The relationship of maternal and fetal toxicity in developmental toxicology bioassays with notes on the biological significance of the "no observed adverse effect level"

Reproductive Toxicology

Volumn 25, Issue 2, 2008, Pages 192-202

  Chernoff, N ^a   Rogers, E H ^a   Gage, M I ^b   Francis, B M ^c  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^b NCBA   (United States)

^c UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

Developmental toxicity bioassay; Fetal; Hazard identification; LOAEL; Mouse; NOAEL; Rabbit; Rat; Risk assessment; Teratology

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL TISSUE; BIOASSAY; CONTROLLED STUDY; CORRELATION ANALYSIS; DATA ANALYSIS; DEVELOPMENTAL TOXICOLOGY BIOASSAY; FETUS WEIGHT; FOOD INTAKE; GESTATION PERIOD; HYPOTHESIS; LITTER SIZE; MALNUTRITION; MOUSE; NONHUMAN; RAT; REVIEW; RISK ASSESSMENT; SENSITIVITY ANALYSIS; STATISTICAL ANALYSIS; TERATOLOGY; WEIGHT GAIN; WEIGHT REDUCTION;

ANIMALS; BIOLOGICAL ASSAY; FEMALE; FETAL WEIGHT; FETUS; LITTER SIZE; MICE; NO-OBSERVED-ADVERSE-EFFECT LEVEL; PREGNANCY; RABBITS; RATS; SPECIES SPECIFICITY;

ORYCTOLAGUS CUNICULUS; RATTUS;

EID: 39749161008     PISSN: 08906238     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.reprotox.2007.12.001     Document Type: Review

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