메뉴 건너뛰기




Volumn 10, Issue 4, 2010, Pages 312-323

Perspectives for novel mixed diruthenium-organic drugs as metallopharmaceuticals in cancer therapy

Author keywords

Anticancer activity; Antitumor metallodrugs; Coordination compounds; Glioma; Medicinal chemistry; Non steroidal antiinflammatory drugs; Ruthenium compounds

Indexed keywords

INDAZOLIUM TETRACHLOROBIS(INDAZOLE)RUTHENATE; NAMI A; RUTHENIUM COMPLEX; UNCLASSIFIED DRUG;

EID: 77951657184     PISSN: 18715206     EISSN: None     Source Type: Journal    
DOI: 10.2174/187152010791162333     Document Type: Review
Times cited : (46)

References (167)
  • 3
    • 71749115320 scopus 로고    scopus 로고
    • Current applications and future potential for bioinorganic chemistry in the development of anticancer drugs
    • van Rijt, S. H.; Sadler, P. J. Current applications and future potential for bioinorganic chemistry in the development of anticancer drugs. Drug Discov. Today, 2009, 14, 1089-1097.
    • (2009) Drug Discov. Today , vol.14 , pp. 1089-1097
    • Van Rijt, S.H.1    Sadler, P.J.2
  • 4
    • 34250614736 scopus 로고    scopus 로고
    • Using coordination chemistry to design new medicines
    • Ronconi, L.; Sadler, P. J. Using coordination chemistry to design new medicines. Coord. Chem. Rev., 2007, 251, 1633-1648.
    • (2007) Coord. Chem. Rev. , vol.251 , pp. 1633-1648
    • Ronconi, L.1    Sadler, P.J.2
  • 6
    • 70349281567 scopus 로고    scopus 로고
    • A categorization of metal anticancer compounds based on their mode of action
    • Gianferrara, T.; Bratsos, I.; Alessio, E. A categorization of metal anticancer compounds based on their mode of action. Dalton Trans., 2009, 37, 7588-7598.
    • (2009) Dalton Trans. , vol.37 , pp. 7588-7598
    • Gianferrara, T.1    Bratsos, I.2    Alessio, E.3
  • 7
    • 33750295521 scopus 로고    scopus 로고
    • Classical and non-classical rutheniumbased anticancer drugs: Towards targeted chemotherapy
    • Ang, W. H.; Dyson, P. J. Classical and non-classical rutheniumbased anticancer drugs: towards targeted chemotherapy. Eur. J. Inorg. Chem., 2006, 20, 4003-4018.
    • (2006) Eur. J. Inorg. Chem. , vol.20 , pp. 4003-4018
    • Ang, W.H.1    Dyson, P.J.2
  • 8
    • 0014691619 scopus 로고
    • Platinum compounds: A new class of potent antitumor agent
    • Rosenberg, B.; Vancamp, L. V.; Trosko, J. E.; Mansour, V. H. Platinum compounds: a new class of potent antitumor agent. Nature, 1969, 222, 385-386.
    • (1969) Nature , vol.222 , pp. 385-386
    • Rosenberg, B.1    Vancamp, L.V.2    Trosko, J.E.3    Mansour, V.H.4
  • 9
    • 24644486532 scopus 로고    scopus 로고
    • Current status of platinum-based antitumor drugs
    • Wong, E.; Giandomenico, C. M. Current status of platinum-based antitumor drugs. Chem Rev., 1999, 99, 2451-2466.
    • (1999) Chem Rev. , vol.99 , pp. 2451-2466
    • Wong, E.1    Giandomenico, C.M.2
  • 10
    • 18244379333 scopus 로고    scopus 로고
    • Cellular processing of platinum anticancer drugs
    • Wang, D.; Lippard, S. J. Cellular processing of platinum anticancer drugs. Nat. Rev. Drug Discov., 2005, 4, 307-320.
    • (2005) Nat. Rev. Drug Discov. , vol.4 , pp. 307-320
    • Wang, D.1    Lippard, S.J.2
  • 11
    • 24644443129 scopus 로고    scopus 로고
    • Modifications of DNA by platinum complexes -Relation to resistance of tumors to platinum antitumor drugs
    • Brabec, V.; Kasparkova, J. Modifications of DNA by platinum complexes -Relation to resistance of tumors to platinum antitumor drugs. Drug Res. Updates, 2005, 8, 131-146.
    • (2005) Drug Res. Updates , vol.8 , pp. 131-146
    • Brabec, V.1    Kasparkova, J.2
  • 12
    • 71549170210 scopus 로고    scopus 로고
    • Non-traditional platinum compounds for improved accumulation, oral bioavailability, and tumor targeting
    • Lovejoy, K. S.; Lippard, S. J. Non-traditional platinum compounds for improved accumulation, oral bioavailability, and tumor targeting. Dalton Trans., 2009, 48, 10651-10659.
    • (2009) Dalton Trans. , vol.48 , pp. 10651-10659
    • Lovejoy, K.S.1    Lippard, S.J.2
  • 14
    • 63449141143 scopus 로고    scopus 로고
    • Platinum anticancer coordination compounds: Study of DNA binding inspires new drug design
    • Reedijk, J. Platinum anticancer coordination compounds: Study of DNA binding inspires new drug design. Eur. J. Inorg. Chem., 2009, 10, 1303-1312.
    • (2009) Eur. J. Inorg. Chem. , vol.10 , pp. 1303-1312
    • Reedijk, J.1
  • 17
    • 33645998774 scopus 로고    scopus 로고
    • Ruthenium complexes as anticancer agents
    • Kostova, I. Ruthenium complexes as anticancer agents. Curr. Med. Chem., 2006, 13, 1085-1107.
    • (2006) Curr. Med. Chem. , vol.13 , pp. 1085-1107
    • Kostova, I.1
  • 18
    • 33947425916 scopus 로고    scopus 로고
    • Ruthenium complexes can target determinants of tumor malignancy
    • Bergamo, A.; Sava, G. Ruthenium complexes can target determinants of tumor malignancy. Dalton Trans., 2007, 13, 1267-1272.
    • (2007) Dalton Trans. , vol.13 , pp. 1267-1272
    • Bergamo, A.1    Sava, G.2
  • 19
    • 75849158241 scopus 로고    scopus 로고
    • Recent developments in ruthenium anticancer drugs
    • Levina, A.; Mitra, A.; Lay, P. A. Recent developments in ruthenium anticancer drugs. Metallomics, 2009, 1, 458-470.
    • (2009) Metallomics , vol.1 , pp. 458-470
    • Levina, A.1    Mitra, A.2    Lay, P.A.3
  • 20
    • 75749151659 scopus 로고    scopus 로고
    • Arene ruthenium complexes as anticancer agents
    • Fink, G. S. Arene ruthenium complexes as anticancer agents. Dalton Trans., 2010, 39, 1673-1688.
    • (2010) Dalton Trans. , vol.39 , pp. 1673-1688
    • Fink, G.S.1
  • 21
    • 0028227096 scopus 로고
    • Structure of serum albumin
    • Carter, D. C.; Ho, J. X., Structure of serum albumin. Adv. Protein Chem., 1994, 45, 153-203.
    • (1994) Adv. Protein Chem. , vol.45 , pp. 153-203
    • Carter, D.C.1    Ho, J.X.2
  • 22
    • 0001231645 scopus 로고    scopus 로고
    • Transferrin as a metal ion mediator
    • Sun, H.; Li, H.; Sadler, P. J. Transferrin as a metal ion mediator. Chem. Rev., 1999, 99, 2817-2842.
    • (1999) Chem. Rev. , vol.99 , pp. 2817-2842
    • Sun, H.1    Li, H.2    Sadler, P.J.3
  • 23
    • 33745763300 scopus 로고    scopus 로고
    • Interactions of antitumor metallodrugs with serum proteins: Advances in characterization using modern analytical methodology
    • Timerbaev, A. R.; Hartinger, C. G.; Aleksenko, S. S.; Keppler, B. K. Interactions of antitumor metallodrugs with serum proteins: advances in characterization using modern analytical methodology. Chem. Rev., 2006, 106, 2224-2248.
    • (2006) Chem. Rev. , vol.106 , pp. 2224-2248
    • Timerbaev, A.R.1    Hartinger, C.G.2    Aleksenko, S.S.3    Keppler, B.K.4
  • 26
    • 33744493093 scopus 로고    scopus 로고
    • The new era in cancer research
    • Varmus, H. The new era in cancer research. Science, 2006, 312, 1162-1165.
    • (2006) Science , vol.312 , pp. 1162-1165
    • Varmus, H.1
  • 27
    • 33744486894 scopus 로고    scopus 로고
    • Metal-based antitumor drugs in the post genomic era
    • Dyson, P. J.; Sava, G. Metal-based antitumor drugs in the post genomic era. Dalton Trans., 2006, 16, 1929-1933.
    • (2006) Dalton Trans. , vol.16 , pp. 1929-1933
    • Dyson, P.J.1    Sava, G.2
  • 28
    • 0002907489 scopus 로고
    • Ruthenium complexes: Potential roles in anticancer pharmaceutics
    • Keppler, B. K., Ed. VCH: New York
    • Clarke, M. J. Ruthenium complexes: potential roles in anticancer pharmaceutics. In: Metal Complexes in Cancer Chemotherapy, Keppler, B. K., Ed. VCH: New York, 1993; pp.129-156.
    • (1993) Metal Complexes in Cancer Chemotherapy , pp. 129-156
    • Clarke, M.J.1
  • 29
    • 0042948708 scopus 로고    scopus 로고
    • Ruthenium metallopharmaceutics
    • Clarke, M. J. Ruthenium metallopharmaceutics. Coord. Chem. Rev., 2003, 236, 209-233.
    • (2003) Coord. Chem. Rev. , vol.236 , pp. 209-233
    • Clarke, M.J.1
  • 30
    • 0001961655 scopus 로고
    • The Development of Tumor-Inhibiting Ruthenium-Dimethylsulfoxide Complexes
    • Keppler, B. K., Ed. VCH: New York
    • Mestroni, G.; Alessio, E.; Sava, G.; Pacor, S.; Coluccia, M. The Development of Tumor-Inhibiting Ruthenium-Dimethylsulfoxide Complexes. In: Metal Complexes in Cancer Chemotherapy, Keppler, B. K., Ed. VCH: New York, 1993; pp.157-185.
    • (1993) Metal Complexes in Cancer Chemotherapy , pp. 157-185
    • Mestroni, G.1    Alessio, E.2    Sava, G.3    Pacor, S.4    Coluccia, M.5
  • 32
    • 0024442416 scopus 로고
    • Antitumor properties of dimethylsulphoxide ruthenium(II) complexes in the lewis lung carcinoma system
    • Sava, G.; Pacor, S.; Zorzet, S.; Alessio, E.; Mestroni, G. Antitumor properties of dimethylsulphoxide ruthenium(II) complexes in the lewis lung carcinoma system. Pharmacol. Res., 1989, 21, 617-628.
    • (1989) Pharmacol. Res. , vol.21 , pp. 617-628
    • Sava, G.1    Pacor, S.2    Zorzet, S.3    Alessio, E.4    Mestroni, G.5
  • 33
    • 0027453436 scopus 로고
    • Anti-leukaemic action of RuCl2(DMSO)4 isomers and prevention of brain involvement on P388 leukaemia and on P338/DDP subline
    • Coluccia, M.; Sava, G.; Loseto, F.; Nassi, A.; Boccarelli, A.; Giordano, D.; Alessio, E.; Mestroni, G. Anti-leukaemic action of RuCl2(DMSO)4 isomers and prevention of brain involvement on P388 leukaemia and on P338/DDP subline. Eur. J. Cancer, 1993, 29A, 1873-1879.
    • (1993) Eur. J. Cancer , vol.29 A , pp. 1873-1879
    • Coluccia, M.1    Sava, G.2    Loseto, F.3    Nassi, A.4    Boccarelli, A.5    Giordano, D.6    Alessio, E.7    Mestroni, G.8
  • 35
    • 0242441018 scopus 로고    scopus 로고
    • Ruthenium(II) sulfoxide-maltolato and -nitroimidazole complexes: Synthesis and MTT assay
    • Wu, A.; Kennedy, D. C.; Patrick, B. O.; James, B. R. Ruthenium(II) sulfoxide-maltolato and -nitroimidazole complexes: Synthesis and MTT assay. Inorg. Chem., 2003, 42, 7579-7586.
    • (2003) Inorg. Chem. , vol.42 , pp. 7579-7586
    • Wu, A.1    Kennedy, D.C.2    Patrick, B.O.3    James, B.R.4
  • 36
    • 0010058247 scopus 로고
    • Chromatographic, spectroscopic and electrochemical characterization of geometrical isomers of the diclorobis2,6-dimethylpyrazine bis(dimethylsulphoxide)ruthenium (II) complex
    • Toma, H. E.; De Oliveira Silva, D. Chromatographic, spectroscopic and electrochemical characterization of geometrical isomers of the diclorobis(2,6-dimethylpyrazine bis(dimethylsulphoxide)ruthenium (II) complex. Polyhedron, 1991, 10, 1699-1704.
    • (1991) Polyhedron , vol.10 , pp. 1699-1704
    • Toma, H.E.1    De Oliveira Silva, D.2
  • 37
    • 0026339845 scopus 로고
    • Elution behavior of Nheterocyclic derivatives of mixed ruthenium(II)-sulfoxide complexes in reversed-phase high performance liquid chromatography
    • Toma, H. E.; De Oliveira Silva, D. Elution behavior of Nheterocyclic derivatives of mixed ruthenium(II)-sulfoxide complexes in reversed-phase high performance liquid chromatography. Chromatographia, 1991, 32, 546-548.
    • (1991) Chromatographia , vol.32 , pp. 546-548
    • Toma, H.E.1    De Oliveira Silva, D.2
  • 38
    • 0000766158 scopus 로고
    • Linkage isomerization and electrochemical behavior of two geometrical isomers of dichlorobis( dimethylsulfoxide)bis(t-butylpyridine)ruthenium(II)
    • De Oliveira Silva, D.; Toma, H. E. Linkage isomerization and electrochemical behavior of two geometrical isomers of dichlorobis( dimethylsulfoxide)bis(t-butylpyridine)ruthenium(II). Can. J. Chem., 1994, 72, 1705-1708.
    • (1994) Can. J. Chem. , vol.72 , pp. 1705-1708
    • De Oliveira Silva, D.1    Toma, H.E.2
  • 39
    • 0032583688 scopus 로고    scopus 로고
    • Photochemical behavior of the dichlorobis(dimethylsulfoxide)bis(t- butylpyridine) ruthenium(II) complex
    • De Oliveira Silva, D.; Saika, J. J.; Toma, H. E. Photochemical behavior of the dichlorobis(dimethylsulfoxide)bis(t-butylpyridine) ruthenium(II) complex. J. Photochem. Photobiol. A: Chem., 1998, 112, 209-212.
    • (1998) J. Photochem. Photobiol. A: Chem. , vol.112 , pp. 209-212
    • De Oliveira Silva, D.1    Saika, J.J.2    Toma, H.E.3
  • 43
    • 37149008995 scopus 로고    scopus 로고
    • Ruthenium anticancer compounds: Challenges and expectations
    • Bratsosa, I.; Jednera, S.; Gianferrara, T.; Alessio, E. Ruthenium anticancer compounds: challenges and expectations. Chimia, 2007, 61, 692-697.
    • (2007) Chimia , vol.61 , pp. 692-697
    • Bratsosa, I.1    Jednera, S.2    Gianferrara, T.3    Alessio, E.4
  • 45
    • 0038015349 scopus 로고    scopus 로고
    • Primary tumor, lung and kidney retention and antimetastasis effect of NAMI-A following different routes of administration
    • Cocchietto, M.; Zorzet, S.; Sorc, A.; Sava, G. Primary tumor, lung and kidney retention and antimetastasis effect of NAMI-A following different routes of administration. Invest. New Drugs, 2003, 21, 55-62.
    • (2003) Invest. New Drugs , vol.21 , pp. 55-62
    • Cocchietto, M.1    Zorzet, S.2    Sorc, A.3    Sava, G.4
  • 48
    • 0032921951 scopus 로고    scopus 로고
    • In vitro cell cycle arrest, in vivo action on solid metastasizing tumors, and host toxicity of the antimetastatic drug NAMI-A and cisplatin
    • Bergamo, A.; Gagliardi, R.; Scarcia, V.; Furlani, A.; Alessio, E.; Mestroni, G.; Sava, G. In vitro cell cycle arrest, in vivo action on solid metastasizing tumors, and host toxicity of the antimetastatic drug NAMI-A and cisplatin J. Pharmacol. Exp. Ther., 1999, 289, 559-564.
    • (1999) J. Pharmacol. Exp. Ther. , vol.289 , pp. 559-564
    • Bergamo, A.1    Gagliardi, R.2    Scarcia, V.3    Furlani, A.4    Alessio, E.5    Mestroni, G.6    Sava, G.7
  • 50
    • 0036450269 scopus 로고    scopus 로고
    • Tumour cell uptake of the metastasis inhibitor ruthenium complex NAMI-A and its in vitro effects on KB cells
    • DOI 10.1007/s00280-002-0504-9
    • Frausin, F.; Cocchietto, M.; Bergamo, A.; Searcia, V.; Furlani, A.; Sava, G. Tumor cell uptake of the metastasis inhibitor ruthenium complex NAMI-A and its in vitro effects on KB cells. Cancer Chemother. Pharmacol., 2002, 50, 405-411. (Pubitemid 35440529)
    • (2002) Cancer Chemotherapy and Pharmacology , vol.50 , Issue.5 , pp. 405-411
    • Frausin, F.1    Cocchietto, M.2    Bergamo, A.3    Scarcia, V.4    Furlani, A.5    Sava, G.6
  • 51
    • 0024442416 scopus 로고
    • Antitumour properties of dimethylsulphoxide ruthenium(II) complexes in the Lewis lung carcinoma system
    • Sava, G.; Pacor, S.; Zorzet, S.; Alessio, E.; Mestroni, G. Antitumor properties of dimethylsulphoxide ruthenium(II) complexes in the lewis lung carcinoma system. Pharmacol. Res., 1989, 21, 617-628. (Pubitemid 19250108)
    • (1989) Pharmacological Research , vol.21 , Issue.5 , pp. 617-628
    • Sava, G.1    Pacor, S.2    Zorzet, S.3    Alessio, E.4    Mestroni, G.5
  • 54
    • 0242441018 scopus 로고    scopus 로고
    • Ruthenium(II) sulfoxide-maltolato and -nitroimidazole complexes: Synthesis and MTT assay
    • Wu, A.; Kennedy, D. C.; Patrick, B. O.; James, B. R. Ruthenium(II) sulfoxide-maltolato and -nitroimidazole complexes: Synthesis and MTT assay. Inorg. Chem., 2003, 42, 7579-7586.
    • (2003) Inorg. Chem. , vol.42 , pp. 7579-7586
    • Wu, A.1    Kennedy, D.C.2    Patrick, B.O.3    James, B.R.4
  • 55
    • 0010058247 scopus 로고
    • Chromatographic, spectroscopic and electrochemical characterization of geometrical isomers of the diclorobis2,6-dimethylpyrazine bis(dimethylsulphoxide)ruthenium (II) complex
    • Toma, H. E.; De Oliveira Silva, D. Chromatographic, spectroscopic and electrochemical characterization of geometrical isomers of the diclorobis(2,6-dimethylpyrazine bis(dimethylsulphoxide)ruthenium (II) complex. Polyhedron, 1991, 10, 1699-1704.
    • (1991) Polyhedron , vol.10 , pp. 1699-1704
    • Toma, H.E.1    De Oliveira Silva, D.2
  • 56
    • 0026339845 scopus 로고
    • Elution behavior of N-heterocyclic derivatives of mixed ruthenium(II)-sulfoxide complexes in reversed-phase high performance liquid chromatography
    • Toma, H. E.; De Oliveira Silva, D. Elution behavior of N-heterocyclic derivatives of mixed ruthenium(II)-sulfoxide complexes in reversed-phase high performance liquid chromatography. Chromatographia, 1991, 32, 546-548.
    • (1991) Chromatographia , vol.32 , pp. 546-548
    • Toma, H.E.1    De Oliveira Silva, D.2
  • 57
    • 0000766158 scopus 로고
    • Linkage isomerization and electrochemical behavior of two geometrical isomers of dichlorobis(dimethylsulfoxide)bis(t-butylpyridine)ruthenium(II)
    • De Oliveira Silva, D.; Toma, H. E. Linkage isomerization and electrochemical behavior of two geometrical isomers of dichlorobis(dimethylsulfoxide)bis(t-butylpyridine)ruthenium(II). Can. J. Chem., 1994, 72, 1705-1708.
    • (1994) Can. J. Chem. , vol.72 , pp. 1705-1708
    • De Oliveira Silva, D.1    Toma, H.E.2
  • 58
    • 0032583688 scopus 로고    scopus 로고
    • Photochemical behavior of the dichlorobis(dimethylsulfoxide)bis(t- butylpyridine) ruthenium(II) complex
    • De Oliveira Silva, D.; Saika, J. J.; Toma, H. E. Photochemical behavior of the dichlorobis(dimethylsulfoxide)bis(t-butylpyridine) ruthenium(II) complex. J. Photochem. Photobiol. A: Chem., 1998, 112, 209-212.
    • (1998) J. Photochem. Photobiol. A: Chem. , vol.112 , pp. 209-212
    • De Oliveira Silva, D.1    Saika, J.J.2    Toma, H.E.3
  • 62
    • 37149008995 scopus 로고    scopus 로고
    • Ruthenium anticancer compounds: Challenges and expectations
    • Bratsosa, I.; Jednera, S.; Gianferrara, T.; Alessio, E. Ruthenium anticancer compounds: challenges and expectations. Chimia, 2007, 61, 692-697.
    • (2007) Chimia , vol.61 , pp. 692-697
    • Bratsosa, I.1    Jednera, S.2    Gianferrara, T.3    Alessio, E.4
  • 64
    • 0038015349 scopus 로고    scopus 로고
    • Primary tumor, lung and kidney retention and antimetastasis effect of NAMI-A following different routes of administration
    • DOI 10.1023/A:1022916310694
    • Cocchietto, M.; Zorzet, S.; Sorc, A.; Sava, G. Primary tumor, lung and kidney retention and antimetastasis effect of NAMI-A following different routes of administration. Invest. New Drugs, 2003, 21, 55-62. (Pubitemid 36628485)
    • (2003) Investigational New Drugs , vol.21 , Issue.1 , pp. 55-62
    • Cocchietto, M.1    Zorzet, S.2    Sorc, A.3    Sava, G.4
  • 69
    • 0036450269 scopus 로고    scopus 로고
    • Tumour cell uptake of the metastasis inhibitor ruthenium complex NAMI-A and its in vitro effects on KB cells
    • DOI 10.1007/s00280-002-0504-9
    • Frausin, F.; Cocchietto, M.; Bergamo, A.; Searcia, V.; Furlani, A.; Sava, G. Tumor cell uptake of the metastasis inhibitor ruthenium complex NAMI-A and its in vitro effects on KB cells. Cancer Chemother. Pharmacol., 2002, 50, 405-411. (Pubitemid 35440529)
    • (2002) Cancer Chemotherapy and Pharmacology , vol.50 , Issue.5 , pp. 405-411
    • Frausin, F.1    Cocchietto, M.2    Bergamo, A.3    Scarcia, V.4    Furlani, A.5    Sava, G.6
  • 70
    • 37149042962 scopus 로고    scopus 로고
    • Systematic design of a targeted organometallic antitumor drug in pre-clinical development
    • Dyson, P. J. Systematic design of a targeted organometallic antitumor drug in pre-clinical development. Chimia, 2007, 61, 698-703.
    • (2007) Chimia , vol.61 , pp. 698-703
    • Dyson, P.J.1
  • 71
    • 0026513746 scopus 로고
    • Studies on DNA damage and induction of SOS repair by novel multifunctional bioreducible compounds.2. A metronidazole adduct of a ruthenium-arene compound
    • Dale, L. D.; Tocher, J. H.; Dyson, T. M.; Edwards, D. I.; Tocher, D. A. Studies on DNA damage and induction of SOS repair by novel multifunctional bioreducible compounds.2. A metronidazole adduct of a ruthenium-arene compound. Anti-Cancer Drug Des., 1992, 7, 3-14.
    • (1992) Anti-Cancer Drug Des. , vol.7 , pp. 3-14
    • Dale, L.D.1    Tocher, J.H.2    Dyson, T.M.3    Edwards, D.I.4    Tocher, D.A.5
  • 72
    • 27144530274 scopus 로고    scopus 로고
    • Organometallic chemistry, biology and medicine: Ruthenium arene anticancer complexes
    • Yan, Y. K.; Melchart, M.; Habtemariam, A.; Sadler, P. J. Organometallic chemistry, biology and medicine: ruthenium arene anticancer complexes. Chem. Commun., 2005, 38, 4764-4776.
    • (2005) Chem. Commun. , vol.38 , pp. 4764-4776
    • Yan, Y.K.1    Melchart, M.2    Habtemariam, A.3    Sadler, P.J.4
  • 73
    • 37149013471 scopus 로고    scopus 로고
    • Ruthenium(II)-arene complex with heterocyclic ligands as prospective antitumor agent
    • John, R. O.; Arion, V. B.; Jakupec, M. A.; Keppler, B. K. Ruthenium(II)-arene complex with heterocyclic ligands as prospective antitumor agent. Met. Ions Biol. Med., 2006, 9, 40-45.
    • (2006) Met. Ions Biol. Med. , vol.9 , pp. 40-45
    • John, R.O.1    Arion, V.B.2    Jakupec, M.A.3    Keppler, B.K.4
  • 74
    • 0041696963 scopus 로고    scopus 로고
    • The synthesis, structural characterization, and in vitro anti-cancer activity of chloro(p-cymene) complexes of ruthenium(II) containing a disulfoxide ligand
    • Huxham, L. A.; Cheu, E. L. S.; Patrick, B. O.; James, B. R. The synthesis, structural characterization, and in vitro anti-cancer activity of chloro(p-cymene) complexes of ruthenium(II) containing a disulfoxide ligand. Inorg. Chim. Acta, 2003, 352, 238-246.
    • (2003) Inorg. Chim. Acta , vol.352 , pp. 238-246
    • Huxham, L.A.1    Cheu, E.L.S.2    Patrick, B.O.3    James, B.R.4
  • 75
    • 67649525571 scopus 로고    scopus 로고
    • Exploring metallodrug-protein interactions by mass spectrometry: Comparisons between platinum coordination complexes and an organometallic ruthenium compound
    • Casini, A.; Gabbiani, C.; Michelucci, E.; Pieraccini, G.; Monet, G.; Dyson, P. J.; Messori, L. Exploring metallodrug-protein interactions by mass spectrometry: comparisons between platinum coordination complexes and an organometallic ruthenium compound. J. Biol. Inorg. Chem., 2009, 14, 761-770.
    • (2009) J. Biol. Inorg. Chem. , vol.14 , pp. 761-770
    • Casini, A.1    Gabbiani, C.2    Michelucci, E.3    Pieraccini, G.4    Monet, G.5    Dyson, P.J.6    Messori, L.7
  • 77
    • 70449687713 scopus 로고    scopus 로고
    • In vivo tumour and metastasis reduction and in vitro effects on invasion assays of the ruthenium RM175 and osmium AFAP51 organometallics in the mammary cancer model
    • Bergamo, A.; Mais, A.; Peacock, A.F.A.; Habtemariam, A.; Sadler, P.J.; Sava, G. In vivo tumour and metastasis reduction and in vitro effects on invasion assays of the ruthenium RM175 and osmium AFAP51 organometallics in the mammary cancer model. J. Inorg. Biochem., 2010, 104, 79-86.
    • (2010) J. Inorg. Biochem. , vol.104 , pp. 79-86
    • Bergamo, A.1    Mais, A.2    Peacock, A.F.A.3    Habtemariam, A.4    Sadler, P.J.5    Sava, G.6
  • 79
    • 33745639435 scopus 로고    scopus 로고
    • Synthesis, molecular characterization, and biological activity of novel synthetic derivatives of chromen-4-one in human cancer cells
    • Barve, V.; Ahmed, F.; Adsule, S.; Banerjee,S.; Kulkarni, S.; Katiyar, P.; Anson, C. E.; Powell, A. K.; Padhye S.; Sarkar, F.H.; Synthesis, molecular characterization, and biological activity of novel synthetic derivatives of chromen-4-one in human cancer cells. J. Med. Chem., 2006, 49, 3800-3808.
    • (2006) J. Med. Chem. , vol.49 , pp. 3800-3808
    • Barve, V.1    Ahmed, F.2    Adsule, S.3    Banerjee, S.4    Kulkarni, S.5    Katiyar, P.6    Anson, C.E.7    Powell, A.K.8    Padhye, S.9    Sarkar, F.H.10
  • 81
    • 0032026991 scopus 로고
    • Diruthenium and diosmium tetracarboxylates: Synthesis, physical properties and applications
    • Aquino, M. A. S. Diruthenium and diosmium tetracarboxylates: synthesis, physical properties and applications. Coord. Chem. Rev., 1988, 170, 141-202.
    • (1988) Coord. Chem. Rev. , vol.170 , pp. 141-202
    • Aquino, M.A.S.1
  • 82
    • 4544327225 scopus 로고    scopus 로고
    • Recent developments in the synthesis and properties of diruthenium tetracarboxylates
    • Aquino, M. A. S. Recent developments in the synthesis and properties of diruthenium tetracarboxylates. Coord. Chem. Rev., 2004, 248, 1025-1045.
    • (2004) Coord. Chem. Rev. , vol.248 , pp. 1025-1045
    • Aquino, M.A.S.1
  • 83
    • 53849094756 scopus 로고    scopus 로고
    • Synthesis, characterization and adsorption properties of porous mixed valent diruthenium(II,III)-terephthalate and diruthenium(II,III)-adipate polymers
    • Ribeiro, G.; Vichi, F. M.; de Oliveira Silva, D. Synthesis, characterization and adsorption properties of porous mixed valent diruthenium(II,III)-terephthalate and diruthenium(II,III)-adipate polymers. J. Mol. Struct., 2008, 890, 209-214.
    • (2008) J. Mol. Struct. , vol.890 , pp. 209-214
    • Ribeiro, G.1    Vichi, F.M.2    De Oliveira Silva, D.3
  • 84
    • 0002449247 scopus 로고
    • Structure of tetra-nbutyratodiruthenium chloride, a compound with a strong metalmetal bond
    • Bennett, M. J.; Caulton, K. G.; Cotton, F. A. Structure of tetra-nbutyratodiruthenium chloride, a compound with a strong metalmetal bond. Inorg. Chem., 1969, 8, 1-6.
    • (1969) Inorg. Chem. , vol.8 , pp. 1-6
    • Bennett, M.J.1    Caulton, K.G.2    Cotton, F.A.3
  • 86
    • 0028050436 scopus 로고
    • Structural evidence for a new metal-binding mode for guanine bases: Implications for the binding of dinuclear antitumor agents to DNA
    • DOI 10.1021/ja00084a093
    • Dunbar, K. R.; Matonic, J. H.; Saharan,V. P.; Crawford, C. A.; Christou, G. Structural evidence for a new metal-binding mode for guanine bases: implications for the binding of dinuclear antitumor agents to DNA. J. Am. Chem. Soc., 1994, 116, 2201-2202. (Pubitemid 24249865)
    • (1994) Journal of the American Chemical Society , vol.116 , Issue.5 , pp. 2201-2202
    • Dunbar, K.R.1    Matonic, J.H.2    Saharan, V.P.3    Crawford, C.A.4    Christou, G.5
  • 87
    • 0029977351 scopus 로고    scopus 로고
    • 6 bridging 9-ethylguanine (9-EtGH) groups in dinuclear metal-metal bonded complexes with bond orders of one, two or four
    • Crawford, C. A.; Day, E. F.; Saharan, V. P.; Folting, K.; Huffman, J. C.; Dunbar, K. R.; Christou G. N-7,O-6 bridging 9-ethylguanine (9-EtGH) groups in dinuclear metal-metal bonded complexes with bond orders of one, two or four. J. Chem. Soc., Chem. Commun., 1996, 1113-1114. (Pubitemid 26171717)
    • (1996) Chemical Communications , Issue.10 , pp. 1113-1114
    • Crawford, C.A.1    Day, E.F.2    Saharan, V.P.3    Folting, K.4    Huffman, J.C.5    Dunbar, K.R.6    Christou, G.7
  • 89
    • 0035825114 scopus 로고    scopus 로고
    • Prospects for changing the burden of nonsteroidal anti-inflammatory drug toxicity
    • Griffin, M. R.; Sheiman, J. M. Prospects for changing the burden of nonsteroidal anti-inflammatory drug toxicity. Am. J. Med., 2001, 110, S33-S37.
    • (2001) Am. J. Med. , vol.110
    • Griffin, M.R.1    Sheiman, J.M.2
  • 90
    • 0025694966 scopus 로고
    • History of aspirin and its mechanism of action
    • Vane, J. R.; Flower, R. J.; Botting, R. M. History of aspirin and its mechanism of action. Stroke, 1990, 21, 12-23.
    • (1990) Stroke , vol.21 , pp. 12-23
    • Vane, J.R.1    Flower, R.J.2    Botting, R.M.3
  • 91
    • 0142182443 scopus 로고    scopus 로고
    • Use of NSAIDs for the chemioprevention of colorectal cancer
    • Herendeen, J. M.; Lindley, C. Use of NSAIDs for the chemioprevention of colorectal cancer. Ann. Pharmacother., 2003, 37, 1664-1674.
    • (2003) Ann. Pharmacother. , vol.37 , pp. 1664-1674
    • Herendeen, J.M.1    Lindley, C.2
  • 92
    • 22644436705 scopus 로고    scopus 로고
    • Non-steroidal anti-inflammatory drugs for the prevention and treatment of cancer
    • Pereg D.; Lishner, M. Non-steroidal anti-inflammatory drugs for the prevention and treatment of cancer. J. Int. Med., 2005, 258, 115-123.
    • (2005) J. Int. Med. , vol.258 , pp. 115-123
    • Pereg, D.1    Lishner, M.2
  • 93
    • 0037138743 scopus 로고    scopus 로고
    • Nonsteroidal antiinflammatory drugs as anticancer agents: Mechanistic, pharmacologic, and clinical issues
    • Thun, M. J.; Henley, S. J.; Patrono, C. Nonsteroidal antiinflammatory drugs as anticancer agents: mechanistic, pharmacologic, and clinical issues. J. Nat. Cancer Inst., 2002, 94, 252-266.
    • (2002) J. Nat. Cancer Inst. , vol.94 , pp. 252-266
    • Thun, M.J.1    Henley, S.J.2    Patrono, C.3
  • 94
    • 0031957722 scopus 로고    scopus 로고
    • Aspirin, NSAIDS, and colon cancer prevention: Mechanisms?
    • Gupta, R. A.; DuBois, R. N. Aspirin, NSAIDS, and colon cancer prevention: mechanisms? Gastroenterology, 1998, 114, 1095-1098.
    • (1998) Gastroenterology , vol.114 , pp. 1095-1098
    • Gupta, R.A.1    DuBois, R.N.2
  • 98
    • 0035815222 scopus 로고    scopus 로고
    • Aspirin and risk for gastric cancer: A population-based case-control study in Sweden
    • Akre, K.; Ekstrom, A. M.; Signorello, L. B.; Hansson, L. E.; Nyren, O. Aspirin and risk for gastric cancer: a population-based case-control study in Sweden. Br. J. Cancer, 2001, 84, 965-968.
    • (2001) Br. J. Cancer , vol.84 , pp. 965-968
    • Akre, K.1    Ekstrom, A.M.2    Signorello, L.B.3    Hansson, L.E.4    Nyren, O.5
  • 99
    • 0034009433 scopus 로고    scopus 로고
    • Nonsteroidal anti-inflammatory drugs and cancer prevention
    • Baron, J. A.; Sandler, R. S. Nonsteroidal anti-inflammatory drugs and cancer prevention. Annu. Rev. Med., 2000, 51, 511-523.
    • (2000) Annu. Rev. Med. , vol.51 , pp. 511-523
    • Baron, J.A.1    Sandler, R.S.2
  • 100
    • 33744479992 scopus 로고    scopus 로고
    • Non-steroidal anti-inflammatory drugs in prevention of gastric cancer. World
    • Dai, Y.; Wang, W. H. Non-steroidal anti-inflammatory drugs in prevention of gastric cancer. World. J. Gastroenterol., 2006, 12, 2884-2889.
    • (2006) J. Gastroenterol. , vol.12 , pp. 2884-2889
    • Dai, Y.1    Wang, W.H.2
  • 101
    • 0032816236 scopus 로고    scopus 로고
    • Aspirin protects against gastric cancer: Results of a case-control study from Moscow, Russia
    • Zaridze, D.; Borisova, E.; Maximovitch, D.; Chkhikvadze, V. Aspirin protects against gastric cancer: results of a case-control study from Moscow, Russia. Int. J. Cancer, 1999, 82, 473-476.
    • (1999) Int. J. Cancer , vol.82 , pp. 473-476
    • Zaridze, D.1    Borisova, E.2    Maximovitch, D.3    Chkhikvadze, V.4
  • 102
    • 0027245529 scopus 로고
    • Reduced risk of large-bowel adenomas among aspirin users
    • The Polyp Prevention Study Group
    • Greenberg, E. R.; Baron, J. A.; Freeman, D. H. Jr.; Mandel, J. S.; Haile, R. Reduced risk of large-bowel adenomas among aspirin users. The Polyp Prevention Study Group. J. Natl. Cancer Inst., 1993, 85, 912-916.
    • (1993) J. Natl. Cancer Inst. , vol.85 , pp. 912-916
    • Greenberg, E.R.1    Baron, J.A.2    Freeman Jr.3    , D.H.4    Mandel, J.S.5    Haile, R.6
  • 103
    • 33947545402 scopus 로고    scopus 로고
    • The use of aspirin for primary prevention of colorectal cancer: A systematic review prepared for the U.S. Preventive Services Task Force
    • Dube, C.; Rostom, A.; Lewin, G.; Tsertsvadze, A.; Barrowman, N.; Code, C.; Sampson, M.; Moher, D. The use of aspirin for primary prevention of colorectal cancer: a systematic review prepared for the U.S. Preventive Services Task Force. Ann. Intern. Med., 2007, 146, 365-375.
    • (2007) Ann. Intern. Med. , vol.146 , pp. 365-375
    • Dube, C.1    Rostom, A.2    Lewin, G.3    Tsertsvadze, A.4    Barrowman, N.5    Code, C.6    Sampson, M.7    Moher, D.8
  • 105
    • 0346258154 scopus 로고    scopus 로고
    • Non-steroidal anti-inflammatory drug use and the risk of gastric cancer: A systematic review and meta-analysis
    • Wang, W. H.; Huang, J. Q.; Zheng,G. F.; Lam, S. K.; Karlberg, J.; Wong, B. C. Non-steroidal anti-inflammatory drug use and the risk of gastric cancer: a systematic review and meta-analysis. J. Natl. Cancer Inst., 2003, 95, 1784-1791.
    • (2003) J. Natl. Cancer Inst. , vol.95 , pp. 1784-1791
    • Wang, W.H.1    Huang, J.Q.2    Zheng, G.F.3    Lam, S.K.4    Karlberg, J.5    Wong, B.C.6
  • 106
    • 0028325496 scopus 로고
    • Aspirin use and lung, colon, and breast cancer incidence in a prospective study
    • Schreinemachers, D. M.; Everson, R. B. Aspirin use and lung, colon, and breast cancer incidence in a prospective study. Epidemiology, 1994, 5, 138-146.
    • (1994) Epidemiology , vol.5 , pp. 138-146
    • Schreinemachers, D.M.1    Everson, R.B.2
  • 107
    • 0025988416 scopus 로고
    • Inhibitory effect of the non-steroidal anti-inflammatory drug, indomethacin on the naturally occurring carcinogen, 1-hydroxyanthraquinone in male ACI/N rats
    • Tanaka, T.; Kojima, T.; Yoshimi, N.; Sugie, S.; Mori, H. Inhibitory effect of the non-steroidal anti-inflammatory drug, indomethacin on the naturally occurring carcinogen, 1-hydroxyanthraquinone in male ACI/N rats. Carcinogenesis, 1991, 12, 1949-1952.
    • (1991) Carcinogenesis , vol.12 , pp. 1949-1952
    • Tanaka, T.1    Kojima, T.2    Yoshimi, N.3    Sugie, S.4    Mori, H.5
  • 109
    • 0031799475 scopus 로고    scopus 로고
    • Cyclooxygenase-2 inhibitors suppress the growth of gastric cancer xenografts via induction of apoptosis in nude mice
    • Sawaoka, H.; Kawano, S.; Tsuji, S.; Tsujii, M.; Gunawan, E. S.; Takei, Y.; Nagano, K.; Hori, M. Cyclooxygenase-2 inhibitors suppress the growth of gastric cancer xenografts via induction of apoptosis in nude mice. Am. J. Physiol., 1998, 274, 1061-1067.
    • (1998) Am. J. Physiol. , vol.274 , pp. 1061-1067
    • Sawaoka, H.1    Kawano, S.2    Tsuji, S.3    Tsujii, M.4    Gunawan, E.S.5    Takei, Y.6    Nagano, K.7    Hori, M.8
  • 111
    • 0032622310 scopus 로고    scopus 로고
    • Prospective study of nonsteroidal anti-inflammatory drugs and breast cancer
    • Harris, R. E.; Kasbari, S.; Farrar, W. B. Prospective study of nonsteroidal anti-inflammatory drugs and breast cancer. Oncol. Rep., 1999, 6, 71-73.
    • (1999) Oncol. Rep. , vol.6 , pp. 71-73
    • Harris, R.E.1    Kasbari, S.2    Farrar, W.B.3
  • 113
    • 0036521678 scopus 로고    scopus 로고
    • Nonsteroidal anti-inflammatory drugs, apoptosis, and colon-cancer chemoprevention
    • Chan, T. A. Nonsteroidal anti-inflammatory drugs, apoptosis, and colon-cancer chemoprevention. Lancet Oncol., 2002, 3, 166-174.
    • (2002) Lancet Oncol. , vol.3 , pp. 166-174
    • Chan, T.A.1
  • 114
    • 0031882916 scopus 로고    scopus 로고
    • Mechanisms underlying nonsteroidal antiinflammatory drug-mediated apoptosis
    • Chan, T. A.; Morin, P. J.; Vogelstein, B.; Kinzler, K. W. Mechanisms underlying nonsteroidal antiinflammatory drug-mediated apoptosis. Proc. Natl. Acad. Sci. USA, 1998, 95, 681-686.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 681-686
    • Chan, T.A.1    Morin, P.J.2    Vogelstein, B.3    Kinzler, K.W.4
  • 115
    • 0242690224 scopus 로고    scopus 로고
    • COX-2 and beyond: Approaches to prostaglandin inhibition in human disease
    • Fitzgerald, G. A. COX-2 and beyond: approaches to prostaglandin inhibition in human disease. Nat. Rev. Drug Discov., 2003, 2, 879-891.
    • (2003) Nat. Rev. Drug Discov. , vol.2 , pp. 879-891
    • Fitzgerald, G.A.1
  • 116
    • 43049168293 scopus 로고    scopus 로고
    • NSAIDs and apoptosis
    • Jana, N. R. NSAIDs and apoptosis. Cell. Mol. Life Sci., 2008, 65, 1295-2130
    • (2008) Cell. Mol. Life Sci. , vol.65 , pp. 1295-2130
    • Jana, N.R.1
  • 117
    • 0030038519 scopus 로고    scopus 로고
    • Nonsteroidal antiinflammatory drugs inhibit the proliferation of colon adenocarcinoma cells: Effects on cell cycle and apoptosis
    • DOI 10.1006/excr.1996.0023
    • Shiff, S. J.; Koutsos, M. I.; Qiao, L.; Rigas, B. Nonsteroidal anti inflammatory drugs inhibit the proliferation of colon adenocarcinoma cells: effects on cell cycle and apoptosis. Expl. Cell Res., 1996, 222, 179-188. (Pubitemid 26043724)
    • (1996) Experimental Cell Research , vol.222 , Issue.1 , pp. 179-188
    • Shiff, S.J.1    Koutsos, M.I.2    Qiao, L.3    Rigas, B.4
  • 118
    • 0034057928 scopus 로고    scopus 로고
    • The effect of non-steroidal anti-inflammatory drugs on human colorectal cancer cells: Evidence of different mechanisms of action
    • Smith, M. L.; Hawcroft, G.; Hull, M. A. The effect of non-steroidal anti-inflammatory drugs on human colorectal cancer cells: evidence of different mechanisms of action. Eur. J. Cancer, 2000, 36, 664-674.
    • (2000) Eur. J. Cancer , vol.36 , pp. 664-674
    • Smith, M.L.1    Hawcroft, G.2    Hull, M.A.3
  • 119
    • 3442886811 scopus 로고    scopus 로고
    • The pathophysiology of mitochondrial cell death
    • Green, D. R.; Kroemer, G. The pathophysiology of mitochondrial cell death. Science, 2004, 305, 626-629.
    • (2004) Science , vol.305 , pp. 626-629
    • Green, D.R.1    Kroemer, G.2
  • 120
    • 20444430478 scopus 로고    scopus 로고
    • Apoptotic pathways: Ten minutes to dead
    • Green, D. R. Apoptotic pathways: ten minutes to dead. Cell, 2005, 121, 671-674.
    • (2005) Cell , vol.121 , pp. 671-674
    • Green, D.R.1
  • 121
    • 26444434342 scopus 로고    scopus 로고
    • Pharmacological manipulation of cell death: Clinical applications in sight?
    • Green, D. R.; Kroemer, G. Pharmacological manipulation of cell death: clinical applications in sight? J. Clin. Invest., 2005, 115, 2610-2617.
    • (2005) J. Clin. Invest. , vol.115 , pp. 2610-2617
    • Green, D.R.1    Kroemer, G.2
  • 125
    • 0040754065 scopus 로고    scopus 로고
    • Preparation and crystal structure of a dimolybdenum(II) complex with the drug ibuprofen
    • Cotton, F. A.; De Oliveira Silva, D. Preparation and crystal structure of a dimolybdenum(II) complex with the drug ibuprofen. Inorg. Chim. Acta, 1996, 249, 57-61.
    • (1996) Inorg. Chim. Acta , vol.249 , pp. 57-61
    • Cotton, F.A.1    De Oliveira Silva, D.2
  • 126
    • 37049076953 scopus 로고
    • Synthesis, spectroscopic, electrochemical, and magnetic properties of dimolybdenum(II,II), diruthenium-(II,III) and -(II,II) complexes containing bridging aspirinate (2-acetoxybenzoate) ligands
    • Carvill, A.; Higgins, P.; McCann, M.; Ryan, H.; Shiels, A. Synthesis, spectroscopic, electrochemical, and magnetic properties of dimolybdenum(II,II), diruthenium-(II,III) and -(II,II) complexes containing bridging aspirinate (2-acetoxybenzoate) ligands. J. Chem. Soc. Dalton Trans, 1989, 2435-2441.
    • (1989) J. Chem. Soc. Dalton Trans , pp. 2435-2441
    • Carvill, A.1    Higgins, P.2    McCann, M.3    Ryan, H.4    Shiels, A.5
  • 127
    • 0034661023 scopus 로고    scopus 로고
    • Synthesis and characterization of a diruthenium-ibuprofenato complex Comparing its anti-inflammatory activity with that of a copper(II)-ibuprofenato complex
    • Andrade, A.; Namora, S. F.; Woisky, R.G.; Wiezel, G.; Najjar, R.; Sertié, J. A. A.; De Oliveira Silva, D. Synthesis and characterization of a diruthenium-ibuprofenato complex Comparing its anti-inflammatory activity with that of a copper(II)-ibuprofenato complex. J. Inorg. Biochem., 2000, 81, 23-27.
    • (2000) J. Inorg. Biochem. , vol.81 , pp. 23-27
    • Andrade, A.1    Namora, S.F.2    Woisky, R.G.3    Wiezel, G.4    Najjar, R.5    Sertié, J.A.A.6    De Oliveira Silva, D.7
  • 128
    • 0017233987 scopus 로고
    • Synthesis and biological evaluation of tetrakis(acetylsalicylato)-μ- dicopper(II)
    • Willians, D. A.; Walz, D.R.; Foye, W.O. Synthesis and biological evaluation of tetrakis(acetylsalicylato)-μ-dicopper(II). J. Pharm. Sci., 1976, 65, 126-128.
    • (1976) J. Pharm. Sci. , vol.65 , pp. 126-128
    • Willians, D.A.1    Walz, D.R.2    Foye, W.O.3
  • 129
    • 0026097552 scopus 로고
    • Synthesis, characterization, and biological screening of a copper flurbiprofen complex with antiinflammatory effects
    • Oga, S.; Taniguchi, S.F.; Najjar, R.; Souza, A. R. Synthesis, characterization, and biological screening of a copper flurbiprofen complex with antiinflammatory effects. J. Inorg. Biochem., 1991, 41, 45-51.
    • (1991) J. Inorg. Biochem. , vol.41 , pp. 45-51
    • Oga, S.1    Taniguchi, S.F.2    Najjar, R.3    Souza, A.R.4
  • 131
    • 0017188479 scopus 로고
    • Role of copper in preventing gastrointestinal damage by acidic anti-inflammatory drugs
    • Boyle, E.; Freeman, P. C.; Goudie, A. C.; Magan, F. R.; Thompson, M. Role of copper in preventing gastrointestinal damage by acidic anti-inflammatory drugs. J. Pharm. Pharmacol., 1976, 28, 865-868.
    • (1976) J. Pharm. Pharmacol. , vol.28 , pp. 865-868
    • Boyle, E.1    Freeman, P.C.2    Goudie, A.C.3    Magan, F.R.4    Thompson, M.5
  • 134
    • 0037405663 scopus 로고    scopus 로고
    • Distinct effects of dinuclear ruthenium(III) complexes on cell proliferation and on cell cycle regulation in human and murine tumor cell lines
    • Bergamo, A.; Stocco, G.; Gava, B.; Cocchietto, M.; Alessio, E.; Serli, B.; Iengo, E.; . Sava, G. Distinct effects of dinuclear ruthenium(III) complexes on cell proliferation and on cell cycle regulation in human and murine tumor cell lines. J. Pharmacol. Expl. Ther., 2003, 305, 725-732.
    • (2003) J. Pharmacol. Expl. Ther. , vol.305 , pp. 725-732
    • Bergamo, A.1    Stocco, G.2    Gava, B.3    Cocchietto, M.4    Alessio, E.5    Serli, B.6    Iengo, E.7    Sava, G.8
  • 136
    • 17144398831 scopus 로고    scopus 로고
    • Possible future issues in the treatment of glioblastomas: Special emphasis on cell migration and the resistance of migrating glioblastoma cells to apoptosis
    • Lefranc, F.; Brotchi, J.; Kiss, R. Possible future issues in the treatment of glioblastomas: Special emphasis on cell migration and the resistance of migrating glioblastoma cells to apoptosis. J. Clin. Oncol., 2005, 23, 2411-2422.
    • (2005) J. Clin. Oncol. , vol.23 , pp. 2411-2422
    • Lefranc, F.1    Brotchi, J.2    Kiss, R.3
  • 137
    • 0038179723 scopus 로고    scopus 로고
    • Cost of migration: Invasion of malignant gliomas and implications for treatment
    • Giese, A.; Bjerkvig, R.; Berens, M. E., Westphal, M. Cost of migration: invasion of malignant gliomas and implications for treatment. J. Clin. Oncol., 2003, 21,1624-1636.
    • (2003) J. Clin. Oncol. , vol.21 , pp. 1624-1636
    • Giese, A.1    Bjerkvig, R.2    Berens, M.E.3    Westphal, M.4
  • 140
    • 0035360795 scopus 로고    scopus 로고
    • Cyclooxygenase-2 expression in human gliomas: Prognostic significance and molecular correlations
    • Shono, T.; Tofilon, P. J.; Bruner, J. M.; Owolabi, O.; Lang, F. F. Cyclooxygenase-2 expression in human gliomas: Prognostic significance and molecular correlations. Cancer Res., 2001, 61, 4375-4381.
    • (2001) Cancer Res. , vol.61 , pp. 4375-4381
    • Shono, T.1    Tofilon, P.J.2    Bruner, J.M.3    Owolabi, O.4    Lang, F.F.5
  • 141
    • 0036159924 scopus 로고    scopus 로고
    • Cyclo-oxygenase inhibitors and thromboxane synthase inhibitors differentially regulate migration arrest, growth inhibition and apoptosis in human glioma cells
    • Kürzel, F.; Hagel, C.; Zapf, S.; Meissner, H.; Westphal, M.; Geise, A. Cyclo-oxygenase inhibitors and thromboxane synthase inhibitors differentially regulate migration arrest, growth inhibition and apoptosis in human glioma cells. Acta Neurochir., 2002, 144, 71-87.
    • (2002) Acta Neurochir. , vol.144 , pp. 71-87
    • Kürzel, F.1    Hagel, C.2    Zapf, S.3    Meissner, H.4    Westphal, M.5    Geise, A.6
  • 142
    • 0345863821 scopus 로고    scopus 로고
    • The eicosanoid cascade: Possible role in gliomas and meningiomas
    • Nathoo, N.; Barnett, G. H.; Golubic, M. The eicosanoid cascade: possible role in gliomas and meningiomas. J. Clin. Pathol., 2004, 57, 6-13.
    • (2004) J. Clin. Pathol. , vol.57 , pp. 6-13
    • Nathoo, N.1    Barnett, G.H.2    Golubic, M.3
  • 143
    • 20944436621 scopus 로고    scopus 로고
    • Prognostic significance of the immunohistochemical index of survivin in glioma: A comparative study with the MIB-1 index
    • Wang, M.; Yoshida, D.; Liu, S.; Teramoto, A. Prognostic significance of the immunohistochemical index of survivin in glioma: a comparative study with the MIB-1 index. J. Neuro Oncol., 2005, 72, 231-238.
    • (2005) J. Neuro Oncol. , vol.72 , pp. 231-238
    • Wang, M.1    Yoshida, D.2    Liu, S.3    Teramoto, A.4
  • 144
    • 10044265497 scopus 로고    scopus 로고
    • Non-cytotoxic drugs as potential treatments for gliomas
    • Drappatz, J.; Wen, P. Non-cytotoxic drugs as potential treatments for gliomas. Curr. Opin. Neurol., 2004, 17, 663-673.
    • (2004) Curr. Opin. Neurol. , vol.17 , pp. 663-673
    • Drappatz, J.1    Wen, P.2
  • 145
    • 11244315274 scopus 로고    scopus 로고
    • Continuous low-dose chemotherapy plus inhibition of cyclooxygenase-2 as an antiangiogenic therapy of glioblastoma multiforme
    • DOI 10.1007/s00432-004-0620-5
    • Tuettenberg, J.; Grobholz, R.; Korn, T.; Wenz, F.; Rever, R.; Vajkoczy, P. Continuous low-dose chemotherapy plus inhibition of cyclooxygenase-2 as an antiangiogenic therapy of glioblastoma multiforme. J. Cancer Res. Clin. Oncol., 2005, 131, 31-40. (Pubitemid 40064455)
    • (2005) Journal of Cancer Research and Clinical Oncology , vol.131 , Issue.1 , pp. 31-40
    • Tuettenberg, J.1    Grobholz, R.2    Korn, T.3    Wenz, F.4    Erber, R.5    Vajkoczy, P.6
  • 146
    • 34147138870 scopus 로고    scopus 로고
    • Convection enhanced drug delivery of novel therapeutic agents to malignant brain tumors
    • Ferguson, S.; Lesniak, M. S. Convection enhanced drug delivery of novel therapeutic agents to malignant brain tumors. Curr. Drug Deliv., 2007, 4, 169-180.
    • (2007) Curr. Drug Deliv. , vol.4 , pp. 169-180
    • Ferguson, S.1    Lesniak, M.S.2
  • 147
    • 85047696884 scopus 로고    scopus 로고
    • Malignant gliomas: Strategies to increase the effectiveness of targeted molecular treatment
    • DOI 10.1586/14737140.6.5.733
    • Wen, P.Y.; Kesari, S.; Drappatz, J. Malignant gliomas: strategies to increase the effectiveness of targeted molecular treatment. Expert Rev. Anticancer Ther., 2006, 6, 733-754. (Pubitemid 44192889)
    • (2006) Expert Review of Anticancer Therapy , vol.6 , Issue.5 , pp. 733-754
    • Wen, P.Y.1    Kesari, S.2    Drappatz, J.3
  • 148
    • 33845352051 scopus 로고    scopus 로고
    • Oncolytic viruses and DNA-repair machinery: Overcoming chemoresistance of gliomas
    • DOI 10.1586/14737140.6.11.1585
    • Jiang, H.; Alonso, M. M.; Gomez-Manzano, C.; Piao, Y.; Fueyo, J. Oncolytic viruses and DNA-repair machinery: overcoming chemoresistance of gliomas. Expert Rev. Anticancer Ther., 2006, 6, 1585-1592. (Pubitemid 44883961)
    • (2006) Expert Review of Anticancer Therapy , vol.6 , Issue.11 , pp. 1585-1592
    • Jiang, H.1    Alonso, M.M.2    Gomez-Manzano, C.3    Piao, Y.4    Fueyo, J.5
  • 149
    • 33750709260 scopus 로고    scopus 로고
    • Chemotherapeutic options for primary brain tumors
    • DOI 10.1007/s11864-006-0022-9
    • Kim, L.; Glantz, M. Chemotherapeutic options for primary brain tumors. Curr. Treat. Options Oncol., 2006, 7, 467-478. (Pubitemid 44697784)
    • (2006) Current Treatment Options in Oncology , vol.7 , Issue.6 , pp. 467-478
    • Kim, L.1    Glantz, M.2
  • 150
    • 33747749871 scopus 로고    scopus 로고
    • Angiogenesis in malignant glioma-a target for antitumor therapy?
    • Tuettenberg, J.; Friedel, C.; Vajkoczy, P. Angiogenesis in malignant glioma-a target for antitumor therapy? Crit. Rev. Oncol. Hematol., 2006, 59, 181-193.
    • (2006) Crit. Rev. Oncol. Hematol. , vol.59 , pp. 181-193
    • Tuettenberg, J.1    Friedel, C.2    Vajkoczy, P.3
  • 151
    • 0022969335 scopus 로고
    • Differential killing of human carcinoma cells supplemented with n-3 and n-6 polyun-saturated fatty acids
    • Begin, M.E.; Ells, G.; Das, U. N.; Horrobin DF. Differential killing of human carcinoma cells supplemented with n-3 and n-6 polyun-saturated fatty acids. J. Natl. Cancer Inst., 1986, 77, 1053-1062.
    • (1986) J. Natl. Cancer Inst. , vol.77 , pp. 1053-1062
    • Begin, M.E.1    Ells, G.2    Das, U.N.3    Horrobin, D.F.4
  • 152
    • 0032710389 scopus 로고    scopus 로고
    • Essential fatty acids, lipid peroxidation and apoptosis
    • Das, U. N. Essential fatty acids, lipid peroxidation and apoptosis. Prostaglandins Leukot. Essent. Fatty Acids, 1999, 61, 157-163.
    • (1999) Prostaglandins Leukot. Essent. Fatty Acids , vol.61 , pp. 157-163
    • Das, U.N.1
  • 154
    • 0028983419 scopus 로고
    • Local application of gamma-linolenic acid in the treatment of human gliomas
    • Das, U. N.; Prasad, V. V.; Reddy, D. R. Local application of gamma-linolenic acid in the treatment of human gliomas. Cancer Lett., 1995, 94, 147-155.
    • (1995) Cancer Lett. , vol.94 , pp. 147-155
    • Das, U.N.1    Prasad, V.V.2    Reddy, D.R.3
  • 155
    • 6444245382 scopus 로고    scopus 로고
    • Highly unsaturated fatty acid induced tumor regression in glioma pharmacodynamics and bioavailability of gamma linolenic acid in an implantation glioma model: Effects on tumor biomass, apoptosis and neuronal tissue histology
    • Leaver, H. A.; Wharton, S. B.; Bell, H. S.; Leaver-Yap, I. M.; Whittle, I. R. Highly unsaturated fatty acid induced tumor regression in glioma pharmacodynamics and bioavailability of gamma linolenic acid in an implantation glioma model: effects on tumor biomass, apoptosis and neuronal tissue histology. Prostaglandins Leukot. Essent. Fatty Acids, 2002, 67,283-292.
    • (2002) Prostaglandins Leukot. Essent. Fatty Acids , vol.67 , pp. 283-292
    • Leaver, H.A.1    Wharton, S.B.2    Bell, H.S.3    Leaver-Yap, I.M.4    Whittle, I.R.5
  • 158
    • 2442628309 scopus 로고    scopus 로고
    • From bench to the clinic: Gamma-linolenic acid therapy of human gliomas
    • Das, U. N. From bench to the clinic: gamma-linolenic acid therapy of human gliomas. Prostaglandins Leukot. Essent. Fatty Acids, 2004, 70, 539-552.
    • (2004) Prostaglandins Leukot. Essent. Fatty Acids , vol.70 , pp. 539-552
    • Das, U.N.1
  • 159
    • 0035980762 scopus 로고    scopus 로고
    • Gamma-linolenic acid and eicosapentaenoic acid induce modifications in mitochondrial metabolism, reactive oxygen species generation, lipid peroxidation and apoptosis in Walker 256 rat carcinosarcoma cells
    • Colquhoun, A.; Schumacher, R. I. Gamma-linolenic acid and eicosapentaenoic acid induce modifications in mitochondrial metabolism, reactive oxygen species generation, lipid peroxidation and apoptosis in Walker 256 rat carcinosarcoma cells. Biochim. Biophys. Acta, 2001, 1533, 207-219.
    • (2001) Biochim. Biophys. Acta , vol.1533 , pp. 207-219
    • Colquhoun, A.1    Schumacher, R.I.2
  • 160
    • 0035071074 scopus 로고    scopus 로고
    • Modifications in mitochondrial metabolism and ultrastructure and their relationship to tumor growth inhibition by gamma-linolenic acid
    • Colquhoun, A.; Schumacher, R. I. Modifications in mitochondrial metabolism and ultrastructure and their relationship to tumor growth inhibition by gamma-linolenic acid. Mol. Cell Biochem, 2001, 218, 13-20.
    • (2001) Mol. Cell Biochem , vol.218 , pp. 13-20
    • Colquhoun, A.1    Schumacher, R.I.2
  • 161
    • 0037071863 scopus 로고    scopus 로고
    • Gamma-linolenic acid alters the composition of mitochondrial membrane subfractions, decreases outer mitochondrial membrane binding of hexokinase and alters carnitine palmitoyltransferase I properties in the Walker 256 rat tumor
    • Colquhoun, A. Gamma-linolenic acid alters the composition of mitochondrial membrane subfractions, decreases outer mitochondrial membrane binding of hexokinase and alters carnitine palmitoyltransferase I properties in the Walker 256 rat tumor. Biochim. Biophys. Acta, 2002, 1583, 74-84.
    • (2002) Biochim. Biophys. Acta , vol.1583 , pp. 74-84
    • Colquhoun, A.1
  • 162
    • 0041303668 scopus 로고    scopus 로고
    • Protective role of glucose-6-phosphate dehydrogenase activity in the metabolic response of C6 rat glioma cells to polyunsaturated fatty acid exposure
    • DOI 10.1002/glia.10246
    • Ramos, K. L.; Colquhoun, A. Protective role of glucose-6-phosphate dehydrogenase activity in the metabolic response of C6 rat glioma cells to polyunsaturated fatty acid exposure. Glia, 2003, 43, 149-166. (Pubitemid 36897276)
    • (2003) GLIA , vol.43 , Issue.2 , pp. 149-166
    • Ramos, K.L.1    Colquhoun, A.2
  • 163
    • 0031000091 scopus 로고    scopus 로고
    • Polyunsaturated fatty acids increase the sensitivity of 36B10 rat astrocytoma cells to radiationinduced cell kill
    • Vartak, S.; Robbins, M. E.; Spector, A. A. Polyunsaturated fatty acids increase the sensitivity of 36B10 rat astrocytoma cells to radiationinduced cell
    • (1997) Lipids , vol.32 , pp. 283-292
    • Vartak, S.1    Robbins, M.E.2    Spector, A.A.3
  • 164
    • 0031960667 scopus 로고    scopus 로고
    • Gammalinolenic acid (GLA) is cytotoxic to 36B10 malignant rat astrocytoma cells but not to 'normal' rat astrocytes
    • Vartak, S.; McCaw, R.; Davis, C. S.; Robbins, M. E.; Spector, A. A. Gammalinolenic acid (GLA) is cytotoxic to 36B10 malignant rat astrocytoma cells but not to 'normal' rat astrocytes. Br. J. Cancer, 1998, 77, 1612-1620.
    • (1998) Br. J. Cancer , vol.77 , pp. 1612-1620
    • Vartak, S.1    McCaw, R.2    Davis, C.S.3    Robbins, M.E.4    Spector, A.A.5
  • 165
    • 63349104691 scopus 로고    scopus 로고
    • Gamma-linolenic acid alters Ku80, E2F1, and bax expression and induces micronucleus formation in C6 glioma cells in vitro
    • Benadiba, M.; Miyake, J. A.; Colquhoun, A. Gamma-linolenic acid alters Ku80, E2F1, and bax expression and induces micronucleus formation in C6 glioma cells in vitro. IUBMB Life, 2009, 61, 244-251.
    • (2009) IUBMB Life , vol.61 , pp. 244-251
    • Benadiba, M.1    Miyake, J.A.2    Colquhoun, A.3
  • 166
    • 38749118595 scopus 로고    scopus 로고
    • Diruthenium (II,III) complexes of ibuprofen, aspirin, naproxen and indomethacin nonsteroidal anti-inflammatory drugs: Synthesis, characterization and their effects on tumor-cell proliferation
    • Ribeiro, G.; Benadiba, M.; Colquhoun, A.; de Oliveira Silva, D. Diruthenium (II,III) complexes of ibuprofen, aspirin, naproxen and indomethacin nonsteroidal anti-inflammatory drugs: synthesis, characterization and their effects on tumor-cell proliferation. Polyhedron, 2008, 27, 1131-1137.
    • (2008) Polyhedron , vol.27 , pp. 1131-1137
    • Ribeiro, G.1    Benadiba, M.2    Colquhoun, A.3    De Oliveira Silva, D.4
  • 167
    • 74049149382 scopus 로고    scopus 로고
    • 4Cl] inhibits C6 rat glioma cell proliferation and induces changes in mitochondrial membrane potential, increased reactive oxygen species generation and apoptosis in vitro
    • 4Cl] inhibits C6 rat glioma cell proliferation and induces changes in mitochondrial membrane potential, increased reactive oxygen species generation and apoptosis in vitro. Cell Biochem. Funct., 2010, 28, 15-23.
    • (2010) Cell Biochem. Funct. , vol.28 , pp. 15-23
    • Ribeiro, G.1    Benadiba, M.2    De Oliveira Silva, D.3    Colquhoun, A.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.