Targeting the active site gate to yield hyperactive variants of 5-aminolevulinate synthase

Journal of Biological Chemistry

Volumn 285, Issue 18, 2010, Pages 13704-13711

  Lendrihas, Thomas ^a   Hunter, Gregory A ^a   Ferreira, Gloria C ^a,b,c  

^a UNIVERSITY OF SOUTH FLORIDA   (United States)

^b UNIVERSITY OF SOUTH FLORIDA   (United States)

^c H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5-AMINOLEVULINATE SYNTHASE; ACTIVE SITE; ALLOSTERIC REGULATION; BACTERIAL CELLS; CATALYTIC EFFICIENCIES; CONFORMATIONAL DYNAMICS; DATA SUPPORT; GENETIC COMPLEMENTATION; IN-VIVO; LOOP CONTROL; LOOP RESIDUES; LOOP VARIANT; NON-CATALYTIC; PRE-STEADY STATE; QUINONOID INTERMEDIATES; REACTION DATA; STEADY STATE;

BIOCHEMISTRY; CLONE CELLS; ENZYMES; ESCHERICHIA COLI; MAMMALS; REACTION INTERMEDIATES; REACTION RATES;

PORPHYRINS;

5 AMINOLEVULINATE SYNTHASE; PORPHYRIN; QUINONE DERIVATIVE;

ARTICLE; BACTERIAL GROWTH; CELL CLONE; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME KINETICS; ESCHERICHIA COLI; FLUORESCENCE; GENETIC COMPLEMENTATION; IN VIVO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN VARIANT; STEADY STATE;

5-AMINOLEVULINATE SYNTHETASE; ALLOSTERIC REGULATION; BACTERIAL PROTEINS; CATALYSIS; CATALYTIC DOMAIN; ESCHERICHIA COLI; GENETIC COMPLEMENTATION TEST; KINETICS; PORPHYRINS; PROTEIN STRUCTURE, SECONDARY; RECOMBINANT PROTEINS; RHODOBACTER CAPSULATUS; SUBSTRATE SPECIFICITY;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; MAMMALIA;

EID: 77951604060     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.074237     Document Type: Article

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