Trans-cis-cis-[RuCl2(DMSO)2(2-amino-5-methyl-thiazole)2], (PMRu52), a novel ruthenium(II) compound acting as a strong inhibitor of cathepsin B

Journal of Inorganic Biochemistry

Volumn 104, Issue 2, 2010, Pages 111-117

  Mura, Pasquale ^a   Camalli, Mercedes ^a   Casini, Angela ^b   Gabbiani, Chiara ^c   Messori, Luigi ^c  

^a CNR   (Italy)

^b EPFL   (Switzerland)

^c UNIVERSITY OF FLORENCE   (Italy)

Author keywords

Anticancer; Cathepsin B; Ruthenium (II) compounds

Indexed keywords

ANTINEOPLASTIC AGENT; CATHEPSIN B; CATHEPSIN B INHIBITOR; CHLORIDE; CYSTEINE PROTEINASE; CYTOCHROME C; DICHLOROBIS(DIMETHYL SULFOXIDE)BIS( 2 AMINO 5 METHYLTHIAZOLE)RUTHENIUM; LIGAND; PHOSPHATE BUFFERED SALINE; RUTHENIUM COMPLEX; SERUM ALBUMIN; UBIQUITIN; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL REACTION KINETICS; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; ELECTROSPRAY MASS SPECTROMETRY; ENZYME ACTIVITY; ENZYME INHIBITION; FRAGMENTATION REACTION; IC 50; IN VITRO STUDY; PH; SEPARATION TECHNIQUE; SPECTROSCOPY; STRUCTURE ACTIVITY RELATION;

ANIMALS; CATALYSIS; CATHEPSIN B; CATTLE; CRYSTALLOGRAPHY, X-RAY; CYTOCHROMES C; ENZYME INHIBITORS; MOLECULAR STRUCTURE; ORGANOMETALLIC COMPOUNDS; RUTHENIUM COMPOUNDS; SPECTROMETRY, FLUORESCENCE; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; UBIQUITIN;

EID: 71849112054     PISSN: 01620134     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jinorgbio.2009.10.002     Document Type: Article

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