Ceramide-dependent regulation of human epidermal keratinocyte CD1d expression during terminal differentiation

Journal of Immunology

Volumn 176, Issue 4, 2006, Pages 2590-2599

  Fishelevich, Rita ^a   Malanina, Alia ^a   Luzina, Irina ^a   Atamas, Sergei ^a   Smyth, Miriam J ^a   Porcelli, Steven A ^b   Gaspari, Anthony A ^a,c,d  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^c BALTIMORE VA MEDICAL CENTER   (United States)

^d NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 1 MICROGLOBULIN; BETA 2 MICROGLOBULIN; CALCINEURIN INHIBITOR; CALCINEURIN PHOSPHATASE INHIBITOR; CALCIUM CHLORIDE; CD1D ANTIGEN; CERAMIDE; CYCLOSPORIN A; FUMONISIN B1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; OLIGOPEPTIDE; PROTEIN KINASE C ZETA; PROTEIN KINASE INHIBITOR; SPHINGOSINE ACYLTRANSFERASE; UNCLASSIFIED DRUG;

ANTIGEN PRESENTATION; ARTICLE; CELL DIFFERENTIATION; CELLULAR DISTRIBUTION; CONFOCAL MICROSCOPY; EPIDERMIS CELL; GENE EXPRESSION REGULATION; GLYCOSYLATION; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOREGULATION; KERATINOCYTE; NATURAL KILLER CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION;

EID: 32044456245     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.176.4.2590     Document Type: Article

References (52)

1. Gaspari, A. A. 1997. The role of keratinocytes in the pathophysiology of contact dermatitis. Immunol. Allergy Clin. North Am. 17: 377-405.
2. Gaspari, A. A., and S. I. Katz. 1988. Induction and functional characterization of Class II MHC (Ia) antigens on murine keratinocytes. J. Immunol. 140: 2956-2963.
3. Gaspari, A. A., M. K. Jenkins, and S. I. Katz. 1988. Class II MHC-bearing keratinocytes induce antigen-specific unresponsiveness in hapten-specific TH1 clones. J. Immunol. 141:2216-2220.
4. Canchis, P. W., A. K. Bhan, S. B. Landau, L. Yang, S. P. Balk, and R. S. Blumberg. 1993. Tissue distribution of the non-polymorphic major histocompatibility complex class I-like molecule, CD1d. Immunology 80: 561-565.
5. Bonish, B., D. Jullien, Y. Dulronc, B. B. Huang, R. Modlin, F. M. Spada, S. A. Porcelli, and B. J. Nickoloff. 2000. Overexpression of CD1d by keratinocytes in psoriasis and CD1d-dependent IFN-γ production by NKT cells. J. Immunol. 165: 4076-4085.
6. Godfrey, D. I., H. R. MacDonald, M. Kronenberg, M. J. Smyth, and L. Van Kaer. 2004. NKT cells: what's in a name? Nat. Rev. Immunol. 4: 231-237.
7. Sieling, P. A. 2000. CD1 restricted T cells: T cells with a unique immunological niche. Clin. Immunol. 96: 3-10.
8. Van der Vliet, H. J. J., N. Nishi, Y. Koezuka, B. M. E. von Blumberg, A. J. M. van den Eertwegh, S. A. Porcelli, H. M. Pinedo, R. J. Scheper, and G. Gicaccone. 2001. Potent expansion of human NKT cells using α-galactosyl- ceramide-loaded monocyte-derived dendritic cells, cultured in the presence of IL-7 and IL-15. J. Immunol. Methods 247: 61-72.
9. Bleicher, P. A., S. P. Balk, S. J. Hagen, R. S. Blumberg, T. J. Flotte, and C. Terhost. 1990. Expression of CD1 on gastrointestinal epithelium. Science 250: 679-682.
10. Colgan S. P., Hershberg R. M., Furuta G. T., Blumberg R. S. 1999. Ligation of intestinal epithelial CD1d induces bioactive IL-10: critical role of the cytoplasmic tail in autocrine signaling. Proc. Natl. Acad. Sci. USA 96: 13938-13943.
11. Lampe, M. A., M. L. Williams, and P. M. Elias. 1983. Human epidermal lipids: characterization and modulations during differentiation. J. Lipid Res. 4: 131-140.
12. Plewig, G., and P. Elias. 1991. M. Stratum corneum lipid function. Dermatologica 183: 77-94.
13. Vielhaber, G., S. Pfeiffer, L. Brade, B. Lindner, T. Goldmann, E. Vollmer, U. Hintze, K.-P. Wittern, and R. Wepf. 2001. Localization of ceramide and glucosylceramide in human epidermis by immunogold electron microscopy. J. Invest. Dermatol. 117: 1126-1136.
14. Selzner, M., A. Bielawska, M. A. Morse, H. A. Rudiger, D. Sindram, Y. A. Hannun, and P. A. Clavien. 2001. Induction of apoptotic cell death and prevention of tumor growth by ceramide analogues in metastatic human colon cancer. Cancer Res. 61: 1233-1240.
15. Merrill, A. H., Jr., M. C. Sullards, E. Wang, K. A. Voss, and R. T. Riley. 2001. Sphingolipid metabolism: roles in signal transduction and disruption by fumonisins. Environ. Health Perspect. (109 Suppl.)2: 283-284.
16. Al-Daraji, W. I., K. R. Grant, K. Ryan, A. Saxton, and N. J. Reynolds. 2002. Localization of calcineurin/NFAT in human skin and psoriasis and inhibition of calcineurin/NFAT activation in human keratinocytes by cyclosporin A. J. Invest. Dermatol. 118: 779-788.
17. Boukamp, P., R. T. Petrussevska, D. Breitkreutz, J. Hornung, A. Markham, and N. E. Fusenig. 1988. Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line. J. Cell Biol. 106: 761-771.
18. Powell, D. J., E. Hajduch, G. Kular, and H. S. Hundal. 2003. Ceramide disables 3-phosphoinositide to the pleckstrin homology domain of protein kinase B (PKB)/Akt by a PKCζ-dependent mechanism. Mol. Cell. Biol. 23: 7794-7808.
19. Eichholtz, T., D. B. de Bont, J. de Widt, R. M. Liskamp, and H. L. Ploegh. 1993. A myrisloylated pseudosubstrate peptide, a novel protein kinase C inhibitor. J. Biol. Chem. 268: 1982-1986.
20. Maniatis, T., E. F. Fritsch, and J. Sambrook. 1982. Molecular Cloning: A Laboratory Manual. Cold Spring Harbor Lab. Press, Plainview, NY.
21. Schmittgen, T. D., and B. A. Zakrajsek. 2000. Effect of experimental treatment on housekeeping gene expression: validation by real-time, quantitative RT-PCR J. Biochem. Biophys. Methods 46: 69-81.
22. Bleicher, P. A., S. P. Balk, S. J. Hagen, R. S. Blumberg, T. J. Flotte, and C. Terhorst. 1990. Expression of murine CD1 on gastrointestinal epithelium. Science 250: 679-682.
23. Jetten, A. M., and B. L. Harvat. 1997. Epidermal differentiation and squamous metaplasia: from stem cell to cell death. J. Dermatol. 24: 711-725.
24. 2-microglobulin in the intracellular transport and surface expression of murine class I histocompatibility molecules. J. Immunol. 142: 2796-2806.
25. Smith, J. D., W. R. Lie, J. Gorka, C. S. Kindle, N. B. Myers, and T. H. Hansen. 1992. Disparate interaction of peptide ligand with nascent versus mature class I major histocompatibility complex molecules: comparisons of peptide binding to alternative forms of Ld in cell lysates and the cell surface. J. Exp. Med. 175: 191-202.
26. 2m association and immune recognition but not surface expression. J. Immunol. 146: 2352-2357.
27. 2-microglobulin leads to the accumulation of a substantial pool of inactive class I MHC heavy chains on the cell surface. Cell 65: 611-620.
28. 2-microglobulin dissociation. J. Immunol. 151: 159-169.
29. + cytolytic T cells. Nature 344: 742-746.
30. 2-Microglobulin- independent MHC Class Ib expressed by human intestinal epithelium. Science 265: 259-262.
31. Rademacher, T. W., R. B. Parekh, and R. A. Dwek. 1988. Glycobiology Annu. Rev. Biochem. 57: 785-838.
32. Kang, S. J., and P. Cresswell. 2002. Regulation of intracellular trafficking of human CD1d by association with MHC class II molecules. EMBO J. 21: 1650-1660.
33. Lozano, J., E. Berra, M. M. Municio, M. T. Diaz-Meco, I. Dominguez, L. Sanz, and J. Moscat. 1994. Protein kinase C ζ isoform is critical for κB-dependent promoter activity by spinhomyelinase. J. Biol. Chem. 269: 19200-19202.
34. Muller, G., M. Ayoub, P. Storz, J. Rennecke, D. Fabbro, and K. Pizenmaier. 1994. PKC ζ is a molecular switch in signal transduction of TNF-α, bifunctionally regulated by ceramide and arachadonic acid. EMBO J. 14: 1961-1969.
35. Bourbon, N. A., J. Yun, and M. Kester. 2000. Ceramide directly activates protein kinase C ζ to regulate a stress-activated protein kinase signaling complex. J. Biol. Chem. 275: 35617-35623.
36. Wang, Y. M., M. L. Seibenhener, M. L. Vandenplas, and M. W. Wooten. 1999. Atypical PKC ζ is activated by ceramide, resulting in NF-κB/JNK kinase and cell survival. J. Neurosci. Res. 55: 293-302.
37. Watt, F. M. 1989. Terminal differentiation of epidermal keratinocytes. Curr. Opin. Cell Biol. 1: 1107-1115.
38. Fuchs, E., and H. Green. 1981. Regulation of terminal differentiation of cultured human keratinocytes by vitamin A. Cell 25: 617-625.
39. Barker, J. N. W., R. S. Mitra, C. E. M. Griffith, V. M. Dixit, and B. J. Nickoloff. 1997. Keratinocytes as initiators of inflammation. Lancet 337: 211-214.
40. Balk, S. P., P. A. Bleicher, and C. Terhost. 1989. Isolation and characterization of cDNA and gene coding for a fourth CD1 molecule. Proc. Natl. Acad. Sci. USA 86: 252-256.
41. Balk, S. P., P. A. Bleicher, C. Terhorst, S. P. Balk, P. A. Bleicher, and C. Terhorst. 1991. Isolation and expression of cDNA encoding the murine homologues of CD1. J. Immunol. 146: 768-774.
42. Blumberg, R. S., C. Terhorst, P. Bleicher, F. V. McDermott, C. H. Allan, S. B. Landau, J. S. Trier, and S. P. Balk. 1991. Expression of a nonpolymorphic MHC class I-like molecule, CD1D, by human intestinal epithelial cells. J. Immunol. 147: 2518-2524.
43. 2-microglobulin binding antigen encoded by the human CD1D gene. Eur. J. Immunol. 21: 71-78.
44. Calabi, F., and A. Bradbury. 1991. The CD1 system. Tissue Antigens 37: 1-9.
45. Jayawardena-Wolf, J., K. Benlagha, Y. H. Chiu, R. Mehr, and A. Bendelac. 2001. CD1d endosomal trafficking is independently regulated by an intrinsic CD1d-encoded tyrosine motif and by the invariant chain. Immunity 15: 897-908.
46. Schreiber, S. L., and G. R. Crabtree. 1992. The mechanism of action of cyclosporine A and FK506. Immunol. Today 13: 136-142.
47. Spada, F. M., F. Borriello, M. Sugita, G. F. Watts, Y. Koezuka, and S. A. Porcelli. 2000. Low expression level but potent antigen presenting function of CD1d on monocyte lineage cells. Eur. J. Immunol. 30: 3468-3477.
48. Groisser, D. S., C. E. Griffiths, C. N. Ellis, and J. J. Voorhees. 1991. A review and update of the clinical uses of cyclosporine in dermatology. Dermatol. Clin. 9: 805-817.
49. 3-induced HL-60 cell differentiation. J. Biol. Chem. 265: 15823-15831.
50. Geilen, C. C., T. Wieder, and C. E. Orfanos. 1997. Ceramide signalling: regulatory role in cell proliferation, differentiation and apoptosis in human epidermis. Arch. Dermatol. Res. 289: 559-566.
51. Bektas, M., Y. Dullin, T. Wieder, T. Kotler, K. Sandhoff, A. Brossmer, P. Ihrig, C. E. Orfanos, and C. C. Geilen. 1998. Induction of apoptosis by synthetic ceramide analogues in human keratinocyte cell line HaCaT. Exp. Dermatol. 7: 342-349.
52. Wakita, H., K. Nishimura, Y. Tokura, F. Furukawa, and M. Takigawa. 1996. Inhibitors of sphingolipid synthesis modulate Interferon (IFN)-γ-induced intercellular adhesion molecule (ICAM)-1 and human leukocyte antigen (HLA)-DR expression on cultured normal human keratinocytes: possible involvement of ceramide in biologic action of IFN-γ. J. Invest. Dermatol. 107: 336-342.