Functional characterization of the atypical integral membrane lipid phosphatase PDP1/PPAPDC2 identifies a pathway for interconversion of isoprenols and isoprenoid phosphates in mammalian cells

Journal of Biological Chemistry

Volumn 285, Issue 18, 2010, Pages 13918-13929

  Miriyala, Sumitra ^a   Subramanian, Thangaiah ^b   Panchatcharam, Manikandan ^a   Ren, Hongmei ^a   McDermott, Mark I ^e   Sunkara, Manjula ^a   Drennan, Tracy ^a   Smyth, Susan S ^a,d   Spielmann, H Peter ^a,c   Morris, Andrew J ^a,b  

^a UNIVERSITY OF KENTUCKY   (United States)

^b UNIVERSITY OF KENTUCKY   (United States)

^c UNIVERSITY OF KENTUCKY   (United States)

^d LEXINGTON VA MEDICAL CENTER   (United States)

^e NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUXOTROPHY; CATALYTIC DOMAINS; CYTOSKELETAL ORGANIZATION; DIPHOSPHATES; ENDOPLASMIC RETICULUM; FARNESYL DIPHOSPHATE; FUNCTIONAL CHARACTERIZATION; GERANYLGERANYL DIPHOSPHATE; GROWTH DEFECTS; IN-CELL; IN-VITRO; INTEGRAL MEMBRANE; INTERCONVERSIONS; ISOPRENOIDS; ISOPRENYLATION; LIPID PHOSPHATE PHOSPHATASE; MAMMALIAN CELLS; MEMBRANE PROTEINS; MEVALONATE PATHWAY; NUCLEAR ENVELOPE; OVER-EXPRESSION; PHOSPHATASE ACTIVITY; PHOSPHOLIPID SUBSTRATE; RHO FAMILY GTPASES; TANDEM MASS SPECTROMETRY;

BIOLOGICAL MEMBRANES; CHEMICAL DETECTION; CHEMICAL PROPERTIES; DEFECTS; GLYCEROL; GROWTH KINETICS; MAMMALS; MASS SPECTROMETRY; PHOSPHOLIPIDS; PROTEINS;

PHOSPHATASES;

ISOPRENALINE PHOSPHATE; ISOPRENOID PHOSPHATE; PHOSPHATASE; POLYISOPRENOID DIPHOSPHATE PHOSPHATASE TYPE 1; PROTEIN PPAPDC2; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME METABOLISM; HUMAN; HUMAN CELL; INSECT CELL; MAMMAL CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; TANDEM MASS SPECTROMETRY; YEAST CELL;

ANIMALS; ENDOPLASMIC RETICULUM; HELA CELLS; HUMANS; INSECTS; MEMBRANE LIPIDS; PHOSPHORIC MONOESTER HYDROLASES; POLYISOPRENYL PHOSPHATES; PROTEIN PRENYLATION; RHO GTP-BINDING PROTEINS; SESQUITERPENES;

MAMMALIA; SACCHAROMYCETALES;

EID: 77951592990     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.083931     Document Type: Article

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