Ofloxacin-like antibiotics inhibit pneumococcal cell wall-degrading virulence factors

Journal of Biological Chemistry

Volumn 280, Issue 20, 2005, Pages 19948-19957

  Fernández Tornero, Carlos ^a   García, Ernesto ^a   De Pascual Teresa, Beatriz ^b   López, Rubens ^a   Giménez Gallego, Guillermo ^a   Romero, Antonio ^a  

^a CENTRO DE INVESTIGACIONES BIOLÓGICAS   (Spain)

^b UNIVERSIDAD SAN PABLO CEU   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

BIODEGRADATION; CELLS; CRYSTAL STRUCTURE; ENZYMES; PROTEINS; VIRUSES;

AUTOLYSIN; CHOLINE BINDING DOMAIN; OFLOXACIN; PNEUMOCOCCAL CELLS;

ANTIBIOTICS;

5 AMINO 1 NAPHTHALENESULFONIC ACID; ALLOXAZINE; ANTIBIOTIC AGENT; AUTOLYSIN; BACTERIAL ENZYME; CHOLINE; LOMEFLOXACIN; LUMICHROME; NAPHTHALENESULFONIC ACID DERIVATIVE; NORFLOXACIN; OFLOXACIN; PHAGE LYTIC ENZYME; PIPEMIDIC ACID; PROTEIN CPL 1; QUINOLONE DERIVATIVE; RIBOFLAVIN; UNCLASSIFIED DRUG; VIRULENCE FACTOR; ANTIINFECTIVE AGENT; N ACETYLMURAMOYLALANINE AMIDASE;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL CELL WALL; BACTERIAL VIRULENCE; CRYSTAL STRUCTURE; DRUG STRUCTURE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; LIPID MEMBRANE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN TERTIARY STRUCTURE; STREPTOCOCCUS INFECTION; STREPTOCOCCUS PNEUMONIAE; BACTERIOLYSIS; BINDING SITE; CELL WALL; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; DRUG DESIGN; DRUG EFFECT; ENZYMOLOGY; MICROBIOLOGICAL EXAMINATION; PATHOGENICITY; THERMODYNAMICS; VIRULENCE; X RAY CRYSTALLOGRAPHY;

PNEUMOCOCCUS; STREPTOCOCCUS PNEUMONIAE;

ANTI-BACTERIAL AGENTS; BACTERIOLYSIS; BINDING SITES; CELL WALL; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; N-ACETYLMURAMOYL-L-ALANINE AMIDASE; OFLOXACIN; PROTEIN STRUCTURE, TERTIARY; STREPTOCOCCUS PNEUMONIAE; THERMODYNAMICS; VIRULENCE;

EID: 21244438712     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M501236200     Document Type: Article

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