Vitamin D action: Lessons learned from genetic mouse models

Annals of the New York Academy of Sciences

Volumn 1192, Issue , 2010, Pages 145-152

  Goltzman, David ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

Bone; Calcium; Extraskeletal vitamin D action; Genetic mouse models; Vitamin D

Indexed keywords

CALCIDIOL 1 MONOOXYGENASE; CALCITRIOL; CALCIUM; PHOSPHORUS; VITAMIN D; VITAMIN D RECEPTOR;

BLOOD PRESSURE; BONE DEVELOPMENT; CALCIUM METABOLISM; CONFERENCE PAPER; GENE DELETION; GENETIC CODE; HEART VENTRICLE HYPERTROPHY; HOMEOSTASIS; MINERALIZATION; NONHUMAN; OSSIFICATION; OSTEOBLAST; PARATHYROID GLAND; PHENOTYPE; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM;

MUS;

EID: 77950633900     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2009.05226.x     Document Type: Conference Paper

References (40)

1. Jones, G. et al. 1998. Current understanding of the molecular actions of vitamin D. Physiol. Rev. 78: 1193-1231.
2. Brenza, H.L. et al. 2000. Regulation of 25- hydroxyvitamin D3 1alpha-hydroxylase gene expression byparathyroid hormone and 1,25-dihydroxyvitamin D3. Arch. Biochem. Biophys. 381: 143-152.
3. Bai, X. et al. 2004. Transgenic mice overexpressing human fibroblast growth factor 23 (R176Q) delineate a putative role for parathyroid hormone in renal phosphate wasting disorders. Endocrinology 145: 5269-5279
4. Dusso, A.S. et al. 1997. γ-Interferon-induced resistance to 1,25-(OH)2D3 in human monocytes and macrophages: a mechanism for the hypercalcemia of various granulomatoses. J. Clin. Endocrinol. Metab. 82: 2222-2232
5. Adams, J.S. et al. 2004. Response element binding proteins and intracellular vitamin D binding proteins: novel regulators of vitamin D trafficking, action and metabolism. J. Steroid Biochem. Mol. Biol. 89-90: 461-465.
6. Haussler,M.R. et al. 2008. Vitamin D receptor: molecular signaling and actions of nutritional ligands in disease prevention. Nutr. Rev. 66(10 Suppl 2): S98-S112.
7. Glorieux, F.H. et al. 1998. Molecular cloning of (25-OH D)-1 alpha-hydroxylase: an approach to the understanding of vitamin D pseudo-deficiency. Recent Prog. Horm. Res. 53: 341-349
8. Liberman, U.A. 2007. Vitamin D-resistant diseases. J. Bone Miner. Res. 22(Suppl 2): V105-V107.
9. Panda, D.K. et al. 2001. Targeted ablation of the 25- hydroxyvitaminD1alpha-hydroxylase enzyme: evidence for skeletal, reproductive, and immune dysfunction. Proc. Natl. Acad. Sci. USA 98: 7498-7503.
10. Dardenne, O. et al. 2001. Targeted inactivation of the 25-hydroxyvitamin D(3)-1(alpha)-hydroxylase gene (CYP27B1) creates an animal model of pseudovitamin D-deficiency rickets. Endocrinology 142: 3135-3141.
11. Yoshizawa, T. et al. 1997. Mice lacking the vitamin D receptor exhibit impaired bone formation,uterine hypoplasia and growth retardation after weaning. Nat. Genet. 16: 391-396.
12. Li, Y.C. et al. 1997. Targeted ablation of the vitamin D receptor: an animal model of vitamin D-dependent rickets type II with alopecia. Proc. Natl. Acad. Sci. USA 94: 9831-9835.
13. Van Cromphaut, S.J. et al. 2001. Duodenal calcium absorption in vitamin D receptor-knockout mice: functional and molecular aspects. Proc. Natl. Acad. Sci. USA 98: 13324-13329.
14. Erben, R.G. et al. 2002. Deletion of deoxyribonucleic acid binding domain of the vitaminDreceptor abrogates genomic and nongenomic functions of vitamin D. Mol. Endocrinol. 16: 1524-1537
15. Panda, D.K. et al. 2004. Inactivation of the 25- hydroxyvitamin D 1α -hydroxylase and vitamin D receptor demonstrates independent and interdependent effects of calcium and vitamin D on skeletal and mineral homeostasis. J. Biol. Chem. 279: 16754-16766
16. Dardenne, O. et al. 2003. Rescue of the pseudo-Vitamin D deficiency rickets phenotype of CYP27B1-deficient mice by treatment with 1,25-dihydroxyVitamin D3: biochemical, histomorphometric, and biomechanical analyses. J. Bone Miner. Res. 18: 637-643.
17. Bouillon, R. et al. 1995. Structure-function relationships in the Vitamin D endocrine system. Endocr. Rev. 6: 200-257
18. Sutton, A.I. et al. 2003. Vitamin D: more than a "bonea- fide" hormone. Molec. Endocrinol. 17: 777-791.
19. Brown, E.M. et al. 2001. Extracellular calcium sensing and extracellular calcium signaling. Physiol.Rev. 81: 239-297.
20. Habener, J.F. et al. 1984. Parathyroid hormone: biochemical aspects of biosynthesis, secretion, action, and metabolism. Physiol. Rev. 64: 985-1053.
21. Moallem, E. et al. 1998. RNA protein binding and posttranscriptional regulation of PTH gene expression by calcium and phosphate. J. Biol. Chem. 273: 5253-5259.
22. Kremer, R. et al. 1989. Influence of calcium and 1,25- dihydroxycholecalciferol on proliferation and protooncogene expression in primary cultures of bovine parathyroid cells. Endocrinology 125: 935-941.
23. Russell, J. et al. 1984. The effects of calcium and Vitamin D metabolites on cytoplasmic mRNA coding for preproparathyroid hormone in isolated parathyroid cells. Trans. Assoc. Am. Phys. 97: 296-303.
24. Amling, M. et al. 1999. Rescue of the skeletal phenotype of vitamin D receptor-ablated mice in the setting of normal mineral ion homeostasis: formal histomorphometric and biomechanical analyses. Endocrinology 140: 4982-4987.
25. Dardenne, O. et al. 2003. Correction of the abnormal mineral ion homeostasis with a high-calcium, highphosphorus, high-lactose diet rescues the PDDR phenotype of mice deficient for the 25-hydroxyvitamin D- 1alpha-hydroxylase (CYP27B1). Bone 32: 332-340.
26. Van Leeuwen, J.P. et al. 2001. Vitamin D control of osteoblast function and bone extracellular matrix mineralization. Crit. Rev. Eukaryot. Gene Expr. 11: 199-226.
27. Xue, Y. et al. 2005. Genetic models show that parathyroid hormone and 1,25-dihydroxyvitamin D3 playdistinct and synergistic roles in postnatal mineral ion homeostasis and skeletal development. Hum. Mol. Genet. 14: 1515-1528.
28. Xue, Y. et al. 2006. Exogenous 1,25-dihydroxyvitamin D3 exerts a skeletal anabolic effect and improves mineral ion homeostasis in mice that are homozygous for both the 1alpha-hydroxylase and parathyroid hormone null alleles. Endocrinology 147: 4801-4810.
29. Suda T. et al. 2003. Vitamin D and bone. J. Cell Biochem. 88: 259-266.
30. Pike, J.W. 1991. Vitamin D3 receptors: structure and function in transcription. Annu. Rev. Nutr. 11: 189-216
31. White, J.H. 2004. Profiling 1,25-dihydroxyvitamin D3- regulated gene expression by microarray analysis. J. Steroid Biochem. Mol. Biol. 89-90: 239-244
32. Bouillon, R. et al. 2008. Vitamin D and health: perspectives frommice and man. J. BoneMiner.Res. 23: 974-979.
33. Hewison, M. et al. 2005. Extra-renal 1α -hydroxylase activity and human disease. In Vitamin D, 2nd ed. D. Feldman, J.W.Pike&F.H. Glorieux,Eds.: 1379-1402. Elsevier Academic Press. New York.
34. Teng, M. et al. 2005. Activated injectable vitamin D and hemodialysis survival: a historical cohort study. J. Am. Soc. Nephrol. 16: 1115-1125.
35. Autier, P. et al. 2007.VitaminDsupplementation and total mortality: a meta-analysis of randomized controlled trials. Arch. Intern. Med. 167: 1730-1737.
36. Yu, S. et al. 2008. The vitamin D receptor is required for iNKT cell development. Proc. Natl. Acad. Sci. USA 105: 5207-5212.
37. Zinser, G.M. et al. 2005. Vitamin D receptor (VDR) ablation alters carcinogen-induced tumorigenesis in mammary gland, epidermis and lymphoid tissues. J. Steroid Biochem. Mol. Biol. 97: 153-164.
38. Zeitz, U. et al. 2003. Impaired insulin secretory capacity in mice lacking a functional vitamin D receptor. FASEB J. 17: 509-511.
39. Li, Y.C. et al. 2002. 1,25-Dihydroxyvitamin D(3) is a negative endocrine regulator of the renin-angiotensin system. J. Clin. Invest. 110: 229-238.
40. Zhou, C. et al. 2008. Calcium-independent and 1,25(OH)2D3-dependent regulation of the reninangiotensin system in 1alpha-hydroxylase knockout mice. Kidney Int. 74: 170-179.