Influence of the hydrostatic pressure and pH on the asymmetric 2-hydroxyketone formation catalyzed by pseudomonas putida benzoylformate decarboxylase and variants thereof

Biotechnology and Bioengineering

Volumn 106, Issue 1, 2010, Pages 18-26

  Berheide, Marco ^a   Peper, Stephanie ^b   Kara, Selin ^a   Long, Wei Sing ^b   Schenkel, Steffen ^b   Pohl, Martina ^c   Niemeyer, Bernd ^b   Liese, Andreas ^a  

^a HAMBURG UNIVERSITY OF TECHNOLOGY   (Germany)

^b HELMUT SCHMIDT UNIVERSITY   (Germany)

^c HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

Benzoylformate decarboxylase; C C bond formation; Enantioselectivity; Enzyme catalysis; High pressure; pH

Indexed keywords

ACTIVE SITE; ASYMMETRIC C-C BOND FORMATION; BIOCATALYSIS; C-C BOND FORMATION; DECARBOXYLASES; ENANTIOMERIC EXCESS; ENZYME CATALYSIS; HIGH PRESSURE; HOT SPOT; INCREASE IN PRESSURE; PSEUDOMONAS PUTIDA; SITE DIRECTED MUTAGENESIS; SUBSTRATE CONCENTRATIONS; THIAMINE DIPHOSPHATES;

ALDEHYDES; CATALYSIS; ELECTRON TRANSITIONS; ENZYMES; HYDRAULICS; HYDRODYNAMICS; HYDROSTATIC PRESSURE; KETONES; PRESSURE EFFECTS;

ENANTIOSELECTIVITY;

2 HYDROXYKETONE; BENZOYLFORMATE DECARBOXYLASE; CARBOXYLYASE; ENZYME VARIANT; KETONE; RECOMBINANT ENZYME; UNCLASSIFIED DRUG;

ARTICLE; ASYMMETRIC SYNTHESIS; CATALYSIS; CONTROLLED STUDY; ENANTIOMER; ENANTIOSELECTIVITY; ENZYME ACTIVITY; ENZYME SUBSTRATE; HYDROSTATIC PRESSURE; NONHUMAN; PH; PSEUDOMONAS PUTIDA; WILD TYPE;

ACETALDEHYDE; AMINO ACID SUBSTITUTION; BACTERIAL PROTEINS; BENZALDEHYDES; CARBOXY-LYASES; HYDROGEN-ION CONCENTRATION; HYDROSTATIC PRESSURE; HYDROXYPROPIOPHENONE; KETONES; MUTANT PROTEINS; PSEUDOMONAS PUTIDA; RECOMBINANT PROTEINS; SUBSTRATE SPECIFICITY;

PSEUDOMONAS PUTIDA;

EID: 77951549438     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.22650     Document Type: Article

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