Structural basis for the interaction between dynein light chain 1 and the glutamate channel homolog GRINL1A

FEBS Journal

Volumn 277, Issue 10, 2010, Pages 2340-2350

  García Mayoral, María F ^a   Martínez Moreno, Mónica ^b   Albar, Juan P ^c   Rodríguez Crespo, Ignacio ^b   Bruix, Marta ^a  

^a INSTITUTO DE QUÍMICA FÍSICA ROCASOLANO   (Spain)

^b UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^c CENTRO NACIONAL DE BIOTECNOLOGÍA   (Spain)

Author keywords

Dynein light chain; Glutamate channel homolog; NMR; Protein protein interactions

Indexed keywords

BCL 2 INTERACTING MEDIATOR; DYNEIN ADENOSINE TRIPHOSPHATASE; DYNEIN LIGHT CHAIN 1; GLUTAMINE; GLUTATHIONE TRANSFERASE; GLYCINE; HYBRID PROTEIN; IONOTROPIC GLUTAMATE RECEPTOR N METHYL DEXTRO ASPARTATE LIKE 1A; IONOTROPIC RECEPTOR; NEURONAL NITRIC OXIDE SYNTHASE; PROTEIN DYNLL1; PROTEIN GRINL1A; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; BETA SHEET; COMPLEX FORMATION; HEART; MOLECULAR MODEL; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; SEQUENCE HOMOLOGY; STRUCTURE ANALYSIS; TWO HYBRID SYSTEM; YEAST;

AMINO ACID SEQUENCE; CONSENSUS SEQUENCE; CYTOPLASMIC DYNEINS; DYNEINS; GENE DELETION; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PEPTIDE FRAGMENTS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN INTERACTION DOMAINS AND MOTIFS; RECEPTORS, GLUTAMATE; TWO-HYBRID SYSTEM TECHNIQUES;

EID: 77951708885     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/j.1742-4658.2010.07649.x     Document Type: Article

References (34)

1. Espindola FS, Suter DM, Partata LB, Cao T, Wolenski JS, Cheney RE, King SM Mooseker MS (2000) The light chain composition of chicken brain myosin-Va: calmodulin, myosin-II essential light chains, and 8-kDa dynein light chain/PIN. Cell Motil Cytoskeleton 47, 269 281.
2. Hodi Z, Nemeth AL, Radnai L, Hetenyi C, Schlett K, Bodor A, Perczel A Nyitray L (2006) Alternatively spliced exon B of myosin Va is essential for binding the tail-associated light chain shared by dynein. Biochemistry 45, 12582 12595.
3. King SM (2008) Dynein-independent functions of DYNLL1/LC8: redox state sensing and transcriptional control. Sci Signal 1, pe51.
4. Harrison A King SM (2000) The molecular anatomy of dynein. Essays Biochem 35, 75 87.
5. King SM (2000) The dynein microtubule motor. Biochim Biophys Acta 1496, 60 75.
6. r 8000 light chain. J Biol Chem 271, 19358 19366.
7. Raux H, Flamand A Blondel D (2000) Interaction of the rabies virus P protein with the LC8 dynein light chain. J Virol 74, 10212 10216.
8. Hernaez B, Diaz-Gil G, Garcia-Gallo M, Ignacio Quetglas J, Rodriguez-Crespo I, Dixon L, Escribano JM Alonso C (2004) The African swine fever virus dynein-binding protein p54 induces infected cell apoptosis. FEBS Lett 569, 224 228.
9. Kubota T, Matsuoka M, Chang TH, Bray M, Jones S, Tashiro M, Kato A Ozato K (2009) Ebolavirus VP35 interacts with the cytoplasmic dynein light chain 8. J Virol 83, 6952 6956.
10. Liang J, Jaffrey SR, Guo W, Snyder SH Clardy J (1999) Structure of the PIN/LC8 dimer with a bound peptide. Nat Struct Biol 6, 735 740.
11. Fan J, Zhang Q, Tochio H, Li M Zhang M (2001) Structural basis of diverse sequence-dependent target recognition by the 8 kDa dynein light chain. J Mol Biol 306, 97 108.
12. Wang W, Lo KW, Kan HM, Fan JS Zhang M (2003) Structure of the monomeric 8-kDa dynein light chain and mechanism of the domain-swapped dimer assembly. J Biol Chem 278, 41491 41499.
13. Williams JC, Roulhac PL, Roy AG, Vallee RB, Fitzgerald MC Hendrickson WA (2007) Structural and thermodynamic characterization of a cytoplasmic dynein light chain-intermediate chain complex. Proc Natl Acad Sci USA 104, 10028 10033.
14. Rodriguez-Crespo I, Yelamos B, Roncal F, Albar JP, Ortiz de Montellano PR Gavilanes F (2001) Identification of novel cellular proteins that bind to the LC8 dynein light chain using a pepscan technique. FEBS Lett 503, 135 141.
15. Lo KW, Naisbitt S, Fan JS, Sheng M Zhang M (2001) The 8-kDa dynein light chain binds to its targets via a conserved (K/R)XTQT motif. J Biol Chem 276, 14059 14066.
16. Naisbitt S, Valtschanoff J, Allison DW, Sala C, Kim E, Craig AM, Weinberg RJ Sheng M (2000) Interaction of the postsynaptic density-95/guanylate kinase domain-associated protein complex with a light chain of myosin-V and dynein. J Neurosci 20, 4524 4534.
17. Jaffrey SR Snyder SH (1996) PIN: an associated protein inhibitor of neuronal nitric oxide synthase. Science 274, 774 777.
18. Rodriguez-Crespo I, Straub W, Gavilanes F Ortiz de Montellano PR (1998) Binding of dynein light chain (PIN) to neuronal nitric oxide synthase in the absence of inhibition. Arch Biochem Biophys 359, 297 304.
19. Navarro-Lerida I, Martinez Moreno M, Roncal F, Gavilanes F, Albar JP Rodriguez-Crespo I (2004) Proteomic identification of brain proteins that interact with dynein light chain LC8. Proteomics 4, 339 346.
20. Fuhrmann JC, Kins S, Rostaing P, El Far O, Kirsch J, Sheng M, Triller A, Betz H Kneussel M (2002) Gephyrin interacts with dynein light chains 1 and 2, components of motor protein complexes. J Neurosci 22, 5393 5402.
21. Roginski RS, Mohan Raj BK, Finkernagel SW Sciorra LJ (2001) Assignment of an ionotropic glutamate receptor-like gene (GRINL1A) to human chromosome 15q22.1 by in situ hybridization. Cytogenet Cell Genet 93, 143 144.
22. Lightcap CM, Sun S, Lear JD, Rodeck U, Polenova T Williams JC (2008) Biochemical and structural characterization of the Pak1-LC8 interaction. J Biol Chem 283, 27314 27324.
23. Roginski RS, Mohan Raj BK, Birditt B Rowen L (2004) The human GRINL1A gene defines a complex transcription unit, an unusual form of gene organization in eukaryotes. Genomics 84, 265 276.
24. Jacob CP, Koutsilieri E, Bartl J, Neuen-Jacob E, Arzberger T, Zander N, Ravid R, Roggendorf W, Riederer P Grunblatt E (2007) Alterations in expression of glutamatergic transporters and receptors in sporadic Alzheimer's disease. J Alzheimers Dis 11, 97 116.
25. Roginski RS, Goubaeva F, Mikami M, Fried-Cassorla E, Nair MR Yang J (2008) GRINL1A colocalizes with N-methyl d-aspartate receptor NR1 subunit and reduces N-methyl d-aspartate toxicity. Neuroreport 19, 1721 1726.
26. Valtschanoff JG Weinberg RJ (2001) Laminar organization of the NMDA receptor complex within the postsynaptic density. J Neurosci 21, 1211 1217.
27. Hall J, Hall A, Pursifull N Barbar E (2008) Differences in dynamic structure of LC8 monomer, dimer, and dimmer-peptide complexes. Biochemistry 47, 11940 11952.
28. Song C, Wen W, Rayala SK, Chen M, Ma J, Zhang M Kumar R (2008) Serine 88 phosphorylation of the 8-kDa dynein light chain 1 is a molecular switch for its dimerization status and functions. J Biol Chem 283, 4004 4013.
29. Nyarko A, Hare M, Hays TS Barbar E (2004) The intermediate chain of cytoplasmic dynein is partially disordered and gains structure upon binding to light-chain LC8. Biochemistry 43, 15595 15603.
30. Puthalakath H, Villunger A, O'Reilly LA, Beaumont JG, Coultas L, Cheney RE, Huang DC Strasser A (2001) Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis. Science 293, 1829 1832.
31. Lajoix AD, Gross R, Aknin C, Dietz S, Granier C Laune D (2004) Cellulose membrane supported peptide arrays for deciphering protein-protein interaction sites: the case of PIN, a protein with multiple natural partners. Mol Divers 8, 281 290.
32. Breeden L Nasmyth K (1985) Regulation of the yeast HO gene. Cold Spring Harb Symp Quant Biol 50, 643 650.
33. Martinez-Moreno M, Navarro-Lerida I, Roncal F, Albar JP, Alonso C, Gavilanes F Rodriguez-Crespo I (2003) Recognition of novel viral sequences that associate with the dynein light chain LC8 identified through a pepscan technique. FEBS Lett 544, 262 267.
34. Koradi R, Billeter M Wüthrich K (1996) molmol: a program for display and analysis of macromolecular structures. J Mol Graph 14, 29 32 51 55.