Caspase-dependent generation of reactive oxygen species in human astrocytoma cells contributes to resistance to TRAIL-mediated apoptosis

Cell Death and Differentiation

Volumn 17, Issue 5, 2010, Pages 833-845

  Choi, K ^a   Ryu, S W ^a   Song, S ^a   Choi, H ^a   Kang, S W ^a   Choi, C ^a  

^a Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

Author keywords

Apoptosis; Caspase; Oxidative modification; ROS

Indexed keywords

CASPASE 3; CYSTEINE; PROTEIN KINASE C DELTA; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 4; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND;

APOPTOSIS; ARTICLE; ASTROCYTOMA CELL; CATALYSIS; CONTROLLED STUDY; ENZYME ACTIVITY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; OXIDATION; PLASMID; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN MODIFICATION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TWO DIMENSIONAL GEL ELECTROPHORESIS;

APOPTOSIS; ASTROCYTOMA; CASPASE 3; CELL LINE, TUMOR; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; HUMANS; IMMUNOBLOTTING; NADPH OXIDASE; REACTIVE OXYGEN SPECIES; TNF-RELATED APOPTOSIS-INDUCING LIGAND;

EID: 77950862839     PISSN: 13509047     EISSN: 14765403     Source Type: Journal    
DOI: 10.1038/cdd.2009.154     Document Type: Article

References (39)

1. Tillman DM, Izeradjene K, Szucs KS, Douglas L, Houghton JA. Rottlerin sensitizes colon carcinoma cells to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis via uncoupling of the mitochondria independent of protein kinase C. Cancer Res 2003; 63: 5118-5125.
2. Fulda S, Wick W, Weller M, Debatin KM. Smac agonists sensitize for Apo2L/TRAILor anticancer drug-induced apoptosis and induce regression of malignant glioma in vivo. Nat Med 2002; 8: 808-815.
3. Kreuz S, Siegmund D, Scheurich P, Wajant H. NF-kB inducers upregulate cFLIP, a cycloheximide-sensitive inhibitor of death receptor signaling. Mol Cell Biol 2001; 21: 3964-3973.
4. Hopkins-Donaldson S, Bodmer JL, Bourloud KB, Brognara CB, Tschopp J, Gross N. Loss of caspase-8 expression in highly malignant human neuroblastoma cells correlates with resistance to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis. Cancer Res 2000; 60: 4315-4319.
5. Choi C, Kutsch O, Park J, Zhou T, Seol D-W, Benveniste EN. Tumor necrosis factor-related apoptosis-inducing ligand induces caspase-dependent Interleukin-8 expression and apoptosis in human astroglioma cells. Mol Cell Biol 2002; 22: 724-736.
6. Choi C, Benveniste EN. Fas ligand/Fas system in the brain: regulator of immune and apoptotic responses. Brain Res Rev 2004; 44: 65-81.
7. Rhee SG. Redox signaling: hydrogen peroxide as intracellular messenger. Exp Mol Med 1999; 31: 53-59.
8. Sauer H, Wartenberg M, Hescheler J. Reactive oxygen species as intracellular messengers during cell growth and differentiation. Cell Physiol Biochem 2001; 11: 173-186.
9. Goossens V, Stange G, Moens K, Pipeleers D, Grooten J. Regulation of tumor necrosis factor-induced, mitochondria- and reactive oxygen species-dependent cell death by the electron flux through the electron transport chain complex I. Antioxid Redox Signal 1999; 1: 285-295.
10. Perez-Cruz I, Carcamo JM, Golde DW. Vitamin C inhibits FAS-induced apoptosis in monocytes and U937 cells. Blood 2003; 102: 336-343.
11. Devadas S, Hinshaw JA, Zaritskaya L, Williams MS. Fas-stimulated generation of reactive oxygen species or exogenous oxidative stress sensitize cells to Fas-mediated apoptosis. Free Radic Biol Med 2003; 35: 648-661.
12. Hampton MB, Orrenius S. Dual regulation of caspase activity by hydrogen peroxide: implications for apoptosis. FEBS Lett 1997; 414: 552-556.
13. Choi K, Han YH, Choi C. N-acetyl cysteine and caffeic acid phenethyl ester sensitize astrocytoma cells to Fas-mediated cell death in a redox-dependent manner. Cancer Lett 2007; 257: 79-86.
14. Hentze H, Schmitz I, Latta M, Krueger A, Krammer PH, Wendel A. Glutathione dependence of caspase-8 activation at the death-inducing signaling complex. J Biol Chem 2002; 277: 5588-5595.
15. Lee MW, Park SC, Kim JH, Kim IK, Han KS, Kim KY et al. The involvement of oxidative stress in tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in HeLa cells. Cancer Lett 2002; 182: 75-82.
16. Lee MW, Park SC, Yang YG, Yim SO, Chae HS, Bach JH et al. The involvement of reactive oxygen species (ROS) and p38 mitogen-activated protein (MAP) kinase in TRAIL/Apo2Linduced apoptosis. FEBS Lett 2002; 512: 313-318.
17. Kim S, Choi K, Kwon D, Benveniste EN, Choi C. Ubiquitin-proteasome pathway as a primary defender against TRAIL-mediated cell death. Cell Mol Life Sci 2004; 61: 1075-1081.
18. Kim JR, Yoon HW, Kwon KS, Lee SR, Rhee SG. Identification of proteins containing cysteine residues that are sensitive to oxidation by hydrogen peroxide at neutral pH. Anal Biochem 2000; 283: 214-221.
19. Kitada M, Koya D, Sugimoto T, Isono M, Araki S, Kashiwagi A et al. Translocation of glomerular p47phox and p67phox by protein kinase C-beta activation is required for oxidative stress in diabetic nephropathy. Diabetes 2003; 52: 2603-2614.
20. Ghayur T, Hugunin M, Talanian RV, Ratnofsky S, Quinlan C, Emoto Y et al. Proteolytic activation of protein kinase C delta by an ICE/CED 3-like protease induces characteristics of apoptosis. J Exp Med 1996; 184: 2399-2404.
21. Datta R, Kojima H, Yoshida K, Kufe D. Caspase-3-mediated cleavage of protein kinase C theta in induction of apoptosis. J Biol Chem 1997; 272: 20317-20320.
22. Hampton MB, Fadeel B, Orrenius S. Redox regulation of the caspases during apoptosis. Ann NY Acad Sci 1998; 854: 328-335.
23. Clement MV, Stamenkovic I. Superoxide anion is a natural inhibitor of Fas-mediated cell death. EMBO J 1996; 15: 216-225.
24. Lee YJ, Shacter E. Oxidative stress inhibits apoptosis in human lymphoma cells. J Biol Chem 1999; 274: 19792-19798.
25. Aronis A, Melendez JA, Golan O, Shilo S, Dicter N, Tirosh O. Potentiation of Fas-mediated apoptosis by attenuated production of mitochondria-derived reactive oxygen species. Cell Death Differ 2003; 10: 335-344.
26. Vaquero EC, Edderkaoui M, Pandol SJ, Gukovsky I, Gukovskaya AS. Reactive oxygen species produced by NAD(P)H oxidase inhibit apoptosis in pancreatic cancer cells. J Biol Chem 2004; 279: 34643-34654.
27. Borutaite V, Brown GC. Caspases are reversibly inactivated by hydrogen peroxide. FEBS Lett 2001; 500: 114-118.
28. Mannick JB, Hausladen A, Liu L, Hess DT, Zeng M, Miao QX et al. Fas-induced caspase denitrosylation. Science 1999; 284: 651-654.
29. Cardone MH, Roy N, Stennicke HR, Salvesen GS, Franke TF, Stanbridge E et al. Regulation of cell death protease caspase-9 by phosphorylation. Science 1998; 282: 1318-1321.
30. Allan LA, Morrice N, Brady S, Magee G, Pathak S, Clarke PR. Inhibition of caspase-9 through phosphorylation at Thr 125 by ERK MAPK. Nat Cell Biol 2003; 5: 647-654.
31. Suzuki Y, Nakabayashi Y, Takahashi R. Ubiquitin-protein ligase activity of X-linked inhibitor of apoptosis protein promotes proteasomal degradation of caspase-3 and enhances its anti-apoptotic effect in Fas-induced cell death. Proc Natl Acad Sci USA 2001; 98: 8662-8667.
32. 2. Mol Cell Biol 2004; 24: 4384-4394.
33. Simizu S, Takada M, Umezawa K, Imoto M. Requirement of caspase-3(-like) proteasemediated hydrogen peroxide production for apoptosis induced by various anticancer drugs. J Biol Chem 1998; 273: 26900-26907.
34. McStay GP, Salvesen GS, Green DR. Overlapping cleavage motif selectivity of caspases: implications for analysis of apoptotic pathways. Cell Death Differ 2008; 15: 322-331.
35. Li L, Lorenzo PS, Bogi K, Blumberg PM, Yuspa SH. Protein kinase Cd targets mitochondria, alters mitochondrial membrane potential, and induces apoptosis in normal and neoplastic keratinocytes when overexpressed by an adenoviral vector. Mol Cell Biol 1999; 19: 8547-8558.
36. Basu A, Lu D, Sun B, Moor AN, Akkaraju GR, Huang J. Proteolytic activation of protein kinase Ce by caspase-mediated processing and transduction of antiapoptotic signals. J Biol Chem 2002; 277: 41850-41856.
37. Choi K, Choi C. Proapoptotic ginsenosides Compound K and Rh2 enhance Fas-induced cell death of human astrocytoma cells through distinct apoptotic signaling pathways. Cancer Res Treat 2009; 41: 36-44.
38. Choi C, Xu X, Oh JW, Lee SJ, Gillespie GY, Park H et al. Fas-induced expression of chemokines in human glioma cells: involvement of extracellular signal-regulated kinase 1/2 and p38 mitogen-activated protein kinase. Cancer Res 2001; 61: 3084-3091.
39. Choi C, Gillespie GY, Van Wagoner NJ, Benveniste EN. Fas engagement increases expression of Interleukin-6 in human glioma cells. J Neurooncol 2002; 56: 13-19.