Lamotrigine add-on therapy in focal epilepsy: Electroencephalographic and neuropsychological evaluation

Clinical Neuropharmacology

Volumn 21, Issue 1, 1998, Pages 41-47

  Marciani, Maria Grazia ^a,b   Stanzione, Paolo ^a,b   Mattia, Donatella ^b   Spanedda, Francesca ^b   Bassetti, Maria A ^a   Maschio, Marta ^a   Bernardi, Giorgio ^a,b  

^a UNIVERSITY OF ROME TOR VERGATA   (Italy)

^b IRCCS FONDAZIONE SANTA LUCIA   (Italy)

Author keywords

Computerized EEG; Epilepsy; Lamotrigine; Mental activity

Indexed keywords

ANTICONVULSIVE AGENT; LAMOTRIGINE;

ADOLESCENT; ADULT; ARITHMETIC; ARTICLE; CLINICAL ARTICLE; COGNITION; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; ELECTROENCEPHALOGRAPHY; FEMALE; FOCAL EPILEPSY; HUMAN; MALE; MENTAL PERFORMANCE; NEUROPSYCHOLOGICAL TEST; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; TASK PERFORMANCE; VERBAL MEMORY; WORD RECOGNITION;

ADOLESCENT; ADULT; ANTICONVULSANTS; ATTENTION; COGNITION; ELECTROENCEPHALOGRAPHY; EPILEPSIES, PARTIAL; FEMALE; HUMANS; MALE; MIDDLE AGED; NEUROPSYCHOLOGICAL TESTS; PSYCHOMOTOR PERFORMANCE; REACTION TIME; TRIAZINES;

EID: 0031911997     PISSN: 03625664     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Miller AA, Wheatley P, Sawyer DA, Baxter MG, Roth B. Pharmacological studies on lamotrigine, a novel potential antiepileptic drug: I. Anticonvulsant profile in mice and rats. Epilepsia 1986;27:483-9.
2. Leach MJ, Marden CM, Miller AA. Pharmacological studies on lamotrigine, a novel potential antiepileptic drug: II. Neurochemical studies on the mechanism of action. Epilepsia 1986;27:490-7.
3. Cheung H, Kamp D, Harris E. An in vitro investigation of the action of lamotrigine on neuronal voltage-activated sodium channels. Epilepsy Res 1992;13:107-12.
4. Leach MJ, Baxter MG, Critchley M. Neurochemical and behavioural aspects of lamotrigine. Epilepsia 1991;32:S4-S8.
5. Smith SE, Meldrum BS, Chir B. Cerebroprotective effect of lamotrigine after focal ischemia in rats. Stroke 1995;26:117-21.
6. Jawad S, Richens A, Goodwin G, Yuen WC. Controlled trial of lamotrigine (Lamictal) for refractory partial seizures. Epilepsia 1989; 30:356-63.
7. Binnie CD, Debets RMC, Engelsman M, et al. Double-blind crossover trial of lamotrigine (Lamictal) as add-on therapy in intractable epilepsy. Epilepsy Res 1989;4:229-9.
8. Loiseau P, Yuen AWC, Duché B, Ménager T, Arné-Bès MC. A randomised double-blind placebo-controlled crossover add-on trial of lamotrigine in patients with treatment-resistant partial seizures. Epilepsy Res 1990;7:136-45.
9. Sander JWAS, Hart YM, Patsalos PN, Duncan JS, Shorvon SD. Lamotrigine and generalized seizures. Epilepsia 1991;(suppl 1 )32:S9.
10. Timmings PL, Richens A. Lamotrigine in primary generalized epilepsy. Lancet 1992;339:1300-1.
11. Pryse-Phillips WEM, Jeavons PM. Effect of carbamazepine (Tegretol) on the electroencephalogram and ward behavior of patients with chronic epilepsy. Epilepsia 1970;11:263-73.
12. Rodin EA, Rim CS, Kitano H, et al. A comparison of the effectiveness of primidone versus carbamazepine in epileptic outpatients. J Nerv Ment Dis 1976;163:41-6.
13. Fink M, Irwin P, Sannita W, Papakostas Y, Green MA. Phenytoin: EEG effects and plasma levels in volunteers. Ther Drug Monit 1979;1:93-103.
14. Benninger C, Matthis P, Scheffner D. Spectral analysis of the EEG in children during the introduction of antiepileptic therapy with valproic acid. Neuropsychobiology 1985;13:93-6.
15. Marciani MG, Maschio MCE, Spanedda F, Gigli GL, Bassetti MA, Bernardi G. Sodium valproate and mental processes in newly referred epileptic patients: a computerized EEG study. Neuropsychobiology 1995;31:210-15.
16. Dodrill CB, Troupin AS. Psychotropic effects of carbamazepine in epilepsy: a double-blind comparison with phenytoin. Neurology 1977;27:1023-8.
17. Thompson PJ, Trimble MR. Sodium valproate and cognitive functioning in normal volunteers. Br J Clin Pharmacol 1981;12:819-24.
18. Kälviäinen R, Äikiä M, Riekkinen PJ. Cognitive adverse effects of antiepileptic drugs: incidence, mechanisms and therapeutic implications. CNS Drugs 1996;5:358-68.
19. Hamilton MJ, Cohen AF, Yuen AWC, et al. Carbamazepine and lamotrigine in healthy volunteers: relevance to early tolerance and clinical trial dosage. Epilepsia 1993;34:166-73.
20. Mervaala E, Kovisto K, Hänninen T, et al. Electrophysiological and neuropsychological profiles of lamotrigine in young and age-associated memory impairment subjects [abstract]. Neurology 1995;(suppl 4)46:259.
21. Van Wieringen A, Binnie CD, Meijer JWA, Peck AW, De Vries J. Comparison of the effects of lamotrigine and phenytoin on the EEG power spectrum and cortical and brainstem-evoked responses of normal human volunteers. Neuropsychobiology 1989;21:157-69.
22. Marciani MG, Spanedda F, Bassetti MA, et al. Effect of lamotrigine on EEG paroxysmal abnormalities and background activity: a computerized analysis. Br J Clin Pharmacol 1996;42:621-7.
23. Gasser T, Bacher P, Mocks J. Transformation towards the normal distribution of broad band spectral parameters of the EEG. Electroenceph Clin Neurophysiol 1982;53:119-24.
24. Caltagirone C, Gainotti C, Masullo C, Miceli G. Validity of some neuropsychological tests in the assessment of mental deterioration. Acta Psychiatr Scand 1979;60:50-6.
25. Duncan JS. Antiepileptic drugs and the electroencephalogram. Epilepsia 1987;28:259-66.
26. Ossetin J. Methods and problems in the assessment of cognitive function in epileptic patients. In: Trimble MR, Reynolds EH, eds. Epilepsy, behaviour and cognitive function. Chichester, England: John Wiley & Sons, 1986:9-26.
27. Ray WJ, Cole HW. EEG alpha activity reflects attentional demands, and beta activity reflects emotional and cognitive processes. Science 1985;228:751-2.
28. Jawad S, Oxley J, Yuen WC, Richens A. The effects of lamotrigine, a novel anticonvulsant, on interictal spikes in patients with epilepsy. Br J Clin Pharmacol 1986;22:191-3.
29. Cohen AF, Ashby L, Crowley D, Land G, Peck AW, Miller AA. Lamotrigine (BW430C), a potential anticonvulsant: effects on the central nervous system in comparison with phenytoin and diazepam. Br J Clin Pharmacol 1985;20:619-29.
30. Smith D, Baker G, Davies G, Dewey M, Chadwick DW. Outcomes of add-on treatment with lamotrigine in partial epilepsy. Epilepsia 1993;34:312-22.