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Volumn 59, Issue 6, 2009, Pages 377-386

Novel targets for anti-retroviral therapy

Author keywords

CCR5; Drug design; HIV; Integrase; Maturation inhibitors; Novel targets

Indexed keywords

8 [(4 AMINOBUTYL)(2 BENZIMIDAZOLYLMETHYL)AMINO] 1,2,3,4 TETRAHYDROQUINOLINE; ANTIRETROVIRUS AGENT; APLAVIROC; APRICITABINE; ATAZANAVIR; AZOFORMAMIDE; BEVIRIMAT; DARUNAVIR; DARUNAVIR PLUS RITONAVIR; EFAVIRENZ; ELVITEGRAVIR; ELVUCITABINE; EMTRICITABINE; ENFUVIRTIDE; ETRAVIRINE; GSK 873140; HGTV 43; IBALIZUMAB; KP 1461; LOPINAVIR PLUS RITONAVIR; MARAVIROC; PLACEBO; RALTEGRAVIR; RILPIVIRINE; RITONAVIR; RITONAVIR PLUS SAQUINAVIR; RITONAVIR PLUS TIPRANAVIR; ROSCOVITINE; TENOFOVIR; UNCLASSIFIED DRUG; UNINDEXED DRUG; VALPROIC ACID; VICRIVIROC;

EID: 71549124948     PISSN: 01634453     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jinf.2009.09.014     Document Type: Review
Times cited : (28)

References (74)
  • 1
    • 31344445595 scopus 로고    scopus 로고
    • UK Group on Transmitted HIV Drug Resistance. Time trends in primary resistance to HIV drugs in the United Kingdom: multicentre observational study
    • Cane P., Chrystie I., Dunn D., Evans B., Geretti A.M., Green H., et al. UK Group on Transmitted HIV Drug Resistance. Time trends in primary resistance to HIV drugs in the United Kingdom: multicentre observational study. BMJ 331 (2005) 1368
    • (2005) BMJ , vol.331 , pp. 1368
    • Cane, P.1    Chrystie, I.2    Dunn, D.3    Evans, B.4    Geretti, A.M.5    Green, H.6
  • 2
    • 0345064200 scopus 로고    scopus 로고
    • Combination antiretroviral therapy and the risk of myocardial infarction
    • for the Data Collection on Adverse Events of Anti-HIV Drugs (DAD) Study Group
    • Friis-Møller N., Sabin C.A., Weber R., d'Arminio Monforte A., El-Sadr W.M., Reiss P., et al., for the Data Collection on Adverse Events of Anti-HIV Drugs (DAD) Study Group. Combination antiretroviral therapy and the risk of myocardial infarction. N Engl J Med 349 (2003) 1993-2003
    • (2003) N Engl J Med , vol.349 , pp. 1993-2003
    • Friis-Møller, N.1    Sabin, C.A.2    Weber, R.3    d'Arminio Monforte, A.4    El-Sadr, W.M.5    Reiss, P.6
  • 4
    • 24644472997 scopus 로고    scopus 로고
    • Prevalence of drug resistant HIV-1 variants in untreated individuals in Europe: implications for clinical management
    • Wensing A.M.J., van de Vijver D.A., Gioacchino A., Asjö B., Balotta C., Boeri E., et al. Prevalence of drug resistant HIV-1 variants in untreated individuals in Europe: implications for clinical management. J Infect Dis 192 (2005) 958-966
    • (2005) J Infect Dis , vol.192 , pp. 958-966
    • Wensing, A.M.J.1    van de Vijver, D.A.2    Gioacchino, A.3    Asjö, B.4    Balotta, C.5    Boeri, E.6
  • 5
    • 0037055016 scopus 로고    scopus 로고
    • Time trends in primary HIV-1 drug resistance among recently infected persons
    • Grant R.M., Hecht F.M., Warmerdam M., Liu L., Liegler T., Petropoulos C.J., et al. Time trends in primary HIV-1 drug resistance among recently infected persons. JAMA 288 (2002) 181-188
    • (2002) JAMA , vol.288 , pp. 181-188
    • Grant, R.M.1    Hecht, F.M.2    Warmerdam, M.3    Liu, L.4    Liegler, T.5    Petropoulos, C.J.6
  • 6
    • 0034871011 scopus 로고    scopus 로고
    • A systematic review of the associations between dose regimens and medication compliance
    • Claxton A.J., Cramer J., and Pierce C. A systematic review of the associations between dose regimens and medication compliance. Clin Ther 23 (2001) 1296-1310
    • (2001) Clin Ther , vol.23 , pp. 1296-1310
    • Claxton, A.J.1    Cramer, J.2    Pierce, C.3
  • 7
    • 11144236109 scopus 로고    scopus 로고
    • Similar adherence rates favour different virologic outcomes for patients treated with nonnucleoside analogues or protease inhibitors
    • Maggiolo F., Ravasio L., Ripamonti D., Gregis G., Quinzan G., Arici C., et al. Similar adherence rates favour different virologic outcomes for patients treated with nonnucleoside analogues or protease inhibitors. Clin Infect Dis 40 (2005) 158-163
    • (2005) Clin Infect Dis , vol.40 , pp. 158-163
    • Maggiolo, F.1    Ravasio, L.2    Ripamonti, D.3    Gregis, G.4    Quinzan, G.5    Arici, C.6
  • 10
    • 34548713478 scopus 로고    scopus 로고
    • Mass spectrometry analysis of HIV-1 Vif reveals an increase in ordered structure upon oligomerization in regions necessary for viral infectivity
    • Auclair J.R., Green K.M., Shandilya S., Evans J.E., Somasundaran M., and Schiffer C.A. Mass spectrometry analysis of HIV-1 Vif reveals an increase in ordered structure upon oligomerization in regions necessary for viral infectivity. Proteins 69 (2007) 270-284
    • (2007) Proteins , vol.69 , pp. 270-284
    • Auclair, J.R.1    Green, K.M.2    Shandilya, S.3    Evans, J.E.4    Somasundaran, M.5    Schiffer, C.A.6
  • 11
    • 33846635484 scopus 로고    scopus 로고
    • Targeting structural flexibility in HIV-1 protease inhibitor binding
    • Hornak V., and Simmerling C. Targeting structural flexibility in HIV-1 protease inhibitor binding. Drug Discov Today 12 (2007) 132-138
    • (2007) Drug Discov Today , vol.12 , pp. 132-138
    • Hornak, V.1    Simmerling, C.2
  • 12
    • 34548168260 scopus 로고    scopus 로고
    • X-ray Crystal structures of HIV-1 protease mutants Complexed with atazanavir
    • Klei H.E., Kish K., Lin P.F., Guo Q., Friborg J., Rose R.E., et al. X-ray Crystal structures of HIV-1 protease mutants Complexed with atazanavir. J Virol 81 (2007) 9525-9535
    • (2007) J Virol , vol.81 , pp. 9525-9535
    • Klei, H.E.1    Kish, K.2    Lin, P.F.3    Guo, Q.4    Friborg, J.5    Rose, R.E.6
  • 13
    • 0026730489 scopus 로고
    • Structure-Based strategies for drug design and discovery
    • Kuntz I.D. Structure-Based strategies for drug design and discovery. Science 257 (1992) 1078-1082
    • (1992) Science , vol.257 , pp. 1078-1082
    • Kuntz, I.D.1
  • 14
    • 0036008846 scopus 로고    scopus 로고
    • Structure-based computational database screening, in vitro assay, and NMR assessment of compounds that target TAR RNA
    • Lind K.E., Du Z., Fujinaga K., Peterlin B.M., and James T.L. Structure-based computational database screening, in vitro assay, and NMR assessment of compounds that target TAR RNA. Chem Biol 9 (2002) 185-193
    • (2002) Chem Biol , vol.9 , pp. 185-193
    • Lind, K.E.1    Du, Z.2    Fujinaga, K.3    Peterlin, B.M.4    James, T.L.5
  • 15
    • 34047263563 scopus 로고    scopus 로고
    • HIV integrase: a target for drug discovery
    • Lutzke R.A., and Plasterk R.H. HIV integrase: a target for drug discovery. Genes Funct 1 (1997) 289-307
    • (1997) Genes Funct , vol.1 , pp. 289-307
    • Lutzke, R.A.1    Plasterk, R.H.2
  • 16
    • 0035806423 scopus 로고    scopus 로고
    • Structure-based drug design
    • Henry C. Structure-based drug design. Chem Eng News 79 (2001) 69-74
    • (2001) Chem Eng News , vol.79 , pp. 69-74
    • Henry, C.1
  • 17
    • 1442355578 scopus 로고    scopus 로고
    • HIV drug resistance
    • Clavel F., and Hance A.J. HIV drug resistance. N Engl J Med 350 (2004) 1023-1035
    • (2004) N Engl J Med , vol.350 , pp. 1023-1035
    • Clavel, F.1    Hance, A.J.2
  • 18
    • 35448948367 scopus 로고    scopus 로고
    • TORO: ninety-six-week virologic and immunologic response and safety evaluation of enfuvirtide with an optimized background of antiretrovirals
    • Reynes J., Arastéh K., Clotet B., Cohen C., Cooper D.A., Delfraissy J.F., et al. TORO: ninety-six-week virologic and immunologic response and safety evaluation of enfuvirtide with an optimized background of antiretrovirals. AIDS Patient Care STDS 21 (2007) 533-543
    • (2007) AIDS Patient Care STDS , vol.21 , pp. 533-543
    • Reynes, J.1    Arastéh, K.2    Clotet, B.3    Cohen, C.4    Cooper, D.A.5    Delfraissy, J.F.6
  • 19
    • 33745869106 scopus 로고    scopus 로고
    • Efficacy and tolerability of 10-day monotherapy with apricitabine in antiretroviral-naive, HIV-infected patients
    • Cahn P., Cassetti I., Wood R., Phanuphak P., Shiveley L., Bethell R.C., and Sawyer J. Efficacy and tolerability of 10-day monotherapy with apricitabine in antiretroviral-naive, HIV-infected patients. AIDS 20 (2006) 1261-1268
    • (2006) AIDS , vol.20 , pp. 1261-1268
    • Cahn, P.1    Cassetti, I.2    Wood, R.3    Phanuphak, P.4    Shiveley, L.5    Bethell, R.C.6    Sawyer, J.7
  • 20
    • 71549141753 scopus 로고    scopus 로고
    • Murphy RL, Schurmann D, Beard A, et al. Tolerance and potent anti-HIV-1 activity of Reverset following 10 days of mono-therapy in treatment-naïve individuals. Program and abstracts of the 11th Conference on Retroviruses and Opportunistic Infections; San Francisco, California; February 8-11, 2004. [abstract 137].
    • Murphy RL, Schurmann D, Beard A, et al. Tolerance and potent anti-HIV-1 activity of Reverset following 10 days of mono-therapy in treatment-naïve individuals. Program and abstracts of the 11th Conference on Retroviruses and Opportunistic Infections; San Francisco, California; February 8-11, 2004. [abstract 137].
  • 21
    • 20444429765 scopus 로고    scopus 로고
    • Mechanism of action of a novel viral mutagenic covert nucleotide: molecular interactions with HIV-1 reverse transcriptase and host cell DNA polymerases
    • Murakami E., Basavapathruni A., Bradley W.D., and Anderson K.S. Mechanism of action of a novel viral mutagenic covert nucleotide: molecular interactions with HIV-1 reverse transcriptase and host cell DNA polymerases. Antivir Res 67 (2005) 10-17
    • (2005) Antivir Res , vol.67 , pp. 10-17
    • Murakami, E.1    Basavapathruni, A.2    Bradley, W.D.3    Anderson, K.S.4
  • 22
    • 21444447772 scopus 로고    scopus 로고
    • Safety, pharmacokinetics, and efficacy of (+/-)-beta-2',3'-dideoxy-5-fluoro-3'-thiacytidine with efavirenz and stavudine in antiretroviral-naive human immunodeficiency virus-infected patients
    • Herzmann C., Arasteh K., Murphy R.L., Schulbin H., Kreckel P., Drauz D., et al. Safety, pharmacokinetics, and efficacy of (+/-)-beta-2',3'-dideoxy-5-fluoro-3'-thiacytidine with efavirenz and stavudine in antiretroviral-naive human immunodeficiency virus-infected patients. Antimicrobial Agents Chemother 49 (2005) 2828-2833
    • (2005) Antimicrobial Agents Chemother , vol.49 , pp. 2828-2833
    • Herzmann, C.1    Arasteh, K.2    Murphy, R.L.3    Schulbin, H.4    Kreckel, P.5    Drauz, D.6
  • 23
    • 2142713068 scopus 로고    scopus 로고
    • Novel 4'-substituted stavudine analog with improved anti-human immunodeficiency virus activity and decreased cytotoxicity
    • Dutschman G.E., Grill S.P., Gullen E.A., Haraguchi K., Takeda S., Tanaka H., et al. Novel 4'-substituted stavudine analog with improved anti-human immunodeficiency virus activity and decreased cytotoxicity. Antimicrob Agents Chemother 48 (2004) 1640-1646
    • (2004) Antimicrob Agents Chemother , vol.48 , pp. 1640-1646
    • Dutschman, G.E.1    Grill, S.P.2    Gullen, E.A.3    Haraguchi, K.4    Takeda, S.5    Tanaka, H.6
  • 24
    • 33748036988 scopus 로고    scopus 로고
    • Short-term antiviral activity of TMC278-a novel NNRTI-in treatment-naive HIV-1-infected subjects
    • Goebel F., Yakovlev A., Pozniak A.L., Vinogradova E., Boogaerts G., Hoetelmans R., et al. Short-term antiviral activity of TMC278-a novel NNRTI-in treatment-naive HIV-1-infected subjects. AIDS 20 (2006) 1721-1726
    • (2006) AIDS , vol.20 , pp. 1721-1726
    • Goebel, F.1    Yakovlev, A.2    Pozniak, A.L.3    Vinogradova, E.4    Boogaerts, G.5    Hoetelmans, R.6
  • 26
    • 71549136954 scopus 로고    scopus 로고
    • Lazzarin A, Queiroz-Telles F, Frank I, et al. TMC114 provides durable viral load suppression in treatment-experienced patients: POWER 1 and 2 combined week 48 analysis. Program and abstracts of the XVI International AIDS Conference: Toronto, Canada. ; August 13-18, 2006. [abstract TUAB0104]
    • Lazzarin A, Queiroz-Telles F, Frank I, et al. TMC114 provides durable viral load suppression in treatment-experienced patients: POWER 1 and 2 combined week 48 analysis. Program and abstracts of the XVI International AIDS Conference: Toronto, Canada. ; August 13-18, 2006. [abstract TUAB0104]
  • 27
    • 71549170043 scopus 로고    scopus 로고
    • Lazzarin, et al. Tipranavir/ritonavir (TPV/r) demonstrates superior treatment response to lopinavir/r (LPV/r), amprenavir/r (APV/r) or saquinavir/r (SQV/r) in PI-experienced patients from the TPV RESIST-1 and RESIST-2 trials. Abstract WePe6.3C07. Program and Abstracts of the 3rd IAS Conference on HIV Pathogenesis and Treatment: Rio de Janeiro, Brazil; July 24-27, 2005.
    • Lazzarin, et al. Tipranavir/ritonavir (TPV/r) demonstrates superior treatment response to lopinavir/r (LPV/r), amprenavir/r (APV/r) or saquinavir/r (SQV/r) in PI-experienced patients from the TPV RESIST-1 and RESIST-2 trials. Abstract WePe6.3C07. Program and Abstracts of the 3rd IAS Conference on HIV Pathogenesis and Treatment: Rio de Janeiro, Brazil; July 24-27, 2005.
  • 28
    • 71549138512 scopus 로고    scopus 로고
    • GlaxoSmithKline. Statement to HIV Patient Community: Information from GlaxoSmithKline on Changes to Studies of Investigational CCR5 Entry Inhibitor Aplaviroc (GW873140). September 15, 2005.
    • GlaxoSmithKline. Statement to HIV Patient Community: Information from GlaxoSmithKline on Changes to Studies of Investigational CCR5 Entry Inhibitor Aplaviroc (GW873140). September 15, 2005.
  • 29
    • 71549154497 scopus 로고    scopus 로고
    • [accessed on 16.04.09]
    • European Medicines Agency. www.emea.europa.eu/humandocs/PDFs/EPAR/celsentri/H-811-en6.pdf [accessed on 16.04.09]
    • European Medicines Agency1
  • 30
    • 54849146700 scopus 로고    scopus 로고
    • MOTIVATE Study Teams. Maraviroc for previously treated patients with R5 HIV-1 infection
    • Gulick R.M., Lalezari J., Goodrich J., Clumeck N., DeJesus E., Horban A., et al. MOTIVATE Study Teams. Maraviroc for previously treated patients with R5 HIV-1 infection. N Engl J Med 359 (2008) 1429-1441
    • (2008) N Engl J Med , vol.359 , pp. 1429-1441
    • Gulick, R.M.1    Lalezari, J.2    Goodrich, J.3    Clumeck, N.4    DeJesus, E.5    Horban, A.6
  • 31
    • 71549143903 scopus 로고    scopus 로고
    • Moyle G, DeJesus E, Boffito M, et al. CXCR4 antagonism: proof of activity with AMD11070. Program and abstracts of the 14th Conference on Retroviruses and Opportunistic Infections: Los Angeles, California; February 25-28, 2007 [abstract 511].
    • Moyle G, DeJesus E, Boffito M, et al. CXCR4 antagonism: proof of activity with AMD11070. Program and abstracts of the 14th Conference on Retroviruses and Opportunistic Infections: Los Angeles, California; February 25-28, 2007 [abstract 511].
  • 32
    • 35549003416 scopus 로고    scopus 로고
    • Characterization of maraviroc resistance in patients failing treatment with CCR5-tropic virus in MOTIVATE 1 and MOTIVATE 2
    • [abstract 10]
    • Mori J., Mosley M., Lewis M., et al. Characterization of maraviroc resistance in patients failing treatment with CCR5-tropic virus in MOTIVATE 1 and MOTIVATE 2. Antivir Ther 12 (2007) S12 [abstract 10]
    • (2007) Antivir Ther , vol.12
    • Mori, J.1    Mosley, M.2    Lewis, M.3
  • 34
    • 71549136284 scopus 로고    scopus 로고
    • [accessed 12.09.09]
    • AIDS Info. Vicriviroc maleate. http://www.aidsinfo.nih.gov/DrugsNew/DrugDetailT.aspx?int_id=405 [accessed 12.09.09]
    • Vicriviroc maleate
    • AIDS Info1
  • 35
    • 2342544143 scopus 로고    scopus 로고
    • Piperazine-Based CCR5 antagonists as HIV-1 inhibitors. IV. Discovery of 1-[(4,6-Dimethyl-5-pyrimidinyl)carbonyl]- 4-[4-{2-methoxy-1(R)- 4-(trifluoromethyl)phenyl}ethyl-3(S)- methyl-1-piperazinyl]- 4-methylpiperidine (Sch-417690/Sch-D), a potent, highly Selective, and orally Bioavailable CCR5 antagonist
    • Tagat J.R., McCombie S.W., Nazareno D., Labroli M.A., Xiao Y., Steensma R.W., et al. Piperazine-Based CCR5 antagonists as HIV-1 inhibitors. IV. Discovery of 1-[(4,6-Dimethyl-5-pyrimidinyl)carbonyl]- 4-[4-{2-methoxy-1(R)- 4-(trifluoromethyl)phenyl}ethyl-3(S)- methyl-1-piperazinyl]- 4-methylpiperidine (Sch-417690/Sch-D), a potent, highly Selective, and orally Bioavailable CCR5 antagonist. J Med Chem 47 (2004) 2405-2408
    • (2004) J Med Chem , vol.47 , pp. 2405-2408
    • Tagat, J.R.1    McCombie, S.W.2    Nazareno, D.3    Labroli, M.A.4    Xiao, Y.5    Steensma, R.W.6
  • 37
    • 42949117215 scopus 로고    scopus 로고
    • Effect of low-dose ritonavir on the pharmacokinetics of the CXCR4 antagonist AMD070 in healthy volunteers
    • Cao Y.J., Flexner C.W., Dunaway S., Park J.G., Klingman K., Wiggins I., et al. Effect of low-dose ritonavir on the pharmacokinetics of the CXCR4 antagonist AMD070 in healthy volunteers. Antimicrob Agents Chemother 52 (2008) 1630-1634
    • (2008) Antimicrob Agents Chemother , vol.52 , pp. 1630-1634
    • Cao, Y.J.1    Flexner, C.W.2    Dunaway, S.3    Park, J.G.4    Klingman, K.5    Wiggins, I.6
  • 38
    • 64149126992 scopus 로고    scopus 로고
    • Understanding the interactions between CXCR4 and AMD11070, a first-in-class small molecule antagonist of the HIV coreceptor
    • Poster 495, Los Angeles; 25-28 February
    • Wong R, Bodart V, Metz M, Labrecque J, Bridger G, Fricker S. Understanding the interactions between CXCR4 and AMD11070, a first-in-class small molecule antagonist of the HIV coreceptor. Poster 495. In: 14th Conference of Retrovirus and Opportunistic infections. Los Angeles; 25-28 February, 2007.
    • (2007) 14th Conference of Retrovirus and Opportunistic infections
    • Wong, R.1    Bodart, V.2    Metz, M.3    Labrecque, J.4    Bridger, G.5    Fricker, S.6
  • 39
    • 0032601402 scopus 로고    scopus 로고
    • HIV integrase structure and function
    • Esposito D., and Craigie R. HIV integrase structure and function. Adv Virus Res 52 (1999) 319-333
    • (1999) Adv Virus Res , vol.52 , pp. 319-333
    • Esposito, D.1    Craigie, R.2
  • 40
    • 63649087422 scopus 로고    scopus 로고
    • Raltegravir: the first HIV type 1 integrase inhibitor
    • Hicks C., and Gulick R.M. Raltegravir: the first HIV type 1 integrase inhibitor. Clin Infect Dis 48 (2009) 931-939
    • (2009) Clin Infect Dis , vol.48 , pp. 931-939
    • Hicks, C.1    Gulick, R.M.2
  • 41
    • 71549131742 scopus 로고    scopus 로고
    • Cooper D, Gatell J, Rockstroh J, et al. Results of BENCHMRK-1, a phase III study evaluating the efficacy and safety of MK-0518, a novel HIV-1 integrase inhibitor, in patients with triple-class resistant virus. Program and abstracts of the 14th Conference on Retroviruses and Opportunistic Infections; Los Angeles: California; February 25-28, 2007 [abstracts 105aLB].
    • Cooper D, Gatell J, Rockstroh J, et al. Results of BENCHMRK-1, a phase III study evaluating the efficacy and safety of MK-0518, a novel HIV-1 integrase inhibitor, in patients with triple-class resistant virus. Program and abstracts of the 14th Conference on Retroviruses and Opportunistic Infections; Los Angeles: California; February 25-28, 2007 [abstracts 105aLB].
  • 42
    • 71549139540 scopus 로고    scopus 로고
    • Steigbigel R, Kumar P, Eron J, et al. Results of BENCHMRK-2, a phase III study evaluating the efficacy and safety of MK-0518, a novel HIV-1 integrase inhibitor, in patients with triple-class resistant virus. Program and abstracts of the 14th Conference on Retroviruses and Opportunistic Infections; Los Angeles, California ; February 25-28, 2007 [abstracts 105bLB].
    • Steigbigel R, Kumar P, Eron J, et al. Results of BENCHMRK-2, a phase III study evaluating the efficacy and safety of MK-0518, a novel HIV-1 integrase inhibitor, in patients with triple-class resistant virus. Program and abstracts of the 14th Conference on Retroviruses and Opportunistic Infections; Los Angeles, California ; February 25-28, 2007 [abstracts 105bLB].
  • 43
    • 71549148504 scopus 로고    scopus 로고
    • Zolopa A, Mullen M, Berger D, et al. The HIV integrase inhibitor GS-9137 demonstrates potent ARV activity in treatment-experienced patients. Program and abstracts of the 14th Conference on Retroviruses and Opportunistic Infections: Los Angeles, California ; February 25-28, 2007 [abstract 143LB].
    • Zolopa A, Mullen M, Berger D, et al. The HIV integrase inhibitor GS-9137 demonstrates potent ARV activity in treatment-experienced patients. Program and abstracts of the 14th Conference on Retroviruses and Opportunistic Infections: Los Angeles, California ; February 25-28, 2007 [abstract 143LB].
  • 45
    • 42049119625 scopus 로고    scopus 로고
    • Mutations associated with failure of raltegravir treatment affect integrase sensitivity to the inhibitor in vitro
    • Malet I., Delelis O., Valantin M.A., Montes B., Soulie C., Wirden M., et al. Mutations associated with failure of raltegravir treatment affect integrase sensitivity to the inhibitor in vitro. Antimicrob Agents Chemother 52 (2008) 1351-1358
    • (2008) Antimicrob Agents Chemother , vol.52 , pp. 1351-1358
    • Malet, I.1    Delelis, O.2    Valantin, M.A.3    Montes, B.4    Soulie, C.5    Wirden, M.6
  • 46
    • 62249163679 scopus 로고    scopus 로고
    • Elvitegravir, an oral HIV integrase inhibitor, for the potential treatment of HIV infection
    • Klibanov O.M. Elvitegravir, an oral HIV integrase inhibitor, for the potential treatment of HIV infection. Curr Opin Investig Drugs 10 (2009) 190-200
    • (2009) Curr Opin Investig Drugs , vol.10 , pp. 190-200
    • Klibanov, O.M.1
  • 47
    • 33748113778 scopus 로고    scopus 로고
    • Antiviral activity, pharmacokinetics, and dose response of the HIV-1 integrase inhibitor GS-9137 (JTK-303) in treatment-naive and treatment-experienced patients
    • for the 183-0101 Study Team
    • DeJesus E., Berger D., Markowitz M., Cohen C., Hawkins T., Ruane P., et al., for the 183-0101 Study Team. Antiviral activity, pharmacokinetics, and dose response of the HIV-1 integrase inhibitor GS-9137 (JTK-303) in treatment-naive and treatment-experienced patients. J Acquir Immune Defic Syndr (2006) 1-5
    • (2006) J Acquir Immune Defic Syndr , pp. 1-5
    • DeJesus, E.1    Berger, D.2    Markowitz, M.3    Cohen, C.4    Hawkins, T.5    Ruane, P.6
  • 48
    • 37849002059 scopus 로고    scopus 로고
    • Broad antiretroviral activity and resistance profile of the novel human immunodeficiency virus integrase inhibitor elvitegravir (JTK-303/GS-9137)
    • Shimura K., Kodama E., Sakagami Y., Matsuzaki Y., Watanabe W., Yamataka K., et al. Broad antiretroviral activity and resistance profile of the novel human immunodeficiency virus integrase inhibitor elvitegravir (JTK-303/GS-9137). J Virol 82 (2008) 764-774
    • (2008) J Virol , vol.82 , pp. 764-774
    • Shimura, K.1    Kodama, E.2    Sakagami, Y.3    Matsuzaki, Y.4    Watanabe, W.5    Yamataka, K.6
  • 49
    • 34948903088 scopus 로고    scopus 로고
    • Safety and pharmacokinetics of Bevirimat (PA-457), a novel inhibitor of human immunodeficiency virus maturation, in healthy volunteers
    • Martin D.E., Blum R., Wilton J., Doto J., Galbraith H., Burgess G.L., et al. Safety and pharmacokinetics of Bevirimat (PA-457), a novel inhibitor of human immunodeficiency virus maturation, in healthy volunteers. Antimicrob Agents Chemother 51 (2007) 3063-3066
    • (2007) Antimicrob Agents Chemother , vol.51 , pp. 3063-3066
    • Martin, D.E.1    Blum, R.2    Wilton, J.3    Doto, J.4    Galbraith, H.5    Burgess, G.L.6
  • 50
    • 71549134430 scopus 로고    scopus 로고
    • Beatty G, Lalezari J, Eron J, et al. Safety and antiviral activity of PA-457, the first-in-class maturation inhibitor, in a 10-day monotherapy study in HIV-1 infected patients. Program and abstracts of the 45th Annual Meeting of the Interscience Conference on Antimicrobial Agents and Chemotherapy: Washington, DC; December 16-19, 2005 [abstract H-416d].
    • Beatty G, Lalezari J, Eron J, et al. Safety and antiviral activity of PA-457, the first-in-class maturation inhibitor, in a 10-day monotherapy study in HIV-1 infected patients. Program and abstracts of the 45th Annual Meeting of the Interscience Conference on Antimicrobial Agents and Chemotherapy: Washington, DC; December 16-19, 2005 [abstract H-416d].
  • 51
    • 71549121475 scopus 로고    scopus 로고
    • Smith P, Forrest A, Beatty G, et al. Pharmacokinetics/pharmacodynamics of PA-457 in a 10-day multiple dose monotherapy trial in HIV-infected patients. Program and abstracts of the 13th Conference on Retroviruses and Opportunistic Infections: Denver, Colorado; February 5-8, 2006 [abstract 52].
    • Smith P, Forrest A, Beatty G, et al. Pharmacokinetics/pharmacodynamics of PA-457 in a 10-day multiple dose monotherapy trial in HIV-infected patients. Program and abstracts of the 13th Conference on Retroviruses and Opportunistic Infections: Denver, Colorado; February 5-8, 2006 [abstract 52].
  • 52
    • 71549141438 scopus 로고    scopus 로고
    • Adamson C, Salzwedel K, Castillo A, et al. Viral resistance to PA-457, a novel inhibitor of HIV-1 maturation. Program and abstracts of the 13th Conference on Retroviruses and Opportunistic Infections: Denver, Colorado; February 5-8, 2006 [abstract 156].
    • Adamson C, Salzwedel K, Castillo A, et al. Viral resistance to PA-457, a novel inhibitor of HIV-1 maturation. Program and abstracts of the 13th Conference on Retroviruses and Opportunistic Infections: Denver, Colorado; February 5-8, 2006 [abstract 156].
  • 53
    • 33745835123 scopus 로고    scopus 로고
    • Preclinical evaluation of a zinc finger inhibitor targeting lentivirus nucleocapsid protein in SIV-infected monkeys
    • Schito M.L., Soloff A.C., Slovitz D., Trichel A., Inman J.K., Appella E., et al. Preclinical evaluation of a zinc finger inhibitor targeting lentivirus nucleocapsid protein in SIV-infected monkeys. Curr HIV Res 4 (2006) 379-386
    • (2006) Curr HIV Res , vol.4 , pp. 379-386
    • Schito, M.L.1    Soloff, A.C.2    Slovitz, D.3    Trichel, A.4    Inman, J.K.5    Appella, E.6
  • 54
    • 0345269262 scopus 로고    scopus 로고
    • In vivo antiviral activity of novel human immunodeficiency virus type 1 nucleocapsid p7 zinc finger inhibitors in a transgenic murine model
    • Schito M.L., Goel A., Song Y., Inman J.K., Fattah R.J., Rice W.G., et al. In vivo antiviral activity of novel human immunodeficiency virus type 1 nucleocapsid p7 zinc finger inhibitors in a transgenic murine model. AIDS Res Hum Retroviruses 19 (2003) 91-101
    • (2003) AIDS Res Hum Retroviruses , vol.19 , pp. 91-101
    • Schito, M.L.1    Goel, A.2    Song, Y.3    Inman, J.K.4    Fattah, R.J.5    Rice, W.G.6
  • 55
    • 0031050622 scopus 로고    scopus 로고
    • Inhibition of multiple phases of human immunodeficiency virus type 1 replication by a dithiane compound that attacks the conserved zinc fingers of retroviral nucleocapsid proteins
    • Rice W.G., Baker D.C., Schaeffer C.A., Graham L., Bu M., Terpening S., et al. Inhibition of multiple phases of human immunodeficiency virus type 1 replication by a dithiane compound that attacks the conserved zinc fingers of retroviral nucleocapsid proteins. Antimicrob Agents Chemother 41 (1997) 419-426
    • (1997) Antimicrob Agents Chemother , vol.41 , pp. 419-426
    • Rice, W.G.1    Baker, D.C.2    Schaeffer, C.A.3    Graham, L.4    Bu, M.5    Terpening, S.6
  • 56
    • 0035808584 scopus 로고    scopus 로고
    • Phase I/II dose escalation and randomized withdrawal study with add-on azodicarbonamide in patients failing on current antiretroviral therapy
    • Goebel F.D., Hemmer R., Schmit J.C., Bogner J.R., de Clercq E., Witvrouw M., et al. Phase I/II dose escalation and randomized withdrawal study with add-on azodicarbonamide in patients failing on current antiretroviral therapy. AIDS 15 (2001) 33-45
    • (2001) AIDS , vol.15 , pp. 33-45
    • Goebel, F.D.1    Hemmer, R.2    Schmit, J.C.3    Bogner, J.R.4    de Clercq, E.5    Witvrouw, M.6
  • 57
    • 33744736316 scopus 로고    scopus 로고
    • Potential use of pharmacological cyclin-dependent kinase inhibitors as anti-HIV therapeutics
    • Pumfery A., de la Fuente C., Berro R., Nekhai S., Kashanchi F., and Chao S.H. Potential use of pharmacological cyclin-dependent kinase inhibitors as anti-HIV therapeutics. Curr Pharm Des 12 (2006) 1949-1961
    • (2006) Curr Pharm Des , vol.12 , pp. 1949-1961
    • Pumfery, A.1    de la Fuente, C.2    Berro, R.3    Nekhai, S.4    Kashanchi, F.5    Chao, S.H.6
  • 59
    • 0036310685 scopus 로고    scopus 로고
    • Pharmacological cyclin-dependent kinase inhibitors inhibit replication of wild-type and drug-resistant strains of herpes simplex virus and human immunodeficiency virus type 1 by targeting cellular, not viral, proteins
    • Schang L.M., Bantly A., Knockaert M., Shaheen F., Meijer L., Malim M.H., et al. Pharmacological cyclin-dependent kinase inhibitors inhibit replication of wild-type and drug-resistant strains of herpes simplex virus and human immunodeficiency virus type 1 by targeting cellular, not viral, proteins. J Virol 76 (2002) 7874-7882
    • (2002) J Virol , vol.76 , pp. 7874-7882
    • Schang, L.M.1    Bantly, A.2    Knockaert, M.3    Shaheen, F.4    Meijer, L.5    Malim, M.H.6
  • 60
    • 0034910933 scopus 로고    scopus 로고
    • Inhibition of human immunodeficiency virus type 1 transcription by chemical cyclin-dependent kinase inhibitors
    • Wang D., de la Fuente C., Deng L., Wang L., Zilberman I., Eadie C., et al. Inhibition of human immunodeficiency virus type 1 transcription by chemical cyclin-dependent kinase inhibitors. J Virol 75 (2001) 7266-7279
    • (2001) J Virol , vol.75 , pp. 7266-7279
    • Wang, D.1    de la Fuente, C.2    Deng, L.3    Wang, L.4    Zilberman, I.5    Eadie, C.6
  • 61
    • 2142753038 scopus 로고    scopus 로고
    • Inhibition of human immunodeficiency virus type 1 tat-trans-activation-responsive region interaction by an antiviral quinolone derivative
    • Richter S., Parolin C., Gatto B., Del Vecchio C., Brocca-Cofano E., Fravolini A., et al. Inhibition of human immunodeficiency virus type 1 tat-trans-activation-responsive region interaction by an antiviral quinolone derivative. Antimicrob Agents Chemother 48 (2004) 1895-1899
    • (2004) Antimicrob Agents Chemother , vol.48 , pp. 1895-1899
    • Richter, S.1    Parolin, C.2    Gatto, B.3    Del Vecchio, C.4    Brocca-Cofano, E.5    Fravolini, A.6
  • 62
    • 29444440832 scopus 로고    scopus 로고
    • Discoveries of Tat-TAR interaction inhibitors for HIV-1
    • Yang M. Discoveries of Tat-TAR interaction inhibitors for HIV-1. Curr Drug Targets Infect Disord 5 (2005) 433-444
    • (2005) Curr Drug Targets Infect Disord , vol.5 , pp. 433-444
    • Yang, M.1
  • 63
    • 33750947321 scopus 로고    scopus 로고
    • The design, synthesis, and biological evaluation of novel substituted purines as HIV-1 Tat-TAR inhibitors
    • Yuan D., He M., Pang R., Lin S.S., Li Z., and Yang M. The design, synthesis, and biological evaluation of novel substituted purines as HIV-1 Tat-TAR inhibitors. Bioorg Med Chem 15 (2007) 265-272
    • (2007) Bioorg Med Chem , vol.15 , pp. 265-272
    • Yuan, D.1    He, M.2    Pang, R.3    Lin, S.S.4    Li, Z.5    Yang, M.6
  • 64
    • 33845927994 scopus 로고    scopus 로고
    • Inhibition of infectious human immunodeficiency virus type 1 virions via lentiviral vector encoded short antisense RNAs
    • Gu S., Ji J., Kim J.D., Yee J.K., and Rossi J.J. Inhibition of infectious human immunodeficiency virus type 1 virions via lentiviral vector encoded short antisense RNAs. Oligonucleotides 16 (2006) 287-295
    • (2006) Oligonucleotides , vol.16 , pp. 287-295
    • Gu, S.1    Ji, J.2    Kim, J.D.3    Yee, J.K.4    Rossi, J.J.5
  • 65
    • 34248657564 scopus 로고    scopus 로고
    • Efficient inhibition of HIV-1 expression by LNA modified antisense oligonucleotides and DNAzymes targeted to functionally selected binding sites
    • Jakobsen M.R., Haasnoot J., Wengel J., Berkhout B., and Kjems J. Efficient inhibition of HIV-1 expression by LNA modified antisense oligonucleotides and DNAzymes targeted to functionally selected binding sites. Retrovirology 264 (2007) 29
    • (2007) Retrovirology , vol.264 , pp. 29
    • Jakobsen, M.R.1    Haasnoot, J.2    Wengel, J.3    Berkhout, B.4    Kjems, J.5
  • 66
    • 34047151422 scopus 로고    scopus 로고
    • LNA derivatives of a kissing aptamer targeted to the trans-activating responsive RNA element of HIV-1
    • Lebars I., Richard T., Di Primo C., and Toulmé J.J. LNA derivatives of a kissing aptamer targeted to the trans-activating responsive RNA element of HIV-1. Blood Cells Mol Dis 38 (2007) 204-209
    • (2007) Blood Cells Mol Dis , vol.38 , pp. 204-209
    • Lebars, I.1    Richard, T.2    Di Primo, C.3    Toulmé, J.J.4
  • 67
    • 2942639506 scopus 로고    scopus 로고
    • Antisense-mediated inhibition of human immunodeficiency virus (HIV) replication by use of an HIV type 1-based vector results in severely attenuated mutants incapable of developing resistance
    • Lu X., Yu Q., Binder G.K., Chen Z., Slepushkina T., Rossi J., and Dropulic B. Antisense-mediated inhibition of human immunodeficiency virus (HIV) replication by use of an HIV type 1-based vector results in severely attenuated mutants incapable of developing resistance. J Virol 78 (2004) 7079-7088
    • (2004) J Virol , vol.78 , pp. 7079-7088
    • Lu, X.1    Yu, Q.2    Binder, G.K.3    Chen, Z.4    Slepushkina, T.5    Rossi, J.6    Dropulic, B.7
  • 68
    • 36849042601 scopus 로고    scopus 로고
    • RNA interference against viruses: strike and counterstrike
    • Haasnoot J., Westerhout E.M., and Berkhout B. RNA interference against viruses: strike and counterstrike. Nat Biotechnol 25 (2007) 1435-1443
    • (2007) Nat Biotechnol , vol.25 , pp. 1435-1443
    • Haasnoot, J.1    Westerhout, E.M.2    Berkhout, B.3
  • 69
    • 9144236197 scopus 로고    scopus 로고
    • Antiretroviral activity of the anti-CD4 monoclonal antibody TNX-355 in patients infected with HIV type 1
    • Kuritzkes D.R., Jacobson J., Powderly W.G., Godofsky E., DeJesus E., Haas F., et al. Antiretroviral activity of the anti-CD4 monoclonal antibody TNX-355 in patients infected with HIV type 1. J Infect Dis 189 (2004) 286-291
    • (2004) J Infect Dis , vol.189 , pp. 286-291
    • Kuritzkes, D.R.1    Jacobson, J.2    Powderly, W.G.3    Godofsky, E.4    DeJesus, E.5    Haas, F.6
  • 70
    • 33744492607 scopus 로고    scopus 로고
    • Synergistic in vitro antiretroviral activity of a humanized monoclonal anti-CD4 antibody (TNX-355) and enfuvirtide (T-20)
    • Zhang X.Q., Sorensen M., Fung M., and Schooley R.T. Synergistic in vitro antiretroviral activity of a humanized monoclonal anti-CD4 antibody (TNX-355) and enfuvirtide (T-20). Antimicrob Agents Chemother 50 (2006) 2231-2233
    • (2006) Antimicrob Agents Chemother , vol.50 , pp. 2231-2233
    • Zhang, X.Q.1    Sorensen, M.2    Fung, M.3    Schooley, R.T.4
  • 71
    • 20444414897 scopus 로고    scopus 로고
    • KP-1212/1461, a nucleoside designed for the treatment of HIV by viral mutagenesis
    • Harris K.S., Brabant W., Styrchak S., Gall A., and Daifuku R. KP-1212/1461, a nucleoside designed for the treatment of HIV by viral mutagenesis. Antivir Res 67 (2005) 1-9
    • (2005) Antivir Res , vol.67 , pp. 1-9
    • Harris, K.S.1    Brabant, W.2    Styrchak, S.3    Gall, A.4    Daifuku, R.5
  • 72
    • 13744259064 scopus 로고    scopus 로고
    • IL-7 is a potent and proviral strain-specific inducer of latent HIV-1 cellular reservoirs of infected individuals on virally suppressive HAART
    • Wang F.X., Xu Y., Sullivan J., Souder E., Argyris E.G., Acheampong E.A., et al. IL-7 is a potent and proviral strain-specific inducer of latent HIV-1 cellular reservoirs of infected individuals on virally suppressive HAART. J Clin Invest 115 (2005) 128-137
    • (2005) J Clin Invest , vol.115 , pp. 128-137
    • Wang, F.X.1    Xu, Y.2    Sullivan, J.3    Souder, E.4    Argyris, E.G.5    Acheampong, E.A.6
  • 73
    • 23744500093 scopus 로고    scopus 로고
    • Depletion of latent HIV-1 infection in vivo: a proof-of-concept study
    • Lehrman G., Hogue I.B., Palmer S., Jennings C., Spina C.A., Wiegand A., et al. Depletion of latent HIV-1 infection in vivo: a proof-of-concept study. Lancet 366 (2005) 549-555
    • (2005) Lancet , vol.366 , pp. 549-555
    • Lehrman, G.1    Hogue, I.B.2    Palmer, S.3    Jennings, C.4    Spina, C.A.5    Wiegand, A.6
  • 74
    • 27344442122 scopus 로고    scopus 로고
    • Valproic acid and HIV-1 latency: beyond the sound bite
    • Smith S.M. Valproic acid and HIV-1 latency: beyond the sound bite. Retrovirology 2 (2005) 56
    • (2005) Retrovirology , vol.2 , pp. 56
    • Smith, S.M.1


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