Do soluble mediators cause ventilator-induced lung injury and multi-organ failure?

Intensive Care Medicine

Volumn 36, Issue 5, 2010, Pages 750-757

  Jaecklin, Thomas ^a   Otulakowski, Gail ^a   Kavanagh, Brian P ^a  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

ARDS; Cytokines; Isolated organ model; Mechanical ventilation

Indexed keywords

ACTIVATED PROTEIN C; ANGIOTENSIN II; ARTIFICIAL LUNG SURFACTANT; BLOOD CLOTTING FACTOR; CAPTOPRIL; CERAMIDE; CYTOKINE; DIPEPTIDYL CARBOXYPEPTIDASE; DROTRECOGIN; FIBRIN; HEPARIN; ICOSANOID; INTERLEUKIN 1; INTERLEUKIN 6; LEXIPAFANT; LOSARTAN; MACROPHAGE INFLAMMATORY PROTEIN 2; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE; NITRIC OXIDE; PHOSPHOLIPASE A2; PLASMINOGEN ACTIVATOR INHIBITOR 1; RECOMBINANT INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; RECOMBINANT TISSUE FACTOR PATHWAY INHIBITOR; SPHINGOLIPID; SPHINGOMYELIN PHOSPHODIESTERASE INHIBITOR; THROMBOCYTE ACTIVATING FACTOR; THROMBOMODULIN; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA ANTIBODY; UNINDEXED DRUG;

ADULT RESPIRATORY DISTRESS SYNDROME; ARTIFICIAL VENTILATION; BIOCHEMISTRY; BODY POSTURE; CELL MEMBRANE PERMEABILITY; COMORBIDITY; CYTOTOXICITY; DRUG RESEARCH; DRUG TARGETING; GENETIC ANALYSIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; ISOLATED LUNG; LIPIDOMICS; LUNG PERFUSION; MASS SPECTROMETRY; MEDICAL RESEARCH; MULTIPLE ORGAN FAILURE; NONHUMAN; PATHOGENICITY; PATIENT CARE; POSITIVE END EXPIRATORY PRESSURE; PROTEOMICS; REVIEW; VENTILATOR INDUCED LUNG INJURY;

HUMANS; INFLAMMATION MEDIATORS; MULTIPLE ORGAN FAILURE; RESPIRATORY DISTRESS SYNDROME, ADULT; VENTILATOR-INDUCED LUNG INJURY; VENTILATORS, MECHANICAL;

EID: 77951205210     PISSN: 03424642     EISSN: 14321238     Source Type: Journal    
DOI: 10.1007/s00134-010-1850-4     Document Type: Review

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