Biochemical and structural characterization of the Pak1-LC8 interaction

Journal of Biological Chemistry

Volumn 283, Issue 40, 2008, Pages 27314-27324

  Lightcap, Christine M ^a,b   Sun, Shangjin ^c   Lear, James D ^d   Rodeck, Ulrich ^a,b   Polenova, Tatyana ^c   Williams, John C ^a,b  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

^c UNIVERSITY OF DELAWARE   (United States)

^d UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BINDING ENERGY; CHEMICAL REACTIONS; DIMERIZATION; HYDROGEN; HYDROGEN BONDS; NUCLEAR MAGNETIC RESONANCE; PHOSPHORYLATION;

ACTIVATED KINASES; BINDING MODULATES; BINDING SEQUENCES; BIO-CHEMICALS; BREAST CANCERS; CONSENSUS SEQUENCES; CRYSTALLOGRAPHIC STUDIES; CURRENT MODELS; DIRECT INTERACTIONS; IN VITRO; LIGHT CHAINS; NUCLEAR LOCALIZATIONS; STRUCTURAL CHARACTERIZATIONS; STRUCTURAL DETAILS; TARGET BINDINGS; TUMOR CELL SURVIVALS;

FLOW INTERACTIONS;

P21 ACTIVATED KINASE 1; PROTEIN DERIVATIVE; PROTEIN LC8; SERINE; UNCLASSIFIED DRUG; CARRIER PROTEIN; CTP PROTEIN, DROSOPHILA; DROSOPHILA PROTEIN; P21 ACTIVATED KINASE;

ANCHORAGE INDEPENDENT GROWTH; ARTICLE; BINDING AFFINITY; CONSENSUS SEQUENCE; CRYSTALLOGRAPHY; HYDROGEN BOND; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; SEQUENCE ANALYSIS; AMINO ACID SUBSTITUTION; ANIMAL; CELL SURVIVAL; CHEMICAL STRUCTURE; CHEMISTRY; DIMERIZATION; DROSOPHILA MELANOGASTER; GENETICS; METABOLISM; NEOPLASM; NUCLEAR MAGNETIC RESONANCE; PHOSPHORYLATION; POINT MUTATION; PROTEIN QUATERNARY STRUCTURE; X RAY CRYSTALLOGRAPHY;

AMINO ACID SUBSTITUTION; ANIMALS; CARRIER PROTEINS; CELL SURVIVAL; CRYSTALLOGRAPHY, X-RAY; DIMERIZATION; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; HYDROGEN BONDING; MODELS, MOLECULAR; NEOPLASMS; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; P21-ACTIVATED KINASES; PHOSPHORYLATION; POINT MUTATION; PROTEIN BINDING; PROTEIN STRUCTURE, QUATERNARY;

EID: 55249119108     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M800758200     Document Type: Article

References (50)

1. King, S. M. (2000) Biochim. Biophys. Acta 1496, 60-75
2. Vallee, R. B., Williams, J. C., Varma, D., and Barnhart, L. E. (2004) J. Neurobiol. 58, 189-200
3. Lajoix, A. D., Gross, R., Aknin, C., Dietz, S., Granier, C., and Laune, D. (2004) Mol. Divers. 8, 281-290
4. Williams, J. C., Roulhac, P. L., Roy, A. G., Vallee, R. B., Fitzgerald, M. C., and Hendrickson, W. A. (2007) Proc. Natl. Acad. Sci. U. S. A. 104, 10028-10033
5. McCauley, S. D., Gilchrist, M., and Befus, A. D. (2007) Life Sci. 80, 959-964
6. Jaffrey, S. R., and Snyder, S. H. (1996) Science 274, 774-777
7. Kaiser, F. J., Tavassoli, K., Van den Bemd, G. J., Chang, G. T. G., Horsthemke, B., Moroy, T., and Ludecke, H. J. (2003) Hum. Mol. Genet. 12, 1349-1358
8. Tan, G. S., Preuss, M. A., Williams, J. C., and Schnell, M. J. (2007) Proc. Natl. Acad. Sci. U. S. A. 104, 7229-7234
9. Moseley, G. W., Roth, D. M., Dejesus, M. A., Leyton, D. L., Filmer, R. P., Pouton, C. W., and Jans, D. A. (2007) Mol. Biol. Cell 18, 3204-3213
10. Navarro-Lerida, I., Martinez Moreno, M., Roncal, F., Gavilanes, F., Albar, J. P., and Rodriguez-Crespo, I. (2004) Proteomics 4, 339-346
11. Liang, J., Jaffrey, S. R., Guo, W., Snyder, S. H., and Clardy, J. (1999) Nat. Struct. Biol. 6, 735-740
12. Fan, J., Zhang, Q., Tochio, H., Li, M., and Zhang, M. (2001) J. Mol. Biol. 306, 97-108
13. Crepieux, P., Kwon, H., Leclerc, N., Spencer, W., Richard, S., Lin, R., and Hiscott, J. (1997) Mol. Cell Biol. 17, 7375-7385
14. Rayala, S. K., den Hollander, P., Balasenthil, S., Yang, Z., Broaddus, R. R., and Kumar, R. (2005) EMBO Rep. 6, 538-549
15. Beckwith, S. M., Roghi, C. H., Liu, B., and Morris, R. N. (1998) J. Cell Biol. 143, 1239-1247
16. Vadlamudi, R. K., Bagheri-Yarmand, R., Yang, Z., Balasenthil, S., Nguyen, D., Sahin, A. A., den Hollander, P., and Kumar, R. (2004) Cancer Cell 5, 575-585
17. Song, Y., Benison, G., Nyarko, A., Hays, T. S., and Barbar, E. (2007) J. Biol. Chem. 282, 17272-17279
18. Song, C., Wen, W., Rayala, S. K., Chen, M., Ma, J., Zhang, M., and Kumar, R. (2008) J. Biol. Chem. 283, 4004-4013
19. Mossessova, E., and Lima, C. D. (2000) Mol. Cell 5, 865-876
20. Marley, J., Lu, M., and Bracken, C. (2001) J. Biomol. NMR 20, 71-75
21. Kharakoz, D. P. (1997) Biochemistry 36, 10276-10285
22. Arkin, M., and Lear, J. D. (2001) Anal. Biochem. 299, 98-107
23. Otwinowski, Z., and Minor, W. (1997) Macromol. Crystallogr. A 276, 307-326
24. Collaborative Computing Project 4 (1994) Acta Crystallogr. Sect. D Biol. Crystallogr. 50, 760-763
25. McCoy, A. J., Grosse-Kunstleve, R. W., Adams, P. D., Winn, M. D., Storoni, L. C., and Read, R. J. (2007) J. Appl. Crystallogr. 40, 658-674
26. Emsley, P., and Cowtan, K. (2004) Acta Crystallogr. Sect. D Biol. Crystallogr. 60, 2126-2132
27. Murshudov, G. N., Vagin, A. A., and Dodson, E. J. (1997) Acta Crystallogr. Sect. D Biol. Crystallogr. 53, 240-255
28. Lovell, S. C., Davis, I. W., Arendall, W. B., III, de Bakker, P. I., Word, J. M., Prisant, M. G., Richardson, J. S., and Richardson, D. C. (2003) Proteins 50, 437-450
29. Delaglio, F., Grzesiek, S., Vuister, G. W., Zhu, G., Pfeifer, J., and Bax, A. (1995) J. Biomol. NMR 6, 277-293
30. Goddard, T., and Kneller, D. (2006) Sparky3, San Francisco, CA
31. Sells, M. A., Pfaff, A., and Chernoff, J. (2000) J. Cell Biol. 151, 1449-1458
32. Lu, J., Sun, Q., Chen, X., Wang, H., Hu, Y., and Gu, J. (2005) Biochem. Biophys. Res. Commun. 331, 153-158
33. Rost, B., and Liu, J. (2003) Nucleic Acids Res. 31, 3300-3304
34. Rashid, T., Banerjee, M., and Nikolic, M. (2001) J. Biol. Chem. 276, 49043-49052
35. Sundberg-Smith, L. J., Doherty, J. T., Mack, C. P., and Taylor, J. M. (2005) J. Biol. Chem. 280, 2055-2064
36. Thiel, D. A., Reeder, M. K., Pfaff, A., Coleman, T. R., Sells, M. A., and Chernoff, J. (2002) Curr. Biol. 12, 1227-1232
37. Iakoucheva, L. M., Radivojac, P., Brown, C. J., O'Connor, T. R., Sikes, J. G., Obradovic, Z., and Dunker, A. K. (2004) Nucleic Acids Res. 32, 1037-1049
38. Barbar, E., Kleinman, B., Imhoff, D., Li, M., Hays, T. S., and Hare, M. (2001) Biochemistry 40, 1596-1605
39. Zwart, P. H., Grosse-Kunstleve, R. W., and Adams, P. D. CCP4 Newsletter; Winter 2007, Contribution 7
40. Day, C. L., Puthalakath, H., Skea, G., Strasser, A., Barsukov, I., Lian, L. Y., Huang, D. C., and Hinds, M. G. (2004) Biochem. J. 377, 597-605
41. Fan, J. S., Zhang, Q., Li, M., Tochio, H., Yamazaki, T., Shimizu, M., and Zhang, M. (1998) J. Biol. Chem. 273, 33472-33481
42. Hodi, Z., Nemeth, A. L., Radnai, L., Hetenyi, C., Schlett, K., Bodor, A., Perczel, A., and Nyitray, L. (2006) Biochemistry 45, 12582-12595
43. Wu, J. Q., and Pollard, T. D. (2005) Science 310, 310-314
44. Mammen, M., Choi, S. K., and Whitesides, G. M. (1998) Angew. Chem. Int. Ed. Eng. 37, 2755-2794
45. Lei, M., Lu, W., Meng, W., Parrini, M. C., Eck, M. J., Mayer, B. J., and Harrison, S. C. (2000) Cell 102, 387-397
46. Pirruccello, M., Sondermann, H., Pelton, J. G., Pellicena, P., Hoelz, A., Chernoff, J., Wemmer, D. E., and Kuriyan, J. (2006) J. Mol. Biol. 361, 312-326
47. Rennefahrt, U. E., Deacon, S. W., Parker, S. A., Devarajan, K., Beeser, A., Chernoff, J., Knapp, S., Turk, B. E., and Peterson, J. R. (2007) J. Biol. Chem. 282, 15667-15678
48. Uversky, V. N., Oldfield, C. J., and Dunker, A. K. (2005) J. Mol. Recognit. 18, 343-384
49. Dyson, H. J., and Wright, P. E. (2005) Nat. Rev. Mol. Cell Biol. 6, 197-208
50. Singh, R. R., Song, C., Yang, Z., and Kumar, R. (2005) J. Biol. Chem. 280, 18130-18137