Novel polyisoprenyl phosphates block phospholipase D and human neutrophil activation in vitro and murine peritoneal inflammation in vivo

British Journal of Pharmacology

Volumn 146, Issue 3, 2005, Pages 344-351

  Levy, Bruce D ^a   Hickey, Lorraine ^a   Morris, Andrew J ^b   Larvie, Mykol ^a   Keledjian, Raquel ^c   Petasis, Nicos A ^c   Bannenberg, Gerard ^a   Serhan, Charles N ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

^c UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

Inflammation; Lipid mediators; Neutrophils; Reactive oxygen species

Indexed keywords

ISOPRENOID; ISOPRENOID PHOSPHATE; PHOSPHATE; PHOSPHOLIPASE D; PHOSPHOLIPASE D1; PHOSPHOLIPASE D1B; PRESQUALENE DIPHOSPHATE; PRESQUALENE MONOPHOSPHATE; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; ZYMOSAN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOACCUMULATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG STRUCTURE; ENZYME ACTIVATION; ENZYME ACTIVITY; IC 50; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; LEUKOCYTE ACTIVATION; MALE; MOLECULAR MIMICRY; MOUSE; NONHUMAN; PERITONEUM; PERITONEUM EXUDATE; PERITONITIS; PRIORITY JOURNAL; STEREOSPECIFICITY; STREPTOMYCES; STREPTOMYCES CHROMOFUSCUS; STRUCTURE ACTIVITY RELATION;

ANIMALS; COMPUTER SIMULATION; HUMANS; MALE; MICE; MICE, INBRED STRAINS; MODELS, MOLECULAR; NEUTROPHIL ACTIVATION; NEUTROPHILS; PERITONITIS; PHOSPHOLIPASE D; POLYISOPRENYL PHOSPHATES; REACTIVE OXYGEN SPECIES; STRUCTURE-ACTIVITY RELATIONSHIP; ZYMOSAN;

EID: 24344462093     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1038/sj.bjp.0706338     Document Type: Article

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