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Volumn 42, Issue 5, 1998, Pages 1133-1138

CNI-H0294, a nuclear importation inhibitor of the human immunodeficiency virus type 1 genome, abrogates virus replication in infected activated peripheral blood mononuclear cells

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 4 (3,5 DIACETYLANILINO) 1,6 DIMETHYLPYRIDINIUM CHLORIDE; ANTIVIRUS AGENT; KARYOPHERIN ALPHA; NUCLEAR PROTEIN; UNCLASSIFIED DRUG;

EID: 0031971090     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/aac.42.5.1133     Document Type: Article
Times cited : (21)

References (53)
  • 1
    • 0026042170 scopus 로고
    • Cytosolic proteins that specifically bind nuclear location signals are receptors for nuclear import
    • Adam, S. A., and L. Gerace. 1991. Cytosolic proteins that specifically bind nuclear location signals are receptors for nuclear import. Cell 66:837-847.
    • (1991) Cell , vol.66 , pp. 837-847
    • Adam, S.A.1    Gerace, L.2
  • 2
    • 0027232944 scopus 로고
    • A novel mode of human immunodeficiency virus type 1 (HIV-1) activation: Ligation of CD28, activates the long terminal repeat
    • Åsjö, B., D. Cefai, P. Debré, Y. Dudoit, and B. Autran. 1993. A novel mode of human immunodeficiency virus type 1 (HIV-1) activation: ligation of CD28, activates the long terminal repeat. J. Virol. 67:4395-4398.
    • (1993) J. Virol. , vol.67 , pp. 4395-4398
    • Åsjö, B.1    Cefai, D.2    Debré, P.3    Dudoit, Y.4    Autran, B.5
  • 7
    • 0027199982 scopus 로고
    • Association of integrase, matrix, and reverse transcriptase antigens of human immunodeficiency virus type 1 with viral nucleic acids following acute infection
    • Bukrinsky, M. I., N. Sharova, T. L. McDonald, T. Pushkarskaya, W. G. Tarpley, and M. Stevenson. 1993. Association of integrase, matrix, and reverse transcriptase antigens of human immunodeficiency virus type 1 with viral nucleic acids following acute infection. Proc. Natl. Acad. Sci. USA 90:6125-6129.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 6125-6129
    • Bukrinsky, M.I.1    Sharova, N.2    McDonald, T.L.3    Pushkarskaya, T.4    Tarpley, W.G.5    Stevenson, M.6
  • 9
    • 0027994484 scopus 로고
    • RAG-1 interacts with the repeated amino acid motif of the human homologue of the yeast protein SRP1
    • Cortes, P., Z.-S. Ye, and D. Baltimore. 1994. RAG-1 interacts with the repeated amino acid motif of the human homologue of the yeast protein SRP1. Proc. Natl. Acad. Sci. USA 91:7633-7637.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 7633-7637
    • Cortes, P.1    Ye, Z.-S.2    Baltimore, D.3
  • 10
    • 0028239241 scopus 로고
    • Rch1, a protein that specifically interacts with the RAG-1 recombination-activating protein
    • Cuomo, C. A., S. A. Kirch, J. Gyuris, R. Brent, and M. A. Ottinger. 1994. Rch1, a protein that specifically interacts with the RAG-1 recombination-activating protein. Proc. Natl. Acad. Sci. USA 91:6156-6160.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 6156-6160
    • Cuomo, C.A.1    Kirch, S.A.2    Gyuris, J.3    Brent, R.4    Ottinger, M.A.5
  • 11
    • 0027193431 scopus 로고
    • Regulation of HIV-1 production by blood mononuclear cells from HIV-infected donors: HIV-1 production depends on T cell-monocyte interaction
    • Diegel, M. L., P. A. Moran, L. K. Gilliland, N. K. Damle, M. S. Hayden, J. M. Zarling, and J. A. Ledbetter. 1993. Regulation of HIV-1 production by blood mononuclear cells from HIV-infected donors: HIV-1 production depends on T cell-monocyte interaction. AIDS Res. Hum. Retroviruses 9:465-473.
    • (1993) AIDS Res. Hum. Retroviruses , vol.9 , pp. 465-473
    • Diegel, M.L.1    Moran, P.A.2    Gilliland, L.K.3    Damle, N.K.4    Hayden, M.S.5    Zarling, J.M.6    Ledbetter, J.A.7
  • 12
    • 0029171804 scopus 로고
    • Nuclear localization signal of HIV-1 as a novel target for therapeutic intervention
    • Dubrovsky, L., P. Ulrich, G. J. Nuovo, K. R. Manogue, A. Cerami, and M. Bukrinsky. 1995. Nuclear localization signal of HIV-1 as a novel target for therapeutic intervention. Mol. Med. 1:217-230.
    • (1995) Mol. Med. , vol.1 , pp. 217-230
    • Dubrovsky, L.1    Ulrich, P.2    Nuovo, G.J.3    Manogue, K.R.4    Cerami, A.5    Bukrinsky, M.6
  • 14
    • 0030747461 scopus 로고    scopus 로고
    • HIV-1 infection of non-dividing cells: Evidence that the amino-terminal basic region of the viral matrix protein is important for gag processing but not for post-entry nuclear import
    • Fouchier, R. A. M., B. E. Meyer, J. H. M. Simon, U. Fischer, and M. H. Malim. 1997. HIV-1 infection of non-dividing cells: evidence that the amino-terminal basic region of the viral matrix protein is important for gag processing but not for post-entry nuclear import. EMBO J. 16:4531-4539.
    • (1997) EMBO J. , vol.16 , pp. 4531-4539
    • Fouchier, R.A.M.1    Meyer, B.E.2    Simon, J.H.M.3    Fischer, U.4    Malim, M.H.5
  • 15
    • 0030987672 scopus 로고    scopus 로고
    • HIV-1 infection of non-dividing cells through the recognition of integrase by the importin/ karyopherin pathway
    • Gallay, P., T. Hope, D. Chin, and D. Trono. 1997. HIV-1 infection of non-dividing cells through the recognition of integrase by the importin/ karyopherin pathway. Proc. Natl. Acad. Sci. USA 94:9825-9830.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 9825-9830
    • Gallay, P.1    Hope, T.2    Chin, D.3    Trono, D.4
  • 16
    • 0030065395 scopus 로고    scopus 로고
    • Role of the karyopherin pathway in human immunodeficiency virus type 1 nuclear import
    • Gallay, P., V. Stitt, C. Mundy, M. Oettinger, and D. Trono. 1996. Role of the karyopherin pathway in human immunodeficiency virus type 1 nuclear import. J. Virol. 70:1027-1032.
    • (1996) J. Virol. , vol.70 , pp. 1027-1032
    • Gallay, P.1    Stitt, V.2    Mundy, C.3    Oettinger, M.4    Trono, D.5
  • 18
    • 0022517187 scopus 로고
    • Tropism of sheep lentiviruses for monocytes: Susceptibility to infection and virus gene expression increase during maturation of monocytes to macrophages
    • Gendelman, H. E., O. Narayan, S. Kennedy-Stoskopf, P. G. E. Kennedy, Z. Ghotbi, J. E. Clements, J. Stanley, and G. Pezeshkpour. 1986. Tropism of sheep lentiviruses for monocytes: susceptibility to infection and virus gene expression increase during maturation of monocytes to macrophages. J. Virol. 58:67-74.
    • (1986) J. Virol. , vol.58 , pp. 67-74
    • Gendelman, H.E.1    Narayan, O.2    Kennedy-Stoskopf, S.3    Kennedy, P.G.E.4    Ghotbi, Z.5    Clements, J.E.6    Stanley, J.7    Pezeshkpour, G.8
  • 19
    • 0029984570 scopus 로고    scopus 로고
    • Nucleocytoplasmic transport
    • Görlich, D., and J. W. Mattaj. 1996. Nucleocytoplasmic transport. Science 271:1513-1518.
    • (1996) Science , vol.271 , pp. 1513-1518
    • Görlich, D.1    Mattaj, J.W.2
  • 20
    • 0029059548 scopus 로고
    • Distinct functions for the two importin subunits in nuclear protein import
    • Görlich, D., F. Vogel, A. D. Mills, E. Hartmann, and R. A. Laskey. 1995. Distinct functions for the two importin subunits in nuclear protein import. Nature (London) 377:246-248.
    • (1995) Nature (London) , vol.377 , pp. 246-248
    • Görlich, D.1    Vogel, F.2    Mills, A.D.3    Hartmann, E.4    Laskey, R.A.5
  • 21
    • 0026073237 scopus 로고
    • Non-mitogenic T cell activation signals are sufficient for induction of human immunodeficiency virus transcription
    • Gruters, R. A., S. A. Otto, B. J. M. Al, A. J. Verhoeven, R. A. W. Van Lier, and F. Miedema. 1991. Non-mitogenic T cell activation signals are sufficient for induction of human immunodeficiency virus transcription. Eur. J. Immunol. 21:167-172.
    • (1991) Eur. J. Immunol. , vol.21 , pp. 167-172
    • Gruters, R.A.1    Otto, S.A.2    Al, B.J.M.3    Verhoeven, A.J.4    Van Lier, R.A.W.5    Miedema, F.6
  • 22
    • 0028089334 scopus 로고
    • Reduced nuclear import of human immunodeficiency virus type 1 preintegration complexes in the presence of a prototypic nuclear targeting signal
    • Gulizia, J., M. P. Dempsey, N. Sharova, M. I. Bukrinsky, L. Spitz, D. Goldfarb, and M. Stevenson. 1994. Reduced nuclear import of human immunodeficiency virus type 1 preintegration complexes in the presence of a prototypic nuclear targeting signal. J. Virol. 68:2021-2025.
    • (1994) J. Virol. , vol.68 , pp. 2021-2025
    • Gulizia, J.1    Dempsey, M.P.2    Sharova, N.3    Bukrinsky, M.I.4    Spitz, L.5    Goldfarb, D.6    Stevenson, M.7
  • 25
    • 0030030578 scopus 로고    scopus 로고
    • Importins/karyopherins meet nucleoporins
    • Hurt, E. C. 1996. Importins/karyopherins meet nucleoporins. Cell 84:509-515.
    • (1996) Cell , vol.84 , pp. 509-515
    • Hurt, E.C.1
  • 28
    • 0026654682 scopus 로고
    • Human immunodeficiency virus infection of cells arrested in the cell cycle
    • Lewis, P., M. Hensel, and M. Emerman. 1992. Human immunodeficiency virus infection of cells arrested in the cell cycle. EMBO J. 11:3053-3058.
    • (1992) EMBO J. , vol.11 , pp. 3053-3058
    • Lewis, P.1    Hensel, M.2    Emerman, M.3
  • 29
    • 0028055281 scopus 로고
    • Passage through mitosis is required for oncoretroviruses but not for the human immunodeficiency virus
    • Lewis, P. F., and M. Emerman. 1994. Passage through mitosis is required for oncoretroviruses but not for the human immunodeficiency virus. J. Virol. 68:510-516.
    • (1994) J. Virol. , vol.68 , pp. 510-516
    • Lewis, P.F.1    Emerman, M.2
  • 30
    • 0029008045 scopus 로고
    • In vivo estimates of division and death rates of human T lymphocytes
    • McLean, A. R., and C. A. Michie. 1995. In vivo estimates of division and death rates of human T lymphocytes. Proc. Natl. Acad. Sci. USA 92:3707-3711.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 3707-3711
    • McLean, A.R.1    Michie, C.A.2
  • 31
    • 0028832520 scopus 로고
    • GTP hydrolysis by Ran occurs at the nuclear pore complex in an early step of protein import
    • Melchior, F., T. Guan, N. Yokoyama, T. Nishimoto, and L. Gerace. 1995. GTP hydrolysis by Ran occurs at the nuclear pore complex in an early step of protein import. J. Cell Biol. 131:571-581.
    • (1995) J. Cell Biol. , vol.131 , pp. 571-581
    • Melchior, F.1    Guan, T.2    Yokoyama, N.3    Nishimoto, T.4    Gerace, L.5
  • 32
    • 0027376308 scopus 로고
    • The GTP-binding protein Ran/TC4 is required for protein import into the nucleus
    • Moore, M. S., and G. Blobel. 1993. The GTP-binding protein Ran/TC4 is required for protein import into the nucleus. Nature 365:661-663.
    • (1993) Nature , vol.365 , pp. 661-663
    • Moore, M.S.1    Blobel, G.2
  • 33
    • 0028170744 scopus 로고
    • Purification of Ran-interacting protein that is required for protein import into the nucleus
    • Moore, M. S., and G. Blobel. 1994. Purification of Ran-interacting protein that is required for protein import into the nucleus. Proc. Natl. Acad. Sci. USA 91:10212-10216.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 10212-10216
    • Moore, M.S.1    Blobel, G.2
  • 34
    • 0027194938 scopus 로고
    • Regulation of HIV-1 production by blood mononuclear cells from HIV-infected donors. I. Lack of correlation between HIV-1 production and cell activation
    • Moran, P. A., M. L. Diegel, J. C. Sias, J. A. Ledbetter, and J. M. Zarling. 1993. Regulation of HIV-1 production by blood mononuclear cells from HIV-infected donors. I. Lack of correlation between HIV-1 production and cell activation. AIDS Res. Hum. Retroviruses 9:455-464.
    • (1993) AIDS Res. Hum. Retroviruses , vol.9 , pp. 455-464
    • Moran, P.A.1    Diegel, M.L.2    Sias, J.C.3    Ledbetter, J.A.4    Zarling, J.M.5
  • 35
    • 0028962511 scopus 로고
    • Previously identified protein of uncertain function is karyopherin α and together with karyopherin β docks import substrate at the nuclear pore complex
    • Moroianu, J., G. Blobel, and A. Radu. 1995. Previously identified protein of uncertain function is karyopherin α and together with karyopherin β docks import substrate at the nuclear pore complex. Proc. Natl. Acad. Sci. USA 92:2008-2011.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 2008-2011
    • Moroianu, J.1    Blobel, G.2    Radu, A.3
  • 36
    • 0031040797 scopus 로고    scopus 로고
    • Differential expression and sequence-specific interaction of karyopherin α with nuclear localization sequences
    • Nadler, S. G., D. Tritschler, O. K. Haffar, J. Blake, A. G. Bruce, and J. S. Cleaveland. 1997. Differential expression and sequence-specific interaction of karyopherin α with nuclear localization sequences. J. Biol. Chem. 272: 4310-4315.
    • (1997) J. Biol. Chem. , vol.272 , pp. 4310-4315
    • Nadler, S.G.1    Tritschler, D.2    Haffar, O.K.3    Blake, J.4    Bruce, A.G.5    Cleaveland, J.S.6
  • 37
    • 0030964105 scopus 로고    scopus 로고
    • Nucleocytoplasmic transport: Signals, mechanisms, and regulation
    • Nigg, E. A. 1997. Nucleocytoplasmic transport: signals, mechanisms, and regulation. Nature 386:779-787.
    • (1997) Nature , vol.386 , pp. 779-787
    • Nigg, E.A.1
  • 38
    • 0028979910 scopus 로고
    • NPI-1, the human homologue of SRP-1, interacts with influenza virus nucleoprotein
    • O'Neill, R. E., and P. Palese. 1995. NPI-1, the human homologue of SRP-1, interacts with influenza virus nucleoprotein. Virology 206:116-125.
    • (1995) Virology , vol.206 , pp. 116-125
    • O'Neill, R.E.1    Palese, P.2
  • 39
    • 0029027836 scopus 로고
    • Identification of NTF2, a cytosolic factor for nuclear protein import that interacts with nuclear pore complex protein p62
    • Paschal, B. M., and L. Gerace. 1995. Identification of NTF2, a cytosolic factor for nuclear protein import that interacts with nuclear pore complex protein p62. J. Cell Biol. 129:925-937.
    • (1995) J. Cell Biol. , vol.129 , pp. 925-937
    • Paschal, B.M.1    Gerace, L.2
  • 42
    • 0028950991 scopus 로고
    • Identification of a protein complex that is required for nuclear protein import and mediates docking of import substrate to distinct nucleoporins
    • Radu, A., G. Blobel, and M. S. Moore. 1995. Identification of a protein complex that is required for nuclear protein import and mediates docking of import substrate to distinct nucleoporins. Proc. Natl. Acad. Sci. USA 92: 1769-1773.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 1769-1773
    • Radu, A.1    Blobel, G.2    Moore, M.S.3
  • 44
    • 0027158091 scopus 로고
    • Integration of murine leukemia virus DNA depends on mitosis
    • Roe, T. Y., T. C. Reynolds, G. Yu., and P. O. Brown. 1993. Integration of murine leukemia virus DNA depends on mitosis. EMBO J. 12:2099-2108.
    • (1993) EMBO J. , vol.12 , pp. 2099-2108
    • Roe, T.Y.1    Reynolds, T.C.2    Yu, G.3    Brown, P.O.4
  • 45
    • 0028813107 scopus 로고
    • The human immunodeficiency virus type 1 vpr gene prevents cell proliferation during chronic infection
    • Rogel, M. E., L. I. Wu, and M. Emerman. 1995. The human immunodeficiency virus type 1 vpr gene prevents cell proliferation during chronic infection. J. Virol. 69:882-888.
    • (1995) J. Virol. , vol.69 , pp. 882-888
    • Rogel, M.E.1    Wu, L.I.2    Emerman, M.3
  • 46
    • 0029868970 scopus 로고    scopus 로고
    • IL-7 upregulates HIV-1 replication in naturally infected peripheral blood mononuclear cells
    • Smithgall, M. D., J. G. P. Wong, K. E. Critchett, and O. K. Haffar. 1996. IL-7 upregulates HIV-1 replication in naturally infected peripheral blood mononuclear cells. J. Immunol. 156:2324-2330.
    • (1996) J. Immunol. , vol.156 , pp. 2324-2330
    • Smithgall, M.D.1    Wong, J.G.P.2    Critchett, K.E.3    Haffar, O.K.4
  • 48
    • 0028958338 scopus 로고
    • Establishment of a stable, inducible form of human immunodeficiency virus type 1 DNA in quiescent CD4 lymphocytes in vitro
    • Spina, C. A., J. C. Guatelli, and D. D. Richman. 1995. Establishment of a stable, inducible form of human immunodeficiency virus type 1 DNA in quiescent CD4 lymphocytes in vitro. J. Virol. 69:2977-2988.
    • (1995) J. Virol. , vol.69 , pp. 2977-2988
    • Spina, C.A.1    Guatelli, J.C.2    Richman, D.D.3
  • 49
    • 0025238945 scopus 로고
    • HIV-1 replication is controlled at the level of T cell activation and proviral integration
    • Stevenson, M., T. L. Stanwick, M. P. Dempsey, and C. A. Lamonica. 1990. HIV-1 replication is controlled at the level of T cell activation and proviral integration. EMBO J. 9:1551-1560.
    • (1990) EMBO J. , vol.9 , pp. 1551-1560
    • Stevenson, M.1    Stanwick, T.L.2    Dempsey, M.P.3    Lamonica, C.A.4
  • 50
    • 0028234528 scopus 로고
    • The nuclear localization signal of the matrix protein of human immunodeficiency virus type 1 allows the establishment of infection in macrophages and quiescent T lymphocytes
    • von Schwedler, U., R. S. Kornbluth, and U. Trono. 1994. The nuclear localization signal of the matrix protein of human immunodeficiency virus type 1 allows the establishment of infection in macrophages and quiescent T lymphocytes. Proc. Natl. Acad. Sci. USA 91:6992-6996.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 6992-6996
    • Von Schwedler, U.1    Kornbluth, R.S.2    Trono, U.3
  • 51
    • 0028988731 scopus 로고
    • Identification of hSRP1 α as a functional receptor for nuclear localization sequences
    • Weis, K., I. W. Mattaj, and A. I. Lamond. 1995. Identification of hSRP1 α as a functional receptor for nuclear localization sequences. Science 268:1049-1053.
    • (1995) Science , vol.268 , pp. 1049-1053
    • Weis, K.1    Mattaj, I.W.2    Lamond, A.I.3
  • 52
    • 0031026336 scopus 로고    scopus 로고
    • TCR-independent CD28-mediated gene expression in peripheral blood lymphocytes from donors chronically infected with HIV-1
    • Wong, J. G. P., M. D. Smithgall, and O. K. Haffar. 1997. TCR-independent CD28-mediated gene expression in peripheral blood lymphocytes from donors chronically infected with HIV-1. Immunology 90:281-285.
    • (1997) Immunology , vol.90 , pp. 281-285
    • Wong, J.G.P.1    Smithgall, M.D.2    Haffar, O.K.3
  • 53
    • 0025342694 scopus 로고
    • HIV-1 entry into quiescent primary lymphocytes: Molecular analysis reveals a labile, latent viral structure
    • Zack, J. A., S. J. Arrigo, S. R. Weitsman, A. S. Go, A. Haislip, and I. S. Y. Chen. 1990. HIV-1 entry into quiescent primary lymphocytes: molecular analysis reveals a labile, latent viral structure. Cell 61:213-222.
    • (1990) Cell , vol.61 , pp. 213-222
    • Zack, J.A.1    Arrigo, S.J.2    Weitsman, S.R.3    Go, A.S.4    Haislip, A.5    Chen, I.S.Y.6


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