Gentisic acid, a compound associated with plant defense and a metabolite of aspirin, heads a new class of in vivo fibroblast growth factor inhibitors

Journal of Biological Chemistry

Volumn 285, Issue 15, 2010, Pages 11714-11729

  Fernández, Israel S ^a   Cuevas, Pedro ^b   Angulo, Javier ^b   López Navajas, Pilar ^a   Canales Mayordomo, Ángeles ^a   González Corrochano, Rocío ^a,b   Lozano, Rosa M ^a   Valverde, Serafín ^c   Jiménez Barbero, Jesús ^a   Romero, Antonio ^a   Giménez Gallego, Guillermo ^a  

^a CENTRO DE INVESTIGACIONES BIOLÓGICAS   (Spain)

^b HOSPITAL RAMÓN Y CAJAL   (Spain)

^c INSTITUTO DE QUÍMICA ORGÁNICA GENERAL   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

A PLANTS; ANGIOGENESIS; CELL RECEPTORS; CHEMICAL CLASS; DIFFERENT MECHANISMS; DISEASE MODELS; EXTRACELLULAR; EXTRACELLULAR MATRICES; FIBROBLAST GROWTH FACTOR; HERBAL REMEDIES; HIGH RESOLUTION; IN-VIVO; INTERCELLULAR SIGNALING; MITOGENESIS; PLANT DEFENSE; POTENTIAL INHIBITORS; SIGNALING COMPLEX; VEGETARIAN DIET;

ACIDS; BIOACTIVITY; CELL CULTURE; CELL MEMBRANES; FIBROBLASTS; GROWTH KINETICS; LEAD COMPOUNDS; PEPTIDES; SIGNALING;

TISSUE;

ACETYLSALICYLIC ACID; CELL RECEPTOR; FIBROBLAST GROWTH FACTOR; FIBROBLAST GROWTH FACTOR RECEPTOR; GENTISIC ACID; PROTEIN INHIBITOR;

ALKAPTONURIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CHEMOTHERAPY; CELL COMMUNICATION; CONTROLLED STUDY; EXTRACELLULAR MATRIX; IN VIVO STUDY; MITOGENESIS; MOUSE; NEOVASCULARIZATION (PATHOLOGY); NONHUMAN; PLANT DEFENSE; PRIORITY JOURNAL;

ANGIOGENESIS INHIBITORS; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ASPIRIN; BINDING, COMPETITIVE; CELL MOVEMENT; DRUG DESIGN; EXTRACELLULAR MATRIX; FIBROBLAST GROWTH FACTORS; GENTISATES; HEPARIN; MICE; MICE, INBRED BALB C; MITOGENS; NIH 3T3 CELLS;

EID: 77951226293     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.064618     Document Type: Article

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