Arachidonic acid induces Fas and FasL upregulation in human leukemia U937 cells via Ca2+/ROS-mediated suppression of ERK/c-Fos pathway and activation of p38 MAPK/ATF-2 pathway

Toxicology Letters

Volumn 191, Issue 2-3, 2009, Pages 140-148

  Liu, Wen Hsin ^a   Chang, Long Sen ^a  

^a NATIONAL SUN YAT SEN UNIVERSITY   (Taiwan)

Author keywords

Arachidonic acid; ATF 2; c Fos; ERK; Fas; p38 MAPK

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 2; ARACHIDONIC ACID; CALCIUM ION; FAS ANTIGEN; FAS LIGAND; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PROCASPASE 8; PROTEIN C FOS; REACTIVE OXYGEN METABOLITE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME DEGRADATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; LEUKEMIA CELL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; UPREGULATION;

ACTIVATING TRANSCRIPTION FACTOR 2; ANTIGENS, CD95; APOPTOSIS; ARACHIDONIC ACID; BLOTTING, WESTERN; CALCIUM SIGNALING; CELL SURVIVAL; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FAS LIGAND PROTEIN; HUMANS; LUCIFERASES; MEMBRANE POTENTIALS; MITOCHONDRIAL MEMBRANES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTO-ONCOGENE PROTEINS C-FOS; REACTIVE OXYGEN SPECIES; RNA INTERFERENCE; RNA, MESSENGER; SIGNAL TRANSDUCTION; SUBCELLULAR FRACTIONS; TRANSFECTION; U937 CELLS; UP-REGULATION;

EID: 70449520163     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxlet.2009.08.016     Document Type: Article

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