Glucocorticoid response and promoter occupancy of the mouse LXRα gene

Biochemical and Biophysical Research Communications

Volumn 312, Issue 3, 2003, Pages 716-724

  Steffensen, Knut R ^a   Holter, Elin ^a   Alikhani, Nyosha ^a   Eskild, Winnie ^b   Gustafsson, Jan Åke ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b UNIVERSITY OF OSLO   (Norway)

Author keywords

Glucocorticoid receptor; Liver X receptor; LXR promoter; Transcription factors

Indexed keywords

CELL NUCLEUS RECEPTOR; CELL RECEPTOR; DEOXYRIBONUCLEASE I; DEOXYRIBONUCLEOPROTEIN; DEXAMETHASONE; GLUCOCORTICOID RECEPTOR; LIVER X RECEPTOR ALPHA; LIVER X RECEPTOR BETA; LXRALPHA PROTEIN; LXRBETA PROTEIN; RECEPTOR; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ANIMAL; ARTICLE; BIOSYNTHESIS; CARBOHYDRATE METABOLISM; CATABOLISM; CELL ACTIVITY; CELL LINE; COMPARATIVE STUDY; CONTROLLED STUDY; DNA FLANKING REGION; DNA FOOTPRINTING; GENE ACTIVITY; GENE CONSTRUCT; GENE DELETION; GENE EXPRESSION REGULATION; GENE IDENTIFICATION; GENETIC IDENTIFICATION; GENETIC TRANSFECTION; GENETICS; HUMAN; LIPID TRANSPORT; LIVER; METABOLISM; MOLECULAR GENETICS; MOUSE; MUTATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PHYSIOLOGY; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DNA INTERACTION; REPORTER GENE; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; SPECIES DIFFERENCE;

EID: 0344983843     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbrc.2003.10.174     Document Type: Article

References (33)

1. Lehmann J.M., Kliewer S.A., Moore L.B., Smith-Oliver T.A., Oliver B.B., Su J.L., Sundseth S.S., Winegar D.A., Blanchard D.E., Spencer T.A., Willson T.M. Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway. J. Biol. Chem. 272:1997;3137-3140.
2. K.R. Steffensen, J.Å. Gustafsson, Putative metabolic effects of the liver X receptor (LXR), Diabetes 53 (Suppl. 1) (2004).
3. Repa J.J., Mangelsdorf D.J. The liver X receptor gene team: potential new players in atherosclerosis. Nat. Med. 8:2002;1243-1248.
4. Francis G.A., Annicotte J.S., Auwerx J. Liver X receptors: Xcreting Xol to combat atherosclerosis. Trends Mol. Med. 8:2002;455-458.
5. Francis G.A., Fayard E., Picard F., Auwerx J. Nuclear receptors and the control of metabolism. Annu. Rev. Physiol. 65:2003;261-311.
6. Edwards P.A., Kast H.R., Anisfeld A.M. BAREing it all: the adoption of LXR and FXR and their roles in lipid homeostasis. J. Lipid Res. 43:2002;2-12.
7. Steffensen K.R., Schuster G.U., Parini P., Holter E., Sadek C.M., Cassel T., Eskild W., Gustafsson J.Å. Different regulation of the LXR alpha promoter activity by isoforms of CCAAT/enhancer-binding proteins. Biochem. Biophys. Res. Commun. 293:2002;1333-1340.
8. Ross S.E., Erickson R.L., Gerin I., DeRose P.M., Bajnok L., Longo K.A., Misek D.E., Kuick R., Hanash S.M., Atkins K.B., Andresen S.M., Nebb H.I., Madsen L., Kristiansen K., MacDougald O.A. Microarray analyses during adipogenesis: understanding the effects of Wnt signaling on adipogenesis and the roles of liver X receptor alpha in adipocyte metabolism. Mol. Cell. Biol. 22:2002;5989-5999.
9. Juvet L.K., Andresen S.M., Schuster G.U., Dalen K.T., Tobin K.A., Hollung K., Haugen F., Jacinto S., Ulven S.M., Bamberg K., Gustafsson J.Å., Nebb H.I. On the role of liver X receptors in lipid accumulation in adipocytes. Mol. Endocrinol. 17:2003;172-182.
10. Stulnig T.M., Steffensen K.R., Gao H., Reimers M., Dahlman-Wright K., Schuster G.U., Gustafsson J.Å. Novel roles of liver X receptors exposed by gene expression profiling in liver and adipose tissue. Mol. Pharmacol. 62:2002;1299-1305.
11. Peet D.J., Turley S.D., Ma W., Janowski B.A., Lobaccaro J.M., Hammer R.E., Mangelsdorf D.J. Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha. Cell. 93:1998;693-704.
12. Alberti S., Schuster G., Parini P., Feltkamp D., Diczfalusy U., Rudling M., Angelin B., Bjorkhem I., Pettersson S., Gustafsson J.Å. Hepatic cholesterol metabolism and resistance to dietary cholesterol in LXRbeta-deficient mice. J. Clin. Invest. 107:2001;565-573.
13. Schuster G.U., Parini P., Wang L., Alberti S., Steffensen K.R., Hansson G.K., Angelin B., Gustafsson J.Å. Accumulation of foam cells in liver X receptor-deficient mice. Circulation. 106:2002;1147-1153.
14. Steffensen K.R., Nilsson M., Schuster G.U., Stulnig T.M., Dahlman-Wright K., Gustafsson J.Å. Gene expression profiling in adipose tissue indicates different transcriptional mechanisms of liver X receptors alpha and beta, respectively. Biochem. Biophys. Res. Commun. 310:2003;589-593.
15. Chawla A., Boisvert W.A., Lee C.H., Laffitte B.A., Barak Y., Joseph S.B., Liao D., Nagy L., Edwards P.A., Curtiss L.K., Evans R.M., Tontonoz P. A PPAR gamma-LXR-ABCA1 pathway in macrophages is involved in cholesterol efflux and atherogenesis. Mol. Cell. 7:2001;161-171.
16. Laffitte B.A., Joseph S.B., Walczak R., Pei L., Wilpitz D.C., Collins J.L., Tontonoz P. Autoregulation of the human liver X receptor alpha promoter. Mol. Cell. Biol. 21:2001;7558-7568.
17. Steffensen K.R., Holter E., Tobin K.A., Leclerc S., Gustafsson J.Å., Guerin S.L., Eskild W. Members of the nuclear factor 1 family reduce the transcriptional potential of the nuclear receptor LXR alpha promoter. Biochem. Biophys. Res. Commun. 289:2001;1262-1267.
18. Whitney K.D., Watson M.A., Goodwin B., Galardi C.M., Maglich J.M., Wilson J.G., Willson T.M., Collins J.L., Kliewer S.A. Liver X receptor (LXR) regulation of the LXR alpha gene in human macrophages. J. Biol. Chem. 276:2001;43509-43515.
19. Li Y., Bolten C., Bhat B.G., Woodring-Dietz J., Li S., Prayaga S.K., Xia C., Lala D.S. Induction of human liver X receptor alpha gene expression via an autoregulatory loop mechanism. Mol. Endocrinol. 16:2002;506-514.
20. Alberti S., Steffensen K.R., Gustafsson J.Å. Structural characterisation of the mouse nuclear oxysterol receptor genes LXR alpha and LXR beta. Gene. 243:2000;93-103.
21. Steffensen K.R., Holter E., Tobin K.A., Leclerc S., Gustafsson J.Å., Guerin S.L., Eskild W. Members of the nuclear factor 1 family reduce the transcriptional potential of the nuclear receptor LXR alpha promoter. Biochem. Biophys. Res. Commun. 289:2001;1262-1267.
22. ′ -flanking region of the human cellular retinol binding protein 1 gene Mol. Endocrinol. 8:1994;732-745.
23. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72:1976;248-254.
24. ′ -regulatory region Mol. Endocrinol. 2:1988;1101-1107.
25. Maxam A.M., Gilbert W. Sequencing end-labeled DNA with base-specific chemical cleavages. Methods Enzymol. 65:1980;499-560.
26. Ko J.H., Miyoshi E., Noda K., Ekuni A., Kang R., Ikeda Y., Taniguchi N. Regulation of the GnT-V promoter by transcription factor Ets-1 in various cancer cell lines. J. Biol. Chem. 274:1999;22941-22948.
27. Oikawa T., Yamada T. Molecular biology of the Ets family of transcription factors. Gene. 303:2003;11-34.
28. Sinclair A.J. bZIP proteins of human gammaherpesviruses. J. Gen. Virol. 84:2003;1941-1949.
29. Kageyama R., Ohtsuka T., Tomita K. The bHLH gene Hes1 regulates differentiation of multiple cell types. Mol. Cells. 10:2000;1-7.
30. Wellington C.L., Walker E.K., Suarez A., Kwok A., Bissada N., Singaraja R., Yang Y.Z., Zhang L.H., James E., Wilson J.E., Francone O., McManus B.M., Hayden M.R. ABCA1 mRNA and protein distribution patterns predict multiple different roles and levels of regulation. Lab. Invest. 82:2002;273-283.
31. Levine M., Tjian R. Transcription regulation and animal diversity. Nature. 424:2003;147-151.
32. Stulnig T.M., Oppermann U., Steffensen K.R., Schuster G.U., Gustafsson J.Å. Liver X receptors downregulate 11beta-hydroxysteroid dehydrogenase type 1 expression and activity. Diabetes. 51:2002;2426-2433.
33. Stafford J.M., Wilkinson J.C., Beechem J.M., Granner D.K. Accessory factors facilitate the binding of glucocorticoid receptor to the phosphoenolpyruvate carboxykinase gene promoter. J. Biol. Chem. 276:2001;39885-39891.