Loss of T cell and B cell quiescence precedes the onset of microbial flora-dependent wasting disease and intestinal inflammation in Gimap5-deficient mice

Journal of Immunology

Volumn 184, Issue 7, 2010, Pages 3743-3754

  Barnes, Michael J ^a   Aksoylar, Halil ^c   Krebs, Philippe ^a   Bourdeau, Tristan ^c   Arnold, Carrie N ^a   Xia, Yu ^a   Khovananth, Kevin ^a   Engel, Isaac ^b   Sovath, Sosathya ^a   Lampe, Kristin ^c   Laws, Eleana ^c   Saunders, Amy ^d   Butcher, Geoffrey W ^d   Kronenberg, Mitchell ^b   Steinbrecher, Kris ^c   Hildeman, David ^c   Grimes, H Leighton ^c   Beutler, Bruce ^a   Hoebe, Kasper ^c  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY   (United States)

^c CINCINNATI CHILDREN S HOSPITAL RESEARCH FOUNDATION   (United States)

^d BABRAHAM INSTITUTE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ETHYLNITROSOUREA; GUANOSINE TRIPHOSPHATASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 7 RECEPTOR ALPHA; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN GIMAP5; PROTEIN KINASE B; UNCLASSIFIED DRUG; GIMAP5 PROTEIN, MOUSE;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANTIBIOTIC THERAPY; ARTICLE; B LYMPHOCYTE; CELL MATURATION; CELL SURVIVAL; CHIMERA; CONTROLLED STUDY; ENTERITIS; ENZYME ACTIVATION; EXTRAMEDULLARY HEMATOPOIESIS; FEMALE; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; HOMEOSTASIS; HOMOZYGOTE; IMMUNE RESPONSE; IMMUNOLOGICAL TOLERANCE; LYMPHOCYTE PROLIFERATION; LYMPHOCYTOPENIA; MALE; MICROFLORA; MOUSE; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; SPLEEN CELL; T LYMPHOCYTE; WASTING SYNDROME; WEIGHT REDUCTION; ANIMAL; C57BL MOUSE; COLITIS; GENETICS; IMMUNOBLOTTING; IMMUNOLOGY; INFLAMMATION; INTESTINE; LIVER DISEASE; MICROBIOLOGY; MOUSE MUTANT; PATHOLOGY; T LYMPHOCYTE SUBPOPULATION;

ANIMALS; B-LYMPHOCYTE SUBSETS; B-LYMPHOCYTES; COLITIS; FEMALE; GTP PHOSPHOHYDROLASES; HEMATOPOIESIS; HEMATOPOIETIC STEM CELLS; HOMEOSTASIS; IMMUNOBLOTTING; INFLAMMATION; INTESTINES; LIVER DISEASES; MALE; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; SELF TOLERANCE; SIGNAL TRANSDUCTION; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES; WASTING SYNDROME;

EID: 77951624234     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.0903164     Document Type: Article

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