Progressive neuronal injury associated with amyloid plaque formation in Alzheimer disease

Journal of Neuropathology and Experimental Neurology

Volumn 57, Issue 7, 1998, Pages 714-717

  Sheng, Jin G ^b,d   Zhou, Xue Q ^b,d   Mrak, Robert E ^a,c   Griffin, W S T ^a,b,e  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^b UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^c UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^d SHANGHAI SECOND MEDICAL UNIVERSITY   (China)

^e CENTRAL ARKANSAS VETERANS HEALTHCARE SYSTEM   (United States)

Author keywords

Alzheimer disease; Neuronal cell injury and loss; TUNEL; amyloid plaque progression

Indexed keywords

AMYLOID BETA PROTEIN;

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; CELLULAR DISTRIBUTION; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; NERVE CELL LESION; NERVE CELL NECROSIS; PRIORITY JOURNAL; PROTEIN LOCALIZATION;

EID: 0031813116     PISSN: 00223069     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005072-199807000-00008     Document Type: Article

References (15)

1. Yankner BA, Duffy LK, Kirschner DA. Neurotrophic and neurotoxic effects of amyloid β protein: Reversal by tachykinin neuropeptides. Science 1990;250:279-82
2. Gavrieli Y, Sherman Y, Ben-Sasson SA. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol 1992;119:493-501
3. Tominaga T, Kure S, Narisawa K, Yoshimoto T. Endonuclease activation following focal ischemic injury in the rat brain. Brain Res 1993;608:21-26
4. Sheng JG, Mrak RE, Griffin WST. Progressive neuronal DNA damage associated with neurofibrillary tangle formation in Alzheimer's disease. J Neuropathol Exp Neurol 1998;57:323-28
5. Anderson A. Su JH, Cotman CW. DNA damage and apoptosis in Alzheimer's disease colocalization with c-jun immunoreactivity, relationship to brain area and effect of postmortem delay. J Neurosci 1996;16:1710-19
6. Mullaart E, Boerrigter ME, Ravid R, Swaab DF, Vijg J. Increased levels of DNA breaks in cerebral cortex of Alzheimer's disease patients. Neurobiol Aging 1990;11:169-73
7. Troncoso JC, Sukhov RR, Kawas CH, Koliatsos VE. In situ labeling of dying cortical neurons in normal aging and in Alzheimer's disease: Correlations with senile plaques and disease progression. J Neuropath Exp Neurol 1996;55:1134-43
8. Su JH, Anderson AJ, Cummings BJ, Cotman CW. Immunohistochemical evidence for apoptosis in Alzheimer's disease. NeuroReport 1994;5:2529-33
9. Lassmann H, Bancher C. Breitschopf H, et al. Cell death in Alzheimer's disease evaluated by DNA fragmentation in situ. Acta Neuropathol 1995;89:35-41
10. Smale G, Nichols NY, Brady DR, Finch CE, Horton WE. Evidence for apoptotic cell death in Alzheimer's disease. Exp Neurol 1995; 133:225-30
11. Rozemuller JM, Eikelenboom P, Stam FC, Beyreuther K, Masters CL. A4 protein in Alzheimer's disease: Primary and secondary cellular events in extracellular amyloid deposition. J Neuropathol Exp Neurol 1989;48:674-91
12. Mirra SS, Heyman A, McKeel D, et al. The consortium to establish a registry for Alzheimer's disease (CERAD). Part II. Standardization of the neuropathological assessment of Alzheimer's disease. Neurology 1991;41:479-86
13. Sheng JG, Mrak RE, Griffin WST. S100β protein expression in Alzheimer disease: Potential role in the pathogenesis of neuritic plaques. J Neurosci Res 1994;39:398-404
14. Griffin WST, Sheng JG, Roberts GW, Mrak RE. Interleukin-1 expression in different plaque types in Alzheimer's disease, significance in plaque evolution. J Neuropathol Exp Neurol 1995;54:276-81
15. Griffin WST, Sheng JG, Royston MC, et al. Glial-neuronal interactions in Alzheimer's disease: The potential role of a 'cytokine cycle' in disease progression. Brain Pathol 1998;8:65-72