A photosensitising adenovirus for photodynamic therapy

Gene Therapy

Volumn 6, Issue 10, 1999, Pages 1742-1750

  Gagnebin, J ^a,b   Brunori, M ^a   Otter, M ^a   Juillerat Jeanneret, L ^b   Monnier, P ^b   Iggo, R ^a  

^a SWISS INST FOR EXP CANCER RESEARCH   (Switzerland)

^b LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

Author keywords

Amino laevulinic acid synthase; Cancer gene therapy; Heme regulatory motif; Phototodynamic therapy; Recombinant adenovirus construction

Indexed keywords

5 AMINOLEVULINATE SYNTHASE; MUTANT PROTEIN; PROTOPORPHYRIN; THYMIDINE KINASE; VIRUS VECTOR;

ADENOVIRUS; ARTICLE; CELL CULTURE; GENE CONSTRUCT; GENE EXPRESSION; GENE THERAPY; HEME SYNTHESIS; HERPES SIMPLEX VIRUS; MITOCHONDRION; NONHUMAN; PHOTODYNAMIC THERAPY; PHOTOSENSITIVITY; PRIORITY JOURNAL; PROTEIN TRANSPORT; VIRUS GENOME; YEAST;

5-AMINOLEVULINATE SYNTHETASE; ADENOVIRIDAE; AMINO ACID SEQUENCE; APOPTOSIS; BASE SEQUENCE; CELL LINE; FLOW CYTOMETRY; GENE THERAPY; GENETIC VECTORS; HUMANS; IN SITU NICK-END LABELING; MICROSCOPY, FLUORESCENCE; MITOCHONDRIA; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PHOTOCHEMOTHERAPY; PHOTOSENSITIZING AGENTS; SKIN NEOPLASMS; TUMOR CELLS, CULTURED;

EID: 0032850194     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3300992     Document Type: Article

References (35)

1. Peng Q et al. 5-Aminolevulinic acid-based photodynamic therapy. Clinical research and future challenges. Cancer 1497; 79: 2282-2308.
2. Dougherty TJ et al. Photodynamic therapy. J Natl Cancer Inst 1998; 90: 889-905.
3. Pastorino JG et al. Protoporphyrin IX, an endogenous Iigand of the peripheral benzodiazepine receptor, potentiates induction of the mitochondrial permeability transition and the killing of cultured hepatocytes by rotenone. J Biol Chem 1994; 269: 31041-31046.
4. Marchetti P et al. Mitochondrial permeability transition triggers lymphocyte apoptosis. J Immunol 1996; 157: 4830-4836.
5. Peng Q et al. 5-Aminolevulinic acid-based photodynamic therapy: principles and experimental research. Photochem Photobiol 1997; 65: 235-251.
6. Cox TC, Bawden MJ, Martin A, May BK. Human erythroid 5-aminolevulinate synthase: promoter analysis and identification of an iron-responsive element in the mRNA. EMBO J 1991; 10: 1891-1902.
7. Lathrop JT, Timko MP. Regulation by heme of mitochondrial protein transport through a conserved amino acid motif. Science 1993; 259: 522-525.
8. Ketner G et al. Efficient manipulation of the human adenovirus genome as an infectious yeast artificial chromosome clone. Proc Natl Acad Sci USA 1994; 91: 6186-6190.
9. Parr MJ et al. Tumor-selective transgene expression in vivo mediated by an E2F-responsive adenoviral vector. Nature Med 1997; 3: 1145-1149.
10. Dahmane N et al. Activation of the transcription factor Glil and the Sonic hedgehog signalling pathway in skin tumours. Nature 1997; 389: 876-881.
11. van de Wetering M et al. Armadillo coactivates transcription driven by the product of the Drosophila segment polarity gene dTCF. Cell 1997; 88: 789-799.
12. Jarriault S et al. Signalling downstream of activated mammalian Notch. Nature 1995; 377: 355-358.
13. Bartkova J et al. The p16-cyclin D/Cdk4-pRb pathway as a functional unit frequently altered in melanoma pathogenesis. Cancer Res 1996; 56: 5475-5483.
14. Morin PJ et al. Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC. Science 1997; 275: 1787-1790.
15. Korinek V et al. Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/-colon carcinoma. Science 1997; 275: 1784-1787.
16. Stone DM et al. The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog. Nature 1996; 384: 129-134.
17. Xie J et al. Activating smoothened mutations in sporadic basal-cell carcinoma. Nature 1998; 391: 90-92.
18. Ellisen LW et al. TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms. Cell 1991; 66: 649-661.
19. Rampino N et al. Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype. Science 1997; 275: 967-969.
20. Grosjean P et al. Photodynamic therapy for cancer of the upper aerodigestive tract using tetra(m-hydroxyphenyl) chlorin. J Clin Laser Med Surg 1996; 14: 281-287.
21. Zou H et al. Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3. Cell 1997; 90: 405-413.
22. Keyse SM, Tyrrell RM. Heme oxygenase is the major 32-kDa stress protein induced in human skin fibroblasts by UVA radiation, hydrogen peroxide, and sodium arsenite. Proc Natl Acad Sic USA 1989; 86: 99-103.
23. He TC et al. A simplified system for generating recombinant adenoviruses. Prof Natl Acad Sci USA 1998; 95: 2509-2514.
24. Chartier C et al. Efficient generation of recombinant adenovirus vectors by homologous recombination in Escherichia coli. J Virol 1996; 70: 4805-4810.
25. Hemsley A et al. A simple method for site-directed mutagenesis using the polymerase chain reaction. Nucleic Acids Res 1989; 17: 6545-6551.
26. Hinds PW et al. Mutant p53 DNA clones from human colon carcinomas cooperate with ras in transforming primary rat cells: a comparison of the 'hot spot' mutant phenotypes. Cell Growth Differ 1990; 1: 571-580.
27. Sikorski RS, Hieter P. A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae. Genetics 1989; 122: 19-27.
28. Larionov V et al. Specific cloning of human DNA as yeast artificial chromosomes by transformation-associated recombination. Proc Natl Acad Sci USA 1996; 93: 491-496.
29. Bouton AH, Smith MM. Fine-structure analysis of the DNA sequence requirements for autonomous replication of Saccharomyces cerevisiae plasmids. Mol Cell Biol 1986; 6: 2354-2363.
30. Guthrie C, Fink G. Guide to yeast genetics and molecular biology. Meth Enzymol 1991; 194.
31. Sambrook J, Fritsch E, Maniatis T. Molecular Cloning: a Laboratory Manual. Cold Spring Harbor Laboratory Press: New York, 1989.
32. Fallaux FJ et al. Characterization of 911: a new helper cell line for the titration and propagation of early region 1-deleted adenoviral vectors. Hum Gene Therapy 1996; 7: 215-222.
33. Pear WS, Nolan GP, Scott ML, Baltimore D. Production of high-titer helper-free retroviruses by transient transfection. Prof Natl Acad Sci USA 1993; 90: 8392-8396.
34. Harlow E, Lane DP. Antibodies: a Laboratory Manual. Cold Spring Harbor Laboratory Press: New York, 1988.
35. Smith SJ, Cox TM. Translational control of erythroid delta-aminolevulinate synthase in immature human erythroid cells by heme. Cell Mol Biol 1997; 43: 103-114.