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Volumn 11, Issue 7, 2010, Pages 1053-1067

Adjunctive antiepileptic drugs in adult epilepsy: How the first add-on could be the last

Author keywords

Adjunctive; Antiepileptic drug; Epilepsies; Treatment

Indexed keywords

ACETAZOLAMIDE; BENZODIAZEPINE; CARBAMAZEPINE; CLOBAZAM; ETHOSUXIMIDE; ETIRACETAM; GABAPENTIN; HARKOSERIDE; LAMOTRIGINE; OXCARBAZEPINE; PHENOBARBITAL; PHENYTOIN; PLACEBO; PREGABALIN; PROGABIDE; TIAGABINE; TOPIRAMATE; VALPROIC ACID; VIGABATRIN; ZONISAMIDE;

EID: 77951264257     PISSN: 14656566     EISSN: None     Source Type: Journal    
DOI: 10.1517/14656561003709755     Document Type: Review
Times cited : (11)

References (91)
  • 1
    • 0026778230 scopus 로고
    • Prevalence of epilepsy in adults in northern Sweden
    • Forsgren L. Prevalence of epilepsy in adults in northern Sweden. Epilepsia 1992;33(3):450-458
    • (1992) Epilepsia , vol.33 , Issue.3 , pp. 450-458
    • Forsgren, L.1
  • 3
    • 16444364594 scopus 로고    scopus 로고
    • The epidemiology of epilepsy in Europe - A systematic review
    • DOI 10.1111/j.1468-1331.2004.00992.x
    • Forsgren L, Beghi E, Oun A, et al. The epidemiology of epilepsy in Europe--a systematic review. Eur J Neurol 2005;12(4):245-253 (Pubitemid 40477131)
    • (2005) European Journal of Neurology , vol.12 , Issue.4 , pp. 245-253
    • Forsgren, L.1    Beghi, E.2    Oun, A.3    Sillanpaa, M.4
  • 4
    • 0029046786 scopus 로고
    • Remission of epilepsy: Results from the National General Practice Study of Epilepsy
    • Cockerell OC, Johnson AL, Sander JW, et al. Remission of epilepsy: results from the National General Practice Study of Epilepsy. Lancet 1995;346(8968):140-144
    • (1995) Lancet , vol.346 , Issue.8968 , pp. 140-144
    • Cockerell, O.C.1    Johnson, A.L.2    Sander, J.W.3
  • 5
    • 0021887675 scopus 로고
    • Comparison of carbamazepine, phenobarbital, phenytoin, and primidone in partial and secondarily generalized tonic-clonic seizures
    • Mattson RH, Cramer JA, Collins JF, et al. Comparison of carbamazepine, phenobarbital, phenytoin, and primidone in partial and secondarily generalized tonic-clonic seizures. N Engl J Med 1985;313:145-151
    • (1985) N Engl J Med , vol.313 , pp. 145-151
    • Mattson, R.H.1    Cramer, J.A.2    Collins, J.F.3
  • 6
    • 70350459429 scopus 로고    scopus 로고
    • Seizure relapse and development of drug resistance following long-term seizure remission
    • Schiller Y. Seizure relapse and development of drug resistance following long-term seizure remission. Arch Neurol 2009;66(10):1233-1239
    • (2009) Arch Neurol , vol.66 , Issue.10 , pp. 1233-1239
    • Schiller, Y.1
  • 7
    • 33746124186 scopus 로고    scopus 로고
    • ILAE treatment guidelines: Evidence-based analysis of antiepileptic drug efficacy and effectiveness as initial monotherapy for epileptic seizures and syndromes
    • DOI 10.1111/j.1528-1167.2006.00585.x
    • Glauser T, Ben-Menachem E, Bourgeois B, et al. ILAE treatment guidelines: evidence-based analysis of antiepileptic drug efficacy and effectiveness as initial monotherapy for epileptic seizures and syndromes. Epilepsia 2006;47(7):1094-1120 (Pubitemid 44086745)
    • (2006) Epilepsia , vol.47 , Issue.7 , pp. 1094-1120
    • Glauser, T.1    Ben-Menachem, E.2    Bourgeois, B.3    Cnaan, A.4    Chadwick, D.5    Guerreiro, C.6    Kalviainen, R.7    Mattson, R.8    Perucca, E.9    Tomson, T.10
  • 8
    • 3042798891 scopus 로고    scopus 로고
    • The neurobiology of antiepileptic drugs
    • Rogawski MA, L€oscher W. The neurobiology of antiepileptic drugs. Nat Rev Neurosci 2004;5(7):553-564 (Pubitemid 38868551)
    • (2004) Nature Reviews Neuroscience , vol.5 , Issue.7 , pp. 553-564
    • Rogawski, M.A.1    Loscher, W.2
  • 9
    • 0036113278 scopus 로고    scopus 로고
    • Les nouveaux anti-épileptiques: 10 Ans apre
    • Baulac M. New antiepileptic drugs: new therapeutic options. Rev Neurol (Paris) 2002;158(5 Pt 2):4S46-54 (Pubitemid 34534846)
    • (2002) Revue Neurologique , vol.158 , Issue.II5
    • Baulac, M.1
  • 11
    • 33947241772 scopus 로고    scopus 로고
    • The SANAD study of effectiveness of carbamazepine gabapentin lamotrigine oxcarbazepine or topiramate for treatment of partial epilepsy: An unblinded randomised controlled trial
    • SANAD Study group
    • Marson AG, Al-Kharusi AM, Alwaidh M, et al.; SANAD Study group. The SANAD study of effectiveness of carbamazepine, gabapentin, lamotrigine, oxcarbazepine, or topiramate for treatment of partial epilepsy: an unblinded randomised controlled trial. Lancet 2007;369(9566):1000-1015
    • (2007) Lancet , vol.369 , Issue.9566 , pp. 1000-1015
    • Marson, A.G.1    Al-Kharusi, A.M.2    Alwaidh, M.3
  • 12
    • 33846850154 scopus 로고    scopus 로고
    • Comparison of levetiracetam and controlled-release carbamazepine in newly diagnosed epilepsy
    • DOI 10.1212/01.wnl.0000252941.50833.4a, PII 0000611420070206000006
    • Brodie MJ, Perucca E, Ryvlin P, et al.; Levetiracetam Monotherapy Study Group. Comparison of levetiracetam and controlled-release carbamazepine in newly diagnosed epilepsy. Neurology 2007;68(6):402-408 (Pubitemid 46208740)
    • (2007) Neurology , vol.68 , Issue.6 , pp. 402-408
    • Brodie, M.J.1    Perucca, E.2    Ryvlin, P.3    Ben-Menachem, E.4    Meencke, H.-J.5
  • 13
    • 0027999211 scopus 로고
    • Valproate in the treatment of partial epilepsies
    • Chadwick D. Valproate in the treatment of partial epilepsies. Epilepsia 1994;35(Suppl 5):S96-8 (Pubitemid 24274714)
    • (1994) Epilepsia , vol.35 , Issue.SUPPL. 5
    • Chadwick, D.1
  • 14
    • 0022973221 scopus 로고
    • A comparative study of progabide, valproate, and placebo as add-on therapy in patients with refractory epilepsy
    • Crawford P, Chadwick D. A comparative study of progabide, valproate, and placebo as add-on therapy in patients with refractory epilepsy. J Neurol Neurosurg Psychiatry 1986;49(11):1251-1257 (Pubitemid 17174026)
    • (1986) Journal of Neurology Neurosurgery and Psychiatry , vol.49 , Issue.11 , pp. 1251-1257
    • Crawford, P.1    Chadwick, D.2
  • 15
    • 0032891687 scopus 로고    scopus 로고
    • Double-blind substitution of vigabatrin and valproate in carbamazepine-resistant partial epilepsy
    • 012 Study group
    • Brodie MJ, Mumford JP. Double-blind substitution of vigabatrin and valproate in carbamazepine-resistant partial epilepsy. 012 Study group. Epilepsy Res 1999;34(2-3):199-205
    • (1999) Epilepsy Res , vol.34 , Issue.2-3 , pp. 199-205
    • Brodie, M.J.1    Mumford, J.P.2
  • 16
    • 0029884831 scopus 로고    scopus 로고
    • Efficacy and safety of add-on divalproex sodium in the treatment of complex partial seizures
    • Willmore LJ, Shu V, Wallin B. Efficacy and safety of add-on divalproex sodium in the treatment of complex partial seizures. The M88-194 Study Group. Neurology 1996;46(1):49-53 (Pubitemid 26156101)
    • (1996) Neurology , vol.46 , Issue.1 , pp. 49-53
    • Willmore, L.J.1    Shu, V.2    Wallin, B.3
  • 18
    • 0033761218 scopus 로고    scopus 로고
    • Selection of antiepileptic drug polytherapy based on mechanisms of action: The evidence reviewed
    • Deckers CL, Czuczwar SJ, Hekster YA, et al. Selection of antiepileptic drug polytherapy based on mechanisms of action: the evidence reviewed. Epilepsia 2000;41(11):1364-1374
    • (2000) Epilepsia , vol.41 , Issue.11 , pp. 1364-1374
    • Deckers, C.L.1    Czuczwar, S.J.2    Hekster, Y.A.3
  • 20
    • 34447344551 scopus 로고    scopus 로고
    • Efficacy and safety of oral lacosamide as adjunctive therapy in adults with partial-onset seizures
    • DOI 10.1111/j.1528-1167.2007.01188.x
    • Ben-Menachem E, Biton V, Jatuzis D, et al. Efficacy and safety of oral lacosamide as adjunctive therapy in adults with partialonset seizures. Epilepsia 2007;48:1308-1317 (Pubitemid 47063096)
    • (2007) Epilepsia , vol.48 , Issue.7 , pp. 1308-1317
    • Ben-Menachem, E.1    Biton, V.2    Jatuzis, D.3    Abou-Khalil, B.4    Doty, P.5    Rudd, G.D.6
  • 21
    • 0027491284 scopus 로고
    • Placebo-controlled study of the efficacy and safety of lamotrigine in patients with partial seizures: U.S Lamotrigine Protocol 0.5 Clinical Trial Group
    • Matsuo F, Bergen D, Faught E, et al. Placebo-controlled study of the efficacy and safety of lamotrigine in patients with partial seizures: U.S. Lamotrigine Protocol 0.5 Clinical Trial Group. Neurology 1993;43(11):2284-2291
    • (1993) Neurology , vol.43 , Issue.11 , pp. 2284-2291
    • Matsuo, F.1    Bergen, D.2    Faught, E.3
  • 24
    • 11144353969 scopus 로고    scopus 로고
    • Efficacy and tolerability of the new antiepileptic drugs ii: Treatment of refractory epilepsy: Report of the therapeutics and technology assessment subcommittee and quality standards subcommittee of the american academy of neurology and the american epilepsy society
    • Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology; Quality Standards Subcommittee of the American Academy of Neurology; American Epilepsy Society
    • French JA, Kanner AM, Bautista J, et al. Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology; Quality Standards Subcommittee of the American Academy of Neurology; American Epilepsy Society. Efficacy and tolerability of the new antiepileptic drugs II: treatment of refractory epilepsy: report of the Therapeutics and Technology Assessment Subcommittee and Quality Standards Subcommittee of the American Academy of Neurology and the American Epilepsy Society. Neurology 2004;62(8):1261-1273
    • (2004) Neurology , vol.62 , Issue.8 , pp. 1261-1273
    • French, J.A.1    Kanner, A.M.2    Bautista, J.3
  • 25
    • 0032773248 scopus 로고    scopus 로고
    • Adding lamotrigine to valproate: Incidence of rash and other adverse effects
    • DOI 10.1111/j.1528-1157.1999.tb00831.x
    • Faught E, Morris G, Jacobson M, et al. Adding lamotrigine to valproate: incidence of rash and other adverse effects. Postmarketing Antiepileptic Drug Survey (PADS) Group. Epilepsia 1999;40(8):1135-1140 (Pubitemid 29372630)
    • (1999) Epilepsia , vol.40 , Issue.8 , pp. 1135-1140
    • Faught, E.1    Morris, G.2    Jacobson, M.3    French, J.4    Harden, C.5    Montouris, G.6    Rosenfeld, W.7
  • 26
    • 0029857729 scopus 로고    scopus 로고
    • Lamotrigine: Clinical experience in 200 patients with epilepsy with follow-up to four years
    • DOI 10.1016/S1059-1311(96)80038-0
    • Buchanan N. Lamotrigine: clinical experience in 200 patients with epilepsy with follow-up to four years. Seizure 1996;5(3):209-214 (Pubitemid 26345844)
    • (1996) Seizure , vol.5 , Issue.3 , pp. 209-214
    • Buchanan, N.1
  • 27
    • 0030975686 scopus 로고    scopus 로고
    • Lamotrigine substitution study: Evidence for synergism with sodium valproate?
    • 105 Study Group
    • Brodie MJ, Yuen AW. Lamotrigine substitution study: evidence for synergism with sodium valproate? 105 Study Group. Epilepsy Res 1997;26(3):423-432
    • (1997) Epilepsy Res , vol.26 , Issue.3 , pp. 423-432
    • Brodie, M.J.1    Yuen, A.W.2
  • 29
    • 33846194013 scopus 로고    scopus 로고
    • Progress report on new antiepileptic drugs: A summary of the Eigth Eilat Conference (EILAT VIII)
    • DOI 10.1016/j.eplepsyres.2006.10.008, PII S0920121106004244
    • Bialer M, Johannessen SI, Kupferberg HJ, et al. Progress report on new antiepileptic drugs: a summary of the Eigth Eilat Conference (EILAT VIII). Epilepsy Res 2007;73:1-52 (Pubitemid 46091734)
    • (2007) Epilepsy Research , vol.73 , Issue.1 , pp. 1-52
    • Bialer, M.1    Johannessen, S.I.2    Kupferberg, H.J.3    Levy, R.H.4    Perucca, E.5    Tomson, T.6
  • 30
    • 34447344551 scopus 로고    scopus 로고
    • Efficacy and safety of oral lacosamide as adjunctive therapy in adults with partial-onset seizures
    • DOI 10.1111/j.1528-1167.2007.01188.x
    • Chung S, Sperling MR, Biton V, et al. Lacosamide: efficacy and safety as oral adjunctive treatment for partial-onset seizures. Epilepsia 2007;48:321 (Pubitemid 47063096)
    • (2007) Epilepsia , vol.48 , Issue.7 , pp. 1308-1317
    • Ben-Menachem, E.1    Biton, V.2    Jatuzis, D.3    Abou-Khalil, B.4    Doty, P.5    Rudd, G.D.6
  • 31
    • 61849088333 scopus 로고    scopus 로고
    • Adjunctive lacosamide for partial-onset seizures: Efficacy and safety results from a randomized controlled trial
    • SP755 Study Group
    • Halász P, Kälviäinen R, Mazurkiewicz-Beldzińska M, et al. SP755 Study Group. Adjunctive lacosamide for partial-onset seizures: efficacy and safety results from a randomized controlled trial. Epilepsia 2009;50(3):443-453
    • (2009) Epilepsia , vol.50 , Issue.3 , pp. 443-453
    • Halász, P.1    Kälviäinen, R.2    Mazurkiewicz-Beldzińska, M.3
  • 32
    • 0028041242 scopus 로고
    • Gabapentin (Neurontin) as add-on therapy in patients with partial seizures: A doubleblind, placebo-controlled study: The international gabapentin study group
    • Anhut H, Ashman P, Feuerstein TJ, et al. Gabapentin (Neurontin) as add-on therapy in patients with partial seizures: a doubleblind, placebo-controlled study: the International Gabapentin Study Group. Epilepsia 1994;35:795-801
    • (1994) Epilepsia , vol.35 , pp. 795-801
    • Anhut, H.1    Ashman, P.2    Feuerstein, T.J.3
  • 33
    • 0025343921 scopus 로고
    • Gabapentin in partial epilepsy
    • UK Gabapentin Study Group
    • UK Gabapentin Study Group. Gabapentin in partial epilepsy. Lancet 1990;335:1114-1117
    • (1990) Lancet , vol.335 , pp. 1114-1117
  • 34
    • 0027374164 scopus 로고
    • Gabapentin as add-on therapy in refractory partial epilepsy: A double-blind, placebocontrolled, parallel-group study
    • The US Gabapentin Study Group No. 5
    • The US Gabapentin Study Group No. 5. Gabapentin as add-on therapy in refractory partial epilepsy: a double-blind, placebocontrolled, parallel-group study. Neurology 1993;43:2292-2298
    • (1993) Neurology , vol.43 , pp. 2292-2298
  • 35
    • 0026095572 scopus 로고
    • Double-blind study of Gabapentin in the treatment of partial seizures
    • Sivenius J, Kalviainen R, Ylinen A, et al. Double-blind study of Gabapentin in the treatment of partial seizures. Epilepsia 1991;32:539-542
    • (1991) Epilepsia , vol.32 , pp. 539-542
    • Sivenius, J.1    Kalviainen, R.2    Ylinen, A.3
  • 36
    • 0038476172 scopus 로고    scopus 로고
    • Dose-response trial of pregabalin adjunctive therapy in patients with partial seizures
    • French JA, Kugler AR, Robbins JL, et al. Dose--response trial of pregabalin adjunctive therapy in patients with partial seizures. Neurology 2003;60:1631-1637 (Pubitemid 36618090)
    • (2003) Neurology , vol.60 , Issue.10 , pp. 1631-1637
    • French, J.A.1    Kugler, A.R.2    Robbins, J.L.3    Knapp, L.E.4    Garofalo, E.A.5
  • 37
    • 0347985301 scopus 로고    scopus 로고
    • Pregabalin add-on treatment: A randomized, double-blind, placebo-controlled, dose-response study in adults with partial seizures
    • DOI 10.1111/j.0013-9580.2004.31203.x
    • Arroyo S, Anhut H, Kugler AR, et al. Pregabalin add-on treatment: a randomized, double-blind, placebo-controlled, dose--response study in adults with partial seizures. Epilepsia 2004;45:20-27 (Pubitemid 38063660)
    • (2004) Epilepsia , vol.45 , Issue.1 , pp. 20-27
    • Arroyo, S.1    Anhut, H.2    Kugler, A.R.3    Lee, C.M.4    Knapp, L.E.5    Garofalo, E.A.6    Messmer, S.7
  • 38
    • 13244277459 scopus 로고    scopus 로고
    • Safety and efficacy of two pregabalin regimens for add-on treatment of partial epilepsy
    • Beydoun A, Uthman BM, Kugler AR, et al. Pregabalin 1008-009 Study Group. Safety and efficacy of two pregabalin regimens for add-on treatment of partial epilepsy. Neurology 2005;64:475-480 (Pubitemid 40189866)
    • (2005) Neurology , vol.64 , Issue.3 , pp. 475-480
    • Beydoun, A.1    Uthman, B.M.2    Kugler, A.R.3    Greiner, M.J.4    Knapp, L.E.5    Garofalo, E.A.6
  • 39
    • 27744434295 scopus 로고    scopus 로고
    • Pregabalin add-on treatment in patients with partial seizures: A novel evaluation of flexible-dose and fixed-dose treatment in a double-blind, placebo-controlled study
    • DOI 10.1111/j.1528-1167.2005.00341.x
    • Elger CE, Brodie MJ, Anhut H, et al. Pregabalin add-on treatment in patients with partial seizures: a novel evaluation of flexible-dose and fixeddose treatment in a double-blind, placebo-controlled study. Epilepsia 2005;46:1926-1936 (Pubitemid 44922003)
    • (2005) Epilepsia , vol.46 , Issue.12 , pp. 1926-1936
    • Elger, C.E.1    Brodie, M.J.2    Anhut, H.3    Lee, C.M.4    Barrett, J.A.5
  • 40
    • 0032812841 scopus 로고    scopus 로고
    • A beneficial effect on mood in partial epilepsy patients treated with gabapentin
    • Harden CL, Lazar LM, Pick LH, et al. A beneficial effect on mood in partial epilepsy patients treated with gabapentin. Epilepsia 1999;40(8):1129-1134
    • (1999) Epilepsia , vol.40 , Issue.8 , pp. 1129-1134
    • Harden, C.L.1    Lazar, L.M.2    Pick, L.H.3
  • 41
    • 61349152335 scopus 로고    scopus 로고
    • Add-on treatment with pregabalin for partial seizures with or without generalisation: Pooled data analysis of four randomised placebo-controlled trials
    • Gil-Nagel A, Zaccara G, Baldinetti F, et al. Add-on treatment with pregabalin for partial seizures with or without generalisation: pooled data analysis of four randomised placebo-controlled trials. Seizure 2009;18(3):184-192
    • (2009) Seizure , vol.18 , Issue.3 , pp. 184-192
    • Gil-Nagel, A.1    Zaccara, G.2    Baldinetti, F.3
  • 42
    • 0024502448 scopus 로고
    • Use of acetazolamide as an adjunct to carbamazepine in refractory partial seizures
    • Oles KS, Penry JK, Cole DL, et al. Use of acetazolamide as an adjunct to carbamazepine in refractory partial seizures. Epilepsia 1989;30(1):74-78
    • (1989) Epilepsia , vol.30 , Issue.1 , pp. 74-78
    • Oles, K.S.1    Penry, J.K.2    Cole, D.L.3
  • 44
    • 0029922566 scopus 로고    scopus 로고
    • Topiramate placebo-controlled dose-ranging trial in refractory partial epilepsy using 200-, 400-, and 600-mg daily dosages
    • Faught E, Wilder BJ, Ramsay RE, et al. Topiramate placebocontrolled dose-ranging trial in refractory partial epilepsy using 200-, 400-, and 600-mg daily dosages: Topiramate YD Study Group. Neurology 1996;46:1684-1690 (Pubitemid 26185793)
    • (1996) Neurology , vol.46 , Issue.6 , pp. 1684-1690
    • Faught, E.1    Wilder, B.J.2    Ramsay, R.E.3    Reife, R.A.4    Kramer, L.D.5    Pledger, G.W.6    Karim, R.M.7
  • 45
    • 0029884747 scopus 로고    scopus 로고
    • Topiramate placebo-controlled dose-ranging trial in refractory partial epilepsy using 600-, 800-, and 1,000-mg daily dosages
    • Privitera M, Fincham R, Penry J, et al. Topiramate placebocontrolled dose-ranging trial in refractory partial epilepsy using 600-, 800-, and 1,000 mg daily dosages: Topiramate YE Study Group. Neurology 1996;46:1678-1683 (Pubitemid 26185792)
    • (1996) Neurology , vol.46 , Issue.6 , pp. 1678-1683
    • Privitera, M.1    Fincham, R.2    Penry, J.3    Reife, R.4    Kramer, L.5    Pledger, G.6    Karim, R.7
  • 48
    • 0035960602 scopus 로고    scopus 로고
    • Randomized controlled trial of zonisamide for the treatment of refractory partial-onset seizures
    • Faught E, Ayala R, Montouris G, et al. The Zonisamide 922 Trial Group. Randomized controlled trial of zonisamide for the treatment of refractory partial-onset seizures. Neurology 2001;57:1774-1779 (Pubitemid 33096682)
    • (2001) Neurology , vol.57 , Issue.10 , pp. 1774-1779
    • Faught, E.1    Ayala, R.2    Montouris, G.G.3    Leppik, I.E.4
  • 49
    • 3042636758 scopus 로고    scopus 로고
    • Randomized, controlled clinical trial of zonisamide as adjunctive treatment for refractory partial seizures
    • Sackellares JC, Ramsay RE, Wilder BJ, et al. Randomized, controlled clinical trial of zonisamide as adjunctive treatment for refractory partial seizures. Epilepsia 2004;45:610-617
    • (2004) Epilepsia , vol.45 , pp. 610-617
    • Sackellares, J.C.1    Ramsay, R.E.2    Wilder, B.J.3
  • 50
    • 46049117310 scopus 로고    scopus 로고
    • Seizure termination by acidosis depends on ASIC1a
    • Ziemann AE, Schnizler MK, Albert GW, et al. Seizure termination by acidosis depends on ASIC1a. Nat Neurosci 2008;11(7):816-822
    • (2008) Nat Neurosci , vol.11 , Issue.7 , pp. 816-822
    • Ziemann, A.E.1    Schnizler, M.K.2    Albert, G.W.3
  • 51
    • 0037477783 scopus 로고    scopus 로고
    • Acetazolamide and autosomal dominant nocturnal frontal lobe epilepsy [1]
    • DOI 10.1046/j.1528-1157.2003.53002.x
    • Varadkar S, Duncan JS, Cross JH. Acetazolamide and autosomal dominant nocturnal frontal lobe epilepsy. Epilepsia 2003;44(7):986-987 (Pubitemid 36842193)
    • (2003) Epilepsia , vol.44 , Issue.7 , pp. 986-987
    • Varadkar, S.1    Duncan, J.S.2    Cross, J.H.3
  • 52
    • 0000777467 scopus 로고
    • Further evaluation of acetazolamide (Diamox) in treatment of epilepsy
    • Lombroso CT, Davidson DT Jr, Gross-Bianchi ML. Further evaluation of acetazolamide (Diamox) in treatment of epilepsy. JAMA 1956;160:268-272
    • (1956) JAMA , vol.160 , pp. 268-272
    • Lombroso, C.T.1    Davidson Jr., D.T.2    Gross-Bianchi, M.L.3
  • 54
    • 0034128353 scopus 로고    scopus 로고
    • Topiramate as add-on therapy: Pooled analysis of randomized controlled trials in adults
    • Reife R, Pledger G, Wu SC. Topiramate as add-on therapy: pooled analysis of randomized controlled trials in adults. Epilepsia 2000;41(Suppl 1):S66-71 (Pubitemid 30202345)
    • (2000) Epilepsia , vol.41 , Issue.SUPPL.4
    • Reife, R.1    Pledger, G.2    Wu, S.-C.3
  • 55
    • 34447275710 scopus 로고    scopus 로고
    • Efficacy and safety of adjunctive zonisamide therapy for refractory partial seizures
    • DOI 10.1016/j.eplepsyres.2007.04.007, PII S0920121107001386
    • Baulac M, Leppik IE. Efficacy and safety of adjunctive zonisamide therapy for refractory partial seizures. Epilepsy Res 2007;75(2-3):75-83 (Pubitemid 47048652)
    • (2007) Epilepsy Research , vol.75 , Issue.2-3 , pp. 75-83
    • Baulac, M.1    Leppik, I.E.2
  • 56
    • 0033811027 scopus 로고    scopus 로고
    • Multicenter double-blind, randomized, placebo-controlled trial of levetiracetam as add-on therapy in patients with refractory partial seizures: European Levetiracetam Study Group
    • Shorvon SD, Lowenthal A, Janz D, et al. Multicenter double-blind, randomized, placebo-controlled trial of levetiracetam as add-on therapy in patients with refractory partial seizures: European Levetiracetam Study Group. Epilepsia 2000;41:1179-1186
    • (2000) Epilepsia , vol.41 , pp. 1179-1186
    • Shorvon, S.D.1    Lowenthal, A.2    Janz, D.3
  • 57
    • 0033775210 scopus 로고    scopus 로고
    • Efficacy and tolerability of levetiracetam 3000 mg/day in patients with refractory partial seizures: A multicenter, double-blind, responder-selected study evaluating monotherapy
    • Ben-Menachem E, Falter U. Efficacy and tolerability of levetiracetam 3000 mg/day in patients with refractory partial seizures: a multicenter, double-blind, responder-selected study evaluating monotherapy. Epilepsia 2000;41:1276-1283
    • (2000) Epilepsia , vol.41 , pp. 1276-1283
    • Ben-Menachem, E.1    Falter, U.2
  • 58
    • 0034162331 scopus 로고    scopus 로고
    • A multicentre, double-blind, randomized, parallel group study to evaluate the tolerability and efficacy of two oral doses of levetiracetam, 2000 mg daily and 4000 mg daily, without titration in patients with refractory epilepsy
    • DOI 10.1053/seiz.2000.0380
    • Betts T, Waegemans T, Crawford P. A multicentre, double-blind, randomized, parallel group study to evaluate the tolerability and efficacy of two oral doses of levetiracetam, 2000 mg daily and 4000 mg daily, without titration in patients with refractory epilepsy. Seizure 2000;9:80-87 (Pubitemid 30209795)
    • (2000) Seizure , vol.9 , Issue.2 , pp. 80-87
    • Betts, T.1    Waegemans, T.2    Crawford, P.3
  • 59
    • 0036159059 scopus 로고    scopus 로고
    • Dose-response effect of levetiracetam 1000 and 2000 mg/day in partial epilepsy
    • DOI 10.1016/S0920-1211(01)00323-0, PII S0920121101003230
    • Boon P, Chauvel P, Pohlmann-Eden B, et al. Dose-response effect of levetiracetam 1000 and 2000 mg/day in partial epilepsy. Epilepsy Res 2002;48(1-2):77-89 (Pubitemid 34127719)
    • (2002) Epilepsy Research , vol.48 , Issue.1-2 , pp. 77-89
    • Boon, P.1    Chauvel, P.2    Pohlmann-Eden, B.3    Otoul, C.4    Wroe, S.5
  • 60
    • 0019454436 scopus 로고
    • Clorazepate and phenobarbital as antiepileptic drugs: A double-blind study
    • Wilensky AJ, Ojemann LM, Temkin NR, et al. Clorazepate and phenobarbital as antiepileptic drugs: a double-blind study. Neurology 1981;31(10):1271-1276
    • (1981) Neurology , vol.31 , Issue.10 , pp. 1271-1276
    • Wilensky, A.J.1    Ojemann, L.M.2    Temkin, N.R.3
  • 61
    • 0032891687 scopus 로고    scopus 로고
    • Double-blind substitution of vigabatrin and valproate in carbamazepine-resistant partial epilepsy.012 Study group
    • Brodie MJ, Mumford JP. Double-blind substitution of vigabatrin and valproate in carbamazepine-resistant partial epilepsy. 012 Study group. Epilepsy Res 1999;34(2-3):199-205
    • (1999) Epilepsy Res , vol.34 , Issue.2-3 , pp. 199-205
    • Brodie, M.J.1    Mumford, J.P.2
  • 64
    • 0023612454 scopus 로고
    • Anticonvulsant drugs and cognitive function: A review of the literature
    • Trimble MR. Anticonvulsant drugs and cognitive function: a review of the literature. Epilepsia 1987;28(Suppl 3):S37-45 (Pubitemid 18021820)
    • (1987) Epilepsia , vol.28 , Issue.SUPPL. 3
    • Trimble, M.R.1
  • 65
    • 0038196961 scopus 로고    scopus 로고
    • Clinically important drug interactions in epilepsy: General features and interactions between antiepileptic drugs
    • DOI 10.1016/S1474-4422(03)00409-5, PII S1474442203004095
    • Patsalos PN, Perucca E. Clinically important drug interactions in epilepsy: general features and interactions between antiepileptic drugs. Lancet Neurol 2003;2(6):347-356 (Pubitemid 38352562)
    • (2003) Lancet Neurology , vol.2 , Issue.6 , pp. 347-356
    • Patsalos, P.N.1    Perucca, E.2
  • 67
    • 0035069775 scopus 로고    scopus 로고
    • Visual field defects with vigabatrin: Epidemiology and therapeutic implications
    • Kälviäinen R, Nousiainen I. Visual field defects with vigabatrin: epidemiology and therapeutic implications. CNS Drugs 2001;15(3):217-230 (Pubitemid 32281182)
    • (2001) CNS Drugs , vol.15 , Issue.3 , pp. 217-230
    • Kalviainen, R.1    Nousiainen, I.2
  • 68
    • 60849124804 scopus 로고    scopus 로고
    • Taurine deficiency is a cause of vigabatrin-induced retinal phototoxicity
    • Jammoul F, Wang Q, Nabbout R, et al. Taurine deficiency is a cause of vigabatrin-induced retinal phototoxicity. Ann Neurol 2009;65(1):98-107
    • (2009) Ann Neurol , vol.65 , Issue.1 , pp. 98-107
    • Jammoul, F.1    Wang, Q.2    Nabbout, R.3
  • 69
    • 14844288465 scopus 로고    scopus 로고
    • Benzodiazepine use, abuse, and dependence
    • O'brien CP. Benzodiazepine use, abuse, and dependence. J Clin Psychiatry 2005;66(Suppl 2):28-33
    • (2005) J Clin Psychiatry , vol.66 , Issue.SUPPL. 2 , pp. 28-33
    • O'Brien, C.P.1
  • 70
    • 0034642227 scopus 로고    scopus 로고
    • Exacerbation of juvenile myoclonic epilepsy with lamotrigine
    • Biraben A, Allain H, Scarabin JM, et al. Exacerbation of juvenile myoclonic epilepsy with lamotrigine. Neurology 2000;55:1757-1758
    • (2000) Neurology , vol.55 , pp. 1757-1758
    • Biraben, A.1    Allain, H.2    Scarabin, J.M.3
  • 71
    • 11144356543 scopus 로고    scopus 로고
    • Therapeutics and technology assessment subcommittee of the american academy of neurology
    • Quality standards subcommittee of the american academy of neurology; American epilepsy society.efficacy and tolerability of the new antiepileptic drugs i: Treatment of new onset epilepsy: Report of the therapeutics and technology assessment subcommittee and quality standards subcommittee of the american academy of neurology and the american epilepsy society
    • French JA, Kanner AM, Bautista J, et al. Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology; Quality Standards Subcommittee of the American Academy of Neurology; American Epilepsy Society. Efficacy and tolerability of the new antiepileptic drugs I: treatment of new onset epilepsy: report of the Therapeutics and Technology Assessment Subcommittee and Quality Standards Subcommittee of the American Academy of Neurology and the American Epilepsy Society. Neurology 2004;62(8):1252-1260
    • (2004) Neurology , vol.62 , Issue.8 , pp. 1252-1260
    • French, J.A.1    Kanner, A.M.2    Bautista, J.3
  • 72
    • 28044462223 scopus 로고    scopus 로고
    • The management of idiopathic generalized epilepsies
    • Benbadis SR. The management of idiopathic generalized epilepsies. Acta Neurol Scand Suppl 2005;181:63-67 (Pubitemid 41687356)
    • (2005) Acta Neurologica Scandinavica, Supplement , vol.112 , Issue.181 , pp. 63-67
    • Benbadis, S.R.1
  • 73
    • 0034858638 scopus 로고    scopus 로고
    • The management of refractory idiopathic epilepsies
    • Perucca E. The management of refractory idiopathic epilepsies. Epilepsia 2001;42(Suppl 3):31-35 (Pubitemid 32781378)
    • (2001) Epilepsia , vol.42 , Issue.SUPPL. 3 , pp. 31-35
    • Perucca, E.1
  • 74
    • 0032443667 scopus 로고    scopus 로고
    • Double-blind, placebo-controlled, crossover study of lamotrigine in treatment-resistant generalised epilepsy
    • DOI 10.1111/j.1528-1157.1998.tb01332.x
    • Beran RG, Berkovic SF, Dunagan FM, et al. Double-blind, placebo-controlled, crossover study of lamotrigine in treatment-resistant generalised epilepsy. Epilepsia 1998;39(12):1329-1333 (Pubitemid 29005633)
    • (1998) Epilepsia , vol.39 , Issue.12 , pp. 1329-1333
    • Beran, R.G.1    Berkovic, S.F.2    Dunagan, F.M.3    Vajda, F.J.E.4    Danta, G.5    Black, A.B.6    Mackenzie, R.7
  • 75
    • 0033187221 scopus 로고    scopus 로고
    • Efficacy of lamotrigine in idiopathic generalized epilepsy syndromes: A video-eeg-controlled, open study
    • Gericke A, Picard F, De Saint-Martin A, et al. Efficacy of lamotrigine in idiopathic generalized epilepsy syndromes: a video-eeg-controlled, open study. Epileptic Disord 1999;1(3):159-165
    • (1999) Epileptic Disord , vol.1 , Issue.3 , pp. 159-165
    • Gericke, A.1    Picard, F.2    De Saint-Martin, A.3
  • 76
    • 35848938482 scopus 로고    scopus 로고
    • Placebo-controlled study of levetiracetam in idiopathic generalized epilepsy
    • DOI 10.1212/01.wnl.0000268699.34614.d3, PII 0000611420071030000006
    • Berkovic SF, Knowlton RC, Leroy RF, et al. Placebo-controlled study of levetiracetam in idiopathic generalized epilepsy. Levetiracetam N01057 Study Group. Neurology 2007;69:1751-1760 (Pubitemid 350059304)
    • (2007) Neurology , vol.69 , Issue.18 , pp. 1751-1760
    • Berkovic, S.F.1    Knowlton, R.C.2    Leroy, R.F.3    Schiemann, J.4    Falter, U.5
  • 77
    • 39749166363 scopus 로고    scopus 로고
    • Levetiracetam for the treatment of idiopathic generalized epilepsy with myoclonic seizures
    • DOI 10.1212/01.wnl.0000297512.18364.40, PII 0000611420080219000006
    • Noachtar S, Andermann E, Meyvisch P, et al. N166 levetiracetam study group Levetiracetam for the treatment of idiopathic generalized epilepsy with myoclonic seizures. Neurology 2008;70:607-616 (Pubitemid 351294638)
    • (2008) Neurology , vol.70 , Issue.8 , pp. 607-616
    • Noachtar, S.1    Andermann, E.2    Meyvisch, P.3    Andermann, F.4    Gough, W.B.5    Schiemann-Delgado, J.6
  • 78
    • 0031883148 scopus 로고    scopus 로고
    • Antiepileptic drugs as a cause of worsening seizures
    • DOI 10.1111/j.1528-1157.1998.tb01268.x
    • Perucca E, Gram L, Avanzini G, et al. Antiepileptic drugs as a cause of worsening of seizures. Epilepsia 1998;39:5-17 (Pubitemid 28116836)
    • (1998) Epilepsia , vol.39 , Issue.1 , pp. 5-17
    • Perucca, E.1    Gram, L.2    Avanzini, G.3    Dulac, O.4
  • 79
    • 0033594522 scopus 로고    scopus 로고
    • A randomized, placebo-controlled study of topiramate in primary generalized tonic-clonic seizures
    • Biton V, Montouris GD, Ritter F, et al. A randomized, placebo-controlled study of topiramate in primary generalized tonic----clonic seizures. Topiramate YTC Study Group. Neurology 1999;52:1330-1337 (Pubitemid 29190520)
    • (1999) Neurology , vol.52 , Issue.7 , pp. 1330-1337
    • Biton, V.1    Montouris, G.D.2    Ritter, F.3    Riviello, J.J.4    Reife, R.5    Lim, P.6    Pledger, G.7
  • 80
    • 27744582895 scopus 로고    scopus 로고
    • Topiramate in patients with juvenile myoclonic epilepsy
    • DOI 10.1001/archneur.62.11.1705
    • Biton V, Bourgeois BF, YTC/YTCE Study Investigators. Topiramate in patients with juvenile myoclonic epilepsy. Arch Neurol 2005;62(11):1705-1708 (Pubitemid 41626666)
    • (2005) Archives of Neurology , vol.62 , Issue.11 , pp. 1705-1708
    • Biton, V.1    Bourgeois, B.F.D.2
  • 81
    • 0025188657 scopus 로고
    • Chronic acetazolamide monotherapy in the treatment of juvenile myoclonic epilepsy
    • Resor SR Jr, Resor LD. Chronic acetazolamide monotherapy in the treatment of juvenile myoclonic epilepsy. Neurology 1990;40(11):1677-1681 (Pubitemid 20383130)
    • (1990) Neurology , vol.40 , Issue.11 , pp. 1677-1681
    • Resor Jr., S.R.1    Resor, L.D.2
  • 82
    • 44349098627 scopus 로고    scopus 로고
    • Zonisamide: Review of pharmacology, clinical efficacy, tolerability, and safety
    • DOI 10.1517/17425255.4.4.493
    • Kothare SV, Kaleyias J. Zonisamide: review of pharmacology, clinical efficacy, tolerability, and safety. Expert Opin Drug Metab Toxicol 2008;4(4):493-506 (Pubitemid 351728521)
    • (2008) Expert Opinion on Drug Metabolism and Toxicology , vol.4 , Issue.4 , pp. 493-506
    • Kothare, S.V.1    Kaleyias, J.2
  • 84
    • 0034598762 scopus 로고    scopus 로고
    • Early identification of refractory epilepsy
    • DOI 10.1056/NEJM200002033420503
    • Kwan P, Brodie MJ. Early identification of refractory epilepsy. N Engl J Med 2000;342(5):314-319 (Pubitemid 30075244)
    • (2000) New England Journal of Medicine , vol.342 , Issue.5 , pp. 314-319
    • Kwan, P.1    Brodie, M.J.2
  • 85
    • 0037161362 scopus 로고    scopus 로고
    • Staged approach to epilepsy management
    • Brodie MJ, Kwan P. Staged approach to epilepsy management. Neurology 2002;58(8 Suppl 5):S2-8 (Pubitemid 34415365)
    • (2002) Neurology , vol.58 , Issue.8 SUPPL. 4
    • Brodie, M.J.1    Kwan, P.2
  • 87
    • 37849053121 scopus 로고    scopus 로고
    • Quantifying the response to antiepileptic drugs: Effect of past treatment history
    • Schiller Y, Najjar Y. Quantifying the response to antiepileptic drugs: effect of past treatment history. Neurology 2008;70(1):54-66
    • (2008) Neurology , vol.70 , Issue.1 , pp. 54-66
    • Schiller, Y.1    Najjar, Y.2
  • 88
    • 68949213747 scopus 로고    scopus 로고
    • Rational polytherapy
    • French JA, Faught E. Rational polytherapy. Epilepsia 2009;50(Suppl 8):63-68
    • (2009) Epilepsia , vol.50 , Issue.SUPPL. 8 , pp. 63-68
    • French, J.A.1    Faught, E.2
  • 89
    • 0033586952 scopus 로고    scopus 로고
    • Patients with refractory seizures
    • DOI 10.1056/NEJM199905203402008
    • Devinsky O. Patients with refractory seizures. N Engl J Med 1999;340(20):1565-1570 (Pubitemid 29228187)
    • (1999) New England Journal of Medicine , vol.340 , Issue.20 , pp. 1565-1570
    • Devinsky, O.1
  • 90
    • 72049100516 scopus 로고    scopus 로고
    • Definition of drug resistant epilepsy: Consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic Strategies
    • Epub ahead of print
    • Kwan P, Arzimanoglou A, Berg AT, et al. Definition of drug resistant epilepsy: Consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic Strategies. Epilepsia 2009 [Epub ahead of print]
    • (2009) Epilepsia
    • Kwan, P.1    Arzimanoglou, A.2    Berg, A.T.3
  • 91
    • 43149120240 scopus 로고    scopus 로고
    • Early surgical treatment for epilepsy
    • DOI 10.1097/WCO.0b013e3282f47931, PII 0001905220080400000013
    • Langfitt JT, Wiebe S. Early surgical treatment for epilepsy. Curr Opin Neurol 2008;21(2):179-183 (Pubitemid 351644160)
    • (2008) Current Opinion in Neurology , vol.21 , Issue.2 , pp. 179-183
    • Langfitt, J.T.1    Wiebe, S.2


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