administrations of Ginkgo biloba extract (EGb 761)]. Therapie 50:137-144.
23. Hecker H, Johannisson R, Koch E, Siegers CP. 2002. In vitro evaluation of the cytotoxic potential of alkylphenols from Ginkgo biloba L. Toxicology 177:167-177.
24. Holson JF, Nemec MD, Stump DG, Kaufman LE, Lindström P, Varsho BJ. 2006. Significance, reliability, and interpretation of developmental and reproductive toxicity study finding. In: Hood RD, editor. Developmental and reproductive toxicology: a pratical approach, 2nd ed. London: Taylor & Francis. p 329-424.
25. Hood RD, Miller DB. 2006. Maternally mediated effects on development. In: Hood RD, editor. Developmental and reproductive toxicology: a practical approach. 2nd ed. London: Taylor & Francis. p 93-124.
26. ICH. 2005. ICH (International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use). ICH Harmonized Tripartite Guideline S5 (R2): detection of toxicity to reproduction for medicinal products and toxicity to male fertility. Geneva, Switzerland.
27. Jacobs BP, Browner WS. 2000. Ginkgo biloba: a living fossil. Am J Med 108:341-342.
28. Khera KS. 1987. Maternal toxicity of drugs and metabolic disorders - a possible etiologic factor in the intrauterine death and congenital malformation: a critique on human data. Crit Rev Toxicol 17:345-375.
29. Kleijnen J, Knipschild P. 1992. Ginkgo biloba. Lancet 340:1136-1139.
30. Koch E. 2005. Inhibition of platelet activating factor (PAF)-induced aggregation of human thrombocytes by ginkgolides: considerations on possible bleeding complications after oral intake of Ginkgo biloba extracts. Phytomedicine 12:10-16. (Pubitemid 40174323)
31. Kordan W, Strzezek J, Fraser L. 2003. Functions of platelet activating factor (PAF) in mammalian reproductive processes: a review. Pol J Vet Sci 6:55-60. (Pubitemid 37025989)
32. Longpre F, Garneau P, Christen Y, Ramassamy C. 2006. Protection by EGb 761 against beta-amyloid-induced neurotoxicity: involvement of NF-kappaB, SIRT1, and MAPKs pathways and inhibition of amyloid fibril formation. Free Radic Biol Med 41:1781-1794. (Pubitemid 44848398)
33. Luo Y, Smith JV, Paramasivam V, Burdick A, Curry KJ, Buford JP, Khan I, Netzer WJ, Xu H, Butko P. 2002. Inhibition of amyloid-beta aggregation and caspase-3 activation by the Ginkgo biloba extract EGb761. Proc Natl Acad Sci USA 99:12197-12202.
34. Mar C, Bent S. 1999. An evidence-based review of the 10 most commonly used herbs. West J Med 171:168-171.
35. Masteikova R, Muselik J, Bernatoniene J, Bernatoniene R. 2007. Antioxidative activity of Ginkgo, Echinacea, and Ginseng tinctures. Medicina (Kaunas) 43:306-309.
36. McKenna DJ, Jones K, Hughes K. 2001. Efficacy, safety, and use of ginkgo biloba in clinical and preclinical applications. Altern Ther Health Med 7:70-86, 88-90. (Pubitemid 32423642)
37. Nathan PJ, Harrison BJ, Bartholomeusz C. 2003. Ginkgo and memory. JAMA 289:546; author reply 547-548.
38. OECD. 2001. Guideline for the testing of chemicals, no. 414: prenatal developmental toxicity study. Paris: Organization for Economic Co-operation and Development.
39. Oh SM, Chung KH. 2004. Estrogenic activities of Ginkgo biloba extracts. Life Sci 74:1325-1335.
40. Oh SM, Chung KH. 2006. Antiestrogenic activities of Ginkgo biloba extracts. J Steroid Biochem Mol Biol 100:167-176. (Pubitemid 44175838)
41. Ondrizek RR, Chan PJ, Patton WC, King A. 1999a. An alternative medicine study of herbal effects on the penetration of zona-free hamster oocytes and the integrity of sperm deoxyribonucleic acid. Fertil Steril 71:517-522. (Pubitemid 29094130)
42. Ondrizek RR, Chan PJ, Patton WC, King A. 1999b. Inhibition of human sperm motility by specific herbs used in alternative medicine. J Assist Reprod Genet 16:87-91. (Pubitemid 29108554)
43. Paick JS, Lee JH. 1996. An experimental study of the effect of ginkgo biloba extract on the human and rabbit corpus cavernosum tissue. J Urol 156:1876-1880.
44. Parker RM. 2006. Testing for reproductive toxicity. In: Hood RD, editor. Developmental and reproductive toxicology - a practical approach. 2nd ed. London: Taylor and Francis. p 525-587.
45. Patterson MB, Balough BJ. 2006. Review of pharmacological therapy for tinnitus. Int Tinnitus J 12:149-159.
46. Pietta PG, Gardana C, Mauri PL, Maffei-Facino R, Carini M. 1995. Identification of flavonoid metabolites after oral administration to rats of a Ginkgo biloba extract. J Chromatogr B Biomed Appl 673:75-80.
47. Pietta PG, Gardanab C, Mauri PL. 1997. Identification of Ginkgo biloba flavonol metabolites after oral administration to humans. J Chromatogr B 693:249-255.
48. Pinto RM, Fernandes ES, Reis JE, Peters VM, Guerra Mde O. 2007. Intrauterine growth retardation after prenatal administration of Ginkgo biloba to rats. Reprod Toxicol 23:480-485. (Pubitemid 46754739)
49. Ramassamy C, Longpre F, Christen Y. 2007. Ginkgo biloba extract (EGb 761) in Alzheimer's disease: is there any evidence? Curr Alzheimer Res 4:253-262.
50. Segura MAM, Delgado SB, Torres RG. 2000. Clinical applications of the extract of the Ginkgo biloba leaf. Rev Fitoterapia 1:95-105.
51. Sierpina VS, Wollschlaeger B, Blumenthal M. 2003. Ginkgo biloba. Am Fam Physician 68:923-926.
52. Skibola CF, Smith MT. 2000. Potential health impacts of excessive flavonoid intake. Free Radic Biol Med 29:375-383.
53. Smith DG, Cappai R, Barnham KJ. 2007. The redox chemistry of the Alzheimer's disease amyloid beta peptide. Biochim Biophys Acta 1768:1976-1990. (Pubitemid 47125850)
54. Smith JV, Luo Y. 2004. Studies on molecular mechanisms of Ginkgo biloba extract. Appl Microbiol Biotechnol 64:465-472. (Pubitemid 38686154)
55. Spinks NR, O'Neill C. 1988. Antagonists of embryo-derived plateletactivating factor prevent implantation of mouse embryos. J Reprod Fertil 84:89-98.
56. Tesch BJ. 2003. Herbs commonly used by women: an evidence-based review. Am J Obstet Gynecol 188(5 Suppl):S44-55.
57. van Beek TA. 2002. Chemical analysis of Ginkgo biloba leaves and extracts. J Chromatogr A 967:21-55. (Pubitemid 34786583)
58. Wang FM, Yao TW, Zeng S. 2003a. Determination of quercetin and kaempferol in human urine after orally administrated tablet of Ginkgo biloba extract by HPLC. J Pharm Biomed Anal 33:317-321. (Pubitemid 37101449)
59. Wang FM, Yao TW, Zeng S. 2003b. Disposition of quercetin and kaempferol in human following an oral administration of Ginkgo biloba extract tablets. Eur J Drug Metab Pharmacokinet 28:173-177. (Pubitemid 37163061)
60. Welt K, Weiss J, Martin R, Hermsdorf T, Drews S, Fitzl G. 2007. Ginkgo biloba extract protects rat kidney from diabetic and hypoxic damage. Phytomedicine 14:196-203. (Pubitemid 46136946)
61. Wheatley D. 2003. Ginkgo and memory. JAMA 289:546-547, author reply 547-548.
62. WHO. 1999. Folium Ginkgo. In: WHO, editor. WHO monographs on selected medicinal plants. Geneva: World Health Organization. p 154-167.
63. Wu Y, Wu Z, Butko P, Christen Y, Lambert MP, Klein WL, Link CD, Luo Y. 2006. Amyloid-beta-induced pathological behaviors are suppressed by Ginkgo biloba extract EGb 761 and ginkgolides in transgenic Caenorhabditis elegans. J Neurosci 26:13102-13113.
64. Xie J, Ding C, Ge Q, Zhou Z, Zhi X. 2008. Simultaneous determination of ginkgolides A, B, C and bilobalide in plasma by LC-MS/MS and its application to the pharmacokinetic study of Ginkgo biloba extract in rats. J Chromatogr B Anal Technol Biomed Life Sci 864:87-94.
65. Yeh KY, Pu HF, Kaphle K, Lin SF,Wu LS, Lin JH, Tsai YF. 2007. Ginkgo biloba extract enhances male copulatory behavior and reduces serum prolactin levels in rats. Horm Behav 53:225-231.