Transcription control and neuronal differentiation by agents that activate the LXR nuclear receptor family

Molecular and Cellular Endocrinology

Volumn 155, Issue 1-2, 1999, Pages 51-60

  Schmidt, Azriel ^a   Vogel, Robert ^a   Holloway, M Katharine ^a   Rutledge, Su Jane ^a   Friedman, Oren ^b   Yang, Zhelin ^b   Rodan, Gideon A ^a   Friedman, Eitan ^b  

^a MERCK RESEARCH LABORATORIES   (United States)

^b DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

5 tetradecyloxy 2 furancarboxylic acid; AP 1; Hydroxycholesterols; NF B; Pheochromocytoma cells; PPAR

Indexed keywords

CHOLESTEROL DERIVATIVE; DNA; FURAN DERIVATIVE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; OLEIC ACID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PIRINIXIC ACID; TRANSCRIPTION FACTOR AP 1;

ANIMAL CELL; ARTICLE; BINDING SITE; LIGAND BINDING; NERVE CELL DIFFERENTIATION; NONHUMAN; PHEOCHROMOCYTOMA CELL; PRIORITY JOURNAL; PROTEIN FAMILY; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

ANIMALS; ANTICHOLESTEREMIC AGENTS; ANTILIPEMIC AGENTS; CELL DIFFERENTIATION; CELL LINE; CHOLESTEROL; COS CELLS; DNA-BINDING PROTEINS; FURANS; NERVE GROWTH FACTORS; NEURONS; OLEIC ACID; PEROXISOME PROLIFERATORS; PYRIMIDINES; RATS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, GLUCOCORTICOID; RECOMBINANT FUSION PROTEINS; TRANS-ACTIVATION (GENETICS); TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TRANSFECTION;

EID: 0032821271     PISSN: 03037207     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0303-7207(99)00115-X     Document Type: Article

References (53)

1. Apfel R., Benbrook D., Lernhardt E., Ortiz M.A., Salbert G., Pfahl M. A novel orphan receptor specific for a subset of thyroid hormone-responsive elements and its interaction with the retinoid/thyroid hormone receptor subfamily. Mol. Cell. Biol. 14:1994;7025-7035.
2. Arbeeny C.M., Meyers D.S., Bergquist K.E., Gregg R.E. Inhibition of fatty acid synthesis decreases very low density lipoprotein secretion in the hamster. J. Lipid Res. 33:1992;843-851.
3. Auphan N., DiDonato J.A., Rosette C., Helmberg A., Karin M. Immunosuppression by glucocorticoids: inhibition of NF-kappa B activity through induction of I kappa B synthesis [see comments]. Science. 270:1995;286-290.
4. Baniahmad A., Tsai M.J. Mechanisms of transcriptional activation by steroid hormone receptors. J. Cell. Biochem. 51:1993;151-156.
5. Bellido, T., Jilka, R.L., Boyce, B.F., Girasole, G., Broxmeyer, H., Dalrymple, S.A., Murray, R., Manologus, S.C., 1995. Regulation of interleukin-6, osteoclastogenesis, and bone mass by androgens. The role of androgen receptor. J. Clin. Invest. 95, 2886-2895.
6. Boie Y., Adam M., Rushmore T.H., Kennedy B.P. Enantioselective activation of the peroxisome proliferator-activated receptor. J. Biol. Chem. 268:1993;5530-5534.
7. Cosgaya J.M., Garacia-Villalba P., Perona R., Aranda A. Comparison of the effects of retinoic acid and nerve growth factor on PC12 cell proliferation, differentiation, and gene expression. J. Neurochem. 66:1996;89-98.
8. Diamond M.I., Miner J.N., Yoshinaga S.K., Yamamoto K.R. Transcription factor interactions: selectors of positive or negative regulation from a single DNA element. Science. 249:1990;1266-1272.
9. Dreyer C., Krey G., Keller H., Givel F., Helftenbein G., Wahli W. Control of the peroxisomal beta-oxidation pathway by a novel family of nuclear hormone receptors. Cell. 68:1992;879-887.
10. Evans R.M. The steroid and thyroid hormone receptor superfamily. Science. 240:1988;889-895.
11. Forman B.M., Tontonoz P., Chen J., Brun R.P., Spiegelman B.M., Evans R.M. 15-Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma. Cell. 83:1995;803-812.
12. Frantz B., Nordby E.C., Bren G., Steffan N., Paya C.V., Kincaid R.L., Tocci M.J., O'Keefe S.J., O'Neill E.A. Calcineurin acts in synergy with PMA to inactivate I kappa B/MAD3, an inhibitor of NF-kappa B. EMBO J. 13:1994;861-870.
13. Gronemeyer H.G.S.K.V.J.J.M., Chambon P. Structure and Functions of the Oestrogen Receptor and other Members of the Nuclear Recptor Family. Steroid Receptors and Disease: Cancer Bone and Circulatory Disorders. 1988;Dekker, New York.
14. Halvorson D.L., McCune S.A. Inhibition of fatty acid synthesis in isolated adipocytes by 5-(tetradecyloxy)-2-furoic. Lipids. 19:1984;851-856.
15. Issenmann I., Greeen S. Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. Nature. 347:1990;645-649.
16. Janowski B.A., Willy P.J., Devi T.R., Falck J.R., Mangelsdorf D.J. An oxysterol signalling pathway mediated by the nuclear receptor LXRa. Nature. 383:1996;728-731.
17. Johnson T.E., Holloway M.K., Vogel R., Rutledge S., Perkins J.J., Rodan G.A., Schmidt A. Structural requirements and cell-type specificity for ligand activation of peroxisome proliferator activated receptors. J. Steroid Biochem. Mol. Biol. 63:1997;1-8.
18. Jonat C., Rahmsdorf H.J., Park K.K., Cato A.C., Gebel S., Ponta H., Herrlich P. Antitumor promotion and antiinflammation: down-modulation of AP-1 (Fos/Jun) activity by glucocorticoid hormone. Cell. 62:1990;1189-1204.
19. Kalio P.J, Poukka H., Molianen A., Janne O.A., Palvimo J.J. Androgen receptor-mediated transcription regulation in the absence of direct interaction with a specific DNA element. Mol. Endocinol. 9:1994;1017-1028.
20. Khan W.A., Blobe G.C., Hannun Y.A. Arachidonic acid and free fatty acids as second messengers and the role of protein kinase C. Cell. Signal. 7:1995;171-184.
21. 2+ mobilization and protein phosphorylation in human platelets in presence or absence of platelet activating factor. Arch. Biochem. Biophys. 298:1992;471-479.
22. Kliewer S.A., Lenhard J.M., Willson T.M., Patel I., Morris D.C., Lehmann J.M. A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor gamma and promotes adipocyte differentiation. Cell. 83:1995;813-819.
23. Lalwani N.D., Reddy M.K., Qureshi S.A., Sirtori C.R., Abiko Y., Reddy J.K. Evaluation of selected hypolipidemic agents for the induction of peroxisomal enzymes and peroxisome proliferation in the rat liver. Hum. Toxicol. 2:1983;27-48.
24. Lehmann J.M., Kliewer S.A., Moore L.B., Smith Oliver T.A., Oliver B.B., Su J.L., Sundseth S.S., Winegar D.A., Blanchard D.E., Spencer T.A., Willson T.M. Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway. J. Biol. Chem. 272:1997;3137-3140.
25. Mangelsdorf D.J., Evans R.M. The RXR heterodimers and orphan receptors. Cell. 83:1995;841-850.
26. Mangelsdorf D.J., Thummel C., Beato M., Herrlich P., Schutz G., Umesono K., Blumberg B., Kastner P., Mark M., Chambon P. et al. The nuclear receptor superfamily: the second decade. Cell. 83:1995;835-839.
27. Maroder M., Farina A.R., Vacca A., Felli M.P., Meco D., Screpanti I., Frati L., Gulino A. Cell-specific bifunctional role of Jun oncogene family members on glucocorticoid receptor-dependent transcription. Mol. Endocrinol. 7:1993;570-584.
28. Mukaida N., Morita M., Ishikawa Y., Rice N., Okamoto S., Kasahara T., Matsushima K. Novel mechanism of glucocorticoid-mediated gene repression. Nuclear factor-kappa B is target for glucocorticoid-mediated interleukin 8 gene repression. J. Biol. Chem. 269:1994;13289-13295.
29. Nunez D., Randon J., Gandhi C., Siafaka Kapadai A., Olson M.S., Hanahan D.J. The inhibition of platelet-activating factor-induced platelet activation by oleic acid is associated with a decrease in polyphosphoinositide metabolism. J. Biol. Chem. 265:1990;18330-18338.
30. O'Malley B. The steroid receptor superfamily: more excitement predicted for the future. Mol. Endocrinol. 4:1990;363-369.
31. O'Malley B.W., Schrader W.T., Mani S., Smith C., Weigel N.L., Conneely O.M., Clark J.H. An alternative ligand-independent pathway for activation of steroid receptors. Recent Prog. Horm. Res. 50:1995;333-347.
32. Otto D.A., Chatzidakis C., Kasziba E., Cook G.A. Reciprocal effects of 5-(tetradecyloxy)-2-furoic acid on fatty acid oxidation. Arch. Biochem. Biophys. 242:1985;23-31.
33. Parker M.G. Steroid and related receptors. Curr. Opin. Cell. Biol. 5:1993;499-504.
34. Parker R.A., Kariya T., Grisar J.M., Petrow V. 5-(Tetradecyloxy)-2-furancarboxylic acid and related hypolipidemic fatty acid-like alkyloxyarylcarboxylic acids. J. Med. Chem. 20:1977;781-791.
35. Perkins N.D., Edwards N.L., Duckett C.S., Agranoff A.B., Schmid R.M., Nabel G.J. A cooperative interaction between NF-kappa B and Sp1 is required for HIV-1 enhancer activation. EMBO J. 12:1993;3551-3558.
36. Pittman R.N., Wang S., DiBenedetto A.J., Mills J.C. A system for characterizing cellular and molecular events in programmed neuronal cell death. J. Neurosci. 13:1993;3669-3680.
37. Pollock J.D., Krempin M., Rudy B. Differential effects of NGF, FGF, EGF, cAMP, and dexamethasone on neurite outgrowth and sodium channel expression in PC12 cells. J. Neurosci. 10:1990;2626-2657.
38. Ray A., Prefontaine K.E. Physical association and functional antagonism between the p65 subunit of transcription factor NF-kappa B and the glucocorticoid receptor. Proc. Natl. Acad. Sci. USA. 91:1994;752-756.
39. Ray A., Prefontaine K.E., Ray P. Down-modulation of interleukin-6 gene expression by 17 beta-estradiol in the absence of high affinity DNA binding by the estrogen receptor. J. Biol. Chem. 269:1994;12940-12946.
40. Ricote M., Li A.C., Willson T.M., Kelly C.J., Glass C.K. The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation. Nature. 391:1998;79-82.
41. Scheinman R.I., Cogswell P.C., Lofquist A.K., Baldwin A.S. Jr. Role of transcriptional activation of I kappa B alpha in mediation of immunosuppression by glucocorticoids [see comments]. Science. 270:1995;283-286.
42. Schmidt A., Endo N., Rutledge S.J., Vogel R., Shinar D., Rodan G.A. Identification of a new member of the steroid hormone receptor superfamily that is activated by peroxisome proliferator and fatty acids. Mol. Endocrinol. 6:1992;1634-1641.
43. Schule R., Muller M., Otsuka Murakami H., Renkawitz R. Cooperativity of the glucocorticoid receptor and the CACCC-box binding factor. Nature. 332:1988;87-90.
44. Schule R., Rangarajan P., Kliewer S., Ransone L.J., Bolado J., Yang N., Verma I.M., Evans R.M. Functional antagonism between oncoprotein c-Jun and the glucocorticoid receptor. Cell. 62:1990;1217-1226.
45. Seol W., Choi H.S., Moore D.D. Isolation of proteins that interact specifically with the retinoid X receptor: two novel orphan receptors. Mol. Endocrinol. 9:1995;72-85.
46. Shinar D.M., Endo N., Rutledge S.J., Vogel R., Rodan G.A., Schmidt A. NER, a new member of the gene family encoding the human steroid hormone nuclear receptor. Gene. 147:1994;273-276.
47. Song C., Kokontis J.M., Hiipakka R.A., Liao S. Ubiquitous receptor: a receptor that modulates gene activation by retinoic acid and thyroid hormone receptors. Proc. Natl. Acad. Sci. USA. 91:1994;10809-10813.
48. Stein B., Baldwin A.J., Ballard D.W., Greene W.C., Angel P., Herrlich P. Cross-coupling of the NF-kappa B p65 and Fos/Jun transcription factors produces potentiated biological function. EMBO J. 12:1993;3879-3891.
49. Teboul M., Enmark E., Li Q., Wikstrom A.C., Pelto Huikko M., Gustafsson J.A. OR-1, a member of the nuclear receptor superfamily that interacts with the 9-cis-retinoic acid receptor. Proc. Natl. Acad. Sci. USA. 92:1995;2096-2100.
50. Truss M., Beato M. Steroid hormone receptors: interaction with deoxyribonucleic acid and transcription factors. Endocr. Rev. 14:1993;459-479.
51. Wang B., Tsai S.Y., Beattie W.G., Tsai M., O'Malley B.W. Coup transcription factor is a member of the steroid receptor superfamily. Nature. 390:1989;163-166.
52. Williams E.J., Furness J., Walsh F.S., Doherty P. Characterisation of the second messenger pathway underlying neurite outgrowth stimulated by FGF. Development. 120:1994;1685-1693.
53. Yokoyama C., Wang X., Briggs M.R., Admon A., Wu J., Hua X., Goldstein J.L., Brown M.S. SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene. Cell. 75:1993;187-197.