Intra-uterine growth retardation after prenatal administration of Ginkgo biloba to rats

Reproductive Toxicology

Volumn 23, Issue 4, 2007, Pages 480-485

  Pinto, Rafael M ^a   Fernandes, Eduardo S ^a   Reis, João E P ^a   Peters, Vera M ^a   Guerra, Martha de O ^a  

^a FEDERAL UNIVERSITY OF JUIZ DE FORA   (Brazil)

Author keywords

Developmental toxicity; Fetogenesis; Ginkgo biloba; Growth retardation; Organogenesis; Pregnancy; Rats

Indexed keywords

GINKGO BILOBA EXTRACT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; BRAIN WEIGHT; CONTROLLED STUDY; FEMALE; FETUS GROWTH; FLUID INTAKE; FOOD INTAKE; GINKGO BILOBA; INTRAUTERINE GROWTH RETARDATION; KIDNEY MASS; LIVER WEIGHT; NONHUMAN; ORGANOGENESIS; OVARY; PRENATAL GROWTH; PRENATAL PERIOD; RAT; STATISTICAL SIGNIFICANCE;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; FETAL GROWTH RETARDATION; FETAL WEIGHT; GESTATIONAL AGE; GINKGO BILOBA; LIVER; MALE; PLANT EXTRACTS; PREGNANCY; RATS; RATS, WISTAR;

GINKGO BILOBA; RATTUS; RATTUS NORVEGICUS;

EID: 34248583789     PISSN: 08906238     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.reprotox.2006.12.008     Document Type: Article

References (46)

1. Eisenberg D.M., Davis R.B., Ettner S.L., et al. Trends in alternative medicine use in the United States, 1990-1997: results of a follow-up national survey. JAMA 280 (1998) 1569-1575
2. Tesch B.J. Herbs commonly used by women: an evidence-based review. Am J Obstet Gynecol 188 (2003) S44-S55
3. Harborne J.B., and Williams C.A. Advances in flavonoid research since 1992. Phytochemistry 55 (2000) 481-504
4. Havsteen B.H. The biochemistry and medical significance of the flavonoids. Pharmacol Ther 96 (2002) 67-202
5. Skibola C.F., and Smith M.T. Potential health impacts of excessive flavonoid intake. Free Radic Biol Med 29 (2000) 375-383
6. Mar C., and Bent S. An evidence-based review of the 10 most commonly used herbs. West J Med 171 (1999) 168-171
7. Smith J.V., and Luo Y. Studies on molecular mechanisms of Ginkgo biloba extract. Appl Microbiol Biotechnol 64 (2004) 465-472
8. Ginkgo biloba. In: Blumenthal M., Brinckmann J., and Wollschlaeger B. (Eds). The ABC clinical guide to herbs (2003), Thieme, New York 185-200
9. World Health Organization (WHO). Folium Ginkgo. In WHO monographs on selected medicinal plants, vol. 1. Geneva: World Health Organization; 1999. p. 154-67.
10. van Beek T.A. Chemical analysis of Ginkgo biloba leaves and extracts. J Chromatogr A 967 (2002) 21-55
11. Pietta P.G., Gardana C., Mauri P.L., Maffei-Facino R., and Carini M. Identification of flavonoid metabolites after oral administration to rats of a Ginkgo biloba extract. J Chromatogr B Biomed Appl 673 (1995) 75-80
12. Pietta P.G., Gardana C., and Mauri P.L. Identification of Gingko biloba flavonol metabolites after oral administration to humans. J Chromatogr B Biomed Sci Appl 693 (1997) 249-255
13. Sierpina V.S., Wollschlaeger B., and Blumenthal M. Ginkgo biloba. Am Fam Physician 68 (2003) 923-926
14. Ondrizek R.R., Chan P.J., Patton W.C., and King A. An alternative medicine study of herbal effects on the penetration of zona-free hamster oocytes and the integrity of sperm deoxyribonucleic acid. Fertil Steril 71 (1999) 517-522
15. Ondrizek R.R., Chan P.J., Patton W.C., and King A. Inhibition of human sperm motility by specific herbs used in alternative medicine. J Assist Reprod Genet 16 (1999) 87-91
16. Li M.W., Yudin A.I., Van de Voort C.A., Sabeur K., Primakoff P., and Overstreet J.W. Inhibition of monkey sperm hyaluronidase activity and heterologous cumulus penetration by flavonoids. Biol Reprod 56 (1997) 1383-1389
17. Baron-Ruppert G., and Luepke N.P. Evidence for toxic effects of alkylphenols from Ginkgo biloba in the hen's egg test (HET). Phytomedicine 8 (2001) 133-138
18. Al-Yahya A.A., Al-Majed A.A., Al-Bekairi A.M., Al-Shabanah O.A., and Qureshi S. Studies on the reproductive, cytological and biochemical toxicity of Ginkgo biloba in Swiss albino mice. J Ethnopharmacol 107 (2006) 222-228
19. Chan W.H. Ginkgolides induce apoptosis and decrease cell numbers in mouse blastocysts. Biochem Biophys Res Commun 338 (2005) 1263-1267
20. Chan W.H. Ginkgolide B induces apoptosis and developmental injury in mouse embryonic stem cells and blastocysts. Hum Reprod 21 (2006) 2985-2995
21. Oh S.M., and Chung K.H. Estrogenic activities of Ginkgo biloba extracts. Life Sci 74 (2004) 1325-1335
22. Oh S.M., and Chung K.H. Antiestrogenic activities of Ginkgo biloba extracts. J Steroid Biochem Mol Biol 100 (2006) 167-176
23. Rubin P. Fortnightly review: drug treatment during pregnancy. BMJ 317 (1998) 1503-1506
24. In: van Beek T.A. (Ed). Ginkgo biloba (2000), Harwood Academic Publishers, Amsterdam
25. Adlercreutz H., Yamada T., Wahala K., and Watanabe S. Maternal and neonatal phytoestrogens in Japanese women during birth. Am J Obstet Gynecol 180 (1999) 737-743
26. Schroder-van der Elst J.P., van der Heide D., Rokos H., Morreale de Escobar G., and Kohrle J. Synthetic flavonoids cross the placenta in the rat and are found in fetal brain. Am J Physiol Endocrinol Metab 274 (1998) 253-256
27. OECD. Guideline for the testing of chemicals-no. 414: prenatal developmental toxicity study (2001), Organization for Economic Co-operation and Development, Paris
28. ICH (International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use). ICH Harmonized Tripartite Guideline S5(R2): detection of toxicity to reproduction for medicinal products and toxicity to male fertility; 2005.
29. ANVISA (Agência Nacional de Vigilância Sanitária [National Agency on Sanitary Vigilance]) Lista de registro simplificado de fitoterápicos. Diário Oficial da União, RE number 89, Brasília, March 16; 2004, http://e-legis.anvisa.gov.br/leisref/public/showAct.php?id=10241 [accessed September 4, 2006].
30. Khera K.S. Maternal toxicity-a possible factor in fetal malformations in mice. Teratology 29 (1984) 411-416
31. Kavlock R.J., Chernoff N., Rogers E., et al. An analysis of fetotoxicity using biochemical endpoints of organ differentiation. Teratology 26 (1982) 183-194
32. Khera K.S. Maternal toxicity: a possible etiological factor in embryo-fetal deaths and fetal malformations of rodent-rabbit species. Teratology 31 (1985) 129-153
33. Khera K.S. Maternal toxicity of drugs and metabolic disorders-a possible etiologic factor in the intrauterine death and congenital malformation: a critique on human data. Crit Rev Toxicol 17 (1987) 345-375
34. Hecker H., Johannisson R., Koch E., and Siegers C.P. In vitro evaluation of the cytotoxic potential of alkylphenols from Ginkgo biloba L. Toxicology 177 (2002) 167-177
35. Gohil K. Genomic responses to herbal extracts: lessons from in vitro and in vivo studies with an extract of Ginkgo biloba. Biochem Pharmacol 64 (2002) 913-917
36. In: Manson J.M., and Wise L.D. (Eds). Teratogens, Casarett and Doull's toxicology. 4th ed. (1991), Pergammon Press, New York 226-254
37. Breinholt V., Hossaini A., Svendsen G.W., Brouwer C., and Nielsen E. Estrogenic activity of flavonoids in mice. The importance of estrogen receptor distribution, metabolism and bioavailability. Food Chem Toxicol 38 (2000) 555-564
38. Stroheker T., Chagnon M.C., Pinnert M.F., Berges R., and Canivenc-Lavier M.C. Estrogenic effects of food wrap packaging xenoestrogens and flavonoids in female Wistar rats: a comparative study. Reprod Toxicol 17 (2003) 421-432
39. Iguchi T., Watanabe H., and Katsu Y. Developmental effects of estrogenic agents on mice, fish, and frogs: a mini-review. Horm Behav 40 (2001) 248-251
40. Jones L.A., and Hajek R.A. Effects of estrogenic chemicals on development. Environ Health Perspect 103 (1995) S63-S67
41. Migliaccio S., Newbold R.R., McLachlan J.A., and Korach K.S. Alterations in estrogen levels during development affects the skeleton: use of an animal model. Environ Health Perspect 103 (1995) S95-S97
42. Sawaki M., Noda S., Muroi T., et al. Evaluation of an in utero through lactational exposure protocol for detection of estrogenic effects of ethinyl estradiol on the offspring of rats: preliminary trial. Reprod Toxicol 17 (2003) 335-343
43. You L., Casanova M., Bartolucci E.J., et al. Combined effects of dietary phytoestrogen and synthetic endocrine-active compound on reproductive development in Sprague-Dawley rats: genistein and methoxychlor. Toxicol Sci 66 (2002) 91-104
44. Awoniyi C.A., Roberts D., Veeramachaneni D.N., Hurst B.S., Tucker K.E., and Schlaff W.D. Reproductive sequelae in female rats after in utero and neonatal exposure to the phytoestrogen genistein. Fertil Steril 70 (1998) 440-447
45. Guittin P., Eléfant E., and Saint-Salvi B. Hierarchization of animal teratology findings for improving the human risk evaluation of drugs. Reprod Toxicol 14 (2000) 369-375
46. Chahoud I., Ligensa A., Dietzel L., and Faqi A.S. Correlation between maternal toxicity and embryo/fetal effects. Reprod Toxicol 13 (1999) 375-381