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Volumn 46, Issue 11, 2002, Pages 3472-3477

Proinflammatory and cytotoxic effects of hexadecylphosphocholine (miltefosine) against drug-resistant strains of Trypanosoma cruzi

Author keywords

[No Author keywords available]

Indexed keywords

BENZNIDAZOLE; MILTEFOSINE; N(G) METHYLARGININE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; PHOSPHOLIPID DERIVATIVE; TUMOR NECROSIS FACTOR ALPHA;

EID: 0036840473     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.46.11.3472-3477.2002     Document Type: Article
Times cited : (48)

References (44)
  • 1
    • 0022366288 scopus 로고
    • Trypanosoma cruzi: Protection in mice immunized with 8-methoxypsolaren-inactivated trypomastigotes
    • Andrews, N. W., M. J. M. Alves, R. I. Schumacher, and W. Colli. 1985. Trypanosoma cruzi: protection in mice immunized with 8-methoxypsolaren-inactivated trypomastigotes. Exp. Parasitol. 60:255-262.
    • (1985) Exp. Parasitol. , vol.60 , pp. 255-262
    • Andrews, N.W.1    Alves, M.J.M.2    Schumacher, R.I.3    Colli, W.4
  • 2
    • 0035167741 scopus 로고    scopus 로고
    • Chemotherapy of cutaneous leishmaniasis: A review
    • Arana, B., N. Rizzo, and A. Diaz. 2001. Chemotherapy of cutaneous leishmaniasis: a review. Med. Microbiol. Immunol. 190:93-95.
    • (2001) Med. Microbiol. Immunol. , vol.190 , pp. 93-95
    • Arana, B.1    Rizzo, N.2    Diaz, A.3
  • 4
    • 0023186694 scopus 로고
    • The activity of alkyl phosphorytcholines and related derivatives against Leishmania donovani
    • Croft, S. L., R. A. Neal, W. Pendergast, and J. H. Chan. 1987. The activity of alkyl phosphorytcholines and related derivatives against Leishmania donovani. Biochem. Pharmacol. 36:2633-2636.
    • (1987) Biochem. Pharmacol. , vol.36 , pp. 2633-2636
    • Croft, S.L.1    Neal, R.A.2    Pendergast, W.3    Chan, J.H.4
  • 5
    • 0030481123 scopus 로고    scopus 로고
    • The activities of four anticancer alkyllysophospholipids against Leishmania donovani, Trypanosoma cruzi and Trypanosoma brucei
    • Croft, S. L., D. Snowdon, and V. Yardley. 1996. The activities of four anticancer alkyllysophospholipids against Leishmania donovani, Trypanosoma cruzi and Trypanosoma brucei. J. Antimicrob. Chemother. 38:1041-1047.
    • (1996) J. Antimicrob. Chemother. , vol.38 , pp. 1041-1047
    • Croft, S.L.1    Snowdon, D.2    Yardley, V.3
  • 6
    • 0035024396 scopus 로고    scopus 로고
    • Activities of hexadecylphosphocholine (miltefosine), Ambisome, and sodium stibogluconate (Pentostam) against Leishmania donovani in immunodeficient scid mice
    • Escobar, P., V. Yardley, and S. L. Croft. 2001. Activities of hexadecylphosphocholine (miltefosine), Ambisome, and sodium stibogluconate (Pentostam) against Leishmania donovani in immunodeficient scid mice. Antimicrob. Agents Chemother. 45:1872-1875.
    • (2001) Antimicrob. Agents Chemother. , vol.45 , pp. 1872-1875
    • Escobar, P.1    Yardley, V.2    Croft, S.L.3
  • 7
    • 0036150927 scopus 로고    scopus 로고
    • Sensitivities of Leishmania species to hexadecylphosphocholine (miltefosine), ET-18-OCH(3) (edelfosine) and amphotericin B
    • Escobar, P., S. Matu, C. Marques, and S. L. Croft. 2002. Sensitivities of Leishmania species to hexadecylphosphocholine (miltefosine), ET-18-OCH(3) (edelfosine) and amphotericin B. Acta Trop. 81:151-157.
    • (2002) Acta Trop. , vol.81 , pp. 151-157
    • Escobar, P.1    Matu, S.2    Marques, C.3    Croft, S.L.4
  • 8
    • 0029066596 scopus 로고
    • Alkylphosphocholine-induced production of nitric oxide and tumor necrosis factor alpha by U937 cells
    • Eue, I., R. Zeisig, and D. Arndt. 1995. Alkylphosphocholine-induced production of nitric oxide and tumor necrosis factor alpha by U937 cells. J. Cancer Res. Clin. Oncol. 121:350-356.
    • (1995) J. Cancer Res. Clin. Oncol. , vol.121 , pp. 350-356
    • Eue, I.1    Zeisig, R.2    Arndt, D.3
  • 9
    • 0035342579 scopus 로고    scopus 로고
    • Growth inhibition of human mammary carcinoma by liposomal hexadecylphosphocholine: Participation of activated macrophages in the antitumor mechanism
    • Eue, I. 2001. Growth inhibition of human mammary carcinoma by liposomal hexadecylphosphocholine: participation of activated macrophages in the antitumor mechanism. Int. J. Cancer 92:426-433.
    • (2001) Int. J. Cancer. , vol.92 , pp. 426-433
    • Eue, I.1
  • 10
    • 0023609713 scopus 로고
    • Susceptibility and natural resistance of Trypanosoma cruzi strains to drugs used in Chagas' disease
    • Filardi, L. S., and Z. Brener. 1987. Susceptibility and natural resistance of Trypanosoma cruzi strains to drugs used in Chagas' disease. Trans. R. Soc. Trop. Med. Hyg. 81:755-759.
    • (1987) Trans. R. Soc. Trop. Med. Hyg. , vol.81 , pp. 755-759
    • Filardi, L.S.1    Brener, Z.2
  • 11
    • 0035175731 scopus 로고    scopus 로고
    • Development status of miltefosine as first oral drug in visceral and cutaneous leishmaniasis
    • Fischer, C., A. Voss, and J. Engel. 2001. Development status of miltefosine as first oral drug in visceral and cutaneous leishmaniasis. Med. Microbiol. Immunol. 190:85-87.
    • (2001) Med. Microbiol. Immunol. , vol.190 , pp. 85-87
    • Fischer, C.1    Voss, A.2    Engel, J.3
  • 15
    • 0027241784 scopus 로고
    • Alkylphosphocholines: A new class of membrane active anticancer agents
    • Hilgard, P., T. Klenner, J. Stekar, and C. Unger. 1993. Alkylphosphocholines: a new class of membrane active anticancer agents. Cancer Chemother. Pharmacol. 32:90-95.
    • (1993) Cancer Chemother. Pharmacol. , vol.32 , pp. 90-95
    • Hilgard, P.1    Klenner, T.2    Stekar, J.3    Unger, C.4
  • 16
    • 0026591104 scopus 로고
    • Hexadecylphosphocholine induces INF-γ secretion and expression of GM-CSF mRNA in human mononuclear cells
    • Hochhuth, C. H., K. Vehmeyer, H. Eibl, and C. Unger. 1992. Hexadecylphosphocholine induces INF-γ secretion and expression of GM-CSF mRNA in human mononuclear cells. Cell. Immunol. 141:161-168.
    • (1992) Cell. Immunol. , vol.141 , pp. 161-168
    • Hochhuth, C.H.1    Vehmeyer, K.2    Eibl, H.3    Unger, C.4
  • 18
    • 0030893937 scopus 로고    scopus 로고
    • Efficacy of anticancer alkylphosphocholines in Trypanosoma brucei subspecies
    • Konstantinov, S. M., R. Kaminsky, R. Brun, M. R. Berger, and U. Zillmann. 1997. Efficacy of anticancer alkylphosphocholines in Trypanosoma brucei subspecies. Acta Trop. 64:145-154.
    • (1997) Acta Trop. , vol.64 , pp. 145-154
    • Konstantinov, S.M.1    Kaminsky, R.2    Brun, R.3    Berger, M.R.4    Zillmann, U.5
  • 19
    • 0026625517 scopus 로고
    • Hexadecylphosphocholine: Oral treatment of visceral leishmaniasis in mice
    • Kuhlencord, A., T. Maniera, H. Eibl, and C. Unger. 1992. Hexadecylphosphocholine: oral treatment of visceral leishmaniasis in mice. Antimicrob. Agents Chemother. 36:1630-1634.
    • (1992) Antimicrob. Agents Chemother. , vol.36 , pp. 1630-1634
    • Kuhlencord, A.1    Maniera, T.2    Eibl, H.3    Unger, C.4
  • 20
    • 0035503414 scopus 로고    scopus 로고
    • Randomized, double-blind, placebo-controlled, multicenter trial of 6% miltefosine solution, a topical chemotherapy in cutaneous metastases from breast cancer
    • Leonard, R., J. Hardy, G. van Tienhoven, S. Houston, P. Simmonds, M. David, and J. Mansi. 2001. Randomized, double-blind, placebo-controlled, multicenter trial of 6% miltefosine solution, a topical chemotherapy in cutaneous metastases from breast cancer. J. Clin. Oncol. 19:4150-4159.
    • (2001) J. Clin. Oncol. , vol.19 , pp. 4150-4159
    • Leonard, R.1    Hardy, J.2    Van Tienhoven, G.3    Houston, S.4    Simmonds, P.5    David, M.6    Mansi, J.7
  • 21
    • 0035025017 scopus 로고    scopus 로고
    • Mechanism of action of anti-proliferative lyso-phospholipid analogues against the protozoan parasite Trypanosoma cruzi: Potentiation of in vitro activity, by sterol biosynthesis inhibitor ketoconazole
    • Lira, R., L. M. Contreras, R. Santa-Rita, and J. A. Urbina. 2001. Mechanism of action of anti-proliferative lyso-phospholipid analogues against the protozoan parasite Trypanosoma cruzi: potentiation of in vitro activity, by sterol biosynthesis inhibitor ketoconazole. J. Antimicrob. Chemother. 47:537-546.
    • (2001) J. Antimicrob. Chemother. , vol.47 , pp. 537-546
    • Lira, R.1    Contreras, L.M.2    Santa-Rita, R.3    Urbina, J.A.4
  • 22
    • 0030995115 scopus 로고    scopus 로고
    • Ether-lipid metabolism, GPI anchor biosynthesis, and signal transduction are putative targets for anti-leishmania alkyl-phospholipid analogues
    • Lux, H., D. T. Hart, P. J. Parker, and T. Klenner. 1996. Ether-lipid metabolism, GPI anchor biosynthesis, and signal transduction are putative targets for anti-leishmania alkyl-phospholipid analogues. Adv. Exp. Med. Biol. 406:201-211.
    • (1996) Adv. Exp. Med. Biol. , vol.406 , pp. 201-211
    • Lux, H.1    Hart, D.T.2    Parker, P.J.3    Klenner, T.4
  • 23
    • 0033758270 scopus 로고    scopus 로고
    • Ether-lipid (alkyl-phospholipid) metabolism and the mechanism of action of ether-lipid analogues in Leishmania
    • Lux, H., N. Heise, T. Klenner, D. T. Hart, and F. R. Opperdoes. 2000. Ether-lipid (alkyl-phospholipid) metabolism and the mechanism of action of ether-lipid analogues in Leishmania. Mol. Biochem. Parasitol. 111:1-14.
    • (2000) Mol. Biochem. Parasitol. , vol.111 , pp. 1-14
    • Lux, H.1    Heise, N.2    Klenner, T.3    Hart, D.T.4    Opperdoes, F.R.5
  • 25
    • 0022760004 scopus 로고
    • Interaction of Trypanosoma cruzi with heart muscle cells: Ultrastructural and cytochemical analysis of endocytic vacuole formation and effect upon myogenesis in vitro
    • Meirelles, M. N. L., T. C. Araújo-Jorge, C. F. Miranda, and H. S. Barbosa. 1986. Interaction of Trypanosoma cruzi with heart muscle cells: ultrastructural and cytochemical analysis of endocytic vacuole formation and effect upon myogenesis in vitro. Eur. J. Cell Biol. 41:198-205.
    • (1986) Eur. J. Cell Biol. , vol.41 , pp. 198-205
    • Meirelles, M.N.L.1    Araújo-Jorge, T.C.2    Miranda, C.F.3    Barbosa, H.S.4
  • 27
    • 0033251390 scopus 로고    scopus 로고
    • Progress towards interruption of transmission of Chagas disease
    • Moncayo, A. 1999. Progress towards interruption of transmission of Chagas disease. Mem. Inst. Oswaldo Cruz 94:401-404.
    • (1999) Mem. Inst. Oswaldo Cruz , vol.94 , pp. 401-404
    • Moncayo, A.1
  • 28
    • 0033752823 scopus 로고    scopus 로고
    • Suppression of posttreatment recurrence of experimental visceral leishmaniasis in T-cell-deficient mice by oral miltefosine
    • Murray, H. W. 2000. Suppression of posttreatment recurrence of experimental visceral leishmaniasis in T-cell-deficient mice by oral miltefosine. Antimicrob. Agents Chemother. 44:3235-3236.
    • (2000) Antimicrob. Agents Chemother. , vol.44 , pp. 3235-3236
    • Murray, H.W.1
  • 29
    • 0034048702 scopus 로고    scopus 로고
    • Visceral leishmanicidal activity of hexadecylphosphocholine (miltefosine) in mice deficient in T cells and activated macrophage microbicidal mechanisms
    • Murray, H. W., and S. Delph-Etiene. 2000. Visceral leishmanicidal activity of hexadecylphosphocholine (miltefosine) in mice deficient in T cells and activated macrophage microbicidal mechanisms. J. Infect. Dis. 181:795-799.
    • (2000) J. Infect. Dis. , vol.181 , pp. 795-799
    • Murray, H.W.1    Delph-Etiene, S.2
  • 30
    • 0033785362 scopus 로고    scopus 로고
    • Visceral leishmaniasis in mice devoid of tumor necrosis factor and response to treatment
    • Murray, H. W., A. Jungbluth, E. Ritter, C. Montelibano, and M. W. Marino. 2000. Visceral leishmaniasis in mice devoid of tumor necrosis factor and response to treatment. Infect. Immun. 68:6289-6293.
    • (2000) Infect. Immun. , vol.68 , pp. 6289-6293
    • Murray, H.W.1    Jungbluth, A.2    Ritter, E.3    Montelibano, C.4    Marino, M.W.5
  • 31
    • 0034913328 scopus 로고    scopus 로고
    • Clinical and experimental advances in treatment of visceral leishmaniasis
    • Murray, H. W. 2001. Clinical and experimental advances in treatment of visceral leishmaniasis. Antimicrob. Agents Chemother. 45:2185-2197.
    • (2001) Antimicrob. Agents Chemother. , vol.45 , pp. 2185-2197
    • Murray, H.W.1
  • 32
    • 17344379918 scopus 로고    scopus 로고
    • Molecular characterization of susceptible and naturally resistant strains of Trypanosoma cruzi to benznidazole and nifurtimox
    • Murta, S. M., R. T. Gazzinelli, Z. Brener, and A. J. Romanha. 1998. Molecular characterization of susceptible and naturally resistant strains of Trypanosoma cruzi to benznidazole and nifurtimox. Mol. Biochem. Parasitol. 93:203-214.
    • (1998) Mol. Biochem. Parasitol. , vol.93 , pp. 203-214
    • Murta, S.M.1    Gazzinelli, R.T.2    Brener, Z.3    Romanha, A.J.4
  • 33
    • 0023804393 scopus 로고
    • Comparative studies of drug susceptibility of five strains of Trypanosoma cruzi in vivo and in vitro
    • Neal, R. A., and J. van Bueren. 1988. Comparative studies of drug susceptibility of five strains of Trypanosoma cruzi in vivo and in vitro. Trans. R. Soc. Trop. Med. Hyg. 82:709-714.
    • (1988) Trans. R. Soc. Trop. Med. Hyg. , vol.82 , pp. 709-714
    • Neal, R.A.1    Van Bueren, J.2
  • 34
    • 0028180378 scopus 로고
    • O-Glycosidically linked N-acetylglucosamine-bound oligosaccharides from glycoproteins of Trypanosoma cruzi
    • Previato, J. O., C. Jones, L. P. B. Gon~alves, R. Wait, L. R. Travassos, and L. Mendonça-Previato. 1994. O-Glycosidically linked N-acetylglucosamine-bound oligosaccharides from glycoproteins of Trypanosoma cruzi. Biochem. J. 301:151-159.
    • (1994) Biochem. J. , vol.301 , pp. 151-159
    • Previato, J.O.1    Jones, C.2    Gonçalves, L.P.B.3    Wait, R.4    Travassos, L.R.5    Mendonça-Previato, L.6
  • 35
    • 0035885286 scopus 로고    scopus 로고
    • Effects of miltefosine on various biochemical parameters in a panel of tumor cell lines with different sensitivities
    • Rybczynska, M., M. Spitaler, N. G. Knebel, G. Boeck, H. Grunicke, and J. Hofmann. 2001. Effects of miltefosine on various biochemical parameters in a panel of tumor cell lines with different sensitivities. Biochem. Pharmacol. 62:765-772.
    • (2001) Biochem. Pharmacol. , vol.62 , pp. 765-772
    • Rybczynska, M.1    Spitaler, M.2    Knebel, N.G.3    Boeck, G.4    Grunicke, H.5    Hofmann, J.6
  • 36
    • 0034712428 scopus 로고    scopus 로고
    • Effect of the alkyl-lysophospholipids on the proliferation and differentiation of Trypanosoma cruzi
    • Santa-Rita, R. M., H. S. Barbosa, M. N. S. L. Meirelles, and S. L. de Castro. 2000. Effect of the alkyl-lysophospholipids on the proliferation and differentiation of Trypanosoma cruzi. Acta Trop. 75:219-228.
    • (2000) Acta Trop. , vol.75 , pp. 219-228
    • Santa-Rita, R.M.1    Barbosa, H.S.2    Meirelles, M.N.S.L.3    De Castro, S.L.4
  • 37
    • 0024391109 scopus 로고
    • Enzymatic formation of nitrogen oxides from L-arginine in bovine brain cytosol
    • Schmidt, H. H. W., P. Wilke, B. Evers, and E. Bohme. 1989. Enzymatic formation of nitrogen oxides from L-arginine in bovine brain cytosol. Biochem. Biophys. Res. Commun. 165:284-291.
    • (1989) Biochem. Biophys. Res. Commun. , vol.165 , pp. 284-291
    • Schmidt, H.H.W.1    Wilke, P.2    Evers, B.3    Bohme, E.4
  • 39
    • 0028807425 scopus 로고
    • Tumor necrosis factor alpha mediates resistance to Trypanosoma cruzi infection in mice by inducing nitric oxide production in infected gamma interferon-activated macrophages
    • Silva, J. S., G. N. R. Vespa, M. A. G. Cardoso, J. C. S. Aliberti, J. C. S., and F. Q. Cunha. 1995. Tumor necrosis factor alpha mediates resistance to Trypanosoma cruzi infection in mice by inducing nitric oxide production in infected gamma interferon-activated macrophages. Infect. Immun. 63:4862-4867.
    • (1995) Infect. Immun. , vol.63 , pp. 4862-4867
    • Silva, J.S.1    Vespa, G.N.R.2    Cardoso, M.A.G.3    Aliberti, J.C.S.4    Cunha, F.Q.5
  • 42
    • 0033256630 scopus 로고    scopus 로고
    • Parasitological cure of Chagas' disease: Is it possible? Is it relevant?
    • Urbina, J. A. 1999. Parasitological cure of Chagas' disease: is it possible? Is it relevant? Mem. Inst. Oswaldo Cruz 94:349-355.
    • (1999) Mem. Inst. Oswaldo Cruz , vol.94 , pp. 349-355
    • Urbina, J.A.1
  • 44
    • 0028842367 scopus 로고
    • Influence of hexadecylphosphorylcholine on the release of tumor necrosis factor and nitroxide from peritoneal macrophages in vitro
    • Zeisig, R., M. Rudolf, I. Eue, and D. Arndt. 1995. Influence of hexadecylphosphorylcholine on the release of tumor necrosis factor and nitroxide from peritoneal macrophages in vitro. J. Cancer Res. Clin. Oncol. 121:69-75.
    • (1995) J. Cancer Res. Clin. Oncol. , vol.121 , pp. 69-75
    • Zeisig, R.1    Rudolf, M.2    Eue, I.3    Arndt, D.4


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