Potent and Selective Inhibitors of Platelet-Derived Growth Factor Receptor Phosphorylation. 3. Replacement of Quinazoline Moiety and Improvement of Metabolic Polymorphism of 4-[4-(N-Substituted (thio)carbamoyl)-1-piperazinyl]-6,7-dimethoxyquinazoline Derivatives

Journal of Medicinal Chemistry

Volumn 46, Issue 23, 2003, Pages 4910-4925

  Matsuno, Kenji ^a,c   Ushiki, Junko ^a   Seishi, Takashi ^a   Ichimura, Michio ^a   Giese, Neill A ^b   Yu, Jin Chen ^b   Takahashi, Shusuke ^a   Oda, Shoji ^a   Nomoto, Yuji ^a  

^a KYOWA HAKKO KOGYO CO LTD   (Japan)

^b MILLENNIUM PHARMACEUTICALS INC   (United States)

^c Pharmaceutical Discov Res Labs   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

2 OXOIMIDAZO[4,5 E]QUINAZOLINE DERIVATIVE; 4 (1,3 DIHYDRO 1,3 DIMETHYL 2 OXO 2H IMIDAZO[4,5 G]QUINAZOLIN 8 YL) N (4 PHENOXYPHENYL) 1 PIPERAZINECARBOXAMIDE; 4 (6 ETHOXY 7 METHOXY 4 QUINAZOLINYL) N (4 PHENOXYPHENYL) 1 PIPERAZINECARBOXAMIDE; 4 (6,7 DIMETHOXY 3 ETHOXYCARBONYL 4 QUINOLYL) N (4 PHENOXYPHENYL) 1 PIPERAZINECARBOXAMIDE; 4 [7 (2 ETHOXYETHOXY) 6 METHOXY 4 QUINAZOLINYL] N (4 PHENOXYPHENYL) 1 PIPERAZINECARBOXAMIDE; 4 [7 ETHOXY 6 METHOXY 4 QUINAZOLINYL] N (4 PHENOXYPHENYL) 1 PIPERAZINECARBOXAMIDE; 4 [7 METHOXY 6 (2 METHOXYETHOXY) 4 QUINAZOLINYL] N (4 PHENOXYPHENYL) 1 PIPERAZINECARBOXAMIDE; 6 (2 METHOXY)ETHOXY 7 METHOXYQUINAZOLINE DERIVATIVE; ALKYL GROUP; ISOQUINOLINE DERIVATIVE; KN 1022; KN 734; N (4 CYANOPHENYL) 4 [7 METHOXY 6 (2 METHOXYETHOXY) 4 QUINAZOLINYL] 1 PIPERAZINECARBOXAMIDE; N (4 PHENOXYPHENYL) 4 (4 PYRAZOLO[3,4 D]PYRIMIDINYL) 1 PIPERAZINECARBOXAMIDE; N (4 PHENOXYPHENYL) 4 (6,7 DIMETHOXY 4 QUINOLYL) 1 PIPERAZINECARBOXAMIDE; PIPERAZINE DERIVATIVE; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; PYRIDOPYRIMIDINE DERIVATIVE; QUINAZOLINE; QUINAZOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG ACTIVITY; DRUG BLOOD LEVEL; DRUG METABOLISM; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; IC 50; MALE; NONHUMAN; PROTEIN PHOSPHORYLATION; RAT; RAT STRAIN; STRUCTURE ACTIVITY RELATION;

EID: 0242267911     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm020505v     Document Type: Article

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