GRINLIA colocalizes with N-methyl D-aspartate receptor NRI subunit and reduces N-methyl D-aspartate toxicity

NeuroReport

Volumn 19, Issue 17, 2008, Pages 1721-1726

  Roginski, Raymond S ^a   Goubaeva, Farida ^b   Mikami, Maya ^b   Fried Cassorla, Emma ^a   Nair, Mohan R ^c   Yang, Jay ^b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b Columbia University ^*  (United States)

^c ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

Author keywords

Complex transcription unit; Excitotoxicity; Gdownl; GRINLIA combined transcript I; Neuroprotection; NRI subunit

Indexed keywords

BRAIN PROTEIN; COMPLEMENTARY DNA; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 1; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR GCOM 1; UNCLASSIFIED DRUG; GLUTAMATE RECEPTOR; GRINL1A PROTEIN, HUMAN; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYLASPARTIC ACID; NR1 NMDA RECEPTOR;

ANIMAL CELL; ARTICLE; CELL MEMBRANE; CONTROLLED STUDY; EXCITOTOXICITY; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; IMMUNOPRECIPITATION; IMMUNOREACTIVITY; NERVE CELL; NEUROTRANSMISSION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; RAT; SIGNAL TRANSDUCTION; WESTERN BLOTTING; ANIMAL; BRAIN CORTEX; CELL CULTURE; CELL LINE; CELL SURVIVAL; CYTOLOGY; DRUG EFFECT; FLUORESCENT ANTIBODY TECHNIQUE; GENETIC TRANSFECTION; GENETICS; HIPPOCAMPUS; METABOLISM; PROTEIN BINDING;

ANIMALS; CELL LINE; CELL MEMBRANE; CELL SURVIVAL; CELLS, CULTURED; CEREBRAL CORTEX; FLUORESCENT ANTIBODY TECHNIQUE; HIPPOCAMPUS; HUMANS; IMMUNOPRECIPITATION; N-METHYLASPARTATE; NEURONS; PROTEIN BINDING; RATS; RECEPTORS, GLUTAMATE; RECEPTORS, N-METHYL-D-ASPARTATE; TRANSFECTION;

EID: 56749131239     PISSN: 09594965     EISSN: None     Source Type: Journal    
DOI: 10.1097/WNR.0b013e328317f05f     Document Type: Article

References (11)

1. Roginski RS, Mohan Raj BK, Birditt B, Rowen L. The human GRINL1A gene defines a complex transcription unit, an unusual form of gene organization in eukaryotes. Genomics 2004; 84:265-276.
2. Lin JW, Wyszynski M, Madhavan R, Sealock R, Kim JU, Sheng M. Yotiao, a novel protein of neuromuscular junction and brain that interacts with specific splice variants of NMDA receptor subunit NR1. J Neurosci 1998; 18:2017-2027.
3. Cummings DD, Wilcox KS, Dichter MA. Calcium-dependent paired-pulse facilitation of miniature EPSC frequency accompanies depression of EPSCs at hippocampal synapses in culture. J Neurosci 1996; 16:5312-5323.
4. Scott DB, Blanpied TA, Swanson GT, Zhang C, Ehlers MD. An NMDA receptor ER retention signal regulated by phosphorylation and alternative splicing. J Neurosci 2001; 21:3063-3072.
5. Fernandez-Monreal M, Lopez-Atalaya JP, Benchenane K, Cacquevel M, Dulin F, Le Caer JP, et al. Arginine 260 of the amino-terminal domain of NR1 subunit is critical for tissue-type plasminogen activator-mediated enhancement of N-methyl-D-aspartate receptor signaling. J Biol Chem 2004; 279:50850-50856.
6. Oyama M, Kozuka-Hata H, Suzuki Y, Semba K, Yamamoto T, Sugano S. Diversity of translation start sites may define increased complexity of the human short ORFeome. Mol Cell Proteomics 2007; 6:1000-1006.
7. Hollmann M, Heinemann S. Cloned glutamate receptors. [Review] [201 refs]. Ann Rev Neurosci 1994; 17:31-108.
8. Collins MO, Husi H, Yu L, Brandon JM, Anderson CN, Blackstock WP, et al. Molecular characterization and comparison of the components and multiprotein complexes in the postsynaptic proteome. J Neurochem 2006; 97 (Suppl 1):16-23.
9. Sattler R, Xiong Z, Lu WY, Hafner M, MacDonald JF, Tymianski M. Specific coupling of NMDA receptor activation to nitric oxide neurotoxicity by PSD-95 protein. Science 1999; 284: 1845-1848.
10. Aarts M, Liu Y, Liu L, Besshoh S, Arundine M, Gurd JW, et al. Treatment of ischemic brain damage by perturbing NMDA receptor- PSD-95 protein interactions. Science 2002; 298: 846-850.
11. Hu X, Malik S, Negroiu CC, Hubbard K, Velalar CN, Hampton B, et al. A Mediator-responsive form of metazoan RNA polymerase II. Proc Natl Acad Sci U S A 2006; 103:9506-9511.