Blocking nuclear import of pre-integration complex: An emerging anti-HIV-1 drug discovery paradigm

Current Medicinal Chemistry

Volumn 17, Issue 6, 2010, Pages 495-503

  Zhan, Peng ^a   Liu, Xinyong ^a   De Clercq, Erik ^b  

^a SHANDONG UNIVERSITY   (China)

^b REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

AIDS; HIV 1; Inhibitors; Integrase (IN); LEDGF p75; Matrix protein (MA); Pre integration complex (PIC); Protein protein interaction; Viral protein R (Vpr)

Indexed keywords

ANTIRETROVIRUS AGENT; CHIBA 3003; CNI H 0294; CYCLOSPORIN A; CYCLOSPORIN A [4 N METHYLISOLEUCINE]; GAG PROTEIN; INTEGRASE; ITI 011; ITI 062; ITI 367; KARYOPHERIN ALPHA; LENS EPITHELIUM DERIVED GROWTH FACTOR; UNCLASSIFIED DRUG; VIRUS PROTEIN; VPR PROTEIN;

CELL TRANSPORT; DRUG BIOAVAILABILITY; DRUG SENSITIVITY; DRUG TARGETING; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LIFE CYCLE; NONHUMAN; NUCLEAR IMPORT; REVIEW; VIRUS CELL INTERACTION; VIRUS REPLICATION;

ACTIVE TRANSPORT, CELL NUCLEUS; ALPHA KARYOPHERINS; ANTI-HIV AGENTS; CELL NUCLEUS; DRUG DISCOVERY; HIV INTEGRASE; HIV-1; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; PROTEIN BINDING; VPR GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS;

EID: 77950662893     PISSN: 09298673     EISSN: None     Source Type: Journal    
DOI: 10.2174/092986710790416335     Document Type: Review

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