메뉴 건너뛰기




Volumn 6, Issue 1, 2010, Pages 123-141

Review of ustekinumab, an interleukin-12 and interleukin-23 inhibitor used for the treatment of plaque psoriasis

Author keywords

Biologics; Interleukin 12; Interleukin 23; Plaque psoriasis; Ustekinumab

Indexed keywords

ADALIMUMAB; ALEFACEPT; BETA INTERFERON; CERTOLIZUMAB PEGOL; CORTICOSTEROID; DISEASE MODIFYING ANTIRHEUMATIC DRUG; ETANERCEPT; GLATIRAMER; INFLIXIMAB; INTERLEUKIN 12; INTERLEUKIN 17; INTERLEUKIN 21; INTERLEUKIN 22; INTERLEUKIN 23; INTERLEUKIN 6; LEFLUNOMIDE; METHOTREXATE; MITOXANTRONE; NATALIZUMAB; NONSTEROID ANTIINFLAMMATORY AGENT; PLACEBO; REMICAIDE; SALAZOSULFAPYRIDINE; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; USTEKINUMAB;

EID: 77950848197     PISSN: 11766336     EISSN: 1178203X     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (65)

References (74)
  • 1
    • 60649092609 scopus 로고    scopus 로고
    • New biologics for psoriasis and psoriatic arthritis
    • Rozenblit M, Lebwohl M. New biologics for psoriasis and psoriatic arthritis. Dermatol Ther. 2009;22(1):56-60.
    • (2009) Dermatol Ther , vol.22 , Issue.1 , pp. 56-60
    • Rozenblit, M.1    Lebwohl, M.2
  • 3
    • 68149124213 scopus 로고    scopus 로고
    • Depression and quality of life in psoriasis
    • Van Voorhees AS, Fried R. Depression and quality of life in psoriasis. Postgrad Med. 2009;121(4):154-161.
    • (2009) Postgrad Med , vol.121 , Issue.4 , pp. 154-161
    • van Voorhees, A.S.1    Fried, R.2
  • 4
    • 77950804319 scopus 로고    scopus 로고
    • National Psoriasis Foundation, Accessed Dec 19, 2009
    • National Psoriasis Foundation. http://www.psoriasis.org/netcommunity/ learn_statistics. Accessed Dec 19, 2009.
  • 6
    • 0036885067 scopus 로고    scopus 로고
    • The lineage decisions of helper T cells
    • Murphy KM, Reiner SL. The lineage decisions of helper T cells. Nat Rev Immunol. 2002;2(12):933-944.
    • (2002) Nat Rev Immunol , vol.2 , Issue.12 , pp. 933-944
    • Murphy, K.M.1    Reiner, S.L.2
  • 7
    • 67649331684 scopus 로고    scopus 로고
    • Ustekinumab: A new option in psoriasis therapy
    • Chien AL, Elder JT, Ellis CN. Ustekinumab: a new option in psoriasis therapy. Drugs. 2009;69(9):1141-1152.
    • (2009) Drugs , vol.69 , Issue.9 , pp. 1141-1152
    • Chien, A.L.1    Elder, J.T.2    Ellis, C.N.3
  • 8
    • 0033638507 scopus 로고    scopus 로고
    • Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12
    • Oppmann B, Lesley R, Blom B, et al. Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity. 2000;13(5):715-725.
    • (2000) Immunity , vol.13 , Issue.5 , pp. 715-725
    • Oppmann, B.1    Lesley, R.2    Blom, B.3
  • 9
    • 34247555353 scopus 로고    scopus 로고
    • Differentiation and function of Th17 T cells
    • Stockinger B, Veldhoen M. Differentiation and function of Th17 T cells. Curr Opin Immunol. 2007;19(3):281-286.
    • (2007) Curr Opin Immunol , vol.19 , Issue.3 , pp. 281-286
    • Stockinger, B.1    Veldhoen, M.2
  • 10
    • 27544490377 scopus 로고    scopus 로고
    • Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
    • Harrington LE, Hatton RD, Mangan PR, et al. Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol. 2005 Nov; 6(11): 1123-1132.
    • (2005) Nat Immunol , vol.6 , Issue.11 , pp. 1123-1132
    • Harrington, L.E.1    Hatton, R.D.2    Mangan, P.R.3
  • 11
    • 60249084148 scopus 로고    scopus 로고
    • Ustekinumab, a human interleukin 12/23 monoclonal antibody, for psoriatic arthritis: Ran-domised, double-blind, placebo-controlled, crossover trial
    • Gottlieb A, Menter A, Mendelsohn A, et al. Ustekinumab, a human interleukin 12/23 monoclonal antibody, for psoriatic arthritis: ran-domised, double-blind, placebo-controlled, crossover trial. Lancet. 2009;373(9664):633-640.
    • (2009) Lancet , vol.373 , Issue.9664 , pp. 633-640
    • Gottlieb, A.1    Menter, A.2    Mendelsohn, A.3
  • 12
    • 60249091170 scopus 로고    scopus 로고
    • Ustekinumab for psoriatic arthritis
    • Cuchacovich RS, Espinoza LR. Ustekinumab for psoriatic arthritis. Lancet. 2009;373(9664):605-606.
    • (2009) Lancet , vol.373 , Issue.9664 , pp. 605-606
    • Cuchacovich, R.S.1    Espinoza, L.R.2
  • 13
    • 56549092012 scopus 로고    scopus 로고
    • Th17 cells: A new therapeutic target in inflammatory dermatoses
    • Asarch A, Barak O, Loo DS, Gottlieb AB. Th17 cells: a new therapeutic target in inflammatory dermatoses. J Dermatolog Treat. 2008;19(6):318-326.
    • (2008) J Dermatolog Treat , vol.19 , Issue.6 , pp. 318-326
    • Asarch, A.1    Barak, O.2    Loo, D.S.3    Gottlieb, A.B.4
  • 14
    • 40049083827 scopus 로고    scopus 로고
    • Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens
    • Zheng Y, Valdez PA, Danilenko DM, et al. Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens. Nat Med. 2008;14(3):282-289.
    • (2008) Nat Med , vol.14 , Issue.3 , pp. 282-289
    • Zheng, Y.1    Valdez, P.A.2    Danilenko, D.M.3
  • 15
    • 33846906224 scopus 로고    scopus 로고
    • Interleukin-22, a T(H)17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis
    • Zheng Y, Danilenko DM, Valdez P, et al. Interleukin-22, a T(H)17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis. Nature. 2007;445(7128):648-651.
    • (2007) Nature , vol.445 , Issue.7128 , pp. 648-651
    • Zheng, Y.1    Danilenko, D.M.2    Valdez, P.3
  • 16
    • 33751546237 scopus 로고    scopus 로고
    • IL-23 stimulates epider-mal hyperplasia via TNF and IL-20R2-dependent mechanisms with implications for psoriasis pathogenesis
    • Chan JR, Blumenschein W, Murphy E, et al. IL-23 stimulates epider-mal hyperplasia via TNF and IL-20R2-dependent mechanisms with implications for psoriasis pathogenesis. J Exp Med. 2006;203(12): 2577-2587.
    • (2006) J Exp Med , vol.203 , Issue.12 , pp. 2577-2587
    • Chan, J.R.1    Blumenschein, W.2    Murphy, E.3
  • 17
    • 54249130813 scopus 로고    scopus 로고
    • Th17 cytokines interleu-kin (IL)-17 and IL-22 modulate distinct inflammatory and keratinocyte-response pathways
    • Nograles KE, Zaba LC, Guttman-Yassky E, et al. Th17 cytokines interleu-kin (IL)-17 and IL-22 modulate distinct inflammatory and keratinocyte-response pathways. Br J Dermatol. 2008;159(5):1092-1102.
    • (2008) Br J Dermatol , vol.159 , Issue.5 , pp. 1092-1102
    • Nograles, K.E.1    Zaba, L.C.2    Guttman-Yassky, E.3
  • 18
    • 33646552450 scopus 로고    scopus 로고
    • IL-22 regulates the expression of genes responsible for antimicrobial defense, cellular differentiation, and mobility in keratinocytes: A potential role in psoriasis
    • Wolk K, Witte E, Wallace E, et al. IL-22 regulates the expression of genes responsible for antimicrobial defense, cellular differentiation, and mobility in keratinocytes: a potential role in psoriasis. Eur J Immunol. 2006;36(5):1309-1323.
    • (2006) Eur J Immunol , vol.36 , Issue.5 , pp. 1309-1323
    • Wolk, K.1    Witte, E.2    Wallace, E.3
  • 19
    • 65549142116 scopus 로고    scopus 로고
    • Differential IL-23 require-ment for IL-22 and IL-17A production during innate immunity against Salmonella enterica serovar Enteritidis
    • Siegemund S, Schütze N, Schulz S, et al. Differential IL-23 require-ment for IL-22 and IL-17A production during innate immunity against Salmonella enterica serovar Enteritidis. Int Immunol. 2009;21(5): 555-565.
    • (2009) Int Immunol , vol.21 , Issue.5 , pp. 555-565
    • Siegemund, S.1    Schütze, N.2    Schulz, S.3
  • 20
    • 71849109959 scopus 로고    scopus 로고
    • Protective immunity to systemic infection with attenuated Salmonella enterica serovar enteritidis in the absence of IL-12 is associated with IL-23-dependent IL-22, but not IL-17
    • Schulz SM, Köhler G, Schütze N, et al. Protective immunity to systemic infection with attenuated Salmonella enterica serovar enteritidis in the absence of IL-12 is associated with IL-23-dependent IL-22, but not IL-17. J Immunol. 2008;181(11):7891-7901.
    • (2008) J Immunol , vol.181 , Issue.11 , pp. 7891-7901
    • Schulz, S.M.1    Köhler, G.2    Schütze, N.3
  • 21
    • 58449115208 scopus 로고    scopus 로고
    • Interleukin-23 orchestrates mucosal responses to Salmonella enterica serotype Typhimurium in the intestine
    • Godinez I, Raffatellu M, Chu H, et al. Interleukin-23 orchestrates mucosal responses to Salmonella enterica serotype Typhimurium in the intestine. Infect Immun. 2009;77(1):387-398.
    • (2009) Infect Immun , vol.77 , Issue.1 , pp. 387-398
    • Godinez, I.1    Raffatellu, M.2    Chu, H.3
  • 22
    • 72849131815 scopus 로고    scopus 로고
    • Th22 cells represent a distinct human T cell subset involved in epidermal immunity and remodeling
    • Eyerich S, Eyerich K, Pennino D, et al. Th22 cells represent a distinct human T cell subset involved in epidermal immunity and remodeling. J Clin Invest. 2009;119(12):3573-3585.
    • (2009) J Clin Invest , vol.119 , Issue.12 , pp. 3573-3585
    • Eyerich, S.1    Eyerich, K.2    Pennino, D.3
  • 23
    • 70350547787 scopus 로고    scopus 로고
    • IL-17 and IL-22 mediate IL-20 subfamily cytokine production in cultured keratinocytes via increased IL-22 receptor expression
    • Tohyama M, Hanakawa Y, Shirakata Y, et al. IL-17 and IL-22 mediate IL-20 subfamily cytokine production in cultured keratinocytes via increased IL-22 receptor expression. Eur J Immunol. 2009;39(10): 2779-2788.
    • (2009) Eur J Immunol , vol.39 , Issue.10 , pp. 2779-2788
    • Tohyama, M.1    Hanakawa, Y.2    Shirakata, Y.3
  • 24
    • 33749151636 scopus 로고    scopus 로고
    • An anti-IL-12p40 antibody down-regulates type 1 cytokines, chemokines, and IL-12/IL-23 in psoriasis
    • Toichi E, Torres G, McCormick TS, et al. An anti-IL-12p40 antibody down-regulates type 1 cytokines, chemokines, and IL-12/IL-23 in psoriasis. J Immunol. 2006 1;177(7):4917-4926.
    • (2006) J Immunol , vol.177 , Issue.7 , pp. 4917-4926
    • Toichi, E.1    Torres, G.2    McCormick, T.S.3    Et al.4
  • 25
    • 23444432216 scopus 로고    scopus 로고
    • TNF inhibition rapidly down-regulates multiple proinflammatory pathways in psoriasis plaques
    • Gottlieb AB, Chamian F, Masud S, et al. TNF inhibition rapidly down-regulates multiple proinflammatory pathways in psoriasis plaques. J Immunol. 2005;175(4):2721-2729.
    • (2005) J Immunol , vol.175 , Issue.4 , pp. 2721-2729
    • Gottlieb, A.B.1    Chamian, F.2    Masud, S.3
  • 26
    • 37549011317 scopus 로고    scopus 로고
    • Amelioration of epider-mal hyperplasia by TNF inhibition is associated with reduced Th17 responses
    • Zaba LC, Cardinale I, Gilleaudeau P, et al. Amelioration of epider-mal hyperplasia by TNF inhibition is associated with reduced Th17 responses. J Exp Med. 2007;204(13):3183-3194.
    • (2007) J Exp Med , vol.204 , Issue.13 , pp. 3183-3194
    • Zaba, L.C.1    Cardinale, I.2    Gilleaudeau, P.3
  • 27
    • 33846608131 scopus 로고    scopus 로고
    • A large-scale genetic associa-tion study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes
    • Cargill M, Schrodi SJ, Chang M, et al. A large-scale genetic associa-tion study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes. Am J Hum Genet. 2007;80(2):273-290.
    • (2007) Am J Hum Genet , vol.80 , Issue.2 , pp. 273-290
    • Cargill, M.1    Schrodi, S.J.2    Chang, M.3
  • 28
    • 34547774225 scopus 로고    scopus 로고
    • Sequence variants in the genes for the interleukin-23 receptor (IL23R) and its ligand (IL12B) confer protection against psoriasis
    • Capon F, Di Meglio P, Szaub J, et al. Sequence variants in the genes for the interleukin-23 receptor (IL23R) and its ligand (IL12B) confer protection against psoriasis. Hum Genet. 2007;122(2):201-206.
    • (2007) Hum Genet , vol.122 , Issue.2 , pp. 201-206
    • Capon, F.1    Di Meglio, P.2    Szaub, J.3
  • 29
    • 42149140747 scopus 로고    scopus 로고
    • Polymorphisms of the IL12B and IL23R genes are associated with psoriasis
    • Nair RP, Ruether A, Stuart PE, et al. Polymorphisms of the IL12B and IL23R genes are associated with psoriasis. J Invest Dermatol. 2008;128(7):1653-1661.
    • (2008) J Invest Dermatol , vol.128 , Issue.7 , pp. 1653-1661
    • Nair, R.P.1    Ruether, A.2    Stuart, P.E.3
  • 30
    • 51049096202 scopus 로고    scopus 로고
    • The expression of interleukin-23 (p19/p40) and inteleukin-12 (p35/p40) in psoriasis skin
    • Chen X, Tan Z, Yue Q, Liu H, Liu Z, Li J. The expression of interleukin-23 (p19/p40) and inteleukin-12 (p35/p40) in psoriasis skin. J Huazhong Univ Sci Technolog Med Sci. 2006;26(6):750-752.
    • (2006) J Huazhong Univ Sci Technolog Med Sci , vol.26 , Issue.6 , pp. 750-752
    • Chen, X.1    Tan, Z.2    Yue, Q.3    Liu, H.4    Liu, Z.5    Li, J.6
  • 31
    • 31144441631 scopus 로고    scopus 로고
    • In vitro and in situ expression of IL-23 by keratinocytes in healthy skin and psoriasis lesions: Enhanced expression in psoriatic skin
    • Piskin G, Sylva-Steenland RM, Bos JD, Teunissen MB. In vitro and in situ expression of IL-23 by keratinocytes in healthy skin and psoriasis lesions: enhanced expression in psoriatic skin. J Immunol. 2006;176(3):1908-1915.
    • (2006) J Immunol , vol.176 , Issue.3 , pp. 1908-1915
    • Piskin, G.1    Sylva-Steenland, R.M.2    Bos, J.D.3    Teunissen, M.B.4
  • 32
    • 0347285359 scopus 로고    scopus 로고
    • Increased expression of interleukin 23 p19 and p40 in lesional skin of patients with psoriasis vulgaris
    • Lee E, Trepicchio WL, Oestreicher JL, et al. Increased expression of interleukin 23 p19 and p40 in lesional skin of patients with psoriasis vulgaris. J Exp Med. 2004;199(1):125-130.
    • (2004) J Exp Med , vol.199 , Issue.1 , pp. 125-130
    • Lee, E.1    Trepicchio, W.L.2    Oestreicher, J.L.3
  • 33
    • 12244281852 scopus 로고    scopus 로고
    • Interleukin-12 p40 gene (IL12B) 3'-untranslated region polymorphism is associated with sus-ceptibility to atopic dermatitis and psoriasis vulgaris
    • Tsunemi Y, Saeki H, Nakamura K, et al. Interleukin-12 p40 gene (IL12B) 3'-untranslated region polymorphism is associated with sus-ceptibility to atopic dermatitis and psoriasis vulgaris. J Dermatol Sci. 2002;30(2):161-166.
    • (2002) J Dermatol Sci , vol.30 , Issue.2 , pp. 161-166
    • Tsunemi, Y.1    Saeki, H.2    Nakamura, K.3
  • 34
    • 59149106117 scopus 로고    scopus 로고
    • Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways
    • Nair RP, Duffin KC, Helms C, et al. Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways. Nat Genet. 2009;41(2):199-204.
    • (2009) Nat Genet , vol.41 , Issue.2 , pp. 199-204
    • Nair, R.P.1    Duffin, K.C.2    Helms, C.3
  • 35
    • 34548133583 scopus 로고    scopus 로고
    • Development, cytokine profile and function of human interleukin 17-producing helper T cells
    • Wilson NJ, Boniface K, Chan JR, et al. Development, cytokine profile and function of human interleukin 17-producing helper T cells. Nat Immunol. 2007;8(9):950-957.
    • (2007) Nat Immunol , vol.8 , Issue.9 , pp. 950-957
    • Wilson, N.J.1    Boniface, K.2    Chan, J.R.3
  • 36
    • 9744265704 scopus 로고    scopus 로고
    • A phase I study evaluating the safety, pharmacokinetics, and clinical response of a human IL-12 p40 antibody in subjects with plaque psoriasis
    • Kauffman CL, Aria N, Toichi E, et al. A phase I study evaluating the safety, pharmacokinetics, and clinical response of a human IL-12 p40 antibody in subjects with plaque psoriasis. J Invest Dermatol. 2004;123(6):1037-1044.
    • (2004) J Invest Dermatol , vol.123 , Issue.6 , pp. 1037-1044
    • Kauffman, C.L.1    Aria, N.2    Toichi, E.3
  • 37
    • 63249125804 scopus 로고    scopus 로고
    • Management of moderate to severe plaque psoriasis (part 2): Clinical update on T-cell modulators and investigational agents
    • Sobell JM, Kalb RE, Weinberg JM. Management of moderate to severe plaque psoriasis (part 2): clinical update on T-cell modulators and investigational agents. J Drugs Dermatol. 2009;8(3):230-238.
    • (2009) J Drugs Dermatol , vol.8 , Issue.3 , pp. 230-238
    • Sobell, J.M.1    Kalb, R.E.2    Weinberg, J.M.3
  • 38
    • 34249039292 scopus 로고    scopus 로고
    • A phase 1, double-blind, placebo-controlled study evaluating single subcutaneous administra-tions of a human interleukin-12/23 monoclonal antibody in subjects with plaque psoriasis
    • Gottlieb AB, Cooper KD, McCormick TS, et al. A phase 1, double-blind, placebo-controlled study evaluating single subcutaneous administra-tions of a human interleukin-12/23 monoclonal antibody in subjects with plaque psoriasis. Curr Med Res Opin. 2007;23(5):1081-1092.
    • (2007) Curr Med Res Opin , vol.23 , Issue.5 , pp. 1081-1092
    • Gottlieb, A.B.1    Cooper, K.D.2    McCormick, T.S.3
  • 39
    • 33846889522 scopus 로고    scopus 로고
    • A human interleukin-12/23 monoclonal antibody for the treatment of psoriasis
    • Krueger GG, Langley RG, Leonardi C, et al. A human interleukin-12/23 monoclonal antibody for the treatment of psoriasis. N Engl J Med. 2007;356(6):580-592.
    • (2007) N Engl J Med , vol.356 , Issue.6 , pp. 580-592
    • Krueger, G.G.1    Langley, R.G.2    Leonardi, C.3
  • 40
    • 43449111187 scopus 로고    scopus 로고
    • Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 76-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 1)
    • Leonardi CL, Kimball AB, Papp KA, et al. Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 76-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 1). Lancet. 2008;371(9625):1665-1674.
    • (2008) Lancet , vol.371 , Issue.9625 , pp. 1665-1674
    • Leonardi, C.L.1    Kimball, A.B.2    Papp, K.A.3
  • 41
    • 43449139402 scopus 로고    scopus 로고
    • Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 52-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 2)
    • Papp KA, Langley RG, Lebwohl M, et al. Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 52-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 2). Lancet. 2008;371(9625):1675-1684.
    • (2008) Lancet , vol.371 , Issue.9625 , pp. 1675-1684
    • Papp, K.A.1    Langley, R.G.2    Lebwohl, M.3
  • 42
    • 69749085182 scopus 로고    scopus 로고
    • Long-term efficacy of biologics in the treatment of psoriasis: What do we really know?
    • Alwawi EA, Krulig E, Gordon KB. Long-term efficacy of biologics in the treatment of psoriasis: what do we really know? Dermatol Ther. 2009;22(5):431-440.
    • (2009) Dermatol Ther , vol.22 , Issue.5 , pp. 431-440
    • Alwawi, E.A.1    Krulig, E.2    Gordon, K.B.3
  • 43
    • 58849118867 scopus 로고    scopus 로고
    • Population pharmacokinetic modeling of ustekinumab, a human monoclonal antibody targeting IL-12/23p40, in patients with moderate to severe plaque psoriasis
    • Zhu Y, Hu C, Lu M, et al. Population pharmacokinetic modeling of ustekinumab, a human monoclonal antibody targeting IL-12/23p40, in patients with moderate to severe plaque psoriasis. J Clin Pharmacol. 2009;49(2):162-175.
    • (2009) J Clin Pharmacol , vol.49 , Issue.2 , pp. 162-175
    • Zhu, Y.1    Hu, C.2    Lu, M.3
  • 46
    • 56549104968 scopus 로고    scopus 로고
    • IL23 differentially regulates the Th1/Th17 balance in ulcerative colitis and Crohn's disease
    • Kobayashi T, Okamoto S, Hisamatsu T, et al. IL23 differentially regulates the Th1/Th17 balance in ulcerative colitis and Crohn's disease. Gut. 2008;57(12):1682-1689.
    • (2008) Gut , vol.57 , Issue.12 , pp. 1682-1689
    • Kobayashi, T.1    Okamoto, S.2    Hisamatsu, T.3
  • 47
    • 53049091561 scopus 로고    scopus 로고
    • A randomized trial of Ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with moderate-to-severe Crohn's disease
    • Sandborn WJ, Feagan BG, Fedorak RN, et al. A randomized trial of Ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with moderate-to-severe Crohn's disease. Gastroenterology. 2008;135(4):1130-1141.
    • (2008) Gastroenterology , vol.135 , Issue.4 , pp. 1130-1141
    • Sandborn, W.J.1    Feagan, B.G.2    Fedorak, R.N.3
  • 48
    • 48849087125 scopus 로고    scopus 로고
    • Repeated subcutaneous injections of IL12/23 p40 neutralising antibody, ustekinumab, in patients with relapsing-remitting multiple sclerosis: A phase II, double-blind, placebo-controlled, randomised, dose-ranging study
    • Segal BM, Constantinescu CS, Raychaudhuri A, et al. Repeated subcutaneous injections of IL12/23 p40 neutralising antibody, ustekinumab, in patients with relapsing-remitting multiple sclerosis: a phase II, double-blind, placebo-controlled, randomised, dose-ranging study. Lancet Neurol. 2008;7(9):796-804.
    • (2008) Lancet Neurol , vol.7 , Issue.9 , pp. 796-804
    • Segal, B.M.1    Constantinescu, C.S.2    Raychaudhuri, A.3
  • 49
    • 0037434789 scopus 로고    scopus 로고
    • Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain
    • Cua DJ, Sherlock J, Chen Y, et al. Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain. Nature. 2003;421(6924):744-748.
    • (2003) Nature , vol.421 , Issue.6924 , pp. 744-748
    • Cua, D.J.1    Sherlock, J.2    Chen, Y.3
  • 50
    • 33646518184 scopus 로고    scopus 로고
    • Pathophysiol-ogy of interleukin-23 in experimental autoimmune encephalomyelitis
    • Touil T, Fitzgerald D, Zhang GX, Rostami AM, Gran B. Pathophysiol-ogy of interleukin-23 in experimental autoimmune encephalomyelitis. Drug News Perspect. 2006;19(2):77-83.
    • (2006) Drug News Perspect , vol.19 , Issue.2 , pp. 77-83
    • Touil, T.1    Fitzgerald, D.2    Zhang, G.X.3    Rostami, A.M.4    Gran, B.5
  • 51
    • 0032536447 scopus 로고    scopus 로고
    • An interleukin (IL)-10/IL-12 immunoregulatory circuit controls susceptibility to autoimmune disease
    • Segal BM, Dwyer BK, Shevach EM. An interleukin (IL)-10/IL-12 immunoregulatory circuit controls susceptibility to autoimmune disease. J Exp Med. 1998;187(4):537-546.
    • (1998) J Exp Med , vol.187 , Issue.4 , pp. 537-546
    • Segal, B.M.1    Dwyer, B.K.2    Shevach, E.M.3
  • 52
    • 66449113393 scopus 로고    scopus 로고
    • Why did IL-12/IL-23 antibody therapy fail in multiple sclerosis?
    • Longbrake EE, Racke MK. Why did IL-12/IL-23 antibody therapy fail in multiple sclerosis? Expert Rev Neurother. 2009;9(3):319-321
    • (2009) Expert Rev Neurother , vol.9 , Issue.3 , pp. 319-321
    • Longbrake, E.E.1    Racke, M.K.2
  • 53
    • 46949089128 scopus 로고    scopus 로고
    • Deficiency of Th17 cells in hyper IgE syndrome due to mutations in STAT3
    • Ma CS, Chew GY, Simpson N, et al. Deficiency of Th17 cells in hyper IgE syndrome due to mutations in STAT3. J Exp Med. 2008;205(7):1551-1557.
    • (2008) J Exp Med , vol.205 , Issue.7 , pp. 1551-1557
    • Ma, C.S.1    Chew, G.Y.2    Simpson, N.3    Et al.4
  • 54
    • 41449110468 scopus 로고    scopus 로고
    • Impaired T(H)17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome
    • Milner JD, Brenchley JM, Laurence A, et al. Impaired T(H)17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome. Nature. 2008;452(7188):773-776.
    • (2008) Nature , vol.452 , Issue.7188 , pp. 773-776
    • Milner, J.D.1    Brenchley, J.M.2    Laurence, A.3
  • 55
    • 0033522220 scopus 로고    scopus 로고
    • Hyper-IgE syndrome with recurrent infections--an autosomal dominant multisystem disorder
    • Grimbacher B, Holland SM, Gallin JI, et al. Hyper-IgE syndrome with recurrent infections--an autosomal dominant multisystem disorder. N Engl J Med. 1999;340(9):692-702.
    • (1999) N Engl J Med , vol.340 , Issue.9 , pp. 692-702
    • Grimbacher, B.1    Holland, S.M.2    Gallin, J.I.3
  • 56
    • 0032577295 scopus 로고    scopus 로고
    • Severe mycobacterial and Salmo-nella infections in interleukin-12 receptor-deficient patients
    • de Jong R, Altare F, Haagen IA, et al. Severe mycobacterial and Salmo-nella infections in interleukin-12 receptor-deficient patients. Science. 1998;280(5368):1435-1438.
    • (1998) Science , vol.280 , Issue.5368 , pp. 1435-1438
    • de Jong, R.1    Altare, F.2    Haagen, I.A.3
  • 57
    • 18244428735 scopus 로고    scopus 로고
    • Impairment of mycobacte-rial immunity in human interleukin-12 receptor deficiency
    • Altare F, Durandy A, Lammas D, et al. Impairment of mycobacte-rial immunity in human interleukin-12 receptor deficiency. Science. 1998;280(5368):1432-1435.
    • (1998) Science , vol.280 , Issue.5368 , pp. 1432-1435
    • Altare, F.1    Durandy, A.2    Lammas, D.3
  • 58
    • 0032535370 scopus 로고    scopus 로고
    • Inherited interleukin 12 deficiency in a child with bacille Calmette-Guérin and Salmonella enteritidis dis-seminated infection
    • Altare F, Lammas D, Revy P, et al. Inherited interleukin 12 deficiency in a child with bacille Calmette-Guérin and Salmonella enteritidis dis-seminated infection. J Clin Invest. 1998;102(12):2035-2040.
    • (1998) J Clin Invest , vol.102 , Issue.12 , pp. 2035-2040
    • Altare, F.1    Lammas, D.2    Revy, P.3
  • 59
    • 0038759100 scopus 로고    scopus 로고
    • The role of interleukin-12 in human infectious dis-eases: Only a faint signature
    • Fieschi C, Casanova JL. The role of interleukin-12 in human infectious dis-eases: only a faint signature. Eur J Immunol. 2003;33(6):1461-1464.
    • (2003) Eur J Immunol , vol.33 , Issue.6 , pp. 1461-1464
    • Fieschi, C.1    Casanova, J.L.2
  • 60
    • 33646152522 scopus 로고    scopus 로고
    • Human host genetic factors in mycobacterial and Salmonella infection: Lessons from single gene disorders in IL-12/IL-23-dependent signaling that affect innate and adaptive immunity
    • Esther van de Vosse, Ottenhoff TH. Human host genetic factors in mycobacterial and Salmonella infection: lessons from single gene disorders in IL-12/IL-23-dependent signaling that affect innate and adaptive immunity. Microbes Infect. 2006;8(4):1167-1173.
    • (2006) Microbes Infect , vol.8 , Issue.4 , pp. 1167-1173
    • van de Vosse, E.1    Ottenhoff, T.H.2
  • 61
    • 8444221890 scopus 로고    scopus 로고
    • Interleukin (IL)-12 and IL-23 are key cytokines for immunity against Salmonella in humans
    • MacLennan C, Fieschi C, Lammas DA, et al. Interleukin (IL)-12 and IL-23 are key cytokines for immunity against Salmonella in humans. J Infect Dis. 2004;190(10):1755-1757.
    • (2004) J Infect Dis , vol.190 , Issue.10 , pp. 1755-1757
    • MacLennan, C.1    Fieschi, C.2    Lammas, D.A.3
  • 62
    • 33749600724 scopus 로고    scopus 로고
    • Inborn errors of IL-12/23- and IFN-gamma-mediated immunity: Molecular, cellular, and clinical features
    • Filipe-Santos O, Bustamante J, Chapgier A, et al. Inborn errors of IL-12/23- and IFN-gamma-mediated immunity: molecular, cellular, and clinical features. Semin Immunol. 2006;18(6):347-361.
    • (2006) Semin Immunol , vol.18 , Issue.6 , pp. 347-361
    • Filipe-Santos, O.1    Bustamante, J.2    Chapgier, A.3
  • 63
    • 37349054996 scopus 로고    scopus 로고
    • From the Medical Board of the National Psoriasis Foundation: Monitoring and vaccinations in patients treated with biologics for psoriasis
    • Lebwohl M, Bagel J, Gelfand JM, et al. From the Medical Board of the National Psoriasis Foundation: monitoring and vaccinations in patients treated with biologics for psoriasis. J Am Acad Dermatol. 2008;58(1):94-105.
    • (2008) J Am Acad Dermatol , vol.58 , Issue.1 , pp. 94-105
    • Lebwohl, M.1    Bagel, J.2    Gelfand, J.M.3
  • 64
    • 47049122733 scopus 로고    scopus 로고
    • National Psoriasis Foundation consensus statement on screening for latent tuberculosis infection in patients with psoriasis treated with systemic and biologic agents
    • Doherty SD, Van Voorhees A, Lebwohl MG, et al. National Psoriasis Foundation consensus statement on screening for latent tuberculosis infection in patients with psoriasis treated with systemic and biologic agents. J Am Acad Dermatol. 2008;59(2):209-217.
    • (2008) J Am Acad Dermatol , vol.59 , Issue.2 , pp. 209-217
    • Doherty, S.D.1    van Voorhees, A.2    Lebwohl, M.G.3
  • 66
    • 77950797598 scopus 로고    scopus 로고
    • Ustekinumab improves health-related quality of life in patients with moderate-to-severe psoriasis: Results from the PHOENIX 1 trial
    • Nov 9. [Epub ahead of print]
    • Lebwohl M, Papp K, Han C, et al. Ustekinumab improves health-related quality of life in patients with moderate-to-severe psoriasis: results from the PHOENIX 1 trial. Br J Dermatol. 2009 Nov 9. [Epub ahead of print]
    • (2009) Br J Dermatol
    • Lebwohl, M.1    Papp, K.2    Han, C.3    Et al.4
  • 67
    • 77649209264 scopus 로고    scopus 로고
    • Population-based exposure-efficacy modeling of ustekinumab in patients with moderate to severe plaque psoriasis
    • Nov 23 [Epub ahead of print]
    • Zhou H, Hu C, Zhu Y, et al. Population-based exposure-efficacy modeling of ustekinumab in patients with moderate to severe plaque psoriasis. J Clin Pharmacol. 2009 Nov 23 [Epub ahead of print].
    • (2009) J Clin Pharmacol
    • Zhou, H.1    Hu, C.2    Zhu, Y.3    Et al.4
  • 68
    • 77950807750 scopus 로고    scopus 로고
    • Stelara™ (ustekinumab) [package insert], Accessed Oct 1, 2009
    • Stelara™ (ustekinumab) [package insert]. http://www.stelarainfo. com/stelarainfo/assets/pdf/PrescribingInformation.pdf. Accessed Oct 1, 2009.
  • 70
    • 33646549560 scopus 로고    scopus 로고
    • Interleukin-12-deficient mice are at greater risk of UV radiation-induced skin tumors and malignant transformation of papillomas to carcinomas
    • Meeran SM, Mantena SK, Meleth S, Elmets CA, Katiyar SK. Interleukin-12-deficient mice are at greater risk of UV radiation-induced skin tumors and malignant transformation of papillomas to carcinomas. Mol Cancer Ther. 2006;5(4):825-832.
    • (2006) Mol Cancer Ther , vol.5 , Issue.4 , pp. 825-832
    • Meeran, S.M.1    Mantena, S.K.2    Meleth, S.3    Elmets, C.A.4    Katiyar, S.K.5
  • 71
    • 77950793133 scopus 로고    scopus 로고
    • Enbrel® (etanercept) [package insert], Accessed Oct 12, 2009
    • Enbrel® (etanercept) [package insert]. http://www.enbrel.com/pdf/ enbrel_pi.pdf. Accessed Oct 12, 2009.
  • 72
    • 77950838339 scopus 로고    scopus 로고
    • Humira® (adalimumab) [package insert], Accessed Oct 1, 2009
    • Humira® (adalimumab) [package insert]. http://www.rxabbott.com/pdf/ humira.pdf. Accessed Oct 1, 2009.
  • 73
    • 77950797599 scopus 로고    scopus 로고
    • Remicade® (infliximab) [package insert], Accessed Oct 12, 2009
    • Remicade® (infliximab) [package insert]. http://www.remicade.com/ remicade/assets/HCP_PPI.pdf. Accessed Oct 12, 2009.
  • 74
    • 77950819755 scopus 로고    scopus 로고
    • Amevive® (alefacept) [package insert], Accessed Oct 12, 2009
    • Amevive® (alefacept) [package insert] http://www.astellas.us/docs/ amevive.pdf. Accessed Oct 12, 2009.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.