메뉴 건너뛰기




Volumn 17, Issue 3, 2010, Pages 198-205

How do angiopoietins Tie in with vascular endothelial growth factors?

Author keywords

Angiogenesis; Angiopoietin; Lymphangiogenesis; Tie2; Vascular endothelial growth factor; Vascular endothelial growth factor B

Indexed keywords

ANGIOPOIETIN; ANGIOPOIETIN 2; ANGIOPOIETIN RECEPTOR; TIE RECEPTOR; VASCULOTROPIN; VASCULOTROPIN B; VASCULOTROPIN RECEPTOR 2; VASCULOTROPIN RECEPTOR 3;

EID: 77951499651     PISSN: 10656251     EISSN: 15317048     Source Type: Journal    
DOI: 10.1097/MOH.0b013e3283386673     Document Type: Review
Times cited : (84)

References (95)
  • 1
    • 60749096085 scopus 로고    scopus 로고
    • Control of vascular morphogenesis and homeostasis through the angiopoietin-Tie system
    • Augustin HG, Koh GY, Thurston G, Alitalo K. Control of vascular morphogenesis and homeostasis through the angiopoietin-Tie system. Nat Rev Mol Cell Biol 2009; 10:165-177.
    • (2009) Nat Rev Mol Cell Biol , vol.10 , pp. 165-177
    • Augustin, H.G.1    Koh, G.Y.2    Thurston, G.3    Alitalo, K.4
  • 2
    • 66349093990 scopus 로고    scopus 로고
    • Vascular endothelial growth factor
    • Ferrara N. Vascular endothelial growth factor. Arterioscler Thromb Vasc Biol 2009; 29:789-791.
    • (2009) Arterioscler Thromb Vasc Biol , vol.29 , pp. 789-791
    • Ferrara, N.1
  • 3
    • 63749125392 scopus 로고    scopus 로고
    • VEGFs and receptors involved in angiogenesis versus lymphangiogenesis
    • Lohela M, Bry M, Tammela T, Alitalo K. VEGFs and receptors involved in angiogenesis versus lymphangiogenesis. Curr Opin Cell Biol 2009; 21:154-165.
    • (2009) Curr Opin Cell Biol , vol.21 , pp. 154-165
    • Lohela, M.1    Bry, M.2    Tammela, T.3    Alitalo, K.4
  • 4
    • 0029001244 scopus 로고
    • Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation
    • Sato TN, Tozawa Y, Deutsch U, et al. Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation. Nature 1995; 367:70-74.
    • (1995) Nature , vol.367 , pp. 70-74
    • Sato, T.N.1    Tozawa, Y.2    Deutsch, U.3
  • 5
    • 0028867704 scopus 로고
    • The receptor tyrosine kinase TIE is required for integrity and survival of vascular endothelial cells
    • Puri MC, Rossant J, Alitalo K, et al. The receptor tyrosine kinase TIE is required for integrity and survival of vascular endothelial cells. EMBO J 1995; 14:5884-5891.
    • (1995) EMBO J , vol.14 , pp. 5884-5891
    • Puri, M.C.1    Rossant, J.2    Alitalo, K.3
  • 6
    • 0030480322 scopus 로고    scopus 로고
    • Requisite roleof angiopoietin-1,aligandforthe TIE2 receptor, during embryonic angiogenesis
    • Suri C, Jones PF, Patan S, et al. Requisite roleof angiopoietin-1, aligandforthe TIE2 receptor, during embryonic angiogenesis. Cell 1996; 87:1171-1180.
    • (1996) Cell , vol.87 , pp. 1171-1180
    • Suri, C.1    Jones, P.F.2    Patan, S.3
  • 7
    • 15144358851 scopus 로고    scopus 로고
    • Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis
    • Maisonpierre PC, Suri C, Jones PF, et al. Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis. Science 1997; 277:55-60.
    • (1997) Science , vol.277 , pp. 55-60
    • Maisonpierre, P.C.1    Suri, C.2    Jones, P.F.3
  • 8
    • 0034648666 scopus 로고    scopus 로고
    • Angiopoietin-2 at high concentration can enhance endothelial cell survival through the phosphatidylinositol 3'-kinase/Akt signal transduction pathway
    • Kim I, Kim JH, Moon SO, et al. Angiopoietin-2 at high concentration can enhance endothelial cell survival through the phosphatidylinositol 3'-kinase/Akt signal transduction pathway. Oncogene 2000; 19:4549-4552.
    • (2000) Oncogene , vol.19 , pp. 4549-4552
    • Kim, I.1    Kim, J.H.2    Moon, S.O.3
  • 9
    • 0035895712 scopus 로고    scopus 로고
    • Biological action of angiopoietin-2 in a fibrin matrix model of angiogenesis is associated with activation of Tie2
    • Teichert-Kuliszewska K, Maisonpierre PC, Jones N, et al. Biological action of angiopoietin-2 in a fibrin matrix model of angiogenesis is associated with activation of Tie2. Cardiovasc Res 2001; 49:659-670.
    • (2001) Cardiovasc Res , vol.49 , pp. 659-670
    • Teichert-Kuliszewska, K.1    Maisonpierre, P.C.2    Jones, N.3
  • 10
    • 33750349223 scopus 로고    scopus 로고
    • Angiopoietin-2 functions as an autocrine protective factor in stressed endothelial cells
    • Daly C, Pasnikowski E, Burova E, et al. Angiopoietin-2 functions as an autocrine protective factor in stressed endothelial cells. Proc Natl Acad Sci USA 2006; 103:15491-15496.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 15491-15496
    • Daly, C.1    Pasnikowski, E.2    Burova, E.3
  • 11
    • 0033580889 scopus 로고    scopus 로고
    • Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF
    • Holash J, Maisonpierre PC, Compton D, et al. Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF. Science 1999; 284:1994-1998.
    • (1999) Science , vol.284 , pp. 1994-1998
    • Holash, J.1    Maisonpierre, P.C.2    Compton, D.3
  • 12
    • 41749093830 scopus 로고    scopus 로고
    • Molecular biology and pathology of lymphangiogenesis
    • Karpanen T, Alitalo K. Molecular biology and pathology of lymphangiogenesis. Annu Rev Pathol 2008; 3:367-397.
    • (2008) Annu Rev Pathol , vol.3 , pp. 367-397
    • Karpanen, T.1    Alitalo, K.2
  • 13
    • 9144236286 scopus 로고    scopus 로고
    • Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins
    • Karkkainen MJ, HaikoP, Sainio K, et al. Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins. Nat Immunol 2004; 5:74-80.
    • (2004) Nat Immunol , vol.5 , pp. 74-80
    • Karkkainen, M.J.1    Haikop Sainio, K.2
  • 14
    • 13844273017 scopus 로고    scopus 로고
    • Vascular endothelial growth factor D is dispensable for development of the lymphatic system
    • Baldwin ME, Halford MM, Roufail S, et al. Vascular endothelial growth factor D is dispensable for development of the lymphatic system. Mol Cell Biol 2005; 25:2441-2449.
    • (2005) Mol Cell Biol , vol.25 , pp. 2441-2449
    • Baldwin, M.E.1    Halford, M.M.2    Roufail, S.3
  • 15
    • 47949083776 scopus 로고    scopus 로고
    • Deletion of vascular endothelial growth factor C (VEGF-C) and VEGF-D is not equivalent to VEGF receptor 3 deletion in mouse embryos
    • Haiko P, Makinen T, Keskitalo S, et al. Deletion of vascular endothelial growth factor C (VEGF-C) and VEGF-D is not equivalent to VEGF receptor 3 deletion in mouse embryos. Mol Cell Biol 2008; 28:4843-4850.
    • (2008) Mol Cell Biol , vol.28 , pp. 4843-4850
    • Haiko, P.1    Makinen, T.2    Keskitalo, S.3
  • 16
    • 70350462418 scopus 로고    scopus 로고
    • VEGF-D deficiency in mice does not affect embryonic or postnatal lymphangiogenesis but reduces lymphatic metastasis
    • Koch M, Dettori D, Van Nuffelen A, et al. VEGF-D deficiency in mice does not affect embryonic or postnatal lymphangiogenesis but reduces lymphatic metastasis. J Pathol 2009; 219:356-364.
    • (2009) J Pathol , vol.219 , pp. 356-364
    • Koch, M.1    Dettori, D.2    Van Nuffelen, A.3
  • 17
    • 18644382318 scopus 로고    scopus 로고
    • Angiopoietin-2 is required for postnatal angiogenesis and lymphatic patterning, and only the latter role is rescued by Angiopoietin-1
    • Gale NW, Thurston G, Hackett SF, et al. Angiopoietin-2 is required for postnatal angiogenesis and lymphatic patterning, and only the latter role is rescued by Angiopoietin-1. Dev Cell 2002; 3:411-423.
    • (2002) Dev Cell , vol.3 , pp. 411-423
    • Gale, N.W.1    Thurston, G.2    Hackett, S.F.3
  • 18
    • 47949099628 scopus 로고    scopus 로고
    • Modes of resistance to antiangiogenic therapy
    • Bergers G, Hanahan D. Modes of resistance to antiangiogenic therapy. Nat Rev Cancer 2008; 8:592-603.
    • (2008) Nat Rev Cancer , vol.8 , pp. 592-603
    • Bergers, G.1    Hanahan, D.2
  • 19
  • 20
    • 34249689753 scopus 로고    scopus 로고
    • Molecular regulation of angiogenesis and lymphangiogenesis
    • Adams RH, Alitalo K. Molecular regulation of angiogenesis and lymphangiogenesis. Nat Rev Mol Cell Biol 2007; 8:464-478.
    • (2007) Nat Rev Mol Cell Biol , vol.8 , pp. 464-478
    • Adams, R.H.1    Alitalo, K.2
  • 21
    • 59649085554 scopus 로고    scopus 로고
    • Angiogenesis: A team effort coordinated by notch
    • Phng LK, Gerhardt H. Angiogenesis: a team effort coordinated by notch. Dev Cell 2009; 16:196-208.
    • (2009) Dev Cell , vol.16 , pp. 196-208
    • Phng, L.K.1    Gerhardt, H.2
  • 22
    • 70349856167 scopus 로고    scopus 로고
    • Arterial-venous segregation by selective cell sprouting: An alternative mode of blood vessel formation
    • Herbert SP, Huisken J, KimTN, et al. Arterial-venous segregation by selective cell sprouting: an alternative mode of blood vessel formation. Science 2009; 326:294-298.
    • (2009) Science , vol.326 , pp. 294-298
    • Herbert, S.P.1    Kimtn, H.J.2
  • 23
    • 70450195982 scopus 로고    scopus 로고
    • Vegfc/Flt4 signalling is suppressed by Dll4 in developing zebrafish intersegmental arteries
    • Hogan BM, Herpers R, Witte M, et al. Vegfc/Flt4 signalling is suppressed by Dll4 in developing zebrafish intersegmental arteries. Development 2009; 136:4001-4009.
    • (2009) Development , vol.136 , pp. 4001-4009
    • Hogan, B.M.1    Herpers, R.2    Witte, M.3
  • 24
    • 48349129069 scopus 로고    scopus 로고
    • Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation
    • Tammela T, Zarkada G, Wallgard E, et al. Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation. Nature 2008; 454:656-660.
    • (2008) Nature , vol.454 , pp. 656-660
    • Tammela, T.1    Zarkada, G.2    Wallgard, E.3
  • 25
    • 0029021660 scopus 로고
    • Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium
    • Fong GH, Rossant J, Gertsenstein M, Breitman ML. Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium. Nature 1995; 376:66-70.
    • (1995) Nature , vol.376 , pp. 66-70
    • Fong, G.H.1    Rossant, J.2    Gertsenstein, M.3    Breitman, M.L.4
  • 26
    • 44649128099 scopus 로고    scopus 로고
    • The VEGF receptor Flt-1 spatially modulates Flk-1 signaling and blood vessel branching
    • Kappas NC, Zeng G, Chappell JC, et al. The VEGF receptor Flt-1 spatially modulates Flk-1 signaling and blood vessel branching. J Cell Biol 2008; 181:847-858.
    • (2008) J Cell Biol , vol.181 , pp. 847-858
    • Kappas, N.C.1    Zeng, G.2    Chappell, J.C.3
  • 27
    • 69949139925 scopus 로고    scopus 로고
    • Bautch VL Local guidance of emerging vessel sprouts requires soluble Flt-1
    • Chappell JC, Taylor SM, Ferrara N, Bautch VL Local guidance of emerging vessel sprouts requires soluble Flt-1. Dev Cell 2009; 17:377-386.
    • (2009) Dev Cell , vol.17 , pp. 377-386
    • Chappell, J.C.1    Taylor, S.M.2    Ferrara, N.3
  • 28
    • 70349464463 scopus 로고    scopus 로고
    • VEGFR1 activity modulates myeloid cell infiltration in growing lung metastases but is not required for spontaneous metastasis formation
    • Dawson MR, Duda DG, Chae SS, et al. VEGFR1 activity modulates myeloid cell infiltration in growing lung metastases but is not required for spontaneous metastasis formation. PLoS One 2009; 4:e6525.
    • (2009) PLoS One , vol.4
    • Dawson, M.R.1    Duda, D.G.2    Chae, S.S.3
  • 29
    • 61949383594 scopus 로고    scopus 로고
    • Vascular endothelial growth factor-B induces myocardium-specific angiogenesis and arteriogenesis via vascular endothelial growth factor receptor-1-and neuropilin receptor-1-dependent mechanisms
    • Lahteenvuo JE, Lahteenvuo MT, Kivela A, et al. Vascular endothelial growth factor-B induces myocardium-specific angiogenesis and arteriogenesis via vascular endothelial growth factor receptor-1-and neuropilin receptor-1-dependent mechanisms. Circulation 2009; 119:845-856.
    • (2009) Circulation , vol.119 , pp. 845-856
    • Lahteenvuo, J.E.1    Lahteenvuo, M.T.2    Kivela, A.3
  • 30
    • 56749174211 scopus 로고    scopus 로고
    • FLT1 and its ligands VEGFB and PlGF: Drug targets for antiangiogenic therapy?
    • Fischer C, Mazzone M, Jonckx B, Carmeliet P. FLT1 and its ligands VEGFB and PlGF: drug targets for antiangiogenic therapy? Nat Rev Cancer 2008; 8:942-956.
    • (2008) Nat Rev Cancer , vol.8 , pp. 942-956
    • Fischer, C.1    Mazzone, M.2    Jonckx, B.3    Carmeliet, P.4
  • 31
    • 55449118233 scopus 로고    scopus 로고
    • Overexpression of vascular endothelial growth factor-B in mouse heart alters cardiac lipid metabolism and induces myocardial hypertrophy
    • Karpanen T, Bry M, Ollila HM, et al. Overexpression of vascular endothelial growth factor-B in mouse heart alters cardiac lipid metabolism and induces myocardial hypertrophy. Circ Res 2008; 103:1018-1026.
    • (2008) Circ Res , vol.103 , pp. 1018-1026
    • Karpanen, T.1    Bry, M.2    Ollila, H.M.3
  • 32
    • 77951499358 scopus 로고    scopus 로고
    • Cardiomyocyte VEGFR-1 activation by VEGF-B induces compensatory hypertrophy and preserves cardiac function after myocardial infarction
    • [Epub ahead of print]
    • Zentilin L, PuligaddaU, Lionetti V, et al. Cardiomyocyte VEGFR-1 activation by VEGF-B induces compensatory hypertrophy and preserves cardiac function after myocardial infarction. FASEB J 2009 [Epub ahead of print].
    • (2009) FASEB J
    • Zentilin, L.1    Puligadda, U.2    Lionetti, V.3
  • 33
    • 21244434808 scopus 로고    scopus 로고
    • Oligomerization and multimerization is critical for angiopoietin-1 to bind and phosphorylate tie2
    • Kim KT, Choi HH, Steinmetz MO, et al. Oligomerization and multimerization is critical for angiopoietin-1 to bind and phosphorylate tie2. J Biol Chem 2005; 280:20126-20131.
    • (2005) J Biol Chem , vol.280 , pp. 20126-20131
    • Kim, K.T.1    Choi, H.H.2    Steinmetz, M.O.3
  • 34
    • 0037219502 scopus 로고    scopus 로고
    • Angiopoietins have distinct modular domains essential for receptor binding, dimerization and super-clustering
    • Davis S, Papadopoulos N, Aldrich TH, et al. Angiopoietins have distinct modular domains essential for receptor binding, dimerization and super-clustering. Nat Struct Biol 2003; 10:38-44.
    • (2003) Nat Struct Biol , vol.10 , pp. 38-44
    • Davis, S.1    Papadopoulos, N.2    Aldrich, T.H.3
  • 35
    • 67349263020 scopus 로고    scopus 로고
    • A designed angiopoietin-2 variant, pentameric COMP-Ang2, strongly activates Tie2 receptor and stimulates angiogenesis
    • Kim HZ, Jung K, Kim HM, et al. A designed angiopoietin-2 variant, pentameric COMP-Ang2, strongly activates Tie2 receptor and stimulates angiogenesis. Biochim Biophys Acta 2009; 1793:772-780.
    • (2009) Biochim Biophys Acta , vol.1793 , pp. 772-780
    • Kim, H.Z.1    Jung, K.2    Kim, H.M.3
  • 36
    • 70349258220 scopus 로고    scopus 로고
    • Oligomerized Tie2 localizes to clathrin-coated pits in response to angiopoietin-1
    • Bogdanovic E, Coombs N, Dumont DJ. Oligomerized Tie2 localizes to clathrin-coated pits in response to angiopoietin-1. Histochem Cell Biol 2009; 132:225-237.
    • (2009) Histochem Cell Biol , vol.132 , pp. 225-237
    • Bogdanovic, E.1    Coombs, N.2    Dumont, D.J.3
  • 37
    • 70350101449 scopus 로고    scopus 로고
    • Angiopoietin-1-induced ubiquitylation of Tie2 by c-Cbl is required for internalization and degradation
    • Wehrle C, Van Slyke P, Dumont DJ. Angiopoietin-1-induced ubiquitylation of Tie2 by c-Cbl is required for internalization and degradation. Biochem J 2009; 423:375-380.
    • (2009) Biochem J , vol.423 , pp. 375-380
    • Wehrle, C.1    Van Slyke, P.2    Dumont, D.J.3
  • 38
    • 66149094158 scopus 로고    scopus 로고
    • VE-PTP controls blood vessel development by balancing Tie-2 activity
    • Winderlich M, Keller L, Cagna G, et al. VE-PTP controls blood vessel development by balancing Tie-2 activity. J Cell Biol 2009; 185:657-671.
    • (2009) J Cell Biol , vol.185 , pp. 657-671
    • Winderlich, M.1    Keller, L.2    Cagna, G.3
  • 39
    • 77949657364 scopus 로고    scopus 로고
    • Hereditary cutaneomucosal venous malformations are caused by TIE2 mutations with widely variable hyper-phosphorylating effects
    • Wouters V, Limaye N, Uebelhoer M, et al. Hereditary cutaneomucosal venous malformations are caused by TIE2 mutations with widely variable hyper-phosphorylating effects. Eur J Hum Genet 2010; 18:414-420.
    • (2010) Eur J Hum Genet , vol.18 , pp. 414-420
    • Wouters, V.1    Limaye, N.2    Uebelhoer, M.3
  • 40
    • 58149152854 scopus 로고    scopus 로고
    • Somatic mutations in angiopoietin receptor gene TEK cause solitary and multiple sporadic venous malformations
    • Limaye N, Wouters V, Uebelhoer M, et al. Somatic mutations in angiopoietin receptor gene TEK cause solitary and multiple sporadic venous malformations. Nat Genet 2009; 41:118-124.
    • (2009) Nat Genet , vol.41 , pp. 118-124
    • Limaye, N.1    Wouters, V.2    Uebelhoer, M.3
  • 41
    • 43049116169 scopus 로고    scopus 로고
    • Differential function of Tie2 at cell-cell contacts and cell-substratum contacts regulated by angiopoietin-1
    • Fukuhara S, Sako K, Minami T, et al. Differential function of Tie2 at cell-cell contacts and cell-substratum contacts regulated by angiopoietin-1. Nat Cell Biol 2008; 10:513-526.
    • (2008) Nat Cell Biol , vol.10 , pp. 513-526
    • Fukuhara, S.1    Sako, K.2    Minami, T.3
  • 42
    • 43049116513 scopus 로고    scopus 로고
    • Angiopoietins assemble distinct Tie2 signalling complexes in endothelial cell-cell and cell-matrix contacts
    • Saharinen P, Eklund L, Miettinen J, et al. Angiopoietins assemble distinct Tie2 signalling complexes in endothelial cell-cell and cell-matrix contacts. Nat Cell Biol 2008; 10:527-537.
    • (2008) Nat Cell Biol , vol.10 , pp. 527-537
    • Saharinen, P.1    Eklund, L.2    Miettinen, J.3
  • 43
    • 0030764063 scopus 로고    scopus 로고
    • Tie2 expression and phosphorylation in angiogenic and quiescent adult tissues
    • Wong AL, Haroon ZA, Werner S, et al. Tie2 expression and phosphorylation in angiogenic and quiescent adult tissues. Circ Res 1997; 81:567-574.
    • (1997) Circ Res , vol.81 , pp. 567-574
    • Wong, A.L.1    Haroon, Z.A.2    Werner, S.3
  • 44
    • 2542453735 scopus 로고    scopus 로고
    • The Tie-2 ligand angiopoietin-2 is stored in and rapidly released upon stimulation from endothelial cell Weibel-Palade bodies
    • Fiedler U, Scharpfenecker M, Koidl S, et al. The Tie-2 ligand angiopoietin-2 is stored in and rapidly released upon stimulation from endothelial cell Weibel-Palade bodies. Blood 2004; 103:4150-4156.
    • (2004) Blood , vol.103 , pp. 4150-4156
    • Fiedler, U.1    Scharpfenecker, M.2    Koidl, S.3
  • 45
    • 61549130907 scopus 로고    scopus 로고
    • Angiopoietin-2 exocytosis is stimulated by sphingosine-1-phosphate in human blood and lymphatic endothelial cells
    • Jang C, Koh YJ, Lim NK, et al. Angiopoietin-2 exocytosis is stimulated by sphingosine-1-phosphate in human blood and lymphatic endothelial cells. Arterioscler Thromb Vasc Biol 2009; 29:401-407.
    • (2009) Arterioscler Thromb Vasc Biol , vol.29 , pp. 401-407
    • Jang, C.1    Koh, Y.J.2    Lim, N.K.3
  • 46
    • 0242443253 scopus 로고    scopus 로고
    • Intrinsic versus microenvironmental regulation of lymphatic endothelial cell phenotype and function
    • Veikkola T, Lohela M, Ikenberg K, et al. Intrinsic versus microenvironmental regulation of lymphatic endothelial cell phenotype and function. FASEB J 2003; 17:2006-2013.
    • (2003) FASEB J , vol.17 , pp. 2006-2013
    • Veikkola, T.1    Lohela, M.2    Ikenberg, K.3
  • 47
    • 58149354667 scopus 로고    scopus 로고
    • Immunohistochemical demonstration of angiopoietin-2 in lymphatic vascular development
    • Shimoda H. Immunohistochemical demonstration of angiopoietin-2 in lymphatic vascular development. Histochem Cell Biol 2009; 131:231-238.
    • (2009) Histochem Cell Biol , vol.131 , pp. 231-238
    • Shimoda, H.1
  • 48
    • 65549145050 scopus 로고    scopus 로고
    • Angiopoietin-1 induces Kruppel-like factor 2 expression through a phosphoinositide 3-kinase/AKT-dependent activation of myocyte enhancer factor 2
    • Sako K, Fukuhara S, Minami T, et al. Angiopoietin-1 induces Kruppel-like factor 2 expression through a phosphoinositide 3-kinase/AKT-dependent activation of myocyte enhancer factor 2. J Biol Chem 2009; 284:5592-5601.
    • (2009) J Biol Chem , vol.284 , pp. 5592-5601
    • Sako, K.1    Fukuhara, S.2    Minami, T.3
  • 49
    • 37848998838 scopus 로고    scopus 로고
    • Angiopoietin-1 prevents VEGF-induced endothelial permeability by sequestering Src through mDia
    • Gavard J, Patel V, Gutkind JS. Angiopoietin-1 prevents VEGF-induced endothelial permeability by sequestering Src through mDia. Dev Cell 2008; 14:25-36.
    • (2008) Dev Cell , vol.14 , pp. 25-36
    • Gavard, J.1    Patel, V.2    Gutkind, J.S.3
  • 50
    • 70350455599 scopus 로고    scopus 로고
    • Phosphorylation of endothelial nitric oxide synthase by atypical PKCzeta contributes to angiopoietin-1-dependent inhibition of VEGF-induced endothelial permeability in vitro
    • Oubaha M, Gratton JP. Phosphorylation of endothelial nitric oxide synthase by atypical PKCzeta contributes to angiopoietin-1-dependent inhibition of VEGF-induced endothelial permeability in vitro. Blood 2009; 114:3343-3351.
    • (2009) Blood , vol.114 , pp. 3343-3351
    • Oubaha, M.1    Gratton, J.P.2
  • 51
    • 64749111597 scopus 로고    scopus 로고
    • Angiopoietin-1 reduces vascular endothelial growth factor-induced brain endothelial permeability via upregulation of ZO-2
    • Lee SW, Kim WJ, Jun HO, et al. Angiopoietin-1 reduces vascular endothelial growth factor-induced brain endothelial permeability via upregulation of ZO-2. Int J Mol Med 2009; 23:279-284.
    • (2009) Int J Mol Med , vol.23 , pp. 279-284
    • Lee, S.W.1    Kim, W.J.2    Jun, H.O.3
  • 52
    • 0033592739 scopus 로고    scopus 로고
    • Functional interaction of vascular en-dothelial-protein-tyrosine phosphatase with the angiopoietin receptor Tie-2
    • Fachinger G, Deutsch U, Risau W. Functional interaction of vascular en-dothelial-protein-tyrosine phosphatase with the angiopoietin receptor Tie-2. Oncogene 1999; 18:5948-5953.
    • (1999) Oncogene , vol.18 , pp. 5948-5953
    • Fachinger, G.1    Deutsch, U.2    Risau, W.3
  • 53
    • 58149291905 scopus 로고    scopus 로고
    • VE-PTP maintains the endothelial barrier via plakoglobin and becomes dissociated from VE-cadherin by leukocytes and by VEGF
    • Nottebaum AF, Cagna G, Winderlich M, et al. VE-PTP maintains the endothelial barrier via plakoglobin and becomes dissociated from VE-cadherin by leukocytes and by VEGF. J Exp Med 2008; 205:2929-2945.
    • (2008) J Exp Med , vol.205 , pp. 2929-2945
    • Nottebaum, A.F.1    Cagna, G.2    Winderlich, M.3
  • 54
    • 61449145430 scopus 로고    scopus 로고
    • Tyrosine phosphatase beta regulates angiopoietin-Tie2 signaling in human endothelial cells
    • Yacyshyn OK, Lai PF, Forse K, et al. Tyrosine phosphatase beta regulates angiopoietin-Tie2 signaling in human endothelial cells. Angiogenesis 2009; 12:25-33.
    • (2009) Angiogenesis , vol.12 , pp. 25-33
    • Yacyshyn, O.K.1    Lai, P.F.2    Forse, K.3
  • 55
    • 33847636046 scopus 로고    scopus 로고
    • Vascular endothelial tyrosine phosphatase (VE-PTP)-null mice undergo vasculogenesis but die embryoni-cally because of defects in angiogenesis
    • Dominguez MG, Hughes VC, Pan L, et al. Vascular endothelial tyrosine phosphatase (VE-PTP)-null mice undergo vasculogenesis but die embryoni-cally because of defects in angiogenesis. Proc Natl Acad Sci USA 2007; 104:3243-3248.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 3243-3248
    • Dominguez, M.G.1    Hughes, V.C.2    Pan, L.3
  • 56
    • 33745107561 scopus 로고    scopus 로고
    • Vascular endothelial cell-specific phosphotyrosine phosphatase (VE-PTP) activity is required for blood vessel development
    • Baumer S, Keller L, Holtmann A, et al. Vascular endothelial cell-specific phosphotyrosine phosphatase (VE-PTP) activity is required for blood vessel development. Blood 2006; 107:4754-4762.
    • (2006) Blood , vol.107 , pp. 4754-4762
    • Baumer, S.1    Keller, L.2    Holtmann, A.3
  • 57
    • 76049103879 scopus 로고    scopus 로고
    • Embryonic stem cell tumor model reveals role of vascular endothelial receptor tyrosine phosphatase in regulating Tie2 pathway in tumor angiogenesis
    • Li Z, Huang H, Boland P, et al. Embryonic stem cell tumor model reveals role of vascular endothelial receptor tyrosine phosphatase in regulating Tie2 pathway in tumor angiogenesis. Proc Natl Acad Sci USA 2009; 106:22399-22404.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 22399-22404
    • Li, Z.1    Huang, H.2    Boland, P.3
  • 58
    • 67049156727 scopus 로고    scopus 로고
    • Maturation of blood vessels by haematopoietic stem cells and progenitor cells: Involvement of apelin/APJ and angiopoietin/Tie2 interactions in vessel caliber size regulation
    • Takakura N, Kidoya H. Maturation of blood vessels by haematopoietic stem cells and progenitor cells: involvement of apelin/APJ and angiopoietin/Tie2 interactions in vessel caliber size regulation. Thromb Haemost 2009; 101:999-1005.
    • (2009) Thromb Haemost , vol.101 , pp. 999-1005
    • Takakura, N.1    Kidoya, H.2
  • 59
    • 70349319448 scopus 로고    scopus 로고
    • Transcriptional profiling reveals a critical role for tyrosine phosphatase VE-PTP in regulation of VEGFR2 activity and endothelial cell morphogenesis
    • Mellberg S, Dimberg A, Bahram F, et al. Transcriptional profiling reveals a critical role for tyrosine phosphatase VE-PTP in regulation of VEGFR2 activity and endothelial cell morphogenesis. FASEB J 2009; 23:1490-1502.
    • (2009) FASEB J , vol.23 , pp. 1490-1502
    • Mellberg, S.1    Dimberg, A.2    Bahram, F.3
  • 60
    • 18544365981 scopus 로고    scopus 로고
    • Multiple angiopoietin recombinant proteins activate the Tie1 receptor tyrosine kinase and promote its interaction with Tie2
    • Saharinen P, Kerkela K, Ekman N, et al. Multiple angiopoietin recombinant proteins activate the Tie1 receptor tyrosine kinase and promote its interaction with Tie2. J Cell Biol 2005; 169:239-243.
    • (2005) J Cell Biol , vol.169 , pp. 239-243
    • Saharinen, P.1    Kerkela, K.2    Ekman, N.3
  • 61
    • 60449109349 scopus 로고    scopus 로고
    • Roles of the receptor tyrosine kinases Tie1 and Tie2 in mediating the effects of angiopoietin-1 on endothelial permeability and apoptosis
    • Milner CS, Hansen TM, Singh H, Brindle NP. Roles of the receptor tyrosine kinases Tie1 and Tie2 in mediating the effects of angiopoietin-1 on endothelial permeability and apoptosis. Microvasc Res 2009; 77:187-191.
    • (2009) Microvasc Res , vol.77 , pp. 187-191
    • Milner, C.S.1    Hansen, T.M.2    Singh, H.3    Brindle, N.P.4
  • 62
    • 0642303635 scopus 로고    scopus 로고
    • Transcriptional and post-translation regulation of the Tie1 receptor by fluid shear stress changes in vascular endothelial cells
    • Chen-Konak L, Guetta-Shubin Y, Yahav H, et al. Transcriptional and post-translation regulation of the Tie1 receptor by fluid shear stress changes in vascular endothelial cells. FASEB J 2003; 17:2121-2123.
    • (2003) FASEB J , vol.17 , pp. 2121-2123
    • Chen-Konak, L.1    Guetta-Shubin, Y.2    Yahav, H.3
  • 63
    • 71349084180 scopus 로고    scopus 로고
    • Effects of angiopoietins-1 and-2 on the receptor tyrosine kinase Tie2 are differentially regulated at the endothelial cell surface
    • Hansen TM, Singh H, Tahir TA, Brindle NP. Effects of angiopoietins-1 and-2 on the receptor tyrosine kinase Tie2 are differentially regulated at the endothelial cell surface. Cell Signal 2010; 22:527-532.
    • (2010) Cell Signal , vol.22 , pp. 527-532
    • Hansen, T.M.1    Singh, H.2    Tahir, T.A.3    Brindle, N.P.4
  • 64
    • 65549129693 scopus 로고    scopus 로고
    • Vascular endothelial growth factor activates the Tie family of receptor tyrosine kinases
    • Singh H, Milner CS, Aguilar Hernandez MM, et al. Vascular endothelial growth factor activates the Tie family of receptor tyrosine kinases. Cell Signal 2009; 21:1346-1350.
    • (2009) Cell Signal , vol.21 , pp. 1346-1350
    • Singh, H.1    Milner, C.S.2    Aguilar Hernandez, M.M.3
  • 65
    • 75149155724 scopus 로고    scopus 로고
    • Loss of endothelial tie receptor impairs lymphatic vessel development
    • D'Amico G, Korhonen E, Waltari M, et al. Loss of Endothelial Tie1 Receptor Impairs Lymphatic Vessel Development. Arterioscler Thromb Vasc Biol 2009; 30:207-209.
    • (2009) Arterioscler Thromb Vasc Biol , vol.30 , pp. 207-209
    • D'Amico, G.1    Korhonen, E.2    Waltari, M.3
  • 66
    • 33947393171 scopus 로고    scopus 로고
    • Abnormal recruitment of perien-dothelial cells to lymphatic capillaries in digestive organs of angiopoietin-2-deficient mice
    • Shimoda H, Bernas MJ, Witte MH, et al. Abnormal recruitment of perien-dothelial cells to lymphatic capillaries in digestive organs of angiopoietin-2-deficient mice. Cell Tissue Res 2007; 328:329-337.
    • (2007) Cell Tissue Res , vol.328 , pp. 329-337
    • Shimoda, H.1    Bernas, M.J.2    Witte, M.H.3
  • 67
    • 46049111407 scopus 로고    scopus 로고
    • Defective remodeling and maturation of the lymphatic vasculature in Angiopoietin-2 deficient mice
    • Dellinger M, Hunter R, Bernas M, et al. Defective remodeling and maturation of the lymphatic vasculature in Angiopoietin-2 deficient mice. Dev Biol 2008; 319:309-320.
    • (2008) Dev Biol , vol.319 , pp. 309-320
    • Dellinger, M.1    Hunter, R.2    Bernas, M.3
  • 68
    • 3242669145 scopus 로고    scopus 로고
    • Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche
    • Arai F, Hirao A, Ohmura M, et al. Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche. Cell 2004; 118:149-161.
    • (2004) Cell , vol.118 , pp. 149-161
    • Arai, F.1    Hirao, A.2    Ohmura, M.3
  • 69
    • 73949131170 scopus 로고    scopus 로고
    • Functional differences between two Tie2 ligands, angiopoietin-1 and-2, in regulation of adult bone marrow hematopoietic stem cells
    • Gomei Y, NakamuraY, Yoshihara H, et al. Functional differences between two Tie2 ligands, angiopoietin-1 and-2, in regulation of adult bone marrow hematopoietic stem cells. Exp Hematol 2009; 38:82-89.
    • (2009) Exp Hematol , vol.38 , pp. 82-89
    • Gomei, Y.1    Nakamura, Y.2    Yoshihara, H.3
  • 70
    • 60149110371 scopus 로고    scopus 로고
    • The haemangioblast generates haematopoietic cells through ahaemogenic endothelium stage
    • Lancrin C, Sroczynska P, Stephenson C, et al. The haemangioblast generates haematopoietic cells through ahaemogenic endothelium stage. Nature 2009;457:892-895.
    • (2009) Nature , vol.457 , pp. 892-895
    • Lancrin, C.1    Sroczynska, P.2    Stephenson, C.3
  • 71
    • 60149102751 scopus 로고    scopus 로고
    • Continuous single-cell imaging of blood generation from haemogenic endothelium
    • Eilken HM, NishikawaS,SchroederT. Continuous single-cell imaging of blood generation from haemogenic endothelium. Nature 2009; 457:896-900.
    • (2009) Nature , vol.457 , pp. 896-900
    • Eilken, H.M.1    Nishikawa, S.2    Schroeder, T.3
  • 72
    • 60149100010 scopus 로고    scopus 로고
    • Runx1 is required for the endothelial to haematopoietic cell transition but not thereafter
    • Chen MJ, Yokomizo T, Zeigler BM, et al. Runx1 is required for the endothelial to haematopoietic cell transition but not thereafter. Nature 2009; 457:887-891.
    • (2009) Nature , vol.457 , pp. 887-891
    • Chen, M.J.1    Yokomizo, T.2    Zeigler, B.M.3
  • 73
    • 69249249201 scopus 로고    scopus 로고
    • Autocrine and paracrine angiopoietin 1/Tie-2 signaling promotes muscle satellite cell self-renewal
    • Abou-Khalil R, Le Grand F, Pallafacchina G, et al. Autocrine and paracrine angiopoietin 1/Tie-2 signaling promotes muscle satellite cell self-renewal. Cell Stem Cell 2009; 5:298-309.
    • (2009) Cell Stem Cell , vol.5 , pp. 298-309
    • Abou-Khalil, R.1    Le Grand, F.2    Pallafacchina, G.3
  • 74
    • 7044235846 scopus 로고    scopus 로고
    • Vascular endothelial growth factor stimulates skeletal muscle regeneration in vivo
    • Arsic N, Zacchigna S, Zentilin L, et al. Vascular endothelial growth factor stimulates skeletal muscle regeneration in vivo. Mol Ther 2004; 10:844-854.
    • (2004) Mol Ther , vol.10 , pp. 844-854
    • Arsic, N.1    Zacchigna, S.2    Zentilin, L.3
  • 75
    • 60549103097 scopus 로고    scopus 로고
    • Host-derived angiopoietin-2 affects early stages of tumor development and vessel maturation but is dispensable for later stages of tumor growth
    • Nasarre P, Thomas M, Kruse K, et al. Host-derived angiopoietin-2 affects early stages of tumor development and vessel maturation but is dispensable for later stages of tumor growth. Cancer Res 2009; 69:1324-1333.
    • (2009) Cancer Res , vol.69 , pp. 1324-1333
    • Nasarre, P.1    Thomas, M.2    Kruse, K.3
  • 76
    • 58149359823 scopus 로고    scopus 로고
    • Angiogenic switch of angiopietins-Tie2 system and its prognostic value in bladder cancer
    • Szarvas T, Jager T, Totsch M, et al. Angiogenic switch of angiopietins-Tie2 system and its prognostic value in bladder cancer. Clin Cancer Res 2008; 14:8253-8262.
    • (2008) Clin Cancer Res , vol.14 , pp. 8253-8262
    • Szarvas, T.1    Jager, T.2    Totsch, M.3
  • 77
    • 63149188174 scopus 로고    scopus 로고
    • Angiopoietin-2 levels are associated with disease progression in metastatic malignant melanoma
    • Helfrich I, Edler L, Sucker A, et al. Angiopoietin-2 levels are associated with disease progression in metastatic malignant melanoma. Clin Cancer Res 2009; 15:1384-1392.
    • (2009) Clin Cancer Res , vol.15 , pp. 1384-1392
    • Helfrich, I.1    Edler, L.2    Sucker, A.3
  • 78
    • 74549172848 scopus 로고    scopus 로고
    • Angiopoietin-2 promotes disease progression of neuroendocrine tumors
    • Detjen KM, Rieke S, Deters A, et al. Angiopoietin-2 promotes disease progression of neuroendocrine tumors. Clin Cancer Res 2010; 16:420-429.
    • (2010) Clin Cancer Res , vol.16 , pp. 420-429
    • Detjen, K.M.1    Rieke, S.2    Deters, A.3
  • 79
    • 7944220649 scopus 로고    scopus 로고
    • Suppression of angiogenesis and tumor growth by selective inhibition of angiopoietin-2
    • Oliner J, Min H, Leal J, et al. Suppression of angiogenesis and tumor growth by selective inhibition of angiopoietin-2. Cancer Cell 2004; 6:507-516.
    • (2004) Cancer Cell , vol.6 , pp. 507-516
    • Oliner, J.1    Min, H.2    Leal, J.3
  • 80
    • 41149139073 scopus 로고    scopus 로고
    • Inhibition of in vivo tumor angiogenesis and growth via systemic delivery of an angiopoietin 2-specific RNA aptamer
    • Sarraf-Yazdi S, Mi J, Moeller BJ, et al. Inhibition of in vivo tumor angiogenesis and growth via systemic delivery of an angiopoietin 2-specific RNA aptamer. J Surg Res 2008; 146:16-23.
    • (2008) J Surg Res , vol.146 , pp. 16-23
    • Sarraf-Yazdi, S.1    Mi, J.2    Moeller, B.J.3
  • 81
    • 73949105871 scopus 로고    scopus 로고
    • A human monoclonal anti-ANG2 antibody leads to broad antitumor activity in combination with VEGF inhibitors and chemotherapy agents in preclinical models
    • Brown JL, Cao ZA, Pinzon-Ortiz M, et al. A human monoclonal anti-ANG2 antibody leads to broad antitumor activity in combination with VEGF inhibitors and chemotherapy agents in preclinical models. Mol Cancer Ther 2010; 9:145-156.
    • (2010) Mol Cancer Ther , vol.9 , pp. 145-156
    • Brown, J.L.1    Cao, Z.A.2    Pinzon-Ortiz, M.3
  • 82
    • 70249114453 scopus 로고    scopus 로고
    • Et al. Safety, pharmacokinetics, and antitumor activity of AMG 386, a selective angiopoietin inhibitor, in adult patients with advanced solid tumors
    • Chap L
    • Herbst RS, Hong D, Chap L, et al. Safety, pharmacokinetics, and antitumor activity of AMG 386, a selective angiopoietin inhibitor, in adult patients with advanced solid tumors. J Clin Oncol 2009; 27:3557-3565.
    • (2009) J Clin Oncol , vol.27 , pp. 3557-3565
    • Herbst, R.S.1    Hong, D.2
  • 83
    • 73649112748 scopus 로고    scopus 로고
    • Contrasting actions of selective inhibitors of angiopoietin-1 and angiopoietin-2 on the normalization of tumor blood vessels
    • Falcon BL, Hashizume H, Koumoutsakos P, et al. Contrasting actions of selective inhibitors of angiopoietin-1 and angiopoietin-2 on the normalization of tumor blood vessels. Am J Pathol 2009; 175:2159-2170.
    • (2009) Am J Pathol , vol.175 , pp. 2159-2170
    • Falcon, B.L.1    Hashizume, H.2    Koumoutsakos, P.3
  • 84
    • 62849096084 scopus 로고    scopus 로고
    • Switching of vascular phenotypes within a murine breast cancer model induced by angiopoietin-2
    • Reiss Y, Knedla A, Tal AO, et al. Switching of vascular phenotypes within a murine breast cancer model induced by angiopoietin-2. J Pathol 2009;217:571-580.
    • (2009) J Pathol , vol.217 , pp. 571-580
    • Reiss, Y.1    Knedla, A.2    Tal, A.O.3
  • 85
    • 32244436305 scopus 로고    scopus 로고
    • Angiopoietin-2 sensitizes endothelial cells to TNF-alpha and has a crucial role in the induction of inflammation
    • Fiedler U, Reiss Y, Scharpfenecker M, et al. Angiopoietin-2 sensitizes endothelial cells to TNF-alpha and has a crucial role in the induction of inflammation. Nat Med 2006; 12:235-239.
    • (2006) Nat Med , vol.12 , pp. 235-239
    • Fiedler, U.1    Reiss, Y.2    Scharpfenecker, M.3
  • 86
    • 0038376002 scopus 로고    scopus 로고
    • Molecular regulation of vessel maturation
    • Jain RK. Molecular regulation of vessel maturation. Nat Med 2003; 9:685-693.
    • (2003) Nat Med , vol.9 , pp. 685-693
    • Jain, R.K.1
  • 87
    • 19944422751 scopus 로고    scopus 로고
    • Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: Role of oxygenation, angiopoietin-1, and matrix metalloproteinases
    • Winkler F, Kozin SV, Tong RT, et al. Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: role of oxygenation, angiopoietin-1, and matrix metalloproteinases. Cancer Cell 2004; 6:553-563.
    • (2004) Cancer Cell , vol.6 , pp. 553-563
    • Winkler, F.1    Kozin, S.V.2    Tong, R.T.3
  • 88
    • 60749124285 scopus 로고    scopus 로고
    • Angiopoietin-1/Tie-2 activation contributes to vascular survival and tumor growth during VEGF blockade
    • Huang J, Bae JO,Tsai JP, et al. Angiopoietin-1/Tie-2 activation contributes to vascular survival and tumor growth during VEGF blockade. Int J Oncol 2009; 34:79-87.
    • (2009) Int J Oncol , vol.34 , pp. 79-87
    • Huang, J.1    Bae Jotsai, J.P.2
  • 89
    • 66349133061 scopus 로고    scopus 로고
    • Angiopoietin-1 overexpression modulates vascular endothelium to facilitate tumor cell dissemination and metastasis establishment
    • Holopainen T, Huang H, Chen C, et al. Angiopoietin-1 overexpression modulates vascular endothelium to facilitate tumor cell dissemination and metastasis establishment. Cancer Res 2009; 69:4656-4664.
    • (2009) Cancer Res , vol.69 , pp. 4656-4664
    • Holopainen, T.1    Huang, H.2    Chen, C.3
  • 90
    • 48449097002 scopus 로고    scopus 로고
    • Role of myeloid cells in tumor angiogenesis and growth
    • Shojaei F, Zhong C, Wu X, et al. Role of myeloid cells in tumor angiogenesis and growth. Trends Cell Biol 2008; 18:372-378.
    • (2008) Trends Cell Biol , vol.18 , pp. 372-378
    • Shojaei, F.1    Zhong, C.2    Wu, X.3
  • 91
    • 52949148222 scopus 로고    scopus 로고
    • Tumor-targeted interferon-alpha delivery by Tie2-expressing monocytes inhibits tumor growth and metastasis
    • De Palma M, Mazzieri R, Politi LS, et al. Tumor-targeted interferon-alpha delivery by Tie2-expressing monocytes inhibits tumor growth and metastasis. Cancer Cell 2008; 14:299-311.
    • (2008) Cancer Cell , vol.14 , pp. 299-311
    • De Palma, M.1    Mazzieri, R.2    Politi, L.S.3
  • 92
    • 67651111095 scopus 로고    scopus 로고
    • A distinguishing gene signature shared by tumor-infiltrating Tie2-expressing monocytes, blood 'resident' monocytes, and embryonic macrophages suggests common functions and developmental relationships
    • Pucci F, Venneri MA, Biziato D, et al. A distinguishing gene signature shared by tumor-infiltrating Tie2-expressing monocytes, blood 'resident' monocytes, and embryonic macrophages suggests common functions and developmental relationships. Blood 2009; 114:901-914.
    • (2009) Blood , vol.114 , pp. 901-914
    • Pucci, F.1    Venneri, M.A.2    Biziato, D.3
  • 93
    • 60649087564 scopus 로고    scopus 로고
    • Accelerated metastasis after short-term treatment with a potent inhibitor of tumor angiogenesis
    • Ebos JM, Lee CR, Cruz-Munoz W, et al. Accelerated metastasis after short-term treatment with a potent inhibitor of tumor angiogenesis. Cancer Cell 2009; 15:232-239.
    • (2009) Cancer Cell , vol.15 , pp. 232-239
    • Ebos, J.M.1    Lee, C.R.2    Cruz-Munoz, W.3
  • 94
    • 60649106195 scopus 로고    scopus 로고
    • Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis
    • Paez-Ribes M, Allen E, Hudock J, et al. Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis. Cancer Cell 2009; 15:220-231.
    • (2009) Cancer Cell , vol.15 , pp. 220-231
    • Paez-Ribes, M.1    Allen, E.2    Hudock, J.3
  • 95
    • 77549088772 scopus 로고    scopus 로고
    • Pathways mediating VEGF-independent tumor angiogenesis
    • [Epub ahead of print]
    • Ferrara N. Pathways mediating VEGF-independent tumor angiogenesis. Cytokine Growth Factor Rev [Epub ahead of print]
    • Cytokine Growth Factor Rev
    • Ferrara, N.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.