Biological action of angiopoietin-2 in a fibrin matrix model of angiogenesis is associated with activation of Tie2

Cardiovascular Research

Volumn 49, Issue 3, 2001, Pages 659-670

  Teichert Kuliszewska, Krystyna ^a   Maisonpierre, Peter C ^b   Jones, Nina ^c   Campbell, Andrew I M ^a   Master, Zubin ^c   Bendeck, Michelle P ^a   Alitalo, Kari ^d   Dumont, Daniel J ^c   Yancopoulos, George D ^b   Stewart, Duncan J ^a  

^a ST MICHAEL'S HOSPITAL   (Canada)

^b REGENERON PHARMACEUTICALS INC   (United States)

^c UNIVERSITY OF TORONTO   (Canada)

^d UNIVERSITY OF HELSINKI   (Finland)

Author keywords

Angiogenesis; Cell culture isolation; Endothelial receptors; Extracellular matrix

Indexed keywords

ANGIOPOIETIN 1; ANGIOPOIETIN 2; TYROSINE KINASE RECEPTOR;

ANGIOGENESIS; ARTICLE; CELL CULTURE; CELL DIFFERENTIATION; ENDOTHELIUM CELL; EXTRACELLULAR MATRIX; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION;

ANALYSIS OF VARIANCE; ANGIOPOIETIN-1; ANGIOPOIETIN-2; ANIMALS; AORTA; BLOTTING, WESTERN; CELL DIFFERENTIATION; CELL DIVISION; CELL LINE; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM, VASCULAR; ENZYME INHIBITORS; GELS; GENE TRANSFER TECHNIQUES; HUMANS; MEMBRANE GLYCOPROTEINS; MODELS, BIOLOGICAL; MUSCLE, SMOOTH, VASCULAR; NEOPLASM PROTEINS; NEOVASCULARIZATION, PHYSIOLOGIC; PROTEINS; PROTO-ONCOGENE PROTEINS; RATS; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTOR, TIE-2;

EID: 0035895712     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0008-6363(00)00231-5     Document Type: Article

References (43)

1. Mechanism of angiogenesis
2. Blood vessel formation: What is its molecular basis?
3. Signaling vascular morphogenesis and maintenance
4. Angiogenesis in cancer, vascular, rheumatoid and other disease
5. A novel endothelial cell surface receptor tyrosine kinase with extracellular epidermal growth factor homology domains
6. Vascularization of the mouse embryo: A study of flk-1, tek, tie and vascular endothelial growth factor expression during development
7. Tek, a novel tyrosine kinase gene located on mouse chromosome 4, is expressed in endothelial cells and their presumptive precursors
8. The endothelial-specific receptor tyrosine kinase, tek, is a member of a new subfamily of receptors
9. Dominant-negative and targeted null mutations in the endothelial receptor tyrosine kinase, tek, reveal a critical role in vasculogenesis of the embryo
10. The Tek/Tie2 receptor signals through a novel Dok-related docking protein, Dok-R
11. The mouse tie receptor tyrosine kinase gene: Expression during embryonic angiogenesis
12. Expression of tie-2,a member of a novel family of receptor tyrosine kinases, in the endothelial cell lineage
13. The receptor tyrosine kinase TIE is required for integrity and survival of vascular endothelial cells
14. Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation
15. TIE1 and TIE2 receptor tyrosine kinases inversely regulate embryonic angiogenesis by the mechanism of intussusceptive microvascular growth
16. Characterization of TEK receptor tyrosine kinase and its ligands, angiopoietin, in human hematopoietic progenitor cells
17. Endothelial receptor tyrosine kinases involved in angiogenesis
18. Distinct rat genes with related profiles of expression define a Tie receptor tyrosine kinase family
19. Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning
20. Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis
21. Requisite role of Angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis
22. Tie2 receptor ligands, angiopoietin-1, and angiopoietin-2, modulate VEGF-induced postnatal neovascularization
23. Cell type-specific expression of angiopoietin-1 and angiopoietin-2 suggests a role in glioblastoma angiogenesis
24. Hypoxia and vascular endothelial growth factor selectively upregulate angiopoietin-2 in bovine microvascular endothelial cells
25. Biological significance of angiopoietin-2 expression in human hepatocellular carcinoma
26. Reciprocal regulation of angiopoietin-1 and angiopoietin-2 following myocardial infarction
27. Direct action of angiopoietin-1 on human endothelium: Evidence for network stabilization, cell survival, and interaction with other angiogenic growth factors
28. Angiopoietin-1 and its receptor Tie2 participate in the regulation of capillary-like tubule formation and survival of endothelial cells
29. Angiopoietin-1 induces sprouting angiogenesis in vitro
30. Identification of Tek/Tie2 binding partners
31. The angiopoietins: Yin and Yang in angiogenesis
32. Role of nitric oxide in the angiogenic response in vitro to basic fibroblast growth factor
33. Coiled coils: New structures and new function
34. Angiopoietin 3 and 4: Diverging gene counterparts in mice and humans
35. Receptor- and heparin-binding domains of basic fibroblast growth factor
36. Is angiopoietin-2 necessary for the initiation of tumor angiogenesis?
37. Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF
38. Regulation of angiopoietin-2 mRNA levels in bovine microvascular endothelial cells by cytokines and hypoxia
39. Vascular endothelial growth factor and angiopoietins working together to build a better blood vessel
40. Direct intramuscular injection of plasmid DNA encoding angiopoietin-1 but not angiopoietin-2 augments revascularization in the rabbit ischemic hindlimb
41. Tyrosine 1101 of Tie2 is the major site of association of p85 and is required for activation of phosphatidylinositol 3-kinase and Akt
42. Angiopoietin-1 regulates endothelial cell survival through the phosphatidylinositol 3′-kinase/Akt signal transduction pathway
43. Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation