MeaA, a putative coenzyme B12-dependent mutase, provides methylmalonyl coenzyme A for monensin biosynthesis in Streptomyces cinnamonensis

Journal of Bacteriology

Volumn 183, Issue 6, 2001, Pages 2071-2080

  Zhang, W ^a   Reynolds, K A ^a  

^a ISBDD   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COBAMAMIDE; GENE PRODUCT; METHYLMALONYL COENZYME A MUTASE; METHYLMALONYLCOENZYME A; MONENSIN; MONENSIN A; MONENSIN B; MONENSIN DERIVATIVE; MUTASE; PROTEIN MEAA; UNCLASSIFIED DRUG;

AMINO ACID METABOLISM; AMINO ACID SEQUENCE; ANTIBIOTIC RESISTANCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; ENZYME STRUCTURE; GENE EXPRESSION; NONHUMAN; NUCLEOTIDE SEQUENCE; PLASMID; PRIORITY JOURNAL; PROTEIN SYNTHESIS; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY; STREPTOMYCES; STREPTOMYCES CINNAMONEUS; STRUCTURE ANALYSIS;

ACETOACETATES; ACYL COENZYME A; BACTERIAL PROTEINS; CARBON RADIOISOTOPES; CLONING, MOLECULAR; COBAMIDES; FATTY ACIDS; GENE DELETION; ISOMERASES; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR SEQUENCE DATA; MONENSIN; PLASMIDS; SEQUENCE ANALYSIS, DNA; STREPTOMYCES; VALINE;

ACTINOBACTERIA (CLASS); AMYCOLATOPSIS MEDITERRANEI; STREPTOMYCES CINNAMONENSIS; STREPTOMYCES CINNAMONEUS; UNCULTURED ACTINOMYCETE;

EID: 0035107077     PISSN: 00219193     EISSN: None     Source Type: Journal    
DOI: 10.1128/JB.183.6.2071-2080.2001     Document Type: Article

References (51)

1. pBluescript II: Gene mapping vectors
2. Biosynthesis of the ansamycin antibiotic rifamycin: Deductions from the molecular analysis of the rif biosynthetic gene cluster of Amycolatopsis mediterranei S699
3. Determination of monensin A and B in the fermentation broth of Streptomyces cinnamonensis by high performance liquid chromatograph
4. Gene expression in Streptomyces: Construction and application of promoter-probe plasmid vectors in Streptomyces lividans
5. Plasmid cloning vectors for the conjugal transfer of DNA from Escherichia coli to Streptomyces spp.
6. Cloning, sequencing, and expression of the gene encoding methylmalonyl-coenzyme A mutase from Streptomyces cinnamonensis
7. Propionyl-CoA carboxylase from Streptomyces coelicolor A3(2): Cloning of the gene encoding the biotin-containing subunit
8. XL1-Blue: A high efficiency plasmid transforming recA Escherichia coli strain with beta-galactosidase selection
9. Molecular characterization of a chromosomal region involved in the oxidation of acetyl-CoA to glyoxylate in the isocitrate-lyase-negative methylotroph Methylobacterium extorquens AM1
10. Fatty-acid biosynthesis in a branched-chain alpha-keto acid dehydrogenase mutant of Streptomyces avermitilis
11. Modular organization of genes required for complex polyketide biosynthesis
12. Erythromycin production in Saccharopolyspora erythraea does not require a functional propionyl-CoA carboxylase
13. 12-binding domains of methionine synthase
14. Monensin, a new biologically active compound. V. Compounds related to monensin
15. A novel alternate anaplerotic pathway to the glyoxylate cycle in Streptomyces
16. An acyl-coenzyme A carboxylase encoding gene associated with jadomycin biosynthesis in Streptomyces venezuelae ISP5230
17. Studies on transformation of Escherichia coli with plasmids
18. Multiple acyl-coenzyme A carboxylases in Pseudomonas citronellolis
19. Genetic contributions to understanding polyketide synthases
20. Source of methylmalonyl-coenzyme A for erythromycin synthesis: Methylmalonyl-coenzyme A mutase from Streptomyces erythreus
21. Isolation and characterization of an acyl-coenzyme A carboxylase from an erythromycin-producing Streptomyces erythreus
22. Cloning, sequencing, overexpression in Escherichia coli, and inactivation of the valine dehydrogenase gene in the polyether antibiotic producer Streptomyces cinnamonensis
23. Role of crotonyl coenzyme A reductase in determining the ratio of polyketides monensin A and monensin B produced by Streptomyces cinnamonensis
24. Analysis of Streptomyces avermitilis genes required for avermectin biosynthesis utilizing a novel intergration vector
25. 12 radicals are generated: The crystal structure of methylmalonyl-coenzyme A mutase at 2 Å resolution
26. Cloning and structural characterization of the genes coding for adenosylcobalamin-dependent methylmalonyl-CoA mutase from Propionibacterium shermanii
27. 12 (cobalamin)-dependent enzymes
28. Denaturation of circular or linear DNA facilitates targeted intergrative transformation of Streptomyces coelicolor A3(2): Possible relevance to other organisms
29. Valine as a precursor of n-butyrate unit in the biosynthesis of macrolide aglycone
30. Ammonium ions suppress the amino acid metabolism involved in the biosynthesis of protylonolide in a mutant of Streptomyces fradiae
31. Effect of ammonium ion, inorganic phosphate and amino acids on the biosynthesis of protylonolide, a precursor of tylosin aglycone
32. 12-binding domain of isobutyryl-CoA mutase from Streptomyces cinnamonensis, reconstitution of mutase activity, and characterization of the recombinant enzyme produced in Escherichia coli
33. Butyrate metabolism in streptomycetes. Characterization of an intramolecular vicinal interchange rearrangement linking isobutyrate and n-butyrate in Streptomyces cinnamonensis
34. Genetic and biochemical characterization of the alpha and beta components of a propionyl-CoA carboxylase complex of Streptomyces coelicolor A3(2)
35. A protein having similarity with methylmalonyl-CoA mutase is required for the assimilation of methanol and ethanol by Methylobacterium extorquens AMI
36. Molecular analysis of the anaerobic succinate degradation pathway in Clostridium kluyveri
37. Ethyl-substituted erythromycin derivatives produced by directed metabolic engineering
38. Compilation and analysis of DNA sequences associated with apparent streptomycete promoters
39. Sequence, transcriptional, and functional analyses of the valine (branched-chain amino acid) dehydrogenase gene of Streptomyces coelicolor
40. Amino acid catabolism and antibiotic synthesis: Valine is a source of precursors for macrolide biosynthesis in Streptomyces ambofaciens and Streptomyces fradiae
41. Mechanistic and structural studies on methylmalonyl-CoA mutase
42. Insertional inactivation of methylmalonyl coenzyme A (CoA) mutase and isobutyryl-CoA mutase genes in Streptomyces cinnamonensis: Influence on polyketide antibiotic biosynthesis
43. In vivo analysis of straight-chain and branched-chain fatty acid biosynthesis in three actinomycetes
44. Identification of a gene required for the terminal step in erythromycin A biosynthesis in Saccharopolyspora erythraea (Streptomyces erythreus)
45. Primary structure and activity of mouse methylmalonyl-CoA mutase
46. 12-dependent isobutyryl-CoA mutase from Streptomyces cinnamonensis
47. Molecular analysis and heterologous expression of the gene encoding methylmalonyl-CoA mutase from a rifamycin SV-producing Amycolatopsis mediterranei U32
48. Cloning and characterization of genes encoding acyl-CoA dehydrogenase (AcdH) homologs from Streptomyces coelicolor and Streptomyces avermitilis
49. Miniprep in 10 minutes