The effect of hyperglycemia on hypoperfusion-induced injury

Investigative Ophthalmology and Visual Science

Volumn 51, Issue 4, 2010, Pages 2197-2207

  Holman, Matthew C ^a,b   Chidlow, Glyn ^a,b   Wood, John P M ^a,b   Casson, Robert J ^a,b  

^a ROYAL ADELAIDE HOSPITAL   (United States)

^b UNIVERSITY OF ADELAIDE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

HEAT SHOCK PROTEIN 27; MESSENGER RNA; AIF1 PROTEIN, RAT; CALCIUM BINDING PROTEIN; GLIAL FIBRILLARY ACIDIC PROTEIN; HSPB1 PROTEIN, RAT; INTERMEDIATE FILAMENT PROTEIN; NERVE PROTEIN; NESTIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL OCCLUSION; BRAIN INFARCTION; BRAIN INJURY; BRAIN PERFUSION; CELL ACTIVATION; CELL INFILTRATION; CELL LOSS; CELL SIZE; CELL SURVIVAL; CONTROLLED STUDY; GLIA CELL; HISTOPATHOLOGY; HYPERGLYCEMIA; IMMUNOHISTOCHEMISTRY; ISCHEMIC PRECONDITIONING; MACROPHAGE; NERVE CELL; NEUROPROTECTION; NONHUMAN; ORGAN PERFUSION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; RETINA GANGLION CELL; RETINA PERFUSION; SHAM PROCEDURE; WHITE MATTER; ANIMAL; BRAIN ISCHEMIA; ENZYME IMMUNOASSAY; EXPERIMENTAL DIABETES MELLITUS; FEMALE; GENETICS; GLIA; GLUCOSE BLOOD LEVEL; MALE; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; REPERFUSION INJURY; RETINA BLOOD VESSEL; RETINA DISEASE; RETINA NERVE CELL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPRAGUE DAWLEY RAT;

ANIMALS; BLOOD GLUCOSE; BRAIN ISCHEMIA; CALCIUM-BINDING PROTEINS; DIABETES MELLITUS, EXPERIMENTAL; FEMALE; GLIAL FIBRILLARY ACIDIC PROTEIN; HSP27 HEAT-SHOCK PROTEINS; HYPERGLYCEMIA; IMMUNOENZYME TECHNIQUES; INTERMEDIATE FILAMENT PROTEINS; MALE; NERVE TISSUE PROTEINS; NEUROGLIA; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY; RETINAL DISEASES; RETINAL NEURONS; RETINAL VESSELS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 77951223615     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.09-4191     Document Type: Article

References (47)

1. Dowling J. The Retina: an Approachable Part of the Brain. Cambridge, MA: Belknap Press; 1987.
2. Winkler BS. A quantitative assessment of glucose metabolism in the isolated rat retina. In: Christen Y, Doly M, Droy-Lefaix M-T, eds. Les Seminaires Ophtalmologiques dIPSEN: Vision et Adaptation. Amsterdam: Elsevier; 1995:78-96.
3. Winkler BS, Sauer MW, Starnes CA. Modulation of the Pasteur effect in retinal cells: implications for understanding compensatory metabolic mechanisms. Exp Eye Res. 2003;76:715-723.
4. Racker E. History of the Pasteur effect and its pathobiology. Mol Cell Biochem. 1974;5:17-23.
5. Seagroves TN, Ryan HE, Lu H, et al. Transcription factor HIF-1 is a necessary mediator of the pasteur effect in mammalian cells. Mol Cell Biol. 2001;21:3436-3444.
6. Kim JW, Tchernyshyov I, Semenza GL, Dang CV. HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia. Cell Metab. 2006;3: 177-185.
7. Verweij BH, Amelink GJ, Muizelaar JP. Current concepts of cerebral oxygen transport and energy metabolism after severe traumatic brain injury. Prog Brain Res. 2007;161:111-124.
8. Brownlee M. Biochemistry and molecular cell biology of diabetic complications. Nature. 2001;414:813-820.
9. Kagansky N, Levy S, Knobler H. The role of hyperglycemia in acute stroke. Arch Neurol. 2001;58:1209-1212.
10. Casson RJ, Chidlow G, Wood JP, Osborne NN. The effect of hyperglycemia on experimental retinal ischemia. Arch Ophthalmol. 2004;122:361-366.
11. Casson RJ, Wood JP, Osborne NN. Hypoglycaemia exacerbates ischaemic retinal injury in rats. Br J Ophthalmol. 2004;88:816-820.
12. Wood JP, Chidlow G, Graham M, Osborne NN. Energy substrate requirements for survival of rat retinal cells in culture: the importance of glucose and monocarboxylates. J Neurochem. 2005;93: 686-697.
13. Melena J, Safa R, Graham M, Casson RJ, Osborne NN. The monocarboxylate transport inhibitor, alpha-cyano-4-hydroxycinnamate,has no effect on retinal ischemia. Brain Res. 2003;989:128-134.
14. Farkas E, Luiten PG, Bari F. Permanent, bilateral common carotid artery occlusion in the rat: a model for chronic cerebral hypoperfusion-related neurodegenerative diseases. Brain Res Rev. 2007; 54:162-180.
15. Chidlow G, Wood JP, Manavis J, Osborne NN, Casson RJ. Expression of osteopontin in the rat retina: effects of excitotoxic and ischemic injuries. Invest Ophthalmol Vis Sci. 2008;49:762-771.
16. Pfaffl MW, Horgan GW, Dempfle L. Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR. Nucleic Acids Res. 2002;30:e36.
17. Yamamoto H, Schmidt-Kastner R, Hamasaki DI, Parel JM. Complex neurodegeneration in retina following moderate ischemia induced by bilateral common carotid artery occlusion in Wistar rats. Exp Eye Res. 2006;82:767-779.
18. Flaris NA, Densmore TL, Molleston MC, Hickey WF. Characterization of microglia and macrophages in the central nervous system of rats: definition of the differential expression of molecules using standard and novel monoclonal antibodies in normal CNS and in four models of parenchymal reaction. Glia. 1993;7:34-40.
19. Ito D, Tanaka K, Suzuki S, Dembo T, Fukuuchi Y. Enhanced expression of Iba1, ionized calcium-binding adapter molecule 1, after transient focal cerebral ischemia in rat brain. Stroke. 2001; 32:1208-1215.
20. Bosco A, Inman DM, Steele MR, et al. Reduced retina microglial activation and improved optic nerve integrity with minocycline treatment in the DBA/2J mouse model of glaucoma. Invest Ophthalmol Vis Sci. 2008;49:1437-1446.
21. Xue LP, Lu J, Cao Q, Kaur C, Ling EA. Nestin expression in Muller glial cells in postnatal rat retina and its upregulation following optic nerve transection. Neuroscience. 2006;143:117-127.
22. Xue LP, Lu J, Cao Q, Hu S, Ding P, Ling EA. Muller glial cells express nestin coupled with glial fibrillary acidic protein in experimentally induced glaucoma in the rat retina. Neuroscience. 2006; 139:723-732.
23. Schlamp CL, Johnson EC, Li Y, Morrison JC, Nickells RW. Changes in Thy1 gene expression associated with damaged retinal ganglion cells. Mol Vis. 2001;7:192-201.
24. Chidlow G, Osborne NN. Rat retinal ganglion cell loss caused by kainate, NMDA and ischemia correlates with a reduction in mRNA and protein of Thy-1 and neurofilament light. Brain Res. 2003;963: 298-306.
25. Krueger Naug AM, Emsley JG, Myers TL, Currie RW, Clarke DB. Injury to retinal ganglion cells induces expression of the small heat shock protein Hsp27 in the rat visual system. Neuroscience. 2002; 110:653-665.
26. Huang W, Fileta JB, Filippopoulos T, Ray A, Dobberfuhl A, Grosskreutz CL. Hsp27 phosphorylation in experimental glaucoma. Invest Ophthalmol Vis Sci. 2007;48:4129-4135.
27. Kalesnykas G, Niittykoski M, Rantala J, et al. The expression of heat shock protein 27 in retinal ganglion and glial cells in a rat glaucoma model. Neuroscience. 2007;150:692-704.
28. Ogata J, Fujishima M, Morotomi Y, Omae T. Cerebral infarction following bilateral carotid artery ligation in normotensive and spontaneously hypertensive rats: a pathological study. Stroke. 1976;7:54-60.
29. Tsuchiya M, Sako K, Yura S, Yonemasu Y. Cerebral blood flow and histopathological changes following permanent bilateral carotid artery ligation in Wistar rats. Exp Brain Res. 1992;89:87-92.
30. Ni JW, Matsumoto K, Li HB, Murakami Y, Watanabe H. Neuronal damage and decrease of central acetylcholine level following permanent occlusion of bilateral common carotid arteries in rat. Brain Res. 1995;673:290-296.
31. Farkas E, Donka G, de Vos RA, Mihaly A, Bari F, Luiten PG. Experimental cerebral hypoperfusion induces white matter injury and microglial activation in the rat brain. Acta Neuropathol. 2004; 108:57-64.
32. Kalesnykas G, Tuulos T, Uusitalo H, Jolkkonen J. Neurodegeneration and cellular stress in the retina and optic nerve in rat cerebral ischemia and hypoperfusion models. Neuroscience. 2008;155: 937-947.
33. Li Y, Roth S, Laser M, Ma JX, Crosson CE. Retinal preconditioning and the induction of heat-shock protein 27. Invest Ophthalmol Vis Sci. 2003;44:1299-1304.
34. Gastinger MJ, Singh RS, Barber AJ. Loss of cholinergic and dopaminergic amacrine cells in streptozotocin-diabetic rat and Ins2Akita-diabetic mouse retinas. Invest Ophthalmol Vis Sci. 2006; 47:3143-3150.
35. Quigley HA. Can diabetes be good for glaucoma?-why can't we believe our own eyes (or data)? Arch Ophthalmol. 2009;127:227-229.
36. Roth S. Endogenous neuroprotection in the retina. Brain Res Bull. 2004;62:461-466.
37. Liu C, Peng M, Laties AM, Wen R. Preconditioning with bright light evokes a protective response against light damage in the rat retina. J Neurosci. 1998;18:1337-1344.
38. Ishii Y, Kwong JM, Caprioli J. Retinal ganglion cell protection with geranylgeranylacetone, a heat shock protein inducer, in a rat glaucoma model. Invest Ophthalmol Vis Sci. 2003;44:1982-1992.
39. Kwong JM, Lam TT, Caprioli J. Hyperthermic pre-conditioning protects retinal neurons from N-methyl-D-aspartate (NMDA)-induced apoptosis in rat. Brain Res. 2003;970:119-130.
40. Sakamoto K, Yonoki Y, Kubota Y, et al. Inducible nitric oxide synthase inhibitors abolished histological protection by late ischemic preconditioning in rat retina. Exp Eye Res. 2006;82:512-518.
41. Shpargel KB, Jalabi W, Jin Y, Dadabayev A, Penn MS, Trapp BD. Preconditioning paradigms and pathways in the brain. Cleve Clin J Med. 2008;75(suppl 2):S77-S82.
42. Ergul A, Li W, Elgebaly MM, Bruno A, Fagan SC. Hyperglycemia, diabetes and stroke: focus on the cerebrovasculature. Vasc Pharmacol. 2009;51:44-49.
43. Vaughn AE, Deshmukh M. Glucose metabolism inhibits apoptosis in neurons and cancer cells by redox inactivation of cytochrome c. Nat Cell Biol. 2008;10:1477-1483.
44. Ott M, Gogvadze V, Orrenius S, Zhivotovsky B. Mitochondria, oxidative stress and cell death. Apoptosis. 2007;12:913-922.
45. Bonnet S, Archer SL, Allalunis-Turner J, et al. A mitochondria-K_ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth. Cancer Cell. 2007;11:37-51.
46. Papandreou I, Cairns RA, Fontana L, Lim AL, Denko NC. HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption. Cell Metab. 2006;3:187-197.
47. Guzy RD, Schumacker PT. Oxygen sensing by mitochondria at complex III: the paradox of increased reactive oxygen species during hypoxia. Exp Physiol. 2006;91:807-819.