Functional interactions between cytochromes P450 1A2 and 2B4 require both enzymes to reside in the same phospholipid vesicle: Evidence for physical complex formation

Journal of Biological Chemistry

Volumn 285, Issue 12, 2010, Pages 8942-8952

  Reed, James R ^a   Eyer, Marilyn ^a   Backes, Wayne L ^a  

^a LOUISIANA STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEX FORMATIONS; CYTOCHROME P450; CYTOCHROMES P450; FUNCTIONAL INTERACTION; IMMUNOPRECIPITATES; LIPID VESICLES; NADPH-CYTOCHROME P450 REDUCTASE; PHOSPHOLIPID VESICLES; PHYSICAL INTERACTIONS; REDUCTION RATE;

CATALYSTS; ENZYMES; LIPOSOMES; METABOLISM; PHOSPHOLIPIDS; TERNARY SYSTEMS;

COMPLEXATION;

CYTOCHROME P450; CYTOCHROME P450 1A2; CYTOCHROME P450 2B4; PHOSPHOLIPID; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE FERRIHEMOPROTEIN REDUCTASE; CROSS LINKING REAGENT; CYTOCHROME P 450 CYP2B4 (RABBIT); CYTOCHROME P-450 CYP2B4 (RABBIT); ISOPROTEIN; PHOSPHATIDYLCHOLINE; UNSPECIFIC MONOOXYGENASE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CROSS LINKING; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME LOCALIZATION; ENZYME METABOLISM; IMMUNOPRECIPITATION; LIPID VESICLE; LIVER MICROSOME; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; RABBIT; ANIMAL; CATTLE; CHEMISTRY; ENZYME SPECIFICITY; GEL CHROMATOGRAPHY; METABOLISM; TIME; TRANSPORT AT THE CELLULAR LEVEL;

ANIMALS; ARYL HYDROCARBON HYDROXYLASES; BIOLOGICAL TRANSPORT; CATTLE; CHROMATOGRAPHY, GEL; CROSS-LINKING REAGENTS; CYTOCHROME P-450 CYP1A2; IMMUNOPRECIPITATION; MICROSOMES, LIVER; PHOSPHATIDYLCHOLINES; PHOSPHOLIPIDS; PROTEIN ISOFORMS; RABBITS; SUBSTRATE SPECIFICITY; TIME FACTORS;

EID: 77950578788     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.076885     Document Type: Article

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