Effects of FTY720, a novel immunosuppressant, on experimental autoimmune uveoretinitis in rats

Experimental Eye Research

Volumn 70, Issue 1, 2000, Pages 7-15

  Kurose, Shinichi ^a   Ikeda, Eiko ^a   Tokiwa, Mitsunori ^b   Hikita, Naofumi ^a   Mochizuki, Manabu ^a,c  

^a KURUME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b KURUME UNIVERSITY HOSPITAL   (Japan)

^c TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

Experimental autoimmune uveoretinitis; FTY720; Immunosuppressant; Rats; Retinal S antigen

Indexed keywords

FINGOLIMOD; RETINA S ANTIGEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOIMMUNITY; CONTROLLED STUDY; DRUG EFFICACY; HISTOPATHOLOGY; IMMUNOSUPPRESSIVE TREATMENT; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; UVEORETINITIS;

EID: 0033980334     PISSN: 00144835     EISSN: None     Source Type: Journal    
DOI: 10.1006/exer.1999.0777     Document Type: Article

References (21)

1. Adachi K., Kohara T., Nakao N., Arita M., Chiba K., Mishina T., Sasaki S., Fujita T. Design, synthesis, and structure-activity relationships of 2-substituted-2-amino-1, 3-propanediols: discovery of a novel immunosuppressant, FTY720. Bioorg. Med. Chem. Lett. 5:1995;853-856.
2. Chiba K., Hoshino Y., Suzuki C., Masubuchi Y., Yanagawa Y., Ohtsuki M., Sasaki S., Fujita T. FTY720, a novel immunosuppressant possessing unique mechanisms. I. Prolongation of skin allograft survival and synergistic effect in combination with cyclosporine in rats. Transplant. Proc. 28:1996;1056-1059.
3. Chiba K., Adachi K. FTY720. Drugs Fut. 22:1997;18-22.
4. Chiba K., Yanagawa Y., Masubuchi Y., Kataoka H., Kawaguchi T., Ohtsuki M., Hoshino Y. FTY720, a novel immunosuppressant, induces sequestration of circulating mature lymphocytes by acceleration of lymphocyte homing in rats. I. FTY720 selectively decreases the number of circulation mature lymphocytes by acceleration of lymphocyte homing. J. Immunol. 160:1998;5037-5044.
5. Dorey C., Cozette J., Faure J. P. A simple and rapid method for isolation of retinal S-antigen. Ophthalmic Res. 14:1982;249-255.
6. Enosawa S., Suzuki S., Kakefuda T., Li X.-K., Amemiy H. Induction of selective cell death targeting on mature T-lymphocytes in rats by a novel immunosuppressant, FTY720. Immunopharmacology. 34:1996;171-179.
7. Fujino Y., Kawashima H., Okumura A., Mochizuki M. Purification and uveogenicity of retinal antigens. Acta Soc. Ophthalmol. Jpn. 91:1987;498-508.
8. Fujita T., Inoue K., Yamamoto S., Ikumoto T., Sasaki S., Toyama R., Chiba K., Hoshino Y., Okumoto T. Fungal metabolites. Part II. A potent immunosuppressive activity found in Isaria sinclairii metabolite. J. Antibiot. 47:1994;208-215.
9. Fujita T., Yoneta M., Hirose R., Sasaki S., Inoue K., Kiuchi M., Hirase S., Adachi K., Arita M., Chiba K. Simple compounds, 2-alkyl-2-amino-1, 3-propanediols have potent immunopressive activity. Bioorg. Med. Chem. Lett. 5:1995;847-852.
10. Hoshino Y., Suzuki C., Ohtsuki M., Masubuchi Y., Amano Y., Chiba K. FTY720, a novel immunosuppressant possessing unique mechanisms. II. Long-term graft survival induction in rat heterotopic cardiac allografts and synergistic effect in combination with cyclosporine A. Transplant. Proc. 28:1996;1060-1061.
11. Kawaguchi T., Hoshino Y., Rahman F., Amano Y., Higashi H., Kataoka H., Ohtsuki M., Teshima K., Chiba K., Kakefuda T., Suzuki S. FTY720, a novel immunosuppressant possessing unique mechanisms. III. Synergistic prolongation of canine renal allograft survival in combination with cyclosporine A. Transplant. Proc. 28:1996;1062-1063.
12. Kawashima H., Fujino Y., Mochizuki M. Effects of a new immunosuppressive agent, FK506, on experimental autoimmune uveoretinitis in rats. Invest. Ophthalmol. Vis. Sci. 29:1998;1265-1271.
13. Masubuchi Y., Kawaguchi T., Ohtsuki M., Suzuki C., Amano Y., Hoshino Y., Chiba K. FTY720, a novel immunosuppressant, possessing unique mechanisms. IV. Prevention of graft versus host reactions in rats. Transplant. Proc. 28:1996;1064-1065.
14. Mochizuki M., Nussenblatt R. B., Kuwabara T., Gery I. Effects of cyclosporine and other immunosuppressive drugs on experimental autoimmune uveoretinitis in rats. Invest. Ophthalmol. Vis. Sci. 26:1985;226-232.
15. Mochizuki M., Kawashima H. Effects of FK506, 15-deoxyspergualin, and cyclosporine on experimental autoimmune uveoretinitis in the rat. Autoimmunity. 8:1990;37-41.
16. Sawa K., Mochizuki M. Effects of bucillamine, a new anti-rheumatic drug, on the experimental autoimmune uveoretinitis in rats. Exp. Eye Res. 58:1994;431-438.
17. Suzuki S., Enosawa S., Kakefuda T., Shinomiya T., Amari M., Naoe S., Hoshino Y., Chiba K. A novel immunosuppressant, FTY720, with a unique mechanism of action, induces long-term graft acceptance in rat and dog allotransplantation. Transplantation. 61:1996a;200-205.
18. Suzuki S., Enosawa S., Kakefuda T., Li X.-K., Mitsusada M., Takahara S., Amemiya H. Immunosuppressive effect of a new drug, FTY720, on lymphocyte responses in vitro and cardiac allograft survival in rats. Transplant Immunol. 4:1996b;252-255.
19. Suzuki S., Enosawa S., Kakefuda T., Amemiya H., Hoshino Y., Chiba K. Long-term graft acceptance in allografted rats and dogs by treatment with a novel immunosuppressant, FTY720. Transplant. Proc. 28:1996c;1375-1376.
20. Suzuki S., Li X.-K., Shinomiya T., Enosawa S., Kakefuda T., Mitsusada M., Amemiya H., Takahara S., Amari M., Naoe S., Hoshino Y., Chiba K. Transplant. Proc. 28:1996d;2049-2050.
21. Yanagawa Y., Sugahara K., Kataoka H., Kawaguchi T., Masubuchi Y., Chiba K. FTY720, a novel immunosuppressant, induces sequestration of circulating mature lymphocytes by acceleration of lymphocyte homing in rats. II. FTY720 prolongs skin allograft survival by decreasing T cell infiltration into grafts but not cytokine production in vivo. J. Immunol. 160:1998;5493-5499.