Disruption of cellular cholesterol transport and homeostasis as a novel mechanism of action of membrane-targeted alkylphospholipid analogues

British Journal of Pharmacology

Volumn 160, Issue 2, 2010, Pages 355-366

  Carrasco, María P ^a   Jiménez López, José M ^a   Ríos Marco, Pablo ^a   Segovia, Josefa L ^a   Marco, Carmen ^a  

^a UNIVERSITY OF GRANADA   (Spain)

Author keywords

Alkylphospholipid analogues; Cholesterol homeostasis; HepG2 cells; Lipid rafts

Indexed keywords

ANTINEOPLASTIC AGENT; EDELFOSINE; ERUCYLPHOSPHOCHOLINE; GERANYLTRANSFERASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; HYDROXYMETHYLGLUTARYL COENZYME A SYNTHASE; LOW DENSITY LIPOPROTEIN RECEPTOR; MILTEFOSINE; PERIFOSINE; STEROL REGULATORY ELEMENT BINDING PROTEIN 2; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL MEMBRANE; CELL PROLIFERATION; CELL STRAIN HEPG2; CELL VIABILITY; CHOLESTEROL ESTERIFICATION; CHOLESTEROL METABOLISM; CHOLESTEROL TRANSPORT; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; HUMAN; HUMAN CELL; LIPID COMPOSITION; LIPID RAFT; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ANTINEOPLASTIC AGENTS; BIOLOGICAL TRANSPORT; BLOTTING, WESTERN; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; CELL MEMBRANE; CHOLESTEROL; DRUG DELIVERY SYSTEMS; ENDOPLASMIC RETICULUM; GENE EXPRESSION REGULATION, NEOPLASTIC; HOMEOSTASIS; HUMANS; LIVER NEOPLASMS; MEMBRANE MICRODOMAINS; PHOSPHOLIPID ETHERS; PHOSPHORYLCHOLINE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 77951675862     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2010.00689.x     Document Type: Article

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